{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:55:49Z","timestamp":1789354549466,"version":"build-2803163510"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1093\/brain\/awt239","type":"journal-article","created":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T20:51:13Z","timestamp":1379191873000},"page":"3062-3075","source":"Crossref","is-referenced-by-count":91,"title":["Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation"],"prefix":"10.1093","volume":"136","author":[{"given":"Hayriye","family":"Cagnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Stuart","family":"Brittain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Foltynie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Limousin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvic","family":"Zrinzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Hariz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Joint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tipu","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"key\n\t\t\t\t20170405114658_awt239-B1","doi-asserted-by":"crossref","first-page":"037112","DOI":"10.1063\/1.2952447","article-title":"External periodic driving of large systems of globally coupled phase oscillators","volume":"18","author":"Antonsen","year":"2008","journal-title":"Chaos"},{"key":"key\n\t\t\t\t20170405114658_awt239-B2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1136\/jnnp.56.8.868","article-title":"Assessing tremor severity","volume":"56","author":"Bain","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170405114658_awt239-B3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00415-010-5773-3","article-title":"Deep brain stimulation in the nucleus ventralis intermedius in patients with essential tremor: habituation of tremor suppression","volume":"258","author":"Barbe","year":"2011","journal-title":"J Neurol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0006-8993(94)01402-4","article-title":"A 10-Hz rhythm reflects the organization of a brainstem network that specifically governs sympathetic nerve discharge","volume":"671","author":"Barman","year":"1995","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170405114658_awt239-B5","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/1531-8257(200009)15:5<919::AID-MDS1024>3.0.CO;2-0","article-title":"Irregular jerky tremor, myoclonus, and thalamus: a study using low-frequency stimulation","volume":"15","author":"Bejjani","year":"2000","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20170405114658_awt239-B6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0140-6736(91)91175-T","article-title":"Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus","volume":"337","author":"Benabid","year":"1991","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170405114658_awt239-B7","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1523\/JNEUROSCI.18-24-10464.1998","article-title":"Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type","volume":"18","author":"Bi","year":"1998","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B8","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.wneu.2011.12.013","article-title":"Reoperation after failed deep brain stimulation for essential tremor","volume":"78","author":"Blomstedt","year":"2012","journal-title":"World Neurosurg"},{"key":"key\n\t\t\t\t20170405114658_awt239-B9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.cub.2013.01.068","article-title":"Tremor suppression by rhythmic transcranial current stimulation","volume":"23","author":"Brittain","year":"2013","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3171\/jns.2004.101.1.0043","article-title":"Tremor cells in the human thalamus: differences among neurological disorders","volume":"101","author":"Brodkey","year":"2004","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20170405114658_awt239-B11","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/j.1460-9568.2009.06922.x","article-title":"Frequency-selectivity of a thalamocortical relay neuron during Parkinson\u2019s disease and deep brain stimulation: a computational study","volume":"30","author":"Cagnan","year":"2009","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B12","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/mds.20047","article-title":"Tremor induced by thalamic deep brain stimulation in patients with complex regional facial pain","volume":"19","author":"Constantoyannis","year":"2004","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20170405114658_awt239-B13","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1212\/WNL.54.4.14A","article-title":"The pathophysiology of essential tremor","volume":"54","author":"Deuschl","year":"2000","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170405114658_awt239-B14","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/16026","article-title":"Coincidence detection and changes of synaptic efficacy in spiny stellate neurons in rat barrel cortex","volume":"2","author":"Egger","year":"1999","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00004691-199603000-00004","article-title":"Central mechanisms of tremor","volume":"13","author":"Elble","year":"1996","journal-title":"J Clin Neurophysiol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B16","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1162\/neco.1996.8.5.979","article-title":"Type I membranes, phase resetting curves, and synchrony","volume":"8","author":"Ermentrout","year":"1996","journal-title":"Neural Comput"},{"key":"key\n\t\t\t\t20170405114658_awt239-B17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/416433a","article-title":"Spike-timing-dependent synaptic modification induced by natural spike trains","volume":"416","author":"Froemke","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170405114658_awt239-B18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0306-4522(98)00235-8","article-title":"High-frequency stimulation of the subthalamic nucleus suppresses experimental resting tremor in the monkey","volume":"88","author":"Gao","year":"1999","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170405114658_awt239-B19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1162\/neco.1995.7.2.307","article-title":"Synchrony in excitatory neural networks","volume":"7","author":"Hansel","year":"1995","journal-title":"Neural Comput"},{"key":"key\n\t\t\t\t20170405114658_awt239-B20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/brain\/83.2.337","article-title":"Physiological observations in stereotaxic operations in extrapyramidal motor disturbances","volume":"83","author":"Hassler","year":"1960","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170405114658_awt239-B21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0140-6736(00)04044-7","article-title":"Tremor-correlated cortical activity in essential tremor","volume":"357","author":"Hellwig","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170405114658_awt239-B22","first-page":"437","article-title":"Improving targeting in image-guided frame-based deep brain stimulation","volume":"67","author":"Holl","year":"2010","journal-title":"Neurosurgery"},{"key":"key\n\t\t\t\t20170405114658_awt239-B23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/jn.00527.2004","article-title":"Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits","volume":"93","author":"Hua","year":"2005","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/jnnp.64.2.273","article-title":"Thalamic neuronal activity correlated with essential tremor","volume":"64","author":"Hua","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170405114658_awt239-B25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1113\/jphysiol.1984.sp015153","article-title":"Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study","volume":"349","author":"Jahnsen","year":"1984","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1113\/jphysiol.1984.sp015154","article-title":"Ionic basis for the electro-responsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro","volume":"349","author":"Jahnsen","year":"1984","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.expneurol.2009.02.005","article-title":"Enhanced synchronization of thalamic theta band local field potentials in patients with essential tremor","volume":"217","author":"Kane","year":"2009","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/brain\/117.3.531","article-title":"Single unit analysis of the human ventral thalamic nuclear group tremor-related activity in functionally identified cells","volume":"117","author":"Lenz","year":"1994","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170405114658_awt239-B29","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1523\/JNEUROSCI.08-03-00754.1988","article-title":"Single unit analysis of the human ventral thalamic nuclear group: correlation of thalamic \u2018tremor cells\u2019 with the 3-6 Hz component of parkinsonian tremor","volume":"8","author":"Lenz","year":"1988","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1126\/science.275.5297.213","article-title":"Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs","volume":"275","author":"Markram","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170405114658_awt239-B31","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1212\/WNL.59.5.706","article-title":"The impact on Parkinson\u2019s disease of electrical parameter settings in STN stimulation","volume":"59","author":"Moro","year":"2002","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170405114658_awt239-B32","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/35046067","article-title":"Calcium stores regulate the polarity and input specificity of synaptic modification","volume":"408","author":"Nishiyama","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170405114658_awt239-B33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnhum.2012.00058","article-title":"Desynchronizing electrical and sensory coordinated reset neuromodulation","volume":"6","author":"Popovych","year":"2012","journal-title":"Front Hum Neurosci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/jnnp.71.2.215","article-title":"Deep brain stimulation of the subthalamic nucleus in Parkinson\u2019s disease: effects of variation in stimulation parameters","volume":"71","author":"Rizzone","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170405114658_awt239-B35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1023\/B:JCNS.0000025686.47117.67","article-title":"High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model","volume":"16","author":"Rubin","year":"2004","journal-title":"J Comput Neurosci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B36","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1126\/science.1824881","article-title":"Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons","volume":"251","author":"Silva","year":"1991","journal-title":"Science"},{"key":"key\n\t\t\t\t20170405114658_awt239-B37","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1098\/rstb.2009.0292","article-title":"Phase-response curves and synchronized neural networks","volume":"365","author":"Smeal","year":"2010","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/cne.902520103","article-title":"Localization of glutamic-acid-decarboxylase-immunoreactive axon terminals in the inferior olive of the rat, with special emphasis on anatomical relations between GABAergic synapses and dendrodendritic gap junctions","volume":"252","author":"Sotelo","year":"1986","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B39","volume-title":"Thalamic oscillations and signaling","author":"Steriade","year":"1990"},{"key":"key\n\t\t\t\t20170405114658_awt239-B40","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1460-9568.1995.tb00657.x","article-title":"Serotonin modulation of inferior olivary oscillations and synchronicity: a multiple-electrode study in the rat cerebellum","volume":"7","author":"Sugihara","year":"1995","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170405114658_awt239-B41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00422-003-0425-7","article-title":"A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations","volume":"89","author":"Tass","year":"2003","journal-title":"Biol Cybern"},{"key":"key\n\t\t\t\t20170405114658_awt239-B42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00422-005-0028-6","article-title":"Long-term anti-kindling effects of desynchronizing brain stimulation: a theoretical study","volume":"94","author":"Tass","year":"2006","journal-title":"Biol Cybern"},{"key":"key\n\t\t\t\t20170405114658_awt239-B43","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/ana.23663","article-title":"Coordinated reset has sustained aftereffects in Parkinsonian monkeys","volume":"72","author":"Tass","year":"2012","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170405114658_awt239-B44","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1212\/01.WNL.0000086371.78447.D2","article-title":"Deep brain stimulation of the VIM thalamic nucleus modifies several features of essential tremor","volume":"61","author":"Vaillancourt","year":"2003","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170405114658_awt239-B45","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00202766","article-title":"Simulation of GABA B -receptor-mediated K+ current in thalamocortical relay neurons: tonic firing, bursting, and oscillations","volume":"71","author":"Wallenstein","year":"1994","journal-title":"Biol Cybern"},{"key":"key\n\t\t\t\t20170405114658_awt239-B46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.physiol.64.092501.114547","article-title":"Short-term synaptic plasticity","volume":"64","author":"Zucker","year":"2002","journal-title":"Annu Rev Physiol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/136\/10\/3062\/11140565\/awt239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T23:47:59Z","timestamp":1563925679000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awt239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,1]]},"published-print":{"date-parts":[[2013,10]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awt239","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}