{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:19:37Z","timestamp":1789982377178,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1093\/brain\/awv203","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T04:43:13Z","timestamp":1440391393000},"page":"2571-2583","source":"Crossref","is-referenced-by-count":81,"title":["Permeability of the blood\u2013brain barrier predicts conversion from optic neuritis to multiple sclerosis"],"prefix":"10.1093","volume":"138","author":[{"given":"Stig P.","family":"Cramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Modvig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle J.","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette L.","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik B. W.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,17]]},"reference":[{"key":"2016040508373768000_138.9.2571.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(03)00006-7"},{"key":"2016040508373768000_138.9.2571.2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.11.2059"},{"key":"2016040508373768000_138.9.2571.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.11.007"},{"key":"2016040508373768000_138.9.2571.4","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-8-4"},{"key":"2016040508373768000_138.9.2571.5","first-page":"1157","article-title":"Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis","volume":"135","author":"Claudio","year":"1989","journal-title":"Am J Pathol"},{"key":"2016040508373768000_138.9.2571.6","doi-asserted-by":"crossref","unstructured":"Clerico M Faggiano F Palace J Rice G Tintor\u00e8 M Durelli L . Recombinant interferon beta or glatiramer acetate for delaying conversion of the first demyelinating event to multiple sclerosis. [Internet]. Cochrane Database Syst Rev 2008: CD005278.[cited 2015 Mar 30] http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18425915","DOI":"10.1002\/14651858.CD005278.pub3"},{"key":"2016040508373768000_138.9.2571.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.12.001"},{"key":"2016040508373768000_138.9.2571.8","doi-asserted-by":"crossref","unstructured":"Cramer SP Larsson HBW . Accurate determination of blood-brain barrier permeability using dynamic contrast-enhanced T1-weighted MRI: a simulation and in vivo study on healthy subjects and multiple sclerosis patients. J Cereb Blood Flow Metab 2014: 1\u201311. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25074746","DOI":"10.1038\/jcbfm.2014.126"},{"key":"2016040508373768000_138.9.2571.9","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00148-4"},{"key":"2016040508373768000_138.9.2571.10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(24)01320-6","article-title":"The blood-brain barrier in neuroinflammatory diseases","volume":"49","author":"de Vries","year":"1997","journal-title":"Pharmacol Rev"},{"key":"2016040508373768000_138.9.2571.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6838-x"},{"key":"2016040508373768000_138.9.2571.12","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.567"},{"key":"2016040508373768000_138.9.2571.13","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510385506"},{"key":"2016040508373768000_138.9.2571.14","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22098"},{"key":"2016040508373768000_138.9.2571.15","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.82"},{"key":"2016040508373768000_138.9.2571.16","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510389102"},{"key":"2016040508373768000_138.9.2571.17","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22136"},{"key":"2016040508373768000_138.9.2571.18","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21328"},{"key":"2016040508373768000_138.9.2571.19","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.12.2327"},{"key":"2016040508373768000_138.9.2571.20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b910b"},{"key":"2016040508373768000_138.9.2571.21","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70071-5"},{"key":"2016040508373768000_138.9.2571.22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077163"},{"key":"2016040508373768000_138.9.2571.23","doi-asserted-by":"crossref","unstructured":"Modvig S Degn M Roed H Sorensen T Larsson H Langkilde A . Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis. Mult Scler J 2015: 1\u201310. [Epub ahead of print].","DOI":"10.1177\/1352458515574148"},{"key":"2016040508373768000_138.9.2571.24","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.727"},{"key":"2016040508373768000_138.9.2571.25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"2016040508373768000_138.9.2571.26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-11"},{"key":"2016040508373768000_138.9.2571.27","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq118"},{"key":"2016040508373768000_138.9.2571.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00097-2"},{"key":"2016040508373768000_138.9.2571.29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00327.x"},{"key":"2016040508373768000_138.9.2571.30","first-page":"702","article-title":"Isolated demyelinating syndromes: Comparison of different MR imaging criteria to predict conversion to clinically definite multiple sclerosis","volume":"21","author":"Tintor\u00e9","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"2016040508373768000_138.9.2571.31","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181a19a5a"},{"key":"2016040508373768000_138.9.2571.32","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200103)45:3<477::AID-MRM1063>3.0.CO;2-4"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/138\/9\/2571\/13800570\/awv203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T23:57:11Z","timestamp":1748563031000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awv203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,17]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,8,24]]},"published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1093\/brain\/awv203"],"URL":"https:\/\/doi.org\/10.1093\/brain\/awv203","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,17]]}}}