{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:09:18Z","timestamp":1791198558475,"version":"4.1.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1093\/brain\/awv145","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T20:27:36Z","timestamp":1433968056000},"page":"2332-2346","source":"Crossref","is-referenced-by-count":110,"title":["Network topology and functional connectivity disturbances precede the onset of Huntington\u2019s disease"],"prefix":"10.1093","volume":"138","author":[{"given":"Deborah L.","family":"Harrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikail","family":"Rubinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Durgerian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyla","family":"Mourany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Reece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Bullmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PREDICT-HD investigators of the Huntington Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,9]]},"reference":[{"key":"2015082803374150000_138.8.2332.1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3874-05.2006"},{"key":"2015082803374150000_138.8.2332.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.07.030"},{"key":"2015082803374150000_138.8.2332.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.004"},{"key":"2015082803374150000_138.8.2332.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.024"},{"key":"2015082803374150000_138.8.2332.5","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.neuroimage.2011.08.044","article-title":"Test-retest reliability of resting-state connectivity network characteristics using fMRI and graph theoretical measures","volume":"59","author":"Braun","year":"2011","journal-title":"Neuroimage"},{"key":"2015082803374150000_138.8.2332.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"2015082803374150000_138.8.2332.7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)7:1<38::AID-HBM4>3.0.CO;2-Q"},{"key":"2015082803374150000_138.8.2332.8","doi-asserted-by":"crossref","first-page":"9686","DOI":"10.1523\/JNEUROSCI.17-24-09686.1997","article-title":"Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate","volume":"17","author":"Chikama","year":"1997","journal-title":"J Neurosci"},{"key":"2015082803374150000_138.8.2332.9","doi-asserted-by":"publisher","DOI":"10.1038\/nphys209"},{"key":"2015082803374150000_138.8.2332.10","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht064"},{"key":"2015082803374150000_138.8.2332.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.017"},{"key":"2015082803374150000_138.8.2332.12","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"2015082803374150000_138.8.2332.13","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21333"},{"key":"2015082803374150000_138.8.2332.14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu132"},{"key":"2015082803374150000_138.8.2332.15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220826110"},{"key":"2015082803374150000_138.8.2332.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"2015082803374150000_138.8.2332.17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704320104"},{"key":"2015082803374150000_138.8.2332.18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181eccfa2"},{"key":"2015082803374150000_138.8.2332.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.03.001"},{"key":"2015082803374150000_138.8.2332.20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4313-13.2014"},{"key":"2015082803374150000_138.8.2332.21","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"2015082803374150000_138.8.2332.22","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2014.895042"},{"key":"2015082803374150000_138.8.2332.23","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22296"},{"key":"2015082803374150000_138.8.2332.24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4854-12.2013"},{"key":"2015082803374150000_138.8.2332.25","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200007)44:1<162::AID-MRM23>3.0.CO;2-E"},{"key":"2015082803374150000_138.8.2332.26","volume-title":"Stroop color and word test: a manual for clinical and experimental uses","author":"Golden","year":"1978"},{"key":"2015082803374150000_138.8.2332.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.10.020"},{"key":"2015082803374150000_138.8.2332.28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088297"},{"key":"2015082803374150000_138.8.2332.29","doi-asserted-by":"crossref","DOI":"10.1088\/1742-5468\/2005\/02\/P02001","article-title":"Cartography of complex networks: modules and universal roles","volume":"2005","author":"Guimera","year":"2005","journal-title":"J Stat Mech"},{"key":"2015082803374150000_138.8.2332.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060159"},{"key":"2015082803374150000_138.8.2332.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.051"},{"key":"2015082803374150000_138.8.2332.32","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.185"},{"key":"2015082803374150000_138.8.2332.33","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301732"},{"key":"2015082803374150000_138.8.2332.34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219562110"},{"key":"2015082803374150000_138.8.2332.35","doi-asserted-by":"publisher","DOI":"10.1038\/72999"},{"key":"2015082803374150000_138.8.2332.36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v028.i08","article-title":"Implementing a class of permutation tests: the coin Package","volume":"28","author":"Hothorn","year":"2008","journal-title":"J Stat Softw"},{"key":"2015082803374150000_138.8.2332.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.021"},{"key":"2015082803374150000_138.8.2332.38","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.87.198701"},{"key":"2015082803374150000_138.8.2332.39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805423105"},{"key":"2015082803374150000_138.8.2332.40","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn018"},{"key":"2015082803374150000_138.8.2332.41","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs410"},{"key":"2015082803374150000_138.8.2332.42","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0315"},{"key":"2015082803374150000_138.8.2332.43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0333-10.2010"},{"key":"2015082803374150000_138.8.2332.44","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22273"},{"key":"2015082803374150000_138.8.2332.45","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0260-2"},{"key":"2015082803374150000_138.8.2332.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.07.014"},{"key":"2015082803374150000_138.8.2332.47","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2010.541228"},{"key":"2015082803374150000_138.8.2332.48","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.71.065103"},{"key":"2015082803374150000_138.8.2332.49","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.6.883"},{"key":"2015082803374150000_138.8.2332.50","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128728"},{"key":"2015082803374150000_138.8.2332.51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fnagi.2014.00078","article-title":"Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD study","volume":"6","author":"Paulsen","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"2015082803374150000_138.8.2332.52","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70238-8"},{"key":"2015082803374150000_138.8.2332.53","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305114"},{"key":"2015082803374150000_138.8.2332.54","first-page":"1715","article-title":"fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's disease","volume":"25","author":"Paulsen","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"2015082803374150000_138.8.2332.55","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1523\/JNEUROSCI.18-21-08979.1998","article-title":"A specific role for the thalamus in mediating the interaction of attention and arousal in humans","volume":"18","author":"Portas","year":"1998","journal-title":"J Neurosci"},{"key":"2015082803374150000_138.8.2332.56","first-page":"87","article-title":"Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study","volume":"39","author":"Poudel","year":"2014","journal-title":"J Psychiatry Neurosci"},{"key":"2015082803374150000_138.8.2332.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.01.013"},{"key":"2015082803374150000_138.8.2332.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.04.018"},{"key":"2015082803374150000_138.8.2332.59","volume-title":"The halstead-reitan neuropsychological test battery: theory and clinical interpretation","author":"Reitan","year":"1993"},{"key":"2015082803374150000_138.8.2332.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.015"},{"key":"2015082803374150000_138.8.2332.61","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.24"},{"key":"2015082803374150000_138.8.2332.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"2015082803374150000_138.8.2332.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.069"},{"key":"2015082803374150000_138.8.2332.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2012.11.006"},{"key":"2015082803374150000_138.8.2332.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.11.016"},{"key":"2015082803374150000_138.8.2332.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.105"},{"key":"2015082803374150000_138.8.2332.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.03.004"},{"key":"2015082803374150000_138.8.2332.68","volume-title":"symbol digit modalities test: manual","author":"Smith","year":"1995"},{"key":"2015082803374150000_138.8.2332.69","doi-asserted-by":"publisher","DOI":"10.1037\/a0020937"},{"key":"2015082803374150000_138.8.2332.70","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"2015082803374150000_138.8.2332.71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001414107"},{"key":"2015082803374150000_138.8.2332.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.024"},{"key":"2015082803374150000_138.8.2332.73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203593109"},{"key":"2015082803374150000_138.8.2332.74","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2874-10.2010"},{"key":"2015082803374150000_138.8.2332.75","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3539-11.2011"},{"key":"2015082803374150000_138.8.2332.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.09.012"},{"key":"2015082803374150000_138.8.2332.77","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1443-09.2009"},{"key":"2015082803374150000_138.8.2332.78","first-page":"369","article-title":"Generative models of rich clubs in Hebbian neuronal networks and large-scale human brain networks","author":"Vertes","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2015082803374150000_138.8.2332.79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021976"},{"key":"2015082803374150000_138.8.2332.80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02253.x"},{"key":"2015082803374150000_138.8.2332.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.068"},{"key":"2015082803374150000_138.8.2332.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.001"},{"key":"2015082803374150000_138.8.2332.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"2015082803374150000_138.8.2332.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.027"},{"key":"2015082803374150000_138.8.2332.85","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31232"},{"key":"2015082803374150000_138.8.2332.86","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1017\/S1355617707071214","article-title":"fMRI detection of early neural dysfunction in preclinical Huntington's disease","volume":"13","author":"Zimbelman","year":"2007","journal-title":"J Int Neuropsychol Soc"},{"key":"2015082803374150000_138.8.2332.87","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr269"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/138\/8\/2332\/13800041\/awv145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T13:55:55Z","timestamp":1566827755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awv145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,9]]},"references-count":87,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,7,23]]},"published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1093\/brain\/awv145"],"URL":"https:\/\/doi.org\/10.1093\/brain\/awv145","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,9]]}}}