{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:51:34Z","timestamp":1783392694291,"version":"3.54.6"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1093\/brain\/aww359","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T13:26:52Z","timestamp":1485782812000},"page":"1117-1127","source":"Crossref","is-referenced-by-count":44,"title":["Therapeutic window of dopamine D2\/3 receptor occupancy to treat psychosis in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"140","author":[{"given":"Suzanne","family":"Reeves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"D\u2019Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Brownings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suki","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,4]]},"reference":[{"key":"key\n\t\t\t\t20170707113914_aww359-B1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/cpt.268","article-title":"A framework for quantifying the influence of adherence and dose individualization","volume":"99","year":"2016","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t20170707113914_aww359-B2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/0091270007310385","article-title":"Sex, race, and smoking impact olanzapine exposure","volume":"48","year":"2008","journal-title":"J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev-pharmtox-011711-113247","article-title":"Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories","volume":"52","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B4","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1176\/appi.ajp.160.8.1413","article-title":"Is regionally selective D2\/D3 dopamine occupancy sufficient for atypical antipsychotic effect? An in vivo quantitative [123I]epidepride SPET study of amisulpride-treated patients","volume":"160","year":"2003","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B5","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/gps.4090","article-title":"Towards a therapeutic window of D2\/3 occupancy for treatment of psychosis in Alzheimer\u2019s disease, with [18F]fallypride positron emission tomography","volume":"29","year":"2014","journal-title":"Int J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B6","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia","volume":"44","year":"1994","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B7","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1208\/s12248-014-9649-9","article-title":"The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family","volume":"16","year":"2014","journal-title":"AAPS J"},{"key":"key\n\t\t\t\t20170707113914_aww359-B8","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/jcbfm.2013.55","article-title":"Establishing test-retest reliability of an adapted [(18)F]fallypride imaging protocol in older people","volume":"33","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170707113914_aww359-B9","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1345\/aph.1E260","article-title":"Population pharmacokinetics III: design, analysis, and application of population pharmacokinetic Studies","volume":"38","year":"2004","journal-title":"Ann Pharmacother"},{"key":"key\n\t\t\t\t20170707113914_aww359-B10","first-page":"538","article-title":"Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine","volume":"49","year":"1992","journal-title":"Relation to extrapyramidal side effects. Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2125.2008.03276.x","article-title":"Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study","volume":"66","year":"2008","journal-title":"Br J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B12","first-page":"189","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","year":"1975","journal-title":"J Psychiatr Res"},{"key":"key\n\t\t\t\t20170707113914_aww359-B13","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/jamapsychiatry.2015.0891","article-title":"Evaluation of antipsychotic dose reduction in late-life Schizophrenia: a prospective dopamine D2\/3 receptor occupancy study","volume":"72","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s002280050483","article-title":"Safety and pharmacokinetics of a single oral dose of amisulpride in healthy elderly volunteers","volume":"54","year":"1998","journal-title":"Eur J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-0031-1286287","article-title":"AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011","volume":"44","year":"2011","journal-title":"Pharmacopsychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B16","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","article-title":"Consensus nomenclature for in vivo imaging of reversibly binding radioligands","volume":"27","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170707113914_aww359-B17","first-page":"559","article-title":"Cognitive function and adherence to anticoagulation treatment in patients with atrial fibrillation","volume":"13","year":"2016","journal-title":"J Geriatr Cardiol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B18","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.euroneuro.2015.08.014","article-title":"Increased all-cause mortality with use of psychotropic medication in dementia patients and controls: a population-based register study","volume":"25","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B19","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/sj.npp.1301492","article-title":"ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia","volume":"33","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B20","doi-asserted-by":"crossref","first-page":"PL103","DOI":"10.1016\/0024-3205(95)02037-J","article-title":"The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study","volume":"57","year":"1995","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20170707113914_aww359-B21","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1038\/npp.2008.33","article-title":"Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride","volume":"33","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B22","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/sj.npp.1301108","article-title":"Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine","volume":"31","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B23","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/jcbfm.2011.54","article-title":"Calculating occupancy when one does not have baseline: a comparison of different options","volume":"31","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170707113914_aww359-B24","first-page":"1028","article-title":"D2 receptor occupancy during high- and low-dose therapy with the atypical antipsychotic amisulpride: a 123I-iodobenzamide SPECT study","volume":"46","year":"2005","journal-title":"J Nucl Med"},{"key":"key\n\t\t\t\t20170707113914_aww359-B25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/JCP.0b013e3182983ffa","article-title":"Estimating dopamine D(2) receptor occupancy for doses of 8 antipsychotics: a meta-analysis","volume":"33","year":"2013","journal-title":"J Clin Psychopharmacol"},{"issue":"3 Pt 1","key":"key\n\t\t\t\t20170707113914_aww359-B26","first-page":"153","article-title":"Simplified reference tissue model for PET receptor studies","volume":"4","year":"1996","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170707113914_aww359-B27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/BF02245616","article-title":"In vivo characteristics of dopamine D2 receptor occupancy by amisulpride in schizophrenia","volume":"124","year":"1996","journal-title":"Psychopharmacology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B28","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jamapsychiatry.2014.3018","article-title":"Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm","volume":"72","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B29","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop","volume":"47","year":"1996","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s disease","volume":"34","year":"1984","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-2008-1076727","article-title":"Striatal D2\/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study","volume":"41","year":"2008","journal-title":"Pharmacopsychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B32","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00004647-199902000-00013","article-title":"Loss of D2 receptor binding with age in rhesus monkeys: importance of correction for differences in striatal size","volume":"19","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170707113914_aww359-B33","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0024-3205(96)00348-7","article-title":"18F-desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors","volume":"59","year":"1996","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20170707113914_aww359-B34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.schres.2008.07.005","article-title":"Amisulpride the \u2018atypical\u2019 atypical antipsychotic\u2013comparison to haloperidol, risperidone and clozapine","volume":"105","year":"2008","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170707113914_aww359-B35","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1006\/nimg.2001.0879","article-title":"Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy\u2014a simulation study based on experimental data","volume":"14","year":"2001","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170707113914_aww359-B36","first-page":"331","article-title":"Reducing the risk of adverse drug events in older adults","volume":"87","year":"2013","journal-title":"Am Fam Physician"},{"key":"key\n\t\t\t\t20170707113914_aww359-B37","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1007\/s00213-016-4379-6","article-title":"A population approach to characterise amisulpride pharmacokinetics in older people and Alzheimer\u2019s disease","volume":"233","year":"2016","journal-title":"Psychopharmacology"},{"key":"key\n\t\t\t\t20170707113914_aww359-B38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1136\/jnnp.2009.172510","article-title":"No effect of donepezil on striatal dopamine release in mild to moderate Alzheimer\u2019s disease","volume":"81","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.pbb.2012.04.002","article-title":"In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes","volume":"102","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"key\n\t\t\t\t20170707113914_aww359-B40","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1056\/NEJMoa061240","article-title":"Effectiveness of atypical antipsychotic drugs in patients with Alzheimer\u2019s disease","volume":"355","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170707113914_aww359-B41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1755-5949.2010.00162.x","article-title":"All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors","volume":"17","year":"2011","journal-title":"CNS Neurosci Ther"},{"key":"key\n\t\t\t\t20170707113914_aww359-B42","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/gps.4133","article-title":"Therapeutic occupation of dopamine D2 antipsychotic receptors in Alzheimer\u2019s disease","volume":"29","year":"2014","journal-title":"Int J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0922-4106(95)90125-6","article-title":"Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand","volume":"291","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B44","first-page":"173P","article-title":"Exploring the interaction of amisulpride with influx and efflux transporters expressed at the blood-brain barrier","volume":"13","year":"2016","journal-title":"Proc Br Pharmacol Soc Abstract"},{"key":"key\n\t\t\t\t20170707113914_aww359-B45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.9758\/cpn.2011.9.1.9","article-title":"Central nervous system drug evaluation using positron emission tomography","volume":"9","year":"2011","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"key\n\t\t\t\t20170707113914_aww359-B46","first-page":"11","article-title":"A rating scale for extrapyramidal side effects","volume":"212","year":"1970","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"key\n\t\t\t\t20170707113914_aww359-B47","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1600-0447.2009.01429.x","article-title":"Amisulpride\u2014dose, plasma concentration, occupancy and response: implications for therapeutic drug monitoring","volume":"120","year":"2009","journal-title":"Acta Psychiatr Scand"},{"key":"key\n\t\t\t\t20170707113914_aww359-B48","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/schbul\/sbn009","article-title":"Cortical dopamine D2\/D3 receptors are a common site of action for antipsychotic drugs\u2014an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literature","volume":"35","year":"2009","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170707113914_aww359-B49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S1461145703003912","article-title":"Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics","volume":"7","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B50","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/sj.mp.4001009","article-title":"Significant dissociation of brain and plasma kinetics with antipsychotics","volume":"7","year":"2002","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B51","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuroimage.2010.06.044","article-title":"Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy","volume":"54","year":"2011","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170707113914_aww359-B52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","year":"2002","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170707113914_aww359-B53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/JGP.0b013e318198776d","article-title":"Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms","volume":"17","year":"2009","journal-title":"Am J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B54","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4088\/JCP.08r04171","article-title":"Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms","volume":"70","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B55","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jagp.2013.01.045","article-title":"Therapeutic window for striatal dopamine D(2\/3) receptor occupancy in older patients with schizophrenia: a pilot PET study","volume":"22","year":"2014","journal-title":"Am J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20170707113914_aww359-B56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/JCP.0b013e3182214aad","article-title":"Dopamine D2 receptor occupancy and clinical effects: a systematic review and pooled analysis","volume":"31","year":"2011","journal-title":"J Clin Psychopharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B57","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2165\/00003088-199732050-00001","article-title":"The electronic medication event monitor. Lessons for pharmacotherapy","volume":"32","year":"1997","journal-title":"Clin Pharmacokinet"},{"key":"key\n\t\t\t\t20170707113914_aww359-B58","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/jcbfm.2011.73","article-title":"The applicability of SRTM in [(18)F]fallypride PET investigations: impact of scan durations","volume":"31","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170707113914_aww359-B59","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1017\/S1461145704004353","article-title":"High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia","volume":"7","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/syn.890160402","article-title":"Imaging endogenous dopamine competition with [11C]raclopride in the human brain","volume":"16","year":"1994","journal-title":"Synapse"},{"key":"key\n\t\t\t\t20170707113914_aww359-B61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00004714-200104000-00013","article-title":"In vivo extrastriatal and striatal D2 dopamine receptor blockade by amisulpride in schizophrenia","volume":"21","year":"2001","journal-title":"J Clin Psychopharmacol"},{"key":"key\n\t\t\t\t20170707113914_aww359-B62","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/j.1532-5415.2010.03011.x","article-title":"The blood-brain barrier: geriatric relevance of a critical brain-body interface","volume":"58","year":"2010","journal-title":"J Am Geriatr Soc"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/140\/4\/1117\/18244848\/aww359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T21:39:44Z","timestamp":1749937184000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/aww359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,4]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,4]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/aww359","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,4]]}}}