{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:31:00Z","timestamp":1793637060879,"version":"4.5.1"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"VA Merit","award":["I01BX001633"],"award-info":[{"award-number":["I01BX001633"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG056060"],"award-info":[{"award-number":["R01-AG056060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2016YFC1306300"],"award-info":[{"award-number":["2016YFC1306300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["81571038"],"award-info":[{"award-number":["81571038"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["81771145"],"award-info":[{"award-number":["81771145"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81171197"],"award-info":[{"award-number":["81171197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81220108010"],"award-info":[{"award-number":["81220108010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"DOI":"10.1093\/brain\/awy354","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T15:11:08Z","timestamp":1546528268000},"page":"787-807","source":"Crossref","is-referenced-by-count":163,"title":["Inhibition of EHMT1\/2 rescues synaptic and cognitive functions for Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"142","author":[{"given":"Yan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"},{"name":"Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"},{"name":"Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"},{"name":"VA Western New York Healthcare System, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"},{"name":"VA Western New York Healthcare System, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"},{"name":"VA Western New York Healthcare System, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Matas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"},{"name":"VA Western New York Healthcare System, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"key\n\t\t\t\t2019022703310676400_awy354-B1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopsych.2008.08.015","article-title":"Epigenetic regulation in human brain-focus on histone lysine methylation","volume":"65","author":"Akbarian","year":"2009","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12014-015-9098-1","article-title":"Histone post-translational modifications in frontal cortex from human donors with Alzheimer\u2019s disease","volume":"12","author":"Anderson","year":"2015","journal-title":"Clin Proteomics"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B3","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1093\/hmg\/dds490","article-title":"Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome","volume":"22","author":"Balemans","year":"2013","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2016.06.003","article-title":"Histone methylation by the Kleefstra syndrome protein EHMT1 mediates homeostatic synaptic scaling","volume":"91","author":"Benevento","year":"2016","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B6","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nprot.2006.205","article-title":"Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study \u2018recognition memory\u2019","volume":"1","author":"Bevins","year":"2006","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.neuron.2008.10.012","article-title":"Decoding the epigenetic language of neuronal plasticity","volume":"60","author":"Borrelli","year":"2008","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B8","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.celrep.2012.09.030","article-title":"Monoacylglycerol lipase is a therapeutic target for Alzheimer\u2019s disease","volume":"2","author":"Chen","year":"2012","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tins.2009.06.002","article-title":"Multiple roles of HDAC inhibition in neurodegenerative conditions","volume":"32","author":"Chuang","year":"2009","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B10","first-page":"220","article-title":"The potential of epigenetic therapies in neurodegenerative diseases","volume":"5","author":"Copped\u00e8","year":"2014","journal-title":"Front Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B11","doi-asserted-by":"crossref","first-page":"e74667","DOI":"10.1371\/journal.pone.0074667","article-title":"Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer\u2019s disease: dissociation between somatosensory cortex and hippocampus","volume":"8","author":"Crouzin","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B12","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3233\/JAD-160167","article-title":"Partial amelioration of synaptic and cognitive deficits by inhibiting cofilin dephosphorylation in an animal model of Alzheimer\u2019s disease","volume":"53","author":"Deng","year":"2016","journal-title":"J Alzheimer\u2019s Disease"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2015.04.064","article-title":"Autism-like deficits in Shank3-deficient mice are rescued by targeting actin regulators","volume":"11","author":"Duffney","year":"2015","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2014.01.038","article-title":"Targeting histone-modifications in Alzheimer\u2019s disease. What is the evidence that this is a promising therapeutic avenue?","volume":"80","author":"Fischer","year":"2014","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.tips.2010.09.003","article-title":"Targeting the correct HDAC(s) to treat cognitive disorders","volume":"31","author":"Fischer","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B16","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nm1113","article-title":"Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs","volume":"10","author":"Forman","year":"2004","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nn.3639","article-title":"Tau promotes neurodegeneration through global chromatin relaxation","volume":"17","author":"Frost","year":"2014","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B18","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1136\/jnnp.73.5.508","article-title":"Relation between medial temporal atrophy and functional brain activity during memory processing in Alzheimer\u2019s disease: a combined MRI and SPECT study","volume":"73","author":"Garrido","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B19","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0896-6273(95)90304-6","article-title":"Cellular basis of working memory","volume":"14","author":"Goldman-Rakic","year":"1995","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10849","article-title":"An epigenetic blockade of cognitive functions in the neurodegenerating brain","volume":"483","author":"Gr\u00e4ff","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-pharmtox-011112-140216","article-title":"The potential of HDAC inhibitors as cognitive enhancers","volume":"53","author":"Gr\u00e4ff","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: a dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B24","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1074\/jbc.M806508200","article-title":"\u03b2-amyloid impairs AMPA receptor trafficking and function by reducing CaMKII synaptic distribution","volume":"284","author":"Gu","year":"2009","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/dneu.22128","article-title":"The emerging role of SHANK genes in neuropsychiatric disorders","volume":"74","author":"Guilmatre","year":"2014","journal-title":"Dev Neurobiol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B26","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1523\/JNEUROSCI.3732-09.2010","article-title":"Histone methylation regulates memory formation","volume":"30","author":"Gupta","year":"2010","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B27","doi-asserted-by":"crossref","first-page":"5440","DOI":"10.1523\/JNEUROSCI.0147-12.2012","article-title":"G9a\/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation","volume":"32","author":"Gupta-Agarwal","year":"2012","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng1966","article-title":"Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome","volume":"39","author":"Heintzman","year":"2007","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/bpa.12335","article-title":"Altered machinery of protein synthesis in Alzheimer\u2019s: from the nucleolus to the ribosome","volume":"26","author":"Hern\u00e1ndez-Ortega","year":"2016","journal-title":"brain pathology"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","article-title":"APP processing and synaptic function","volume":"37","author":"Kamenetz","year":"2003","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B31","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1523\/JNEUROSCI.3356-12.2013","article-title":"Histonemethyltransferase mll2 (kmt2b) is required for memory formation in mice","volume":"33","author":"Kerimoglu","year":"2013","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2008.10.006","article-title":"Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model","volume":"33","author":"Kimura","year":"2009","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B33","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1086\/505693","article-title":"Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome","volume":"79","author":"Kleefstra","year":"2006","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ajhg.2012.05.003","article-title":"Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability","volume":"91","author":"Kleefstra","year":"2012","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B35","doi-asserted-by":"crossref","first-page":"e1000569","DOI":"10.1371\/journal.pbio.1000569","article-title":"Epigenetic regulation of learning and memory by Drosophila EHMT\/G9a","volume":"9","author":"Kramer","year":"2011","journal-title":"Plos Biol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molcel.2007.01.017","article-title":"Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methytransferase","volume":"25","author":"Kubicek","year":"2007","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2015.05.002","article-title":"The epigenetics of aging and neurodegeneration","volume":"131","author":"Lardenoije","year":"2015","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B38","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2007.01.015","article-title":"The role of chromatin during transcription","volume":"128","author":"Li","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B39","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.neurobiolaging.2012.12.028","article-title":"Disruption of neocortical histone H3 homeostasis by soluble A\u03b2: implications for Alzheimer\u2019s disease","volume":"34","author":"Lithner","year":"2013","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B40","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.1021\/jm401480r","article-title":"Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP","volume":"56","author":"Liu","year":"2013","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B41","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ajmg.b.32201","article-title":"Epigenetic studies in Alzheimer\u2019s disease: current findings, caveats, and considerations for future studies","volume":"162B","author":"Lunnon","year":"2013","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.arr.2012.11.001","article-title":"Association between prefrontal activity and volume change in prefrontal and medial temporal lobes in aging and dementia: a review","volume":"12","author":"Maillet","year":"2013","journal-title":"Ageing Res Rev"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B43","doi-asserted-by":"crossref","first-page":"16708","DOI":"10.1073\/pnas.1205414109","article-title":"Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum","volume":"109","author":"Malmquist","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B44","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.pneurobio.2008.10.001","article-title":"Epigenetic principles and mechanisms underlying nervous system functions in health and disease","volume":"86","author":"Mehler","year":"2008","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.31887\/DCNS.2014.16.3\/mmillan","article-title":"The epigenetic dimension of Alzheimer\u2019s disease: causal, consequence, or curiosity?","volume":"16","author":"Millan","year":"2014","journal-title":"Dialogues Clin Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.03.004","article-title":"Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer\u2019s disease: an integrative review","volume":"156","author":"Millan","year":"2017","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/B978-0-12-800977-2.00008-5","article-title":"The future of neuroepigenetics in the human brain","volume":"128","author":"Mitchell","year":"2014","journal-title":"Prog Mol Biol Transl Sci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B48","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1001\/archneur.58.11.1813","article-title":"The genetic and pathological classification of familial frontotemporal dementia","volume":"58","author":"Morris","year":"2001","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B49","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41593-018-0154-9","article-title":"A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer\u2019s disease","volume":"21","author":"Mostafavi","year":"2018","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-3-319-53889-1_17","article-title":"Alzheimer\u2019s disease and histone code alterations","volume":"978","author":"Narayan","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B51","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/ng.646","article-title":"Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome","volume":"42","author":"Ng","year":"2010","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B52","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B53","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.1186088","article-title":"Altered histone acetylation is associated with age-dependent memory impairment in mice","volume":"328","author":"Peleg","year":"2010","journal-title":"Science"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B54","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-0270(98)00169-1","article-title":"Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer\u2019s disease","volume":"87","author":"Pompl","year":"1999","journal-title":"J Neurosci Methods"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B56","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41593-018-0110-8","article-title":"Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition","volume":"21","author":"Qin","year":"2018","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuroimage.2004.10.045","article-title":"Verbal episodic memory impairment in Alzheimer\u2019s disease: a combined structural and functional MRI study","volume":"25","author":"R\u00e9my","year":"2005","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B58","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/nn.3214","article-title":"REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors","volume":"15","author":"Rodenas-Ruano","year":"2012","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B59","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.neuron.2009.11.019","article-title":"Control of cognition and adaptive behavior by the GLP\/G9a epigenetic suppressor complex","volume":"64","author":"Schaefer","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B60","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.cell.2014.01.065","article-title":"Activity-dependent p25 generation regulates synaptic plasticity and A\u03b2-induced cognitive impairment","volume":"157","author":"Seo","year":"2014","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B61","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1242\/jcs.113.11.1851","article-title":"The shank family of scaffold proteins","volume":"113","author":"Sheng","year":"2000","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B62","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/1531-8249(199911)46:5<708::AID-ANA5>3.0.CO;2-K","article-title":"FTDP-17: an early-onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation","volume":"46","author":"Sperfeld","year":"1999","journal-title":"Ann Neurol"},{"issue":"6","key":"key\n\t\t\t\t2019022703310676400_awy354-B63","doi-asserted-by":"crossref","first-page":"e21050","DOI":"10.1371\/journal.pone.0021050","article-title":"P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating","volume":"6","author":"Takeuchi","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B64","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1523\/JNEUROSCI.3056-15.2016","article-title":"Histone modification of Nedd4 ubiquitin ligase controls the loss of AMPA receptors and cognitive impairment induced by repeated stress","volume":"36","author":"Wei","year":"2016","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B65","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/B978-0-12-420170-5.00011-8","article-title":"Epigenetics of memory and plasticity","volume":"122","author":"Woldemichael","year":"2014","journal-title":"Prog Mol Biol Transl Sci"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B66","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature11208","article-title":"Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function","volume":"486","author":"Won","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B67","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B68","doi-asserted-by":"crossref","first-page":"14075","DOI":"10.1073\/pnas.0906791106","article-title":"Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory","volume":"106","author":"Yuen","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B69","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/mp.2010.50","article-title":"Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory","volume":"16","author":"Yuen","year":"2011","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B70","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.neuron.2011.12.033","article-title":"Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex","volume":"73","author":"Yuen","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019022703310676400_awy354-B71","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1523\/JNEUROSCI.4396-06.2007","article-title":"Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer\u2019s disease pathogenesis","volume":"27","author":"Zhao","year":"2007","journal-title":"J Neurosci"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/142\/3\/787\/27986608\/awy354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T13:49:40Z","timestamp":1662731380000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/142\/3\/787\/5298257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":71,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,1,22]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awy354","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2019,1,22]]}}}