{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:24:40Z","timestamp":1789827880337,"version":"4.0.1"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Reta Lila Weston Institute for Neurological Studies"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Parkinson\u2019s UK Tissue Bank"},{"name":"Parkinson\u2019s UK","award":["258197"],"award-info":[{"award-number":["258197"]}]},{"name":"Parkinson\u2019s UK","award":["SC037554"],"award-info":[{"award-number":["SC037554"]}]},{"DOI":"10.13039\/100000864","name":"Michael J Fox Foundation for Parkinson\u2019s Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CBD Solutions Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"DOI":"10.1093\/brain\/awy157","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T07:10:05Z","timestamp":1526627405000},"page":"2419-2431","source":"Crossref","is-referenced-by-count":78,"title":["Somatic copy number gains of \u03b1-synuclein (SNCA) in Parkinson\u2019s disease and multiple system atrophy brains"],"prefix":"10.1093","volume":"141","author":[{"given":"Katya","family":"Mokretar","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience, UCL Institute of Neurology, University College London, London, UK"},{"name":"Department of Academic Haematology, University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pease","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, UCL Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Willem","family":"Taanman","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, UCL Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Soenmez","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, UCL Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, UCL Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammaryn","family":"Lashley","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurodegenerative diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Ling","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurodegenerative diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Gentleman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Houlden","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L","family":"Holton","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurodegenerative diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H V","family":"Schapira","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, UCL Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Nacheva","sequence":"additional","affiliation":[{"name":"Department of Academic Haematology, University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Proukakis","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, UCL Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"key\n\t\t\t\t20180726035953_awy157-B1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature11629","article-title":"Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells","volume":"492","author":"Abyzov","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180726035953_awy157-B2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2353\/ajpath.2010.090955","article-title":"Selective cell death of hyperploid neurons in Alzheimer\u2019s disease","volume":"177","author":"Arendt","year":"2010","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ajhg.2009.01.024","article-title":"Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants","volume":"84","author":"Arlt","year":"2009","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B4","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10531","article-title":"Somatic retrotransposition alters the genetic landscape of the human brain","volume":"479","author":"Baillie","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180726035953_awy157-B5","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","article-title":"Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders","volume":"119","author":"Beach","year":"2010","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B6","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/hmg\/ddh134","article-title":"Somatic and germline mosaicism in sporadic early-onset Alzheimer\u2019s disease","volume":"13","author":"Beck","year":"2004","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20180726035953_awy157-B8","doi-asserted-by":"crossref","first-page":"e05116","DOI":"10.7554\/eLife.05116","article-title":"Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer\u2019s disease brains","volume":"4","author":"Bushman","year":"2015","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180726035953_awy157-B9","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.celrep.2014.07.043","article-title":"Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain","volume":"8","author":"Cai","year":"2014","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180726035953_awy157-B10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aak9787","article-title":"Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)","volume":"356","author":"Chen","year":"2017","journal-title":"Science"},{"key":"key\n\t\t\t\t20180726035953_awy157-B11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0896-6273(00)80671-6","article-title":"Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins","volume":"22","author":"Chun","year":"1999","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180726035953_awy157-B12","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1093\/brain\/awv114","article-title":"Expanding the spectrum of neuronal pathology in multiple system atrophy","volume":"138","author":"Cykowski","year":"2015","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180726035953_awy157-B13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuron.2014.12.028","article-title":"Cell lineage analysis in human brain using endogenous retroelements","volume":"85","author":"Evrony","year":"2015","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180726035953_awy157-B14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.parkreldis.2015.11.005","article-title":"Genome-wide estimate of the heritability of multiple system atrophy","volume":"22","author":"Federoff","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"key\n\t\t\t\t20180726035953_awy157-B15","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1474-9726.2012.00826.x","article-title":"Changes in neuronal DNA content variation in the human brain during aging","volume":"11","author":"Fischer","year":"2012","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20180726035953_awy157-B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmedgenet-2012-101322","article-title":"Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime","volume":"50","author":"Forsberg","year":"2013","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B17","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/15384101.2015.1004937","article-title":"Neuronal cell cycle: the neuron itself and its circumstances","volume":"14","author":"Frade","year":"2015","journal-title":"Cell cycle"},{"key":"key\n\t\t\t\t20180726035953_awy157-B18","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1073\/pnas.0909343106","article-title":"Evolution in health and medicine Sackler colloquium: somatic evolutionary genomics: mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration","volume":"107","author":"Frank","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180726035953_awy157-B19","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jalz.2015.02.007","article-title":"On the identification of low allele frequency mosaic mutations in the brains of Alzheimer disease patients","volume":"11","author":"Frigerio","year":"2015","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t20180726035953_awy157-B20","first-page":"266","article-title":"Diversity of pathological features other than Lewy bodies in familial Parkinson\u2019s disease due to SNCA mutations","volume":"2","author":"Fujishiro","year":"2013","journal-title":"Am J Neurodegener Dis"},{"key":"key\n\t\t\t\t20180726035953_awy157-B21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1101\/gr.134395.111","article-title":"A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?","volume":"22","author":"Fungtammasan","year":"2012","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180726035953_awy157-B22","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.expneurol.2013.07.015","article-title":"Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra","volume":"248","author":"Garcia-Reitboeck","year":"2013","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrg.2015.16","article-title":"Single-cell genome sequencing: current state of the science","volume":"17","author":"Gawad","year":"2016","journal-title":"Nat Rev Gene"},{"key":"key\n\t\t\t\t20180726035953_awy157-B24","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nbt.2720","article-title":"Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells","volume":"31","author":"Gole","year":"2013","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B25","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.neuron.2016.02.004","article-title":"The complete genome sequences, unique mutational spectra, and developmental potency of adult neurons revealed by cloning","volume":"89","author":"Hazen","year":"2016","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180726035953_awy157-B26","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1073\/pnas.0611671104","article-title":"The pRb\/E2F cell-cycle pathway mediates cell death in Parkinson\u2019s disease","volume":"104","author":"H\u00f6glinger","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180726035953_awy157-B27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.nbd.2009.01.003","article-title":"Aneuploidy in the normal, Alzheimer\u2019s disease and ataxia-telangiectasia brain: differential expression and pathological meaning","volume":"34","author":"Iourov","year":"2009","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20180726035953_awy157-B28","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1001\/jamaneurol.2014.994","article-title":"A 6.4 Mb duplication of the \u03b1-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations","volume":"71","author":"Kara","year":"2014","journal-title":"JAMA Neurol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/mds.25499","article-title":"The many faces of alpha-synuclein mutations","volume":"28","author":"Kasten","year":"2013","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20180726035953_awy157-B30","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1093\/hmg\/dds335","article-title":"Using genome-wide complex trait analysis to quantify \u2018missing heritability\u2019 in Parkinson\u2019s disease","volume":"21","author":"Keller","year":"2012","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00401-013-1096-7","article-title":"\u03b1-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson\u2019s disease and multiple system atrophy?","volume":"125","author":"Kiely","year":"2013","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B32","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/ejhg.2016.56","article-title":"Digital PCR for discriminating mosaic deletions and for determining proportion of tumor cells in specimen","volume":"24","author":"Kluwe","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B33","doi-asserted-by":"crossref","first-page":"13409","DOI":"10.1073\/pnas.1415287111","article-title":"Single cell sequencing reveals low levels of aneuploidy across mammalian tissues","volume":"111","author":"Knouse","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180726035953_awy157-B34","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1093\/brain\/awt192","article-title":"Disease duration and the integrity of the nigrostriatal system in Parkinson\u2019s disease","volume":"136","author":"Kordower","year":"2013","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180726035953_awy157-B35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/nan.12465","article-title":"Invited review: somatic mutations in neurodegeneration","volume":"44","author":"Leija-Salazar","year":"2018","journal-title":"Neuropathol Appl Neurobiol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.aab1785","article-title":"Somatic mutation in single human neurons tracks developmental and transcriptional history","volume":"350","author":"Lodato","year":"2015","journal-title":"Science"},{"key":"key\n\t\t\t\t20180726035953_awy157-B37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1239503","article-title":"Genetics. Genome mosaicism\u2013one human, multiple genomes","volume":"341","author":"Lupski","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20180726035953_awy157-B38","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ng.2311","article-title":"Exploring the variation within","volume":"44","author":"Macosko","year":"2012","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B39","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1126\/science.1243472","article-title":"Mosaic copy number variation in human neurons","volume":"342","author":"McConnell","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20180726035953_awy157-B40","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180726035953_awy157-B41","doi-asserted-by":"crossref","first-page":"e9591","DOI":"10.1371\/journal.pone.0009591","article-title":"Early embryonic chromosome instability results in stable mosaic pattern in human tissues","volume":"5","author":"Mkrtchyan","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180726035953_awy157-B42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/ldv022","article-title":"The genetics of Parkinson\u2019s disease","volume":"114","author":"Mullin","year":"2015","journal-title":"Br Med Bull"},{"key":"key\n\t\t\t\t20180726035953_awy157-B43","doi-asserted-by":"crossref","first-page":"e0180467","DOI":"10.1371\/journal.pone.0180467","article-title":"DNA isolation protocol effects on nuclear DNA analysis by microarrays, droplet digital PCR, and whole genome sequencing, and on mitochondrial DNA copy number estimation","volume":"12","author":"Nacheva","year":"2017","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180726035953_awy157-B44","doi-asserted-by":"crossref","first-page":"12139","DOI":"10.1038\/ncomms12139","article-title":"Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling","volume":"7","author":"Nichterwitz","year":"2016","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180726035953_awy157-B45","doi-asserted-by":"crossref","first-page":"18018","DOI":"10.1073\/pnas.1213736109","article-title":"Extensive genetic variation in somatic human tissues","volume":"109","author":"O\u2019Huallachain","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180726035953_awy157-B46","first-page":"1017","article-title":"Sudan Black B treatment reduces autofluorescence and improves resolution of in situ hybridization specific fluorescent signals of brain sections","volume":"25","author":"Oliveira","year":"2010","journal-title":"Histol Histopathol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B47","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.parkreldis.2015.08.015","article-title":"Phenotypic spectrum of alpha-synuclein mutations: new insights from patients and cellular models","volume":"22","author":"Petrucci","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"key\n\t\t\t\t20180726035953_awy157-B48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/mds.25502","article-title":"Somatic alpha-synuclein mutations in Parkinson\u2019s disease: hypothesis and preliminary data","volume":"28","author":"Proukakis","year":"2013","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20180726035953_awy157-B49","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/mds.25883","article-title":"Analysis of Parkinson\u2019s disease brain-derived DNA for alpha-synuclein coding somatic mutations","volume":"29","author":"Proukakis","year":"2014","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20180726035953_awy157-B50","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1523\/JNEUROSCI.4560-04.2005","article-title":"Constitutional aneuploidy in the normal human brain","volume":"25","author":"Rehen","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180726035953_awy157-B51","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.21380","article-title":"Genomic investigation of alpha-synuclein multiplication and parkinsonism","volume":"63","author":"Ross","year":"2008","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B52","doi-asserted-by":"crossref","first-page":"6872","DOI":"10.1038\/sj.onc.1207809","article-title":"Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer","volume":"23","author":"Rozier","year":"2004","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20180726035953_awy157-B53","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3324\/haematol.2013.085175","article-title":"Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features","volume":"98","author":"Schwab","year":"2013","journal-title":"Haematologica"},{"key":"key\n\t\t\t\t20180726035953_awy157-B54","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1073\/pnas.1525564113","article-title":"Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem\/progenitor cells","volume":"113","author":"Schwer","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180726035953_awy157-B55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/pin.12562","article-title":"Diagnostic utility of automated SureFISH (Dako Omnis) in the diagnosis of musculoskeletal translocation-related sarcomas","volume":"67","author":"Sugita","year":"2017","journal-title":"Pathol Int"},{"key":"key\n\t\t\t\t20180726035953_awy157-B56","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/jclinpath-2016-204311","article-title":"Assessment of ALK gene rearrangement in lung cancer using a new rapid automated SureFISH (Dako Omnis) assay","volume":"70","author":"Takeda","year":"2017","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B57","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev-cellbio-101011-155822","article-title":"LINE-1 retrotransposition in the nervous system","volume":"28","author":"Thomas","year":"2012","journal-title":"Annu Rev Cell Dev Biol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1755-8166-4-13","article-title":"Comparative genomic hybridization on microarray (a-CGH) in constitutional and acquired mosaicism may detect as low as 8% abnormal cells","volume":"4","author":"Valli","year":"2011","journal-title":"Mol Cytogenet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng.491","article-title":"Somatic mutations of the Parkinson\u2019s disease\u2013associated gene PARK2 in glioblastoma and other human malignancies","volume":"42","author":"Veeriah","year":"2010","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180726035953_awy157-B60","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/humu.22344","article-title":"High-resolution survey in familial Parkinson disease genes reveals multiple independent copy number variation events in PARK2","volume":"34","author":"Wang","year":"2013","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20180726035953_awy157-B61","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cell.2015.12.039","article-title":"Long neural genes harbor recurrent DNA break clusters in neural stem\/progenitor cells","volume":"164","author":"Wei","year":"2016","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180726035953_awy157-B62","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1002\/cne.22436","article-title":"Neuronal DNA content variation (DCV) with regional and individual differences in the human brain","volume":"518","author":"Westra","year":"2010","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180726035953_awy157-B63","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.neurobiolaging.2011.02.017","article-title":"Heritability of Parkinson disease in Swedish twins: a longitudinal study","volume":"32","author":"Wirdefeldt","year":"2011","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20180726035953_awy157-B64","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1523\/JNEUROSCI.21-08-02661.2001","article-title":"DNA replication precedes neuronal cell death in Alzheimer\u2019s disease","volume":"21","author":"Yang","year":"2001","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180726035953_awy157-B65","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.neurobiolaging.2014.12.016","article-title":"Aneuploidy in Lewy body diseases","volume":"36","author":"Yang","year":"2015","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20180726035953_awy157-B66","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/mds.26869","article-title":"Increased aneuploidy is not a universal feature across \u03b1-synucleinopathies","volume":"32","author":"Yang","year":"2017","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20180726035953_awy157-B67","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nmeth.4140","article-title":"Scalable whole-genome single-cell library preparation without preamplification","volume":"14","author":"Zahn","year":"2017","journal-title":"Nat Methods"},{"key":"key\n\t\t\t\t20180726035953_awy157-B68","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nrg3871","article-title":"A copy number variation map of the human genome","volume":"16","author":"Zarrei","year":"2015","journal-title":"Nat Rev Genet"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/141\/8\/2419\/25219708\/awy157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T01:56:13Z","timestamp":1571363773000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/141\/8\/2419\/5039696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":68,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,6,15]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awy157","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8]]},"published":{"date-parts":[[2018,6,15]]}}}