{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:33:32Z","timestamp":1791419612349,"version":"4.3.3"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1093\/brain\/awt355","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T20:46:27Z","timestamp":1390509987000},"page":"819-833","source":"Crossref","is-referenced-by-count":186,"title":["HTT-lowering reverses Huntington\u2019s disease immune dysfunction caused by NF\u03baB pathway dysregulation"],"prefix":"10.1093","volume":"137","author":[{"given":"Ulrike","family":"Tr\u00e4ger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Andre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Lahiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Magnusson-Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grueninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sirinathsinghji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Kahlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith L.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Hummerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Antoniou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian P.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Luthi-Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Lowdell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bj\u00f6rkqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Ostroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Aronin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Tabrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"key\n\t\t\t\t20170425182212_awt355-B1","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1189\/jlb.0909610","article-title":"TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes\/macrophages","volume":"87","author":"Alciato","year":"2010","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.178.2.669","article-title":"CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40","volume":"178","author":"Alderson","year":"1993","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425182212_awt355-B4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/exnr.1994.1031","article-title":"Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology","volume":"125","author":"Anderson","year":"1994","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease","volume":"4","author":"Andrew","year":"1993","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170425182212_awt355-B6","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nature07774","article-title":"Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation","volume":"458","author":"Aouadi","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170425182212_awt355-B7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.chembiol.2011.12.020","article-title":"TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease","volume":"19","author":"Baldo","year":"2012","journal-title":"Chem Biol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/BJ20040544","article-title":"Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology","volume":"382 (Pt 2)","author":"Beinke","year":"2004","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170425182212_awt355-B9","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1523\/JNEUROSCI.2126-08.2008","article-title":"Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner","volume":"28","author":"Benn","year":"2008","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B10","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease","volume":"205","author":"Bj\u00f6rkqvist","year":"2008","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425182212_awt355-B11","doi-asserted-by":"crossref","first-page":"18259","DOI":"10.1523\/JNEUROSCI.4008-12.2012","article-title":"Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington\u2019s disease","volume":"32","author":"Bouchard","year":"2012","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B12","first-page":"1202","article-title":"The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size","volume":"60","author":"Brinkman","year":"1997","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170425182212_awt355-B13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00401-012-1009-1","article-title":"Reduced astrocytic NF-\u03baB activation by laquinimod protects from cuprizone-induced demyelination","volume":"124","author":"Br\u00fcck","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B14","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1111\/j.1460-9568.2005.03985.x","article-title":"Akt is altered in an animal model of Huntington's disease and in patients","volume":"21","author":"Colin","year":"2005","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B15","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1056\/NEJMoa1104318","article-title":"Placebo-controlled trial of oral laquinimod for multiple sclerosis","volume":"366","author":"Comi","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170425182212_awt355-B16","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/pr0700753","article-title":"Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates","volume":"6","author":"Dalrymple","year":"2007","journal-title":"J Proteome Res"},{"key":"key\n\t\t\t\t20170425182212_awt355-B17","doi-asserted-by":"crossref","first-page":"17204","DOI":"10.1073\/pnas.0708285104","article-title":"Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits","volume":"104","author":"DiFiglia","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425182212_awt355-B18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.nbd.2011.12.019","article-title":"P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease","volume":"45","author":"Fan","year":"2012","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20170425182212_awt355-B19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170425182212_awt355-B20","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.immunol.16.1.111","article-title":"CD40 and CD154 in cell-mediated immunity","volume":"16","author":"Grewal","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nmeth779","article-title":"Real-time imaging of ligand-induced IKK activation in intact cells and in living mice","volume":"2","author":"Gross","year":"2005","journal-title":"Nat Methods"},{"key":"key\n\t\t\t\t20170425182212_awt355-B23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170425182212_awt355-B24","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170425182212_awt355-B25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1101\/gad.183434.111","article-title":"NF-\u03baB, the first quarter-century: remarkable progress and outstanding questions","volume":"26","author":"Hayden","year":"2012","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170425182212_awt355-B26","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170425182212_awt355-B27","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/hmg\/ddt036","article-title":"A critical role of astrocyte-mediated nuclear factor-\u03baB-dependent inflammation in Huntington's disease","volume":"22","author":"Hsiao","year":"2013","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170425182212_awt355-B28","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1073\/pnas.94.14.7531","article-title":"Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease","volume":"94","author":"Hunot","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425182212_awt355-B29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0962-8924(00)01729-3","article-title":"The IKK complex: an integrator of all signals that activate NF-kappaB?","volume":"10","author":"Isra\u00ebl","year":"2000","journal-title":"Trends Cell Biol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B30","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1073\/pnas.94.6.2642","article-title":"Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease","volume":"94","author":"Kaltschmidt","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425182212_awt355-B31","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1523\/JNEUROSCI.2675-04.2004","article-title":"Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity","volume":"24","author":"Khoshnan","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nbd.2011.04.015","article-title":"The role of I\u03baB kinase complex in the neurobiology of Huntington's disease","volume":"43","author":"Khoshnan","year":"2011","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20170425182212_awt355-B33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1523\/JNEUROSCI.4846-11.2012","article-title":"Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease","volume":"32","author":"Kwan","year":"2012","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B34","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1172\/JCI64484","article-title":"Mutant huntingtin impairs immune cell migration in Huntington disease","volume":"122","author":"Kwan","year":"2012","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425182212_awt355-B35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2010-08-265892","article-title":"Cytokine release from innate immune cells: association with diverse membrane trafficking pathways","volume":"118","author":"Lacy","year":"2011","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170425182212_awt355-B36","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170425182212_awt355-B37","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0896-6273(93)90127-D","article-title":"Huntington's disease gene (IT15) is widely expressed in human and rat tissues","volume":"11","author":"Li","year":"1993","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170425182212_awt355-B38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/cyto.a.21068","article-title":"Quantifying nuclear p65 as a parameter for NF-\u03baB activation: correlation between ImageStream cytometry, microscopy, and Western blot","volume":"79","author":"Maguire","year":"2011","journal-title":"Cytometry A"},{"key":"key\n\t\t\t\t20170425182212_awt355-B39","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/sj.cdd.4401837","article-title":"Roles for NF-kappaB in nerve cell survival, plasticity, and disease","volume":"13","author":"Mattson","year":"2006","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170425182212_awt355-B40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/cr.2010.179","article-title":"Nuclear initiated NF-\u03baB signaling: NEMO and ATM take center stage","volume":"21","author":"Miyamoto","year":"2011","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20170425182212_awt355-B41","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/hmg\/ddr075","article-title":"Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease","volume":"20","author":"Munsie","year":"2011","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170425182212_awt355-B42","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1126\/science.1056784","article-title":"Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity","volume":"291","author":"Nucifora","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425182212_awt355-B43","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","article-title":"NF-kappa B: a crucial transcription factor for glial and neuronal cell function","volume":"20","author":"O'Neill","year":"1997","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.expneurol.2008.10.008","article-title":"Implication of the JNK pathway in a rat model of Huntington's disease","volume":"215","author":"Perrin","year":"2009","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B45","doi-asserted-by":"crossref","first-page":"H2210","DOI":"10.1152\/ajpheart.00688.2007","article-title":"CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion","volume":"293","author":"Rajesh","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B47","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI45130","article-title":"Oligonucleotide therapeutic approaches for Huntington disease","volume":"121","author":"Sah","year":"2011","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425182212_awt355-B48","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jnen\/60.2.161","article-title":"Early and progressive accumulation of reactive microglia in the Huntington disease brain","volume":"60","author":"Sapp","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B49","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1096\/fj.04-1517fje","article-title":"Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia","volume":"18","author":"Simard","year":"2004","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170425182212_awt355-B50","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/mp.2011.28","article-title":"The role of immunity in Huntington's disease","volume":"16","author":"Soulet","year":"2011","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170425182212_awt355-B51","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.4161\/cc.9.17.12718","article-title":"Does Huntingtin play a role in selective macroautophagy?","volume":"9","author":"Steffan","year":"2010","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170425182212_awt355-B52","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","article-title":"The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription","volume":"97","author":"Steffan","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425182212_awt355-B53","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/ijc.2910170504","article-title":"Establishment and characterization of a human histiocytic lymphoma cell line (U-937)","volume":"17","author":"Sundstr\u00f6m","year":"1976","journal-title":"Int J Cancer"},{"issue":"Pt 7","key":"key\n\t\t\t\t20170425182212_awt355-B54","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington's disease gene carriers","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425182212_awt355-B55","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1515\/REVNEURO.2010.21.4.299","article-title":"NF-kappaB signaling in neurite growth and neuronal survival","volume":"21","author":"Teng","year":"2010","journal-title":"Rev Neurosci"},{"key":"key\n\t\t\t\t20170425182212_awt355-B56","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","author":"The Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170425182212_awt355-B57","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200909067","article-title":"IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome","volume":"187","author":"Thompson","year":"2009","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B58","first-page":"25","article-title":"TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study","volume":"8","author":"Tobinick","year":"2006","journal-title":"MedGenMed"},{"key":"key\n\t\t\t\t20170425182212_awt355-B59","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the brain: widespread pathology in Huntington's disease","volume":"8","author":"van der Burg","year":"2009","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20170425182212_awt355-B60","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1172\/JCI64565","article-title":"Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression","volume":"122","author":"Weiss","year":"2012","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425182212_awt355-B61","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset","volume":"101","author":"Wexler","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425182212_awt355-B62","doi-asserted-by":"crossref","first-page":"RRN1231","DOI":"10.1371\/currents.RRN1231","article-title":"Abnormal peripheral chemokine profile in Huntington's disease","volume":"3","author":"Wild","year":"2011","journal-title":"PLoS Curr"},{"key":"key\n\t\t\t\t20170425182212_awt355-B63","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","article-title":"Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration","volume":"145","author":"Zwilling","year":"2011","journal-title":"Cell"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/137\/3\/819\/13797635\/awt355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T20:02:41Z","timestamp":1565121761000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awt355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,1,22]]},"published-print":{"date-parts":[[2014,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awt355","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718249593.793491042","asserted-by":"object"}]},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1,22]]}}}