{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:38:26Z","timestamp":1794440306930,"version":"4.9.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"German Center for Neurodegenerative Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["Horizon 2020"],"award-info":[{"award-number":["Horizon 2020"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National MS Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005062","name":"Fujirebio","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001320","name":"Wolfson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000368","name":"Brain Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006314","name":"Biogen Idec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50AG005681"],"award-info":[{"award-number":["P50AG005681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01AG003991"],"award-info":[{"award-number":["P01AG003991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01AG026276"],"award-info":[{"award-number":["P01AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UF01AG032438"],"award-info":[{"award-number":["UF01AG032438"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.1093\/brain\/awy050","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T15:11:09Z","timestamp":1518102669000},"page":"1529-1544","source":"Crossref","is-referenced-by-count":145,"title":["Data-driven models of dominantly-inherited Alzheimer\u2019s disease progression"],"prefix":"10.1093","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-3909","authenticated-orcid":false,"given":"Neil P","family":"Oxtoby","sequence":"first","affiliation":[{"name":"Progression of Neurodegenerative Disease Group, Centre for Medical Image Computing, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L","family":"Young","sequence":"additional","affiliation":[{"name":"Progression of Neurodegenerative Disease Group, Centre for Medical Image Computing, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Cash","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3AR, UK"},{"name":"Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L S","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Fagan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick C","family":"Fox","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3AR, UK"},{"name":"UK Dementia Research Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Schott","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3AR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C","family":"Alexander","sequence":"additional","affiliation":[{"name":"Progression of Neurodegenerative Disease Group, Centre for Medical Image Computing, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"key\n\t\t\t\t20181004074230_awy050-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt59","article-title":"Autosomal-dominant Alzheimer\u2019s disease: a review and proposal for the prevention of Alzheimer\u2019s disease","volume":"3","author":"Bateman","year":"2011","journal-title":"Alzheimers Res Ther"},{"key":"key\n\t\t\t\t20181004074230_awy050-B2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20181004074230_awy050-B3","doi-asserted-by":"crossref","first-page":"E4502","DOI":"10.1073\/pnas.1317918110","article-title":"Regional variability of imaging biomarkers in autosomal dominant Alzheimer\u2019s disease","volume":"110","author":"Benzinger","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20181004074230_awy050-B4","first-page":"637","article-title":"Clinical Dementia Rating (CDR)","volume":"24","author":"Berg","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"key\n\t\t\t\t20181004074230_awy050-B5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/neup.12205","article-title":"Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN)","volume":"35","author":"Cairns","year":"2015","journal-title":"Neuropathology"},{"key":"key\n\t\t\t\t20181004074230_awy050-B49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v076.i01","article-title":"Stan: a probabilistic programming language","volume":"76","author":"Carpenter","year":"2017","journal-title":"J Stat Softw"},{"key":"key\n\t\t\t\t20181004074230_awy050-B6","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1212\/WNL.0b013e3182a841c6","article-title":"The pattern of atrophy in familial Alzheimer disease","volume":"81","author":"Cash","year":"2013","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20181004074230_awy050-B7","doi-asserted-by":"crossref","first-page":"S400","DOI":"10.1016\/j.jalz.2013.10.003","article-title":"Estimating long-term multivariate progression from short-term data","volume":"10","author":"Donohue","year":"2014","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t20181004074230_awy050-B8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11263-012-0592-x","article-title":"Toward a comprehensive framework for the spatiotemporal statistical analysis of longitudinal shape data","volume":"103","author":"Durrleman","year":"2013","journal-title":"Int J Comp Vis"},{"key":"key\n\t\t\t\t20181004074230_awy050-B9","doi-asserted-by":"crossref","first-page":"226ra30","DOI":"10.1126\/scitranslmed.3007901","article-title":"Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer\u2019s disease","volume":"6","author":"Fagan","year":"2014","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20181004074230_awy050-B10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/jamaneurol.2014.3314","article-title":"Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study","volume":"72","author":"Fleisher","year":"2015","journal-title":"JAMA Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"key\n\t\t\t\t20181004074230_awy050-B12","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.neuroimage.2012.01.062","article-title":"An event-based model for disease progression and its application in familial Alzheimer\u2019s disease and Huntington\u2019s disease","volume":"60","author":"Fonteijn","year":"2012","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20181004074230_awy050-B13","volume-title":"Bayesian data analysis","author":"Gelman","year":"2014"},{"key":"key\n\t\t\t\t20181004074230_awy050-B14","article-title":"Modeling the brain morphology distribution in the general aging population","volume-title":"Proceedings of SPIE","author":"Huizinga","year":"2016"},{"key":"key\n\t\t\t\t20181004074230_awy050-B15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroimage.2017.02.058","article-title":"Multifactorial causal model of brain (dis)organization and therapeutic intervention: application to Alzheimer\u2019s disease","volume":"152","author":"Iturria-Medina","year":"2017","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20181004074230_awy050-B16","doi-asserted-by":"crossref","first-page":"e1003956","DOI":"10.1371\/journal.pcbi.1003956","article-title":"Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders","volume":"10","author":"Iturria-Medina","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B18","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.neuroimage.2012.07.059","article-title":"A computational neurodegenerative disease progression score: method and results with the Alzheimer\u2019s Disease Neuroimaging Initiative cohort","volume":"63","author":"Jedynak","year":"2012","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20181004074230_awy050-B19","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/brain\/awm319","article-title":"Automatic classification of MR scans in Alzheimer\u2019s disease","volume":"131","author":"Kl\u00f6ppel","year":"2008","journal-title":"Brain"},{"key":"key\n\t\t\t\t20181004074230_awy050-B20","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/ana.23908","article-title":"Comparing positron emission tomography imaging and cerebrospinal fluid measurements of \u03b2-amyloid","volume":"74","author":"Landau","year":"2013","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B21","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.neurobiolaging.2014.07.046","article-title":"Disentangling normal aging from Alzheimer\u2019s disease in structural magnetic resonance images","volume":"36","author":"Lorenzi","year":"2015","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20181004074230_awy050-B22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3233\/JAD-2011-110365","article-title":"A disease state fingerprint for evaluation of Alzheimer\u2019s disease","volume":"27","author":"Mattila","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"key\n\t\t\t\t20181004074230_awy050-B23","doi-asserted-by":"crossref","first-page":"975","DOI":"10.4155\/cli.12.93","article-title":"Developing an international network for Alzheimer\u2019s research: the Dominantly Inherited Alzheimer Network","volume":"2","author":"Morris","year":"2012","journal-title":"Clin Invest"},{"key":"key\n\t\t\t\t20181004074230_awy050-B24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/WCO.0000000000000460","article-title":"Imaging plus X: multimodal models of neurodegenerative disease","volume":"30","author":"Oxtoby","year":"2017","journal-title":"Curr Opin Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B25","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-12289-2_8","article-title":"Learning imaging biomarker trajectories from noisy Alzheimer\u2019s disease data using a Bayesian multilevel model","volume-title":"Bayesian and grAphical models for biomedical imaging. Lecture notes in computer science","author":"Oxtoby","year":"2014"},{"key":"key\n\t\t\t\t20181004074230_awy050-B26","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","article-title":"A network diffusion model of disease progression in dementia","volume":"73","author":"Raj","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20181004074230_awy050-B27","volume-title":"Gaussian processes for machine learning","author":"Rasmussen","year":"2006"},{"key":"key\n\t\t\t\t20181004074230_awy050-B28","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(12)70228-4","article-title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer\u2019s disease in the presenilin 1 E280A kindred: a case-control study","volume":"11","author":"Reiman","year":"2012","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B29","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1474-4422(06)70550-6","article-title":"Tracking atrophy progression in familial Alzheimer\u2019s disease: a serial MRI study","volume":"5","author":"Ridha","year":"2006","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B30","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/brain\/awv004","article-title":"Early behavioural changes in familial Alzheimer\u2019s disease in the Dominantly Inherited Alzheimer Network","volume":"138","author":"Ringman","year":"2015","journal-title":"Brain"},{"key":"key\n\t\t\t\t20181004074230_awy050-B31","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/S1474-4422(16)30193-4","article-title":"Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer\u2019s disease: a case series","volume":"15","author":"Ryan","year":"2016","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1212\/WNL.0000000000000596","article-title":"Symptom onset in autosomal dominant Alzheimer disease","volume":"83","author":"Ryman","year":"2014","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20181004074230_awy050-B33","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1073\/pnas.052587399","article-title":"Mapping the evolution of regional atrophy in Alzheimer\u2019s disease: unbiased analysis of fluid-registered serial MRI","volume":"99","author":"Scahill","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20181004074230_awy050-B34","first-page":"564","article-title":"A mixed-effect model with time reparametrization for longitudinal univariate manifold-valued data","volume":"24","author":"Schiratti","year":"2015","journal-title":"Inf Process Med Imaging"},{"key":"key\n\t\t\t\t20181004074230_awy050-B35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12883-015-0410-5","article-title":"Dissociation of amyloid biomarkers in PET and CSF in Alzheimer\u2019s disease: a case report","volume":"15","author":"Schroeter","year":"2015","journal-title":"BMC Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20181004074230_awy050-B38","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S1474-4422(16)30229-0","article-title":"Neurological manifestations of autosomal dominant familial Alzheimer\u2019s disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)","volume":"15","author":"Tang","year":"2016","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B39","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s11222-016-9696-4","article-title":"Practical Bayesian model evaluation using leave-one-out cross-validation and WAIC","volume":"27","author":"Vehtari","year":"2016","journal-title":"Stat Comput"},{"key":"key\n\t\t\t\t20181004074230_awy050-B40","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-59050-9_10","article-title":"A discriminative event based model for Alzheimer\u2019s disease progression modeling","volume-title":"Information Processing in Medical Imaging. IPMI 2017. Lecture Notes in Computer Science","author":"Venkatraghavan","year":"2017"},{"key":"key\n\t\t\t\t20181004074230_awy050-B41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20181004074230_awy050-B42","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jalz.2011.09.172","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative: a review of papers published since its inception","volume":"8","author":"Weiner","year":"2012","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t20181004074230_awy050-B43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pscychresns.2014.08.005","article-title":"Prognostic classification of mild cognitive impairment and Alzheimer\u2019s disease: MRI independent component analysis","volume":"224","author":"Willette","year":"2014","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20181004074230_awy050-B44","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3233\/JAD-2011-110551","article-title":"Quantifying the pathophysiological timeline of Alzheimer\u2019s disease","volume":"26","author":"Yang","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"key\n\t\t\t\t20181004074230_awy050-B45","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1093\/brain\/awu176","article-title":"A data-driven model of biomarker changes in sporadic Alzheimer\u2019s disease","volume":"137","author":"Young","year":"2014","journal-title":"Brain"},{"key":"key\n\t\t\t\t20181004074230_awy050-B46","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/978-3-319-19992-4_56","article-title":"Multiple orderings of events in disease progression","volume-title":"Information processing in medical imaging","author":"Young","year":"2015"},{"key":"key\n\t\t\t\t20181004074230_awy050-B47","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.nicl.2013.05.004","article-title":"Accurate multimodal probabilistic prediction of conversion to Alzheimer\u2019s disease in patients with mild cognitive impairment","volume":"2","author":"Young","year":"2013","journal-title":"Neuroimage Clin"},{"key":"key\n\t\t\t\t20181004074230_awy050-B48","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuron.2012.03.004","article-title":"Predicting regional neurodegeneration from the healthy brain functional connectome","volume":"73","author":"Zhou","year":"2012","journal-title":"Neuron"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/141\/5\/1529\/25901390\/awy050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T12:59:06Z","timestamp":1570712346000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/141\/5\/1529\/4951528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,3,22]]},"published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awy050","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/250654","asserted-by":"object"}]},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5]]},"published":{"date-parts":[[2018,3,22]]}}}