{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:15:52Z","timestamp":1791350152120,"version":"4.3.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1093\/brain\/awu064","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T22:06:28Z","timestamp":1396044388000},"page":"1762-1771","source":"Crossref","is-referenced-by-count":237,"title":["Non-invasive assessment of Alzheimer\u2019s disease neurofibrillary pathology using 18F-THK5105 PET"],"prefix":"10.1093","volume":"137","author":[{"given":"Nobuyuki","family":"Okamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Furumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle T.","family":"Fodero-Tavoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Yates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Pejoska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitsuka","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"key\n\t\t\t\t20170405114645_awu064-B1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3233\/JAD-2011-101980","article-title":"\u201cEnd-stage\u201d neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?","volume":"25","author":"Abner","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"key\n\t\t\t\t20170405114645_awu064-B2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease","volume":"1","author":"Arnold","year":"1991","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170405114645_awu064-B3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170405114645_awu064-B4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archneur.1993.00540040011008","article-title":"Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older","volume":"50","author":"Berg","year":"1993","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/archneur.55.3.326","article-title":"Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype","volume":"55","author":"Berg","year":"1998","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archneur.1995.00540250089017","article-title":"Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease","volume":"52","author":"Bierer","year":"1995","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/cercor\/4.2.138","article-title":"Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital","volume":"4","author":"Bouras","year":"1994","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170405114645_awu064-B8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3233\/JAD-122059","article-title":"Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807","volume":"34","author":"Checn","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key\n\t\t\t\t20170405114645_awu064-B10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3233\/JAD-130098","article-title":"Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808","volume":"38","author":"Chien","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"key\n\t\t\t\t20170405114645_awu064-B11","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/brain\/awr038","article-title":"18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease","volume":"134","author":"Fodero-Tavoletti","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170405114645_awu064-B12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease","volume":"41","author":"Gomez-Isla","year":"1997","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B13","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996","article-title":"Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease","volume":"16","author":"Gomez-Isla","year":"1996","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170405114645_awu064-B14","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170405114645_awu064-B15","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170405114645_awu064-B37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00259-012-2261-2","article-title":"Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology","volume":"40","author":"Harada","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"key\n\t\t\t\t20170405114645_awu064-B16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11307-013-0667-2","article-title":"Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain","volume":"16","author":"Harada","year":"2014","journal-title":"Mol Imaging Biol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/archneur.56.6.713","article-title":"Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease","volume":"56","author":"Haroutunian","year":"1999","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B18","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B19","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.1899488","article-title":"A68: a major subunit of paired helical filaments and derivatized forms of normal Tau","volume":"251","author":"Lee","year":"1991","journal-title":"Science"},{"key":"key\n\t\t\t\t20170405114645_awu064-B20","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuron.2013.07.037","article-title":"Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls","volume":"79","author":"Maruyama","year":"2013","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170405114645_awu064-B21","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/j.1471-4159.2006.03989.x","article-title":"Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics","volume":"97","author":"Masters","year":"2006","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170405114645_awu064-B22","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1212\/01.wnl.0000228230.26044.a4","article-title":"[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease","volume":"67","author":"Mintun","year":"2006","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170405114645_awu064-B23","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1111\/ejn.12229","article-title":"Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission","volume":"37","author":"Mohamed","year":"2013","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170405114645_awu064-B24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/jcbfm.1992.81","article-title":"Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects","volume":"12","author":"Muller-Gartner","year":"1992","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170405114645_awu064-B25","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.2967\/jnumed.112.117341","article-title":"Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease","volume":"54","author":"Okamura","year":"2013","journal-title":"J Nucleic Med"},{"key":"key\n\t\t\t\t20170405114645_awu064-B26","doi-asserted-by":"crossref","first-page":"10857","DOI":"10.1523\/JNEUROSCI.1738-05.2005","article-title":"Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease","volume":"25","author":"Okamura","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170405114645_awu064-B27","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.neurobiolaging.2009.04.002","article-title":"Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease","volume":"30","author":"Price","year":"2009","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20170405114645_awu064-B28","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1212\/01.wnl.0000261919.22630.ea","article-title":"Imaging beta-amyloid burden in aging and dementia","volume":"68","author":"Rowe","year":"2007","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170405114645_awu064-B29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00019442-200201000-00004","article-title":"Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease","volume":"10","author":"Shoghi-Jadid","year":"2002","journal-title":"Am J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20170405114645_awu064-B30","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMoa054625","article-title":"PET of brain amyloid and tau in mild cognitive impairment","volume":"355","author":"Small","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170405114645_awu064-B31","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.neuron.2012.02.006","article-title":"In vivo spreading of tau pathology","volume":"73","author":"Soto","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170405114645_awu064-B32","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t20170405114645_awu064-B33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/ana.22320","article-title":"Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-(1)(1)C]-2-(4'-methylaminophenyl)- 6-hydroxybenzothiazole","volume":"69","author":"Stankoff","year":"2011","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2217\/fnl.12.34","article-title":"The challenges of tau imaging","volume":"7","author":"Villemagne","year":"2012","journal-title":"Future Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.22248","article-title":"Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease","volume":"69","author":"Villemagne","year":"2011","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170405114645_awu064-B36","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1474-4422(13)70194-7","article-title":"Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study","volume":"12","author":"Vos","year":"2013","journal-title":"Lancet Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T03:51:43Z","timestamp":1648698703000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awu064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,27]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,3,27]]},"published-print":{"date-parts":[[2014,6]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awu064","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718329717.793503322","asserted-by":"object"}]},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3,27]]}}}