{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:09:25Z","timestamp":1791407365541,"version":"4.3.3"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1093\/brain\/awu162","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T00:02:21Z","timestamp":1403308941000},"page":"2546-2555","source":"Crossref","is-referenced-by-count":186,"title":["Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"137","author":[{"given":"Ricarda A. L.","family":"Menke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"K\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Filippini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwena\u00eblle","family":"Douaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Talbot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"issue":"Pt 6","key":"key\n\t\t\t\t20170425180250_awu162-B1","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1093\/brain\/119.6.2105","article-title":"Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET study","volume":"119","author":"Abrahams","year":"1996","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425180250_awu162-B2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0028-3932(99)00146-3","article-title":"Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)","volume":"38","author":"Abrahams","year":"2000","journal-title":"Neuropsychologia"},{"key":"key\n\t\t\t\t20170425180250_awu162-B3","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/hbm.22286","article-title":"Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS","volume":"35","author":"Agosta","year":"2013","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20170425180250_awu162-B4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/17482960802603841","article-title":"Longitudinal assessment of grey matter contraction in amyotrophic lateral sclerosis: a tensor based morphometry study","volume":"10","author":"Agosta","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"key\n\t\t\t\t20170425180250_awu162-B5","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1460-9568.2010.07445.x","article-title":"MRI predictors of long-term evolution in amyotrophic lateral sclerosis","volume":"32","author":"Agosta","year":"2010","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170425180250_awu162-B6","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","article-title":"The epidemiology of ALS: a conspiracy of genes, environment and time","volume":"9","author":"Al-Chalabi","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00401-012-1022-4","article-title":"The genetics and neuropathology of amyotrophic lateral sclerosis","volume":"124","author":"Al-Chalabi","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B8","article-title":"Non-linear registration, aka spatial normalisation","author":"Andersson","year":"2007"},{"key":"key\n\t\t\t\t20170425180250_awu162-B9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1212\/WNL.0b013e31829c5eee","article-title":"Multiparametric MRI study of ALS stratified for the C9orf72 genotype","volume":"81","author":"Bede","year":"2013","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B66","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/jnnp-2012-302674","article-title":"Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality","volume":"84","author":"Bede","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B10","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1212\/01.wnl.0000437313.80913.2c","article-title":"Basal ganglia involvement in amyotrophic lateral sclerosis","volume":"81","author":"Bede","year":"2013","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B67","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170425180250_awu162-B11","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1212\/WNL.0b013e31826e9b1d","article-title":"Presymptomatic studies in ALS: Rationale, challenges, and approach","volume":"79","author":"Benatar","year":"2012","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B12","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/17482960701548139","article-title":"A longitudinal study of diffusion tensor MRI in ALS","volume":"8","author":"Blain","year":"2007","journal-title":"Amyotroph Lateral Scler"},{"key":"key\n\t\t\t\t20170425180250_awu162-B13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrneurol.2011.151","article-title":"Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations","volume":"7","author":"Bowser","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B14","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrneurol.2013.221","article-title":"Amyotrophic lateral sclerosisa model of corticofugal axonal spread","volume":"9","author":"Braak","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"key\n\t\t\t\t20170425180250_awu162-B16","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/jnnp.33.3.338","article-title":"The central nervous system in motor neurone disease","volume":"33","author":"Brownell","year":"1970","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1474-4422(12)70014-5","article-title":"Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study","volume":"11","author":"Byrne","year":"2012","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"key":"key\n\t\t\t\t20170425180250_awu162-B19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1212\/01.wnl.0000167602.38643.29","article-title":"A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS\/FTLD","volume":"65","author":"Chang","year":"2005","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jmri.24218","article-title":"Diffusion tensor MRI of the corpus callosum in amyotrophic lateral sclerosis","volume":"39","author":"Chapman","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"key\n\t\t\t\t20170425180250_awu162-B21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3109\/17482968.2010.516265","article-title":"Grey matter volume changes over the whole brain in amyotrophic lateral sclerosis: A voxel-wise meta-analysis of voxel based morphometry studies","volume":"11","author":"Chen","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"key\n\t\t\t\t20170425180250_awu162-B22","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/hbm.20527","article-title":"Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics","volume":"30","author":"Ciccarelli","year":"2009","journal-title":"Hum Brain Mapp"},{"issue":"Pt 12","key":"key\n\t\t\t\t20170425180250_awu162-B23","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1093\/brain\/awr279","article-title":"Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis","volume":"134","author":"Douaud","year":"2011","journal-title":"Brain"},{"issue":"Pt 9","key":"key\n\t\t\t\t20170425180250_awu162-B24","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/brain\/awm184","article-title":"Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia","volume":"130","author":"Douaud","year":"2007","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425180250_awu162-B25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/mus.880150215","article-title":"Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron?","volume":"15","author":"Eisen","year":"1992","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20170425180250_awu162-B26","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1212\/WNL.0b013e31828f18ac","article-title":"Cognitive changes predict functional decline in ALS: a population-based longitudinal study","volume":"80","author":"Elamin","year":"2013","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B27","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1212\/WNL.0b013e318214359f","article-title":"Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia","volume":"76","author":"Elamin","year":"2011","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B28","doi-asserted-by":"crossref","first-page":"e85190","DOI":"10.1371\/journal.pone.0085190","article-title":"Multiple kernel learning captures a systems-level functional connectivity biomarker signature in amyotrophic lateral sclerosis","volume":"8","author":"Fekete","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170425180250_awu162-B29","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1468-1331.2010.02951.x","article-title":"EFNS guidelines on the use of neuroimaging in the management of motor neuron diseases","volume":"17","author":"Filippi","year":"2010","journal-title":"Eur J Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B30","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1212\/WNL.0b013e3181fb84d1","article-title":"Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis","volume":"75","author":"Filippini","year":"2010","journal-title":"Neurology"},{"issue":"1 Pt 1","key":"key\n\t\t\t\t20170425180250_awu162-B31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170425180250_awu162-B32","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1212\/01.WNL.0000058901.75728.4E","article-title":"Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS","volume":"60","author":"Ince","year":"2003","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B33","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170425180250_awu162-B34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med Image Anal"},{"key":"key\n\t\t\t\t20170425180250_awu162-B35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/14660820510038538","article-title":"Global brain atrophy and corticospinal tract alterations in ALS, as investigated by voxel-based morphometry of 3-D MRI","volume":"6","author":"Kassubek","year":"2005","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"key\n\t\t\t\t20170425180250_awu162-B36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2202-13-141","article-title":"Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis","volume":"13","author":"Keil","year":"2012","journal-title":"BMC Neurosci"},{"key":"key\n\t\t\t\t20170425180250_awu162-B37","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Kiernan","year":"2011","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170425180250_awu162-B38","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3109\/21678421.2013.794843","article-title":"Myelin imaging in amyotrophic and primary lateral sclerosis","volume":"14","author":"Kolind","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key\n\t\t\t\t20170425180250_awu162-B39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.nicl.2012.12.003","article-title":"Structural imaging differences and longitudinal changes in primary lateral sclerosis and amyotrophic lateral sclerosis","volume":"2","author":"Kwan","year":"2012","journal-title":"Neuroimage Clin"},{"key":"key\n\t\t\t\t20170425180250_awu162-B40","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/archneurol.2012.1122","article-title":"Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis","volume":"69","author":"Menke","year":"2012","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B68","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/gps.1610","article-title":"The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening","volume":"21","author":"Mioshi","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/17482968.2010.495158","article-title":"Timelines in the diagnostic evaluation of people with suspected amyotrophic lateral sclerosis (ALS)\/motor neuron disease (MND)\u2014a 20-year review: can we do better?","volume":"11","author":"Mitchell","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"key\n\t\t\t\t20170425180250_awu162-B42","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1212\/01.wnl.0000260065.57832.87","article-title":"Quantitative objective markers for upper and lower motor neuron dysfunction in ALS","volume":"68","author":"Mitsumoto","year":"2007","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/jmri.21217","article-title":"Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation","volume":"27","author":"Ng","year":"2008","journal-title":"J Magn Reson Imaging"},{"key":"key\n\t\t\t\t20170425180250_awu162-B44","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0b013e3181b6bbbd","article-title":"ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration","volume":"73","author":"Ravits","year":"2009","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B45","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuroimage.2006.09.025","article-title":"Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis","volume":"34","author":"Sage","year":"2007","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170425180250_awu162-B46","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.3174\/ajnr.A2658","article-title":"Cognitive functions and white matter tract damage in amyotrophic lateral sclerosis: a diffusion tensor tractography study","volume":"32","author":"Sarro","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B47","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/jnnp.64.4.492","article-title":"Functional magnetic resonance imaging of human brain activity in a verbal fluency task","volume":"64","author":"Schlosser","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/17482968.2010.517850","article-title":"Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study","volume":"12","author":"Senda","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"key\n\t\t\t\t20170425180250_awu162-B49","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1552-6569.2011.00679.x","article-title":"Diffusion tensor imaging of basal ganglia and thalamus in amyotrophic lateral sclerosis","volume":"23","author":"Sharma","year":"2013","journal-title":"J Neuroimaging"},{"key":"key\n\t\t\t\t20170425180250_awu162-B50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/jnnp.23.4.269","article-title":"Nerve fibre degeneration in the brain in amyotrophic lateral sclerosis","volume":"23","author":"Smith","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B51","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20170425180250_awu162-B52","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170425180250_awu162-B53","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170425180250_awu162-B54","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170425180250_awu162-B55","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1212\/WNL.0b013e318281ccec","article-title":"Whole-brain MRI spectroscopy measures are related to disability in ALS","volume":"80","author":"Stagg","year":"2013","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425180250_awu162-B56","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/jnnp-2012-302315","article-title":"Why are upper motor neuron signs difficult to elicit in amyotrophic lateral sclerosis?","volume":"83","author":"Swash","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B69","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/jnnp.2006.101758","article-title":"Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability","volume":"78","author":"Thivard","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B57","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/21678421.2013.785569","article-title":"Motor and extramotor neurodegeneration in amyotrophic lateral sclerosis: a 3T high angular resolution diffusion imaging (HARDI) study","volume":"14","author":"Trojsi","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key\n\t\t\t\t20170425180250_awu162-B58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2217\/bmm.12.26","article-title":"Neuroimaging in amyotrophic lateral sclerosis","volume":"6","author":"Turner","year":"2012","journal-title":"Biomark Med"},{"key":"key\n\t\t\t\t20170425180250_awu162-B59","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.nbd.2003.12.012","article-title":"Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [(11)C](R)-PK11195 positron emission tomography study","volume":"15","author":"Turner","year":"2004","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20170425180250_awu162-B60","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S1474-4422(11)70049-7","article-title":"Towards a neuroimaging biomarker for amyotrophic lateral sclerosis","volume":"10","author":"Turner","year":"2011","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B61","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1474-4422(13)70036-X","article-title":"Controversies and priorities in amyotrophic lateral sclerosis","volume":"12","author":"Turner","year":"2013","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20170425180250_awu162-B62","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/jnnp.74.7.995","article-title":"Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990\u20132002","volume":"74","author":"Turner","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Pt 4","key":"key\n\t\t\t\t20170425180250_awu162-B63","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/brain\/awr016","article-title":"Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging study","volume":"134","author":"van der Graaff","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425180250_awu162-B64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/jnnp-2011-300909","article-title":"Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis","volume":"83","author":"Verstraete","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425180250_awu162-B65","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans Med Imaging"}],"container-title":["Brain"],"original-title":[],"language":"en","deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T11:20:33Z","timestamp":1498130433000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awu162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":69,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,6,20]]},"published-print":{"date-parts":[[2014,9]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awu162","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6,20]]}}}