{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:15:59Z","timestamp":1790270159208,"version":"4.1.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50 AG16574"],"award-info":[{"award-number":["P50 AG16574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01 AG06786"],"award-info":[{"award-number":["U01 AG06786"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG034676"],"award-info":[{"award-number":["R01 AG034676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG41851"],"award-info":[{"award-number":["R01 AG41851"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R37 AG11378"],"award-info":[{"award-number":["R37 AG11378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Elsie and Marvin Dekelboum Family Foundation"},{"name":"Robert H. and Clarice Smith and Abigail Van Buren Alzheimer\u2019s Disease Research Program"},{"DOI":"10.13039\/100007048","name":"Mayo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015595","name":"GHR Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015595","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alexander Family Alzheimer\u2019s Disease Research Professorship of the Mayo Clinic"},{"name":"Liston Award, Schuler Foundation"},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alexander Family Alzheimer\u2019s Disease Research Professorship of the Mayo Foundation"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG49704"],"award-info":[{"award-number":["R01 AG49704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AG44170"],"award-info":[{"award-number":["P50 AG44170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG06786"],"award-info":[{"award-number":["U01 AG06786"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 AG55151"],"award-info":[{"award-number":["RF1 AG55151"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-15\u20131"],"award-info":[{"award-number":["W81XWH-15\u20131"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biogen, Roche, and Lundbeck"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As more biomarkers for Alzheimer\u2019s disease and age-related brain conditions become available, more sophisticated analytic approaches are needed to take full advantage of the information they convey. Most work has been done using categorical approaches but the joint relationships of tau PET, amyloid PET and cortical thickness in their continuous distributions to cognition have been under-explored. We evaluated non-demented subjects over age 50 years in the Mayo Clinic Study of Aging, 2037 of whom had undergone 3 T MRI scan, 985 amyloid PET scan with 11C-Pittsburgh compound B (PIB) and MRI, and 577 PIB-PET, 18F-AV1451 flortaucipir PET and MRI. Participants received a nine-test cognitive battery. Three test scores (logical memory delayed recall, visual reproduction delayed recall and auditory verbal learning test delayed recall) were used to generate a memory composite z-score. We used Gradient Boosting Machine models to analyse the relationship between regional cortical thickness, flortaucipir PET signal, PIB-PET signal and memory z-scores. Age, education, sex and number of test exposures were included in the model as covariates. In this population-based study of non-demented subjects, most of the associations between biomarkers and memory z-scores accrued after 70 years of age. Entorhinal cortex exhibited the strongest associations between biomarkers and memory z-scores. Other temporal regions showed similar but attenuated associations, and non-temporal regions had negligible associations between memory z-scores and biomarkers. Entorhinal flortaucipir PET signal, PIB-PET signal and entorhinal cortical thickness were independently and additively associated with declining memory z-scores. In contrast to global PIB-PET signal where only very high amyloid-\u03b2 levels were associated low memory z-scores, entorhinal flortaucipir PET signal just above background levels was associated with low memory z-scores. The lowest memory z-scores occurred with the confluence of elevated entorhinal flortaucipir PET signal and lower entorhinal cortical thickness.<\/jats:p>","DOI":"10.1093\/brain\/awz025","type":"journal-article","created":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T04:24:02Z","timestamp":1547958242000},"page":"1148-1160","source":"Crossref","is-referenced-by-count":90,"title":["Entorhinal cortex tau, amyloid-\u03b2, cortical thickness and memory performance in non-demented subjects"],"prefix":"10.1093","volume":"142","author":[{"given":"David S","family":"Knopman","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S","family":"Lundt","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry M","family":"Therneau","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanthi","family":"Vemuri","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J","family":"Lowe","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejal","family":"Kantarci","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Gunter","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L","family":"Senjem","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M","family":"Mielke","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M","family":"Machulda","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F","family":"Boeve","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Graff-Radford","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina M","family":"Albertson","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Clifford R","family":"Jack","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"2020030521285943500_awz025-B75"},{"key":"2020030521285943500_awz025-B1","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1093\/brain\/awt273","article-title":"Cell number changes in Alzheimer\u2019s disease relate to dementia, not to plaques and tangles","volume":"136","author":"Andrade-Moraes","year":"2013","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer\u2019s disease","volume":"1","author":"Arnold","year":"1991","journal-title":"Cereb Cortex"},{"key":"2020030521285943500_awz025-B3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer\u2019s disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B4","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1474-4422(16)30029-1","article-title":"Relation of cerebral vessel disease to Alzheimer\u2019s disease dementia and cognitive function in elderly people: a cross-sectional study","volume":"15","author":"Arvanitakis","year":"2016","journal-title":"Lancet Neurol"},{"key":"2020030521285943500_awz025-B5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"2020030521285943500_awz025-B6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal"},{"key":"2020030521285943500_awz025-B7","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1093\/brain\/awy150","article-title":"Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults","volume":"8","author":"Bilgel","year":"2018","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological staging of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol (Berl)"},{"key":"2020030521285943500_awz025-B9","doi-asserted-by":"crossref","first-page":"338ra366","DOI":"10.1126\/scitranslmed.aaf2362","article-title":"Tau and Abeta imaging, CSF measures, and cognition in Alzheimer\u2019s disease","volume":"8","author":"Brier","year":"2016","journal-title":"Sci Transl Med"},{"key":"2020030521285943500_awz025-B10","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1002\/hbm.23672","article-title":"Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: results of the ENIGMA plasticity working group","volume":"38","author":"Brouwer","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"2020030521285943500_awz025-B11","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S1474-4422(16)30125-9","article-title":"Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer\u2019s disease pathophysiology (SNAP) or Alzheimer\u2019s disease pathology: a longitudinal study","volume":"15","author":"Burnham","year":"2016","journal-title":"Lancet Neurol"},{"key":"2020030521285943500_awz025-B12","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1093\/brain\/awq187","article-title":"Larger temporal volume in elderly with high versus low beta-amyloid deposition","volume":"133","author":"Chetelat","year":"2010","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ana.24711","article-title":"In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum","volume":"80","author":"Cho","year":"2016","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B14","doi-asserted-by":"crossref","first-page":"e114478","DOI":"10.1371\/journal.pone.0114478","article-title":"Longitudinal assessment of global and regional rate of grey matter atrophy in 1,172 healthy older adults: modulation by sex and age","volume":"9","author":"Crivello","year":"2014","journal-title":"PLoS One"},{"key":"2020030521285943500_awz025-B15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.neuroimage.2008.12.016","article-title":"Registration based cortical thickness measurement","volume":"45","author":"Das","year":"2009","journal-title":"Neuroimage"},{"key":"2020030521285943500_awz025-B16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neurobiolaging.2018.01.024","article-title":"Longitudinal and cross-sectional structural magnetic resonance imaging correlates of AV-1451 uptake","volume":"66","author":"Das","year":"2018","journal-title":"Neurobiol Aging"},{"key":"2020030521285943500_awz025-B17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B18","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1212\/WNL.0b013e3181a82634","article-title":"Longitudinal pattern of regional brain volume change differentiates normal aging from MCI","volume":"72","author":"Driscoll","year":"2009","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0197-4580(97)00047-X","article-title":"Prevalence, incidence and duration of Braak\u2019s stages in the general population: can we know?","volume":"18","author":"Duyckaerts","year":"1997","journal-title":"Neurobiol Aging"},{"key":"2020030521285943500_awz025-B20","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/brain\/awq185","article-title":"Education, the brain and dementia: neuroprotection or compensation?","volume":"133","author":"Brayne","year":"2010","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B21","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/cercor\/bhs379","article-title":"Accelerating cortical thinning: unique to dementia or universal in aging?","volume":"24","author":"Fjell","year":"2014","journal-title":"Cereb Cortex"},{"key":"2020030521285943500_awz025-B22","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer\u2019s disease","volume":"41","author":"Gomez-Isla","year":"1997","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B24","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1212\/WNL.0000000000004733","article-title":"Increased florbetapir binding in the temporal neocortex from age 20 to 60 years","volume":"89","author":"Gonneaud","year":"2017","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B25","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1212\/WNL.0000000000004643","article-title":"In vivo staging of regional amyloid deposition","volume":"89","author":"Grothe","year":"2017","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"key":"2020030521285943500_awz025-B27","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1212\/01.WNL.0000115115.98960.37","article-title":"Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain","volume":"62","author":"Ingelsson","year":"2004","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrneurol.2015.251","article-title":"Suspected non-Alzheimer disease pathophysiology - concept and controversy","volume":"12","author":"Jack","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"2020030521285943500_awz025-B29","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer\u2019s disease and amnestic mild cognitive impairment","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B30","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1212\/WNL.49.3.786","article-title":"Medial temporal atrophy on MRI in normal aging and very mild Alzheimer\u2019s disease","volume":"49","author":"Jack","year":"1997","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B31","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/brain\/awy059","article-title":"Longitudinal tau PET in ageing and Alzheimer\u2019s disease","volume":"141","author":"Jack","year":"2018","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B32","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/WNL.52.7.1397","article-title":"Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment","volume":"52","author":"Jack","year":"1999","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut-points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2020030521285943500_awz025-B34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau PET imaging in aging and early Alzheimer\u2019s disease","volume":"79","author":"Johnson","year":"2015","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cortex.2017.09.018","article-title":"Tau, amyloid, and cascading network failure across the Alzheimer\u2019s disease spectrum","volume":"97","author":"Jones","year":"2017","journal-title":"Cortex"},{"key":"2020030521285943500_awz025-B36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/1531-8249(200004)47:4<430::AID-ANA5>3.0.CO;2-I","article-title":"Use of structural magnetic resonance imaging to predict who will get Alzheimer\u2019s disease","volume":"47","author":"Killiany","year":"2000","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B37","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1212\/WNL.0000000000001884","article-title":"Effects of education on aging-related cortical thinning among cognitively normal individuals","volume":"85","author":"Kim","year":"2015","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B38","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1212\/WNL.0000000000002100","article-title":"Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging","volume":"85","author":"Knopman","year":"2015","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B39","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1001\/jamaneurol.2013.182","article-title":"Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly with \u03b2-amyloidosis","volume":"70","author":"Knopman","year":"2013","journal-title":"JAMA Neurol"},{"key":"2020030521285943500_awz025-B40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neurobiolaging.2018.01.017","article-title":"Joint associations of beta-amyloidosis and cortical thickness with cognition","volume":"65","author":"Knopman","year":"2018","journal-title":"Neurobiol Aging"},{"key":"2020030521285943500_awz025-B41","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1523\/JNEUROSCI.0485-18.2018","article-title":"Subthreshold amyloid predicts tau deposition in aging","volume":"38","author":"Leal","year":"2018","journal-title":"J Neurosci"},{"key":"2020030521285943500_awz025-B42","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/j.neuroimage.2010.10.050","article-title":"Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults","volume":"54","author":"Leritz","year":"2011","journal-title":"Neuroimage"},{"key":"2020030521285943500_awz025-B43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroimage.2017.02.051","article-title":"Amyloid and tau PET demonstrate region-specific associations in normal older people","volume":"150","author":"Lockhart","year":"2017","journal-title":"Neuroimage"},{"key":"2020030521285943500_awz025-B44","article-title":"Cross-sectional associations of Tau-PET signal with cognition in cognitively unimpaired adults","author":"Lowe","journal-title":"Neurology, submitted for publication"},{"key":"2020030521285943500_awz025-B45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.dadm.2018.01.005","article-title":"Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants","volume":"10","author":"Lowe","year":"2018","journal-title":"Alzheimers Dement (Amst)"},{"key":"2020030521285943500_awz025-B46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/brain\/awx320","article-title":"Widespread brain tau and its association with ageing, Braak stage and Alzheimer\u2019s dementia","volume":"141","author":"Lowe","year":"2018","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B47","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1523\/JNEUROSCI.3769-16.2017","article-title":"Tau and beta-amyloid are associated with medial temporal lobe structure, function, and memory encoding in normal aging","volume":"37","author":"Marks","year":"2017","journal-title":"J Neurosci"},{"key":"2020030521285943500_awz025-B48","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/brain\/awv050","article-title":"Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer\u2019s disease spectrum","volume":"138","author":"Murray","year":"2015","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B49","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-011-0826-y","article-title":"Alzheimer\u2019s disease is not \u201cbrain aging\u201d: neuropathological, genetic, and epidemiological human studies","volume":"121","author":"Nelson","year":"2011","journal-title":"Acta Neuropathol"},{"key":"2020030521285943500_awz025-B50","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/nen.0b013e31815c5efb","article-title":"Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles \u201cdo count\u201d when staging disease severity","volume":"66","author":"Nelson","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"2020030521285943500_awz025-B51","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer\u2019s disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B52","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","article-title":"Earliest accumulation of beta-amyloid occurs within the default-mode network and concurrently affects brain connectivity","volume":"8","author":"Palmqvist","year":"2017","journal-title":"Nat Commun"},{"key":"2020030521285943500_awz025-B53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J Intern Med"},{"key":"2020030521285943500_awz025-B54","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1212\/WNL.0b013e3181f11d85","article-title":"Prevalence of mild cognitive impairment is higher in men than in women. The Mayo Clinic Study of Aging","volume":"75","author":"Petersen","year":"2010","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/jamaneurol.2015.3098","article-title":"Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community","volume":"73","author":"Petersen","year":"2015","journal-title":"JAMA Neurol"},{"key":"2020030521285943500_awz025-B56","first-page":"748","article-title":"Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition","volume":"140","author":"Pontecorvo","year":"2017","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ana.25246","article-title":"Combined neuropathological pathways account for age-related risk of dementia","volume":"84","author":"Power","year":"2018","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B58","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B59","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000115751","article-title":"The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics","volume":"30","author":"Roberts","year":"2008","journal-title":"Neuroepidemiology"},{"key":"2020030521285943500_awz025-B60","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1212\/WNL.0b013e3182452862","article-title":"The incidence of MCI differs by subtype and is higher in men: The Mayo Clinic Study of Aging","volume":"78","author":"Roberts","year":"2012","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1212\/WNL.0000000000000055","article-title":"Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal","volume":"82","author":"Roberts","year":"2014","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B62","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/brain\/awy146","article-title":"Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated","volume":"141","author":"Robinson","year":"2018","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B63","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.neurobiolaging.2010.04.007","article-title":"Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging","volume":"31","author":"Rowe","year":"2010","journal-title":"Neurobiol Aging"},{"key":"2020030521285943500_awz025-B64","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1056\/NEJMoa0806142","article-title":"Age, neuropathology, and dementia","volume":"360","author":"Savva","year":"2009","journal-title":"N Engl J Med"},{"key":"2020030521285943500_awz025-B65","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"key":"2020030521285943500_awz025-B66","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.21706","article-title":"The neuropathology of probable Alzheimer disease and mild cognitive impairment","volume":"66","author":"Schneider","year":"2009","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B67","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Scholl","year":"2016","journal-title":"Neuron"},{"key":"2020030521285943500_awz025-B68","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/brain\/aww023","article-title":"Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages","volume":"139","author":"Schwarz","year":"2016","journal-title":"Brain"},{"key":"2020030521285943500_awz025-B69","doi-asserted-by":"crossref","first-page":"P792","DOI":"10.1016\/j.jalz.2017.06.1071","article-title":"The mayo clinic adult lifespan template: better quantification across the lifespan","volume":"13","author":"Schwarz","year":"2017","journal-title":"Alzheimer\u2019s Dement"},{"key":"2020030521285943500_awz025-B70","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.nicl.2016.05.017","article-title":"A large scale comparison of cortical thickness and volume methods for measuring Alzheimer\u2019s disease severity","volume":"11","author":"Schwarz","year":"2016","journal-title":"Neuroimage Clin"},{"key":"2020030521285943500_awz025-B71","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1523\/JNEUROSCI.0639-16.2016","article-title":"In vivo tau, amyloid, and gray matter profiles in the aging brain","volume":"36","author":"Sepulcre","year":"2016","journal-title":"J Neurosci"},{"key":"2020030521285943500_awz025-B72","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann Neurol"},{"key":"2020030521285943500_awz025-B73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.dadm.2016.12.010","article-title":"Tau-PET uptake: regional variation in average SUVR and impact of amyloid deposition","volume":"6","author":"Vemuri","year":"2017","journal-title":"Alzheimers Dement (Amst)"},{"key":"2020030521285943500_awz025-B74","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/142\/4\/1148\/28229554\/awz025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/142\/4\/1148\/28229554\/awz025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:12:30Z","timestamp":1606090350000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/142\/4\/1148\/5316327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":75,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,2,12]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awz025","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,2,12]]}}}