{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:51:51Z","timestamp":1791165111368,"version":"4.1.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1093\/brain\/awv214","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T16:57:46Z","timestamp":1443200266000},"page":"3016-3029","source":"Crossref","is-referenced-by-count":119,"title":["Altered PDE10A expression detectable early before symptomatic onset in Huntington\u2019s disease"],"prefix":"10.1093","volume":"138","author":[{"given":"Flavia","family":"Niccolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Haider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Reis Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Muhlert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andri C.","family":"Tziortzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham E.","family":"Searle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Natesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Piccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shitij","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenii A.","family":"Rabiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger N.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Tabrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Politis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"2015100801173435000_138.10.3016.1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000037"},{"key":"2015100801173435000_138.10.3016.2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310412"},{"key":"2015100801173435000_138.10.3016.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"2015100801173435000_138.10.3016.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00134.x"},{"key":"2015100801173435000_138.10.3016.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"2015100801173435000_138.10.3016.6","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.122895"},{"key":"2015100801173435000_138.10.3016.7","volume-title":"Beck Depression Inventory manual (2nd ed.)","author":"Beck","year":"1996"},{"key":"2015100801173435000_138.10.3016.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.018"},{"key":"2015100801173435000_138.10.3016.9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080178"},{"key":"2015100801173435000_138.10.3016.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.018"},{"key":"2015100801173435000_138.10.3016.11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00270.2012"},{"key":"2015100801173435000_138.10.3016.12","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6A6930.2006"},{"key":"2015100801173435000_138.10.3016.13","first-page":"219","article-title":"Behavioral changes in huntington disease","volume":"14","author":"Craufurd","year":"2001","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"2015100801173435000_138.10.3016.14","doi-asserted-by":"publisher","DOI":"10.1038\/nature11846"},{"key":"2015100801173435000_138.10.3016.15","doi-asserted-by":"crossref","DOI":"10.1016\/B978-012161340-2\/50069-X","article-title":"Measuring neurotransmitter release with PET: methodological issues","volume-title":"Quantitative functional brain imaging with positron emission tomography","author":"Dagher","year":"1998"},{"key":"2015100801173435000_138.10.3016.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.08.009"},{"key":"2015100801173435000_138.10.3016.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.057"},{"key":"2015100801173435000_138.10.3016.18","first-page":"1591","article-title":"Metabolic network abnormalities in early Huntington's disease: an [(18)F]FDG PET study","volume":"42","author":"Feigin","year":"2001","journal-title":"J Nucl Med"},{"key":"2015100801173435000_138.10.3016.19","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm217"},{"key":"2015100801173435000_138.10.3016.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"2015100801173435000_138.10.3016.21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0031-6997(24)01396-6","article-title":"Actions of caffeine in the brain with special reference to factors that contribute to its widespread use","volume":"51","author":"Fredholm","year":"1999","journal-title":"Pharmacol Rev"},{"key":"2015100801173435000_138.10.3016.22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18438"},{"key":"2015100801173435000_138.10.3016.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013417"},{"key":"2015100801173435000_138.10.3016.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.02.014"},{"key":"2015100801173435000_138.10.3016.25","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0932-8_18"},{"key":"2015100801173435000_138.10.3016.26","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0303"},{"key":"2015100801173435000_138.10.3016.27","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"2015100801173435000_138.10.3016.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.11.009"},{"key":"2015100801173435000_138.10.3016.29","doi-asserted-by":"crossref","DOI":"10.1002\/cne.903040406","article-title":"Organization of striatopallidal, striatonigral, and nigrostriatal projections in the macaque","author":"Hedreen","year":"1991","journal-title":"J Comp Neurol"},{"key":"2015100801173435000_138.10.3016.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03796.x"},{"key":"2015100801173435000_138.10.3016.31","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25591"},{"key":"2015100801173435000_138.10.3016.32","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(02)91132-8"},{"key":"2015100801173435000_138.10.3016.33","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh105"},{"key":"2015100801173435000_138.10.3016.34","first-page":"213","article-title":"Topography of cerebral atrophy in early Huntington\u2019s disease: a voxel based morphometric MRI study","volume":"75","author":"Kassubek","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2015100801173435000_138.10.3016.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00241.x"},{"key":"2015100801173435000_138.10.3016.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.11.016"},{"key":"2015100801173435000_138.10.3016.37","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1523\/JNEUROSCI.20-10-03798.2000","article-title":"Convergent inputs from thalamic motor nuclei and frontal cortical areas to the dorsal striatum in the primate","volume":"20","author":"McFarland","year":"2000","journal-title":"J Neurosci"},{"key":"2015100801173435000_138.10.3016.38","first-page":"1936","article-title":"Correction of head movement on PET studies: comparison of methods","volume":"47","author":"Montgomery","year":"2006","journal-title":"J Nucl Med"},{"key":"2015100801173435000_138.10.3016.39","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2518-08.2008","article-title":"Distinct roles of PDE4 and PDE10A in the regulation of cAMP\/PKA signalling in the striatum","author":"Nishi","year":"2008","journal-title":"J Neurosci"},{"key":"2015100801173435000_138.10.3016.40","first-page":"91","article-title":"Functional anatomy of the basal ganglia","volume":"20","author":"Parent","year":"1995","journal-title":"I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Rev"},{"key":"2015100801173435000_138.10.3016.41","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128728"},{"key":"2015100801173435000_138.10.3016.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.08.006"},{"key":"2015100801173435000_138.10.3016.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2011.02.005"},{"key":"2015100801173435000_138.10.3016.44","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.131409"},{"key":"2015100801173435000_138.10.3016.45","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21008"},{"key":"2015100801173435000_138.10.3016.46","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn244"},{"key":"2015100801173435000_138.10.3016.47","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380605"},{"key":"2015100801173435000_138.10.3016.48","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70245-3"},{"key":"2015100801173435000_138.10.3016.49","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1954"},{"key":"2015100801173435000_138.10.3016.50","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.132910"},{"key":"2015100801173435000_138.10.3016.51","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02754-9"},{"key":"2015100801173435000_138.10.3016.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2006.04.013"},{"key":"2015100801173435000_138.10.3016.53","doi-asserted-by":"publisher","DOI":"10.1118\/1.598130"},{"key":"2015100801173435000_138.10.3016.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.018"},{"key":"2015100801173435000_138.10.3016.55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049483"},{"key":"2015100801173435000_138.10.3016.56","doi-asserted-by":"crossref","first-page":"791\u2212801","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol"},{"key":"2015100801173435000_138.10.3016.57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69411"},{"key":"2015100801173435000_138.10.3016.58","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23532"},{"key":"2015100801173435000_138.10.3016.59","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"2015100801173435000_138.10.3016.60","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.146332"},{"key":"2015100801173435000_138.10.3016.61","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/00004647-199911000-00003","article-title":"Multiresolution analysis of emission tomography images in the wavelet domain","volume":"19","author":"Turkheimer","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"2015100801173435000_138.10.3016.62","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1006\/nimg.2001.0764","article-title":"Estimation of the number of \u201ctrue\u201d null hypotheses in multivariate analysis of neuroimaging data","volume":"13","author":"Turkheimer","year":"2001","journal-title":"Neuroimage"},{"key":"2015100801173435000_138.10.3016.63","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs397"},{"key":"2015100801173435000_138.10.3016.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.044"},{"key":"2015100801173435000_138.10.3016.65","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25010"},{"key":"2015100801173435000_138.10.3016.66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02390.x"},{"key":"2015100801173435000_138.10.3016.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.07.011"},{"key":"2015100801173435000_138.10.3016.68","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60111-1"},{"key":"2015100801173435000_138.10.3016.69","volume-title":"SF-36 Health survey: manual and interpretation guide","author":"Ware","year":"1993"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/138\/10\/3016\/17347700\/awv214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T20:21:06Z","timestamp":1748636466000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awv214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,21]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,9,25]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1093\/brain\/awv214"],"URL":"https:\/\/doi.org\/10.1093\/brain\/awv214","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,21]]}}}