{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:35:25Z","timestamp":1791243325897,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1093\/brain\/awu257","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T02:20:52Z","timestamp":1410574852000},"page":"2922-2937","source":"Crossref","is-referenced-by-count":75,"title":["c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy"],"prefix":"10.1093","volume":"137","author":[{"given":"Janina","family":"Hantke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Carty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Wagstaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Turmaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel K.","family":"Wilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Quintes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Koltzenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Baas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhona","family":"Mirsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristj\u00e1n R.","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"key\n\t\t\t\t20170425173944_awu257-B1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"c-Jun Reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170425173944_awu257-B2","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/emboj\/21.7.1782","article-title":"Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver","volume":"21","author":"Behrens","year":"2002","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170425173944_awu257-B3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/brain\/120.5.813","article-title":"Charcot-Marie-Tooth disease type 1A with 17p11.2 duplication. Clinical and electrophysiological phenotype study and factors influencing disease severity in 119 cases","volume":"120","author":"Birouk","year":"1997","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425173944_awu257-B4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archneur.1970.00480280083010","article-title":"Muscle fiber types: how many and what kind?","volume":"23","author":"Brooke","year":"1970","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170425173944_awu257-B5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1084\/jem.20122005","article-title":"Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice","volume":"210","author":"D'Antonio","year":"2013","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170425173944_awu257-B6","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1523\/JNEUROSCI.14-05-02911.1994","article-title":"The differential control of c-jun expression in regenerating sensory neurons and their associated glial cells","volume":"14","author":"De Felipe","year":"1994","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170425173944_awu257-B7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/(SICI)1097-4547(19990515)56:4<334::AID-JNR2>3.0.CO;2-#","article-title":"Schwann cell development in embryonic mouse nerves","volume":"56","author":"Dong","year":"1999","journal-title":"J Neurosci Res"},{"key":"key\n\t\t\t\t20170425173944_awu257-B8","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/glia.22346","article-title":"Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor","volume":"60","author":"Doddrell","year":"2012","journal-title":"Glia"},{"key":"key\n\t\t\t\t20170425173944_awu257-B9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1749-6632.1999.tb08574.x","article-title":"P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells","volume":"883","author":"Feltri","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170425173944_awu257-B10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.201205025","article-title":"c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling","volume":"198","author":"Fontana","year":"2012","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170425173944_awu257-B11","doi-asserted-by":"crossref","first-page":"9646","DOI":"10.1523\/JNEUROSCI.1620-06.2006","article-title":"Schwann cells express motor and sensory phenotypes that regulate axon regeneration","volume":"26","author":"Hoke","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170425173944_awu257-B12","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(05)67665-9","article-title":"Guillain-Barre syndrome","volume":"366","author":"Hughes","year":"2005","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170425173944_awu257-B13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1529-8027.2011.00360.x","article-title":"c-Jun expression in human neuropathies: a pilot study","volume":"16","author":"Hutton","year":"2011","journal-title":"J Peripher Nerv Syst"},{"key":"key\n\t\t\t\t20170425173944_awu257-B14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/hmg\/5.5.563","article-title":"Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA","volume":"5","author":"Huxley","year":"1996","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170425173944_awu257-B15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/hmg\/7.3.449","article-title":"Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice","volume":"7","author":"Huxley","year":"1998","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170425173944_awu257-B16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/(SICI)1098-2752(1998)18:2<119::AID-MICR10>3.0.CO;2-0","article-title":"Functional indices for sciatic, peroneal, and posterior tibial nerve lesions in the mouse","volume":"18","author":"Inserra","year":"1998","journal-title":"Microsurgery"},{"key":"key\n\t\t\t\t20170425173944_awu257-B17","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/glia.20761","article-title":"Negative regulation of myelination: relevance for development, injury, and demyelinating disease","volume":"56","author":"Jessen","year":"2008","journal-title":"Glia"},{"key":"key\n\t\t\t\t20170425173944_awu257-B18","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1212\/WNL.43.9.1806","article-title":"Nerve conduction studies in Charcot-Marie-Tooth polyneuropathy associated with a segmental duplication of chromosome 17","volume":"43","author":"Kaku","year":"1993","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425173944_awu257-B19","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/ana.20285","article-title":"A novel endogenous erythropoietin mediated pathway prevents axonal degeneration","volume":"56","author":"Keswani","year":"2004","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170425173944_awu257-B20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-0270(97)00042-3","article-title":"A low-cost method to analyse footprint patterns","volume":"75","author":"Klapdor","year":"1997","journal-title":"J Neurosci Methods"},{"key":"key\n\t\t\t\t20170425173944_awu257-B21","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/glia.22638","article-title":"Nonuniform molecular features of myelinating Schwann cells in models for CMT1: distinct disease patterns are associated with NCAM and c-Jun upregulation","volume":"62","author":"Klein","year":"2014","journal-title":"Glia"},{"issue":"Pt 7","key":"key\n\t\t\t\t20170425173944_awu257-B22","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/brain\/123.7.1516","article-title":"Neurological dysfunction and axonal degeneration in Charcot-Marie-Tooth disease type 1A","volume":"123","author":"Krajewski","year":"2000","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425173944_awu257-B23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/jnnp.68.2.191","article-title":"Isolated absence of F waves and proximal axonal dysfunction in Guillain-Barre syndrome with antiganglioside antibodies","volume":"68","author":"Kuwabara","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170425173944_awu257-B24","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1073\/pnas.0407836102","article-title":"Analysis of congenital hypomyelinating Egr2Lo\/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination","volume":"102","author":"Le","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425173944_awu257-B25","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.exger.2012.12.008","article-title":"Dietary restriction supports peripheral nerve health by enhancing endogenous protein quality control mechanisms","volume":"48","author":"Lee","year":"2013","journal-title":"Exp Gerontol"},{"key":"key\n\t\t\t\t20170425173944_awu257-B26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/mus.10419","article-title":"Motor unit number estimate of distal and proximal muscles in Charcot-Marie-Tooth disease","volume":"28","author":"Lewis","year":"2003","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20170425173944_awu257-B27","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1523\/JNEUROSCI.16-17-05351.1996","article-title":"Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage","volume":"16","author":"Magyar","year":"1996","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170425173944_awu257-B28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1083\/jcb.200803013","article-title":"c-Jun is a negative regulator of myelination","volume":"181","author":"Parkinson","year":"2008","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170425173944_awu257-B29","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1093\/brain\/awf230","article-title":"PMP22 overexpression causes dysmyelination in mice","volume":"125","author":"Robaglia-Schlupp","year":"2002","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425173944_awu257-B30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1469-7580.2002.00039.x","article-title":"Comparison of a new pmp22 transgenic mouse line with other mouse models and human patients with CMT1A","volume":"200","author":"Robertson","year":"2002","journal-title":"J Anat"},{"key":"key\n\t\t\t\t20170425173944_awu257-B31","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s00415-008-0999-z","article-title":"Sensory loss, pains, motor deficit and axonal regeneration in length-dependent diabetic polyneuropathy","volume":"255","author":"Said","year":"2008","journal-title":"J Neurol"},{"issue":"Pt 8","key":"key\n\t\t\t\t20170425173944_awu257-B32","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/brain\/122.8.1563","article-title":"Distal axonopathy in peripheral nerves of PMP22-mutant mice","volume":"122","author":"Sancho","year":"1999","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170425173944_awu257-B33","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/glia.20751","article-title":"Molecular mechanisms of inherited demyelinating neuropathies","volume":"56","author":"Scherer","year":"2008","journal-title":"Glia"},{"key":"key\n\t\t\t\t20170425173944_awu257-B34","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0896-6273(00)80128-2","article-title":"A transgenic rat model of Charcot-Marie-Tooth disease","volume":"16","author":"Sereda","year":"1996","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170425173944_awu257-B35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1212\/01.wnl.0000297553.36441.ce","article-title":"Neuropathy progression in Charcot-Marie-Tooth disease type 1A","volume":"70","author":"Shy","year":"2008","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170425173944_awu257-B36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/(SICI)1097-4547(19960301)43:5<511::AID-JNR1>3.0.CO;2-L","article-title":"Axon-Schwann cell interactions regulate the expression of c-jun in Schwann cells","volume":"43","author":"Shy","year":"1996","journal-title":"J Neurosci Res"},{"key":"key\n\t\t\t\t20170425173944_awu257-B37","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrn1196","article-title":"Disease mechanisms in inherited neuropathies","volume":"4","author":"Suter","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20170425173944_awu257-B38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/mus.10432","article-title":"Neurophysiological changes in demyelinating and axonal forms of acute experimental autoimmune neuritis in the Lewis rat","volume":"28","author":"Taylor","year":"2003","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20170425173944_awu257-B39","doi-asserted-by":"crossref","first-page":"52, 54","DOI":"10.2144\/00291bm09","article-title":"Preparation of PCR-quality mouse genomic DNA with hot sodiumhydroxide and tris (HotSHOT)","volume":"29","author":"Truett","year":"2000","journal-title":"Biotechniques"},{"key":"key\n\t\t\t\t20170425173944_awu257-B40","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/NEN.0b013e318217eba0","article-title":"Myelin and axon pathology in a long-term study of PMP22-overexpressing mice","volume":"70","author":"Verhamme","year":"2011","journal-title":"J Neuropathol Exp Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/137\/11\/2922\/13797158\/awu257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T23:23:38Z","timestamp":1565825018000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awu257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,9,12]]},"published-print":{"date-parts":[[2014,11]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awu257","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,12]]}}}