{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:05:17Z","timestamp":1790359517239,"version":"4.1.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"European Union\u2019s Seventh Framework Programme","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020"},{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"crossref","award":["MGU0343"],"award-info":[{"award-number":["MGU0343"]}],"id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/brain\/awy247","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T21:17:36Z","timestamp":1536700656000},"source":"Crossref","is-referenced-by-count":28,"title":["n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis"],"prefix":"10.1093","author":[{"given":"Federica","family":"Frigerio","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCSS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCSS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Craparotta","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mario Negri Institute for Pharmacological Research IRCSS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Marchini","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mario Negri Institute for Pharmacological Research IRCSS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin A","family":"van Vliet","sequence":"additional","affiliation":[{"name":"Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Foerch","sequence":"additional","affiliation":[{"name":"UCB Biopharma SPRL, Braine l\u2019Alleud, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vandenplas","sequence":"additional","affiliation":[{"name":"UCB Biopharma SPRL, Braine l\u2019Alleud, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Leclercq","sequence":"additional","affiliation":[{"name":"UCB Biopharma SPRL, Braine l\u2019Alleud, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[{"name":"Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Stichting Epilepsie Instellingen Nederland (SEIN), Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Porcu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mario Negri Institute for Pharmacological Research IRCSS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Pistorius","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain A","family":"Colas","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond V","family":"Hansen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Perretti","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK"},{"name":"Centre for inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal M","family":"Kaminski","sequence":"additional","affiliation":[{"name":"UCB Biopharma SPRL, Braine l\u2019Alleud, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesmond","family":"Dalli","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London, London, UK"},{"name":"Centre for inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Vezzani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCSS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"key\n\t\t\t\t20181010234242212_awy247-B1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/epi.13783","article-title":"Neuroinflammatory targets and treatments for epilepsy validated in experimental models","volume":"58","author":"Aronica","year":"2017","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.nbd.2007.01.015","article-title":"Complement activation in experimental and human temporal lobe epilepsy","volume":"26","author":"Aronica","year":"2007","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1528-1167.2011.03033.x","article-title":"Inflammation in epilepsy: clinical observations","volume":"52","author":"Aronica","year":"2011","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B5","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/np4009865","article-title":"Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions","volume":"77","author":"Aursnes","year":"2014","journal-title":"J Nat Prod"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B6","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1093\/brain\/awn271","article-title":"A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta","volume":"131","author":"Balosso","year":"2008","journal-title":"Brain"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.expneurol.2013.05.010","article-title":"The dual role of TNF-alpha and its receptors in seizures","volume":"247C","author":"Balosso","year":"2013","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B8","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1523\/JNEUROSCI.1301-17.2017","article-title":"Inhibition of IL-1\u03b2 signaling normalizes NMDA-dependent neurotransmission and reduces seizure susceptibility in a mouse model of creutzfeldt-jakob disease","volume":"37","author":"Bertani","year":"2017","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.eplepsyres.2007.10.002","article-title":"Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex","volume":"78","author":"Boer","year":"2008","journal-title":"Epilepsy Res"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B10","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1111\/epi.13457","article-title":"Transient and chronic seizure-induced inflammation in human focal epilepsy","volume":"57","author":"Butler","year":"2016","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B11","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.drudis.2014.06.023","article-title":"Resolution of inflammation: targeting GPCRs that interact with lipids and peptides","volume":"19","author":"Cash","year":"2014","journal-title":"Drug Discov Today"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B12","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1073\/pnas.1209362110","article-title":"Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications","volume":"110","author":"Cristante","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B13","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1038\/srep01940","article-title":"Novel n-3 immunoresolvents: structures and actions","volume":"3","author":"Dalli","year":"2013","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4939-7592-1_4","article-title":"Lipid mediator metabolomics via lc-ms\/ms profiling and analysis","volume":"1730","author":"Dalli","year":"2018","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B15","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1046\/j.1460-9568.2000.00140.x","article-title":"Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus","volume":"12","author":"De Simoni","year":"2000","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12974-018-1063-2","article-title":"Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade","volume":"15","author":"DeSena","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B17","doi-asserted-by":"crossref","first-page":"18024","DOI":"10.1038\/nrdp.2018.24","article-title":"Epilepsy","volume":"4","author":"Devinsky","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tox.2007.05.032","article-title":"Prolonged inflammatory gene response following soman-induced seizures in mice","volume":"238","author":"Dhote","year":"2007","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B19","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0022-2275(20)31527-3","article-title":"Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid","volume":"42","author":"Ferdinandusse","year":"2001","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B20","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin","year":"2008"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B21","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jamaneurol.2015.0941","article-title":"Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein","volume":"72","author":"Gershen","year":"2015","journal-title":"JAMA Neurol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/jnc.12607","article-title":"Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke","volume":"129","author":"Hawkins","year":"2014","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/ilar.46.2.148","article-title":"Environmental enrichment for laboratory rodents","volume":"46","author":"Hutchinson","year":"2005","journal-title":"ILAR J"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nbd.2016.12.007","article-title":"Blockade of the IL-1R1\/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy","volume":"99","author":"Iori","year":"2017","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B25","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1073\/pnas.1218498110","article-title":"Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation","volume":"110","author":"Jiang","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B26","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/nm.2834","article-title":"Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects","volume":"18","author":"Jimenez-Mateos","year":"2012","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4172\/2155-9899.1000456","article-title":"Intractable epilepsy (IE) and responses to anakinra, a human recombinant IL-1 receptor antagonist (IL-1Ra): case reports","volume":"7","author":"Jyonouchi","year":"2016","journal-title":"J Clin Cell Immunol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B28","doi-asserted-by":"crossref","first-page":"2318.e1","DOI":"10.1016\/j.neurobiolaging.2010.04.001","article-title":"The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat","volume":"32","author":"Kelly","year":"2011","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/ana.24806","article-title":"Febrile infection-related epilepsy syndrome treated with anakinra","volume":"80","author":"Kenney-Jung","year":"2016","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s40122-017-0075-4","article-title":"Fundamentals of and critical issues in lipid autacoid medicine: a review","volume":"6","author":"Keppel Hesselink","year":"2017","journal-title":"Pain Ther"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/epi.13965","article-title":"Commonalities in epileptogenic processes from different acute brain insults: do they translate?","volume":"59","author":"Klein","year":"2018","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/epi.13778","article-title":"Neuroinflammation imaging markers for epileptogenesis","volume":"58","author":"Koepp","year":"2017","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B33","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMra1004418","article-title":"Drug-resistant epilepsy","volume":"365","author":"Kwan","year":"2011","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ana.23567","article-title":"Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage","volume":"72","author":"Librizzi","year":"2012","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B35","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"Loscher","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.01.037","article-title":"Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury","volume":"1502","author":"Luo","year":"2013","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B37","doi-asserted-by":"crossref","first-page":"43807","DOI":"10.1074\/jbc.M305841200","article-title":"Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression","volume":"278","author":"Marcheselli","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B38","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s13311-011-0039-z","article-title":"Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice","volume":"8","author":"Maroso","year":"2011","journal-title":"Neurotherapeutics"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-016-0540-8","article-title":"Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection","volume":"13","author":"Martini","year":"2016","journal-title":"J Neuroinflammation"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/epi.13786","article-title":"Neurobehavioral comorbidities of epilepsy: role of inflammation","volume":"58","author":"Mazarati","year":"2017","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B41","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/j.1528-1167.2011.03081.x","article-title":"The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis","volume":"52","author":"Musto","year":"2011","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B42","doi-asserted-by":"crossref","first-page":"e0116543","DOI":"10.1371\/journal.pone.0116543","article-title":"Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1","volume":"10","author":"Musto","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nbd.2013.07.015","article-title":"Pharmacological blockade of IL-1\u03b2\/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy","volume":"59","author":"No\u00e9","year":"2013","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B44","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1093\/brain\/awx117","article-title":"Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy","volume":"140","author":"Pauletti","year":"2017","journal-title":"Brain"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B45","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.seizure.2013.04.023","article-title":"TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue","volume":"22","author":"Pernhorst","year":"2013","journal-title":"Seizure"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.eplepsyres.2004.10.003","article-title":"Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat","volume":"63","author":"Pitkanen","year":"2005","journal-title":"Epilepsy Res"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI89429","article-title":"Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans","volume":"127","author":"Rathod","year":"2017","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neulet.2011.02.040","article-title":"Inflammation and prevention of epileptogenesis","volume":"497","author":"Ravizza","year":"2011","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.nbd.2006.06.003","article-title":"The IL-1beta system in epilepsy-associated malformations of cortical development","volume":"24","author":"Ravizza","year":"2006","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B50","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2007.08.012","article-title":"Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy","volume":"29","author":"Ravizza","year":"2008","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B52","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2015.03.083","article-title":"Lipoxins and aspirin-triggered lipoxins in resolution of inflammation","volume":"760","author":"Romano","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.eplepsyres.2009.03.006","article-title":"Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy","volume":"85","author":"Scharfman","year":"2009","journal-title":"Epilepsy Res"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.immunol.25.022106.141647","article-title":"Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways","volume":"25","author":"Serhan","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B55","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1096\/fj.201601222R","article-title":"Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms","volume":"31","author":"Serhan","year":"2017","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B56","article-title":"New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration","author":"Serhan","year":"2017","journal-title":"Mol Aspects Med"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B57","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B58","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1096\/fj.11-201442","article-title":"Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain","volume":"26","author":"Serhan","year":"2012","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B59","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12974-016-0546-2","article-title":"Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex","volume":"13","author":"Sun","year":"2016","journal-title":"J Neuroinflamm"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B60","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1528-1167.2010.02654.x","article-title":"Polyunsaturated fatty acids and epilepsy","volume":"51","author":"Taha","year":"2010","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.yebeh.2012.12.004","article-title":"A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats\u2013implications for treating complex partial seizures","volume":"27","author":"Taha","year":"2013","journal-title":"Epilepsy Behav EB"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2013.09.004","article-title":"Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo","volume":"1537","author":"Taha","year":"2013","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B63","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.2174\/1381612823666170926113754","article-title":"Inflammation and epilepsy: preclinical findings and potential clinical translation","volume":"23","author":"Terrone","year":"2017","journal-title":"Curr Pharm Des"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B65","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuropharm.2012.04.004","article-title":"The role of inflammation in epileptogenesis","volume":"69","author":"Vezzani","year":"2013","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B66","doi-asserted-by":"crossref","first-page":"a022699","DOI":"10.1101\/cshperspect.a022699","article-title":"Immunity and inflammation in epilepsy","volume":"6","author":"Vezzani","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B67","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.bbi.2011.03.018","article-title":"IL-1 receptor\/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures","volume":"25","author":"Vezzani","year":"2011","journal-title":"Brain Behav Immun"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B68","doi-asserted-by":"crossref","first-page":"11534","DOI":"10.1073\/pnas.190206797","article-title":"Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice","volume":"97","author":"Vezzani","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B69","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1528-1157.43.s.5.14.x","article-title":"Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis","volume":"43","author":"Vezzani","year":"2002","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B70","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.10.027","article-title":"Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability","volume":"96","author":"Vezzani","year":"2015","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B71","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/nan.12444","article-title":"Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies","volume":"44","author":"van Vliet","year":"2018","journal-title":"Neuropathol Appl Neurobiol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B72","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1172\/JCI92001","article-title":"Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy","volume":"127","author":"Walker","year":"2017","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B73","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jalz.2013.12.024","article-title":"Resolution of inflammation is altered in Alzheimer\u2019s disease","volume":"11","author":"Wang","year":"2015","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B74","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbrc.2011.04.013","article-title":"Lipoxin A4 inhibits the production of proinflammatory cytokines induced by beta-amyloid in vitro and in vivo","volume":"408","author":"Wu","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B75","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0006-8993(99)01997-6","article-title":"Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation","volume":"846","author":"Xiao","year":"1999","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B76","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ana.23928","article-title":"Neuroprotectin\/protectin D1 protects against neuropathic pain in mice after nerve trauma","volume":"74","author":"Xu","year":"2013","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B77","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nm.2123","article-title":"Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions","volume":"16","author":"Xu","year":"2010","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20181010234242212_awy247-B78","doi-asserted-by":"crossref","first-page":"e15816","DOI":"10.1371\/journal.pone.0015816","article-title":"Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPAR\u03b3-mediated mechanisms in Alzheimer\u2019s disease models","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS One"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awy247\/25995303\/awy247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T03:14:51Z","timestamp":1662002091000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awy247\/5126410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":76,"URL":"https:\/\/doi.org\/10.1093\/brain\/awy247","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,10]]}}}