{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:27:07Z","timestamp":1780694827941,"version":"3.54.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AG027924, RF1 AG051504, and P01 NS074969"],"award-info":[{"award-number":["R37AG027924, RF1 AG051504, and P01 NS074969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"DOI":"10.1093\/brain\/awx284","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T11:09:58Z","timestamp":1508324998000},"page":"3301-3316","source":"Crossref","is-referenced-by-count":24,"title":["Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-\u03b242 in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"140","author":[{"given":"Mitsuru","family":"Shinohara","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-9700","authenticated-orcid":false,"given":"Shunsuke","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Nix","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritam","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrone L","family":"Rosenberry","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"key\n\t\t\t\t20180226040538_awx284-B1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00401-014-1287-x","article-title":"Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease","volume":"127","author":"Bayer","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B2","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1186\/1471-2202-14-108","article-title":"Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration","volume":"14","author":"Becker","year":"2013","journal-title":"BMC Neurosci"},{"issue":"Pt 3","key":"key\n\t\t\t\t20180226040538_awx284-B3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","author":"Bolte","year":"2006","journal-title":"J Microsc"},{"key":"key\n\t\t\t\t20180226040538_awx284-B4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B5","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180226040538_awx284-B6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13024-016-0115-2","article-title":"Immunotherapy targeting pyroglutamate-3 Abeta: prospects and challenges","volume":"11","author":"Cynis","year":"2016","journal-title":"Mol Neurodegener"},{"key":"key\n\t\t\t\t20180226040538_awx284-B7","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.neuron.2012.10.029","article-title":"A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer's disease mice","volume":"76","author":"Demattos","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180226040538_awx284-B8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00005072-199704000-00001","article-title":"The pathogenesis of senile plaques","volume":"56","author":"Dickson","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuroscience.2006.08.027","article-title":"High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain","volume":"143","author":"Guntert","year":"2006","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180226040538_awx284-B10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00401-011-0806-2","article-title":"Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Abeta deposits in hippocampus via distinct cellular mechanisms","volume":"121","author":"Hartlage-Rubsamen","year":"2011","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B11","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1074\/jbc.M608220200","article-title":"The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation","volume":"282","author":"Hori","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180226040538_awx284-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging\u2013Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t20180226040538_awx284-B13","first-page":"1823","article-title":"Full-length amyloid-beta (1-42) and amino-terminally modified and truncated amyloid-beta 42 deposit in diffuse plaques","volume":"149","author":"Iwatsubo","year":"1996","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180226040538_awx284-B15","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1021\/bi015685+","article-title":"APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques","volume":"41","author":"Kalback","year":"2002","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20180226040538_awx284-B16","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and Abeta in Alzheimer's disease: accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180226040538_awx284-B17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nrd3505","article-title":"The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics","volume":"10","author":"Karran","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20180226040538_awx284-B18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1523\/JNEUROSCI.21-02-00372.2001","article-title":"Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease","volume":"21","author":"Kawarabayashi","year":"2001","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180226040538_awx284-B19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.7326\/0003-4819-140-7-200404060-00008","article-title":"Survival after initial diagnosis of Alzheimer disease","volume":"140","author":"Larson","year":"2004","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20180226040538_awx284-B21","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1021\/bi015800g","article-title":"Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression","volume":"41","author":"Liu","year":"2002","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20180226040538_awx284-B22","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/acs.analchem.5b03891","article-title":"Amyloid plaque in the human brain can decompose from abeta(1-40\/1-42) by spontaneous nonenzymatic processes","volume":"88","author":"Lyons","year":"2016","journal-title":"Anal Chem"},{"key":"key\n\t\t\t\t20180226040538_awx284-B23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00401-014-1296-9","article-title":"Pyroglutamylated amyloid-beta is associated with hyperphosphorylated tau and severity of Alzheimer's disease","volume":"128","author":"Mandler","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B24","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180226040538_awx284-B25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abbi.1993.1112","article-title":"Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer\u2032s disease","volume":"301","author":"Miller","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20180226040538_awx284-B26","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1750-3639.2010.00375.x","article-title":"Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme","volume":"20","author":"Miners","year":"2010","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B27","doi-asserted-by":"crossref","first-page":"10810","DOI":"10.1021\/bi0508237","article-title":"Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques","volume":"44","author":"Miravalle","year":"2005","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20180226040538_awx284-B28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/alzrt121","article-title":"Overlapping profiles of Abeta peptides in the Alzheimer's disease and pathological aging brains","volume":"4","author":"Moore","year":"2012","journal-title":"Alzheimers Res Ther"},{"key":"key\n\t\t\t\t20180226040538_awx284-B29","doi-asserted-by":"crossref","first-page":"17082","DOI":"10.1016\/S0021-9258(18)41896-0","article-title":"Mass spectrometry of purified amyloid beta protein in Alzheimer's disease","volume":"267","author":"Mori","year":"1992","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180226040538_awx284-B30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/alzrt254","article-title":"Is pathological aging a successful resistance against amyloid-beta or preclinical Alzheimer\u2019s disease?","volume":"6","author":"Murray","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"key\n\t\t\t\t20180226040538_awx284-B31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(91)91092-F","article-title":"Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease","volume":"541","author":"Namba","year":"1991","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180226040538_awx284-B32","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1073\/pnas.91.18.8378","article-title":"Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging","volume":"91","author":"Naslund","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180226040538_awx284-B33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0006-8993(96)01329-7","article-title":"Distribution of apolipoprotein E in senile plaques in brains with Alzheimer's disease: investigation with the confocal laser scan microscope","volume":"750","author":"Nishiyama","year":"1997","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180226040538_awx284-B34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature11060","article-title":"Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta","volume":"485","author":"Nussbaum","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180226040538_awx284-B35","doi-asserted-by":"crossref","first-page":"23895","DOI":"10.1074\/jbc.270.41.23895","article-title":"Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro","volume":"270","author":"Pike","year":"1995","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180226040538_awx284-B36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00401-010-0690-1","article-title":"Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease","volume":"120","author":"Portelius","year":"2010","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000369465","article-title":"Brain amyloid-beta fragment signatures in pathological ageing and Alzheimer's disease by hybrid immunoprecipitation mass spectrometry","volume":"15","author":"Portelius","year":"2015","journal-title":"Neurodegener Dis"},{"key":"key\n\t\t\t\t20180226040538_awx284-B38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1586\/14789450.5.2.225","article-title":"Targeted proteomics in Alzheimer's disease: focus on amyloid-beta","volume":"5","author":"Portelius","year":"2008","journal-title":"Expert Rev Proteomics"},{"key":"key\n\t\t\t\t20180226040538_awx284-B39","doi-asserted-by":"crossref","first-page":"a006379","DOI":"10.1101\/cshperspect.a006379","article-title":"Proteolytic degradation of amyloid beta-protein","volume":"2","author":"Saido","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"key\n\t\t\t\t20180226040538_awx284-B40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-3940(96)12970-0","article-title":"Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain","volume":"215","author":"Saido","year":"1996","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20180226040538_awx284-B41","doi-asserted-by":"crossref","first-page":"33747","DOI":"10.1074\/jbc.M111.246561","article-title":"\u03b2-Amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid","volume":"286","author":"Schieb","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180226040538_awx284-B42","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1021\/bi900818a","article-title":"Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides","volume":"48","author":"Schlenzig","year":"2009","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20180226040538_awx284-B43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-016-0084-5","article-title":"Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site","volume":"11","author":"Schonherr","year":"2016","journal-title":"Mol Neurodegener"},{"key":"key\n\t\t\t\t20180226040538_awx284-B44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2217\/nmt.13.20","article-title":"What can we learn from regional vulnerability to amyloid-\u03b2 accumulation in nondemented individuals?","volume":"3","author":"Shinohara","year":"2013","journal-title":"Neurodegener Dis Manag"},{"issue":"Pt 5","key":"key\n\t\t\t\t20180226040538_awx284-B45","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1093\/brain\/awu046","article-title":"Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease","volume":"137","author":"Shinohara","year":"2014","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180226040538_awx284-B46","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-013-1086-9","article-title":"Brain regional correlation of amyloid-beta with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-beta accumulation","volume":"125","author":"Shinohara","year":"2013","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B47","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.90.17.8098","article-title":"Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180226040538_awx284-B48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-005-1053-1","article-title":"Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner","volume":"110","author":"Thal","year":"2005","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B49","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180226040538_awx284-B50","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/gps.3946","article-title":"Survival in dementia and predictors of mortality: a review","volume":"28","author":"Todd","year":"2013","journal-title":"Int J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20180226040538_awx284-B51","doi-asserted-by":"crossref","first-page":"12787","DOI":"10.1523\/JNEUROSCI.3657-09.2009","article-title":"The \u03b2-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential","volume":"29","author":"Vassar","year":"2009","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180226040538_awx284-B52","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.1073\/pnas.1010461107","article-title":"Spatial correlation between brain aerobic glycolysis and amyloid-beta (Abeta) deposition","volume":"107","author":"Vlassenko","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180226040538_awx284-B53","first-page":"12","article-title":"\u03b2-amyloid degradation and Alzheimer's disease","author":"Wang","year":"2006","journal-title":"J Biomed Biotechnol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B54","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7085","article-title":"The levels of soluble versus insoluble brain amyloid-\u03b2 distinguish Alzheimer's disease from normal and pathologic aging","volume":"158","author":"Wang","year":"1999","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180226040538_awx284-B55","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00389492","article-title":"Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition","volume":"88","author":"Yamaguchi","year":"1994","journal-title":"Acta Neuropathol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/140\/12\/3301\/24174730\/awx284.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T21:15:30Z","timestamp":1719522930000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/140\/12\/3301\/4638263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,17]]},"references-count":55,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,11,17]]},"published-print":{"date-parts":[[2017,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awx284","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,12]]},"published":{"date-parts":[[2017,11,17]]}}}