{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:57:32Z","timestamp":1792414652152,"version":"4.4.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/501100000334","name":"International Spinal Research Trust","doi-asserted-by":"publisher","award":["STR116"],"award-info":[{"award-number":["STR116"]}],"id":[{"id":"10.13039\/501100000334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"DOI":"10.1093\/brain\/awy007","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T21:16:29Z","timestamp":1515446189000},"page":"1017-1027","source":"Crossref","is-referenced-by-count":66,"title":["Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury"],"prefix":"10.1093","volume":"141","author":[{"given":"Hilary Z","family":"Hu","sequence":"first","affiliation":[{"name":"1 College of Veterinary Medicine, Iowa State University, 1800 Christensen Drive, Ames IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Granger","sequence":"additional","affiliation":[{"name":"2 Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, AL9 7TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Balakrishna","family":"Pai","sequence":"additional","affiliation":[{"name":"3 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, 313 Ferst Drive, Atlanta, GA 30332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi V","family":"Bellamkonda","sequence":"additional","affiliation":[{"name":"4 Department of Biomedical Engineering, Duke University Pratt School of Engineering, 101 Science Drive, Campus Box 90281, Durham NC 27708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick D","family":"Jeffery","sequence":"additional","affiliation":[{"name":"1 College of Veterinary Medicine, Iowa State University, 1800 Christensen Drive, Ames IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"key\n\t\t\t\t20180327040649_awy007-B1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/jme.28.5.322","article-title":"Sham surgery controls: intracerebral grafting of fetal tissue for Parkinson's disease and proposed criteria for use of sham surgery controls","volume":"28","author":"Albin","year":"2002","journal-title":"J Med Ethics"},{"key":"key\n\t\t\t\t20180327040649_awy007-B2","doi-asserted-by":"crossref","first-page":"10856","DOI":"10.1523\/JNEUROSCI.2980-06.2006","article-title":"Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury","volume":"26","author":"Barritt","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180327040649_awy007-B3","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1523\/JNEUROSCI.4369-13.2014","article-title":"Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury","volume":"34","author":"Bartus","year":"2014","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180327040649_awy007-B4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/sj.sc.3102174","article-title":"International urodynamic basic spinal cord injury data set","volume":"46","author":"Biering-S\u00f8rensen","year":"2008","journal-title":"Spinal Cord"},{"key":"key\n\t\t\t\t20180327040649_awy007-B5","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1073\/pnas.1121604109","article-title":"Chondroitinase ABC promotes selective reactivation of somatosensory cortex in squirrel monkeys after a cervical dorsal column lesion","volume":"109","author":"Bowes","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180327040649_awy007-B6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.brainresbull.2010.06.015","article-title":"Manipulating the glial scar: chondroitinase ABC as a therapy for spinal cord injury","volume":"84","author":"Bradbury","year":"2011","journal-title":"Brain Res Bull"},{"key":"key\n\t\t\t\t20180327040649_awy007-B7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/416636a","article-title":"Chondroitinase ABC promotes functional recovery after spinal cord injury","volume":"416","author":"Bradbury","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180327040649_awy007-B8","doi-asserted-by":"crossref","first-page":"11998","DOI":"10.1523\/JNEUROSCI.3877-08.2008","article-title":"Chondroitinase ABC-mediated plasticity of spinal sensory function","volume":"28","author":"Cafferty","year":"2008","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180327040649_awy007-B9","first-page":"839","article-title":"Utility of urodynamic testing in the diganosis of urinary incontinence in dogs","volume":"165","author":"Combrisson","year":"1989","journal-title":"Rec Med Vet"},{"key":"key\n\t\t\t\t20180327040649_awy007-B10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.expneurol.2007.05.001","article-title":"How does chondroitinase promote functional recovery in the damaged CNS?","volume":"206","author":"Crespo","year":"2007","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180327040649_awy007-B11","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.2460\/ajvr.67.9.1613","article-title":"Correlation of motor evoked potentials with magnetic resonance imaging and neurologic findings in Doberman Pinschers with and without signs of cervical spondylomyelopathy","volume":"67","author":"da Costa","year":"2006","journal-title":"Am J Vet Res"},{"key":"key\n\t\t\t\t20180327040649_awy007-B12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/sj.sc.3102007","article-title":"Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials","volume":"45","author":"Fawcett","year":"2007","journal-title":"Spinal Cord"},{"key":"key\n\t\t\t\t20180327040649_awy007-B13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/mds.21775","article-title":"Ethics of sham surgery: perspective of patients","volume":"23","author":"Frank","year":"2008","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20180327040649_awy007-B14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1352458509359727","article-title":"The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group","volume":"16","author":"Freedman","year":"2010","journal-title":"Mult Scler"},{"key":"key\n\t\t\t\t20180327040649_awy007-B15","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/nn.2377","article-title":"Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation","volume":"12","author":"Garcia-Alias","year":"2009","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180327040649_awy007-B16","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/jvim.14651","article-title":"Acquisition of involuntary spinal locomotion (spinal walking) in dogs with irreversible thoracolumbar spinal cord lesion: 81 dogs","volume":"31","author":"Gallucci","year":"2017","journal-title":"J Vet Intern Med"},{"key":"key\n\t\t\t\t20180327040649_awy007-B17","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/brain\/aws268","article-title":"Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model","volume":"135","author":"Granger","year":"2012","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180327040649_awy007-B18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0021-9975(78)90033-6","article-title":"Spinal cord injuries: a pathological study of naturally occurring lesions in the dog and cat","volume":"88","author":"Griffiths","year":"1978","journal-title":"J Comp Pathol"},{"key":"key\n\t\t\t\t20180327040649_awy007-B19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1748-5827.2012.01244.x","article-title":"The cutaneous trunci reflex for localising and grading thoracolumbar spinal cord injuries in dogs","volume":"53","author":"Gutierrez-Quintana","year":"2012","journal-title":"J Small Anim Pract"},{"key":"key\n\t\t\t\t20180327040649_awy007-B20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2202-8-77","article-title":"Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis","volume":"8","author":"Hamilton","year":"2007","journal-title":"BMC Neurosci"},{"key":"key\n\t\t\t\t20180327040649_awy007-B21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/(SICI)1520-6777(1996)15:5<483::AID-NAU5>3.0.CO;2-B","article-title":"Bladder compliance in neurologically intact women","volume":"15","author":"Harris","year":"1996","journal-title":"Neurourol Urodyn"},{"key":"key\n\t\t\t\t20180327040649_awy007-B22","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1523\/JNEUROSCI.4459-10.2011","article-title":"Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection","volume":"31","author":"Jefferson","year":"2011","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180327040649_awy007-B23","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1089\/neu.2009.1149","article-title":"A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury","volume":"28","author":"Kwon","year":"2011","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180327040649_awy007-B24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.expneurol.2013.05.012","article-title":"Demonstrating efficacy in preclinical studies of cellular therapies for spinal cord injury - how much is enough?","volume":"248","author":"Kwon","year":"2013","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180327040649_awy007-B25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2015.04.008","article-title":"Large animal and primate models of spinal cord injury for the testing of novel therapies","volume":"269","author":"Kwon","year":"2015","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180327040649_awy007-B26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/08977150150502622","article-title":"Effects of enriched housing on functional recovery after spinal cord contusive injury in the adult rat","volume":"18","author":"Lankhorst","year":"2001","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180327040649_awy007-B27","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1073\/pnas.0905437106","article-title":"Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury","volume":"107","author":"Lee","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180327040649_awy007-B28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/neu.2010.1645","article-title":"Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research","volume":"28","author":"Levine","year":"2011","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180327040649_awy007-B29","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1471-4159.2007.05066.x","article-title":"Chondroitinase ABC has a lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain","volume":"104","author":"Lin","year":"2008","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20180327040649_awy007-B30","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1523\/JNEUROSCI.5467-05.2006","article-title":"Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury","volume":"26","author":"Massey","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180327040649_awy007-B31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.2000.17.1","article-title":"Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury","volume":"17","author":"Metz","year":"2000","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180327040649_awy007-B32","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1089\/neu.2016.4745","article-title":"Targeting translational successes through CANSORT-SCI: Using pet dogs to identify effective treatments for spinal cord injury","volume":"34","author":"Moore","year":"2017","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180327040649_awy007-B33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/neu.1997.14.151","article-title":"Serial recording of somatosensory and myoelectric motor evoked potentials: role in assessing functional recovery after graded spinal cord injury in the rat","volume":"14","author":"Nashmi","year":"1997","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180327040649_awy007-B34","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1090-0233(03)00025-X","article-title":"Transcranial magnetic stimulation: review of the technique, basic principles and applications","volume":"166","author":"Nollet","year":"2003","journal-title":"Vet J"},{"key":"key\n\t\t\t\t20180327040649_awy007-B35","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.2460\/ajvr.1993.54.11.1935","article-title":"Somatosensory potentials in dogs with naturally acquired thoracolumbar spinal cord disease","volume":"54","author":"Poncelet","year":"1993","journal-title":"Am J Vet Res"},{"key":"key\n\t\t\t\t20180327040649_awy007-B36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1750-3639.2006.00001.x","article-title":"Histological and ultrastructural analysis of white matter damage after naturally-occurring spinal cord injury","volume":"16","author":"Smith","year":"2006","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20180327040649_awy007-B37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1532-950X.1993.tb00360.x","article-title":"Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease","volume":"22","author":"Sylvestre","year":"1993","journal-title":"Vet Surg"},{"key":"key\n\t\t\t\t20180327040649_awy007-B38","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1089\/neu.2009.1177","article-title":"A systematic review of cellular transplantation therapies for spinal cord injury","volume":"28","author":"Tetzlaff","year":"2011","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180327040649_awy007-B39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0090-4295(79)90164-X","article-title":"Compliance of the bladder: an attempt to establish normal values","volume":"14","author":"Toppercer","year":"1979","journal-title":"Urology"},{"key":"key\n\t\t\t\t20180327040649_awy007-B40","doi-asserted-by":"crossref","first-page":"e1002468","DOI":"10.1371\/journal.pbio.1002468","article-title":"Olfactory ensheathing cell transplantation in experimental spinal cord injury: effect size and reporting bias of 62 experimental treatments: a systematic review and meta-analysis","volume":"14","author":"Watzlawick","year":"2016","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t20180327040649_awy007-B41","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijpharm.2015.02.034","article-title":"Large-scale manufacturing of GMP-compliant anti-EGFR targeted nanocarriers: production of doxorubicin-loaded anti-EGFR-immunoliposomes for a first-in-man clinical trial","volume":"484","author":"Wicki","year":"2015","journal-title":"Int J Pharm"},{"key":"key\n\t\t\t\t20180327040649_awy007-B42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0014-4886(02)00052-3","article-title":"Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC","volume":"182","author":"Yick","year":"2003","journal-title":"Exp Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/141\/4\/1017\/24497623\/awy007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T10:35:57Z","timestamp":1719743757000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/141\/4\/1017\/4850499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,2,9]]},"published-print":{"date-parts":[[2018,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awy007","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4]]},"published":{"date-parts":[[2018,2,9]]}}}