{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:27:55Z","timestamp":1790213275678,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,17]],"date-time":"2019-03-17T00:00:00Z","timestamp":1552780800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Steunfonds Marguerite-Marie Delacroix, Research Foundation Flanders","award":["V429317N"],"award-info":[{"award-number":["V429317N"]}]},{"name":"COST Action","award":["CA16118"],"award-info":[{"award-number":["CA16118"]}]},{"name":"COST Action","award":["STSM 39032"],"award-info":[{"award-number":["STSM 39032"]}]},{"name":"European Network on Brain Malformations, Neuro-MIG","award":["CA16118"],"award-info":[{"award-number":["CA16118"]}]},{"name":"Senior Clinical Investigator Fellowship"},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ErasmusMC Mrace","award":["#104673"],"award-info":[{"award-number":["#104673"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/brain\/awz045","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T23:23:45Z","timestamp":1550445825000},"page":"867-884","source":"Crossref","is-referenced-by-count":35,"title":["Heterogeneous clinical phenotypes and cerebral malformations reflected by rotatin cellular dynamics"],"prefix":"10.1093","volume":"142","author":[{"given":"Laura V","family":"Vandervore","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"},{"name":"Neurogenetics Research Group, Research Cluster Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel, Brussels, Belgium"},{"name":"Center for Medical Genetics, UZ Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Schot","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmee","family":"Kasteleijn","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renske","family":"Oegema","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"},{"name":"Department of Pathology, Clinical Bio-informatics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Stouffs","sequence":"additional","affiliation":[{"name":"Neurogenetics Research Group, Research Cluster Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel, Brussels, Belgium"},{"name":"Center for Medical Genetics, UZ Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gheldof","sequence":"additional","affiliation":[{"name":"Neurogenetics Research Group, Research Cluster Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel, Brussels, Belgium"},{"name":"Center for Medical Genetics, UZ Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna M","family":"Grochowska","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne L T","family":"van der Sterre","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontine M A","family":"van Unen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Wilke","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Elfferich","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"van der Spek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical Bio-informatics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Heijsman","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"},{"name":"Department of Pathology, Clinical Bio-informatics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Grandone","sequence":"additional","affiliation":[{"name":"Dipartimento della Donna, del Bambino, di Chirurgia Generale e Specialistica, Seconda Universit\u00e0 degli studi della Campania \u201cL. Vanvitelli\u201d, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen A A","family":"Demmers","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Proteomics Center, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick H W","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Proteomics Center, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan A","family":"Slotman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Optical Imaging Center, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert-Jan","family":"Kremers","sequence":"additional","affiliation":[{"name":"Department of Pathology, Optical Imaging Center, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben J","family":"Schaaf","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"},{"name":"Center for Lysosomal and Metabolic Diseases, Erasmus Medical Center (Erasmus MC), 3015 CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy G","family":"Masius","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton J","family":"van Essen","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Groningen, University Medical Center Groningen, RB, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rump","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Groningen, University Medical Center Groningen, RB, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"van Haeringen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, LUMC, Leiden University Medical Center, Postzone K-5-R, Postbus 9600, RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Juliana Hospital, Els Borst-Eilersplein 275, 2545 AA Den Haag, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut","family":"Altunoglu","sequence":"additional","affiliation":[{"name":"Department of Medical genetics, Istanbul Medical Faculty, Istanbul University, Topkap\u0131 Mahallesi, Turgut \u00d6zal Millet Cd, 34093 Fatih\/\u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Kalayci","sequence":"additional","affiliation":[{"name":"Department of Medical genetics, Istanbul Medical Faculty, Istanbul University, Topkap\u0131 Mahallesi, Turgut \u00d6zal Millet Cd, 34093 Fatih\/\u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A","family":"Poot","sequence":"additional","affiliation":[{"name":"Department of Cell biology, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B","family":"Dobyns","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, WA, USA"},{"name":"Center for Integrative Brain Research, Seattle Children\u2019s Research Institute, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Bahi-Buisson","sequence":"additional","affiliation":[{"name":"Imagine Institute, INSERM UMR-1163, Laboratory Genetics and Embryology of Congenital Malformations, Paris Descartes University, Institut des Maladies G\u00e9n\u00e9tiques 24, Boulevard de Montparnasse, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans W","family":"Verheijen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C","family":"Jansen","sequence":"additional","affiliation":[{"name":"Neurogenetics Research Group, Research Cluster Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel, Brussels, Belgium"},{"name":"Center for Medical Genetics, UZ Brussel, Brussels, Belgium"},{"name":"Pediatric Neurology Unit, Department of Pediatrics, UZ Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia M S","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,16]]},"reference":[{"key":"2019042609531240200_awz045-B1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cub.2013.12.016","article-title":"STIL Microcephaly mutations interfere with APC\/C-mediated degradation and cause centriole amplification","volume":"24","author":"Arquint","year":"2014","journal-title":"Curr Biol"},{"key":"2019042609531240200_awz045-B2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.molonc.2011.07.007","article-title":"p53: guardian of ploidy","volume":"5","author":"Aylon","year":"2011","journal-title":"Mol Oncol"},{"key":"2019042609531240200_awz045-B3","volume-title":"Tubulinopathies Overview","author":"Bahi-Buisson"},{"key":"2019042609531240200_awz045-B4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejmg.2015.02.001","article-title":"Warsaw breakage syndrome\u2013a further report, emphasising cutaneous findings","volume":"58","author":"Bailey","year":"2015","journal-title":"Eur J Med Genet"},{"key":"2019042609531240200_awz045-B5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jneumeth.2017.07.004","article-title":"Visualization of migration of human cortical neurons generated from induced pluripotent stem cells","volume":"289","author":"Bamba","year":"2017","journal-title":"J Neurosci Methods"},{"issue":"Pt 5","key":"2019042609531240200_awz045-B6","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/brain\/aws019","article-title":"A developmental and genetic classification for malformations of cortical development: update 2012","volume":"135","author":"Barkovich","year":"2012","journal-title":"Brain"},{"key":"2019042609531240200_awz045-B7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.devcel.2010.05.017","article-title":"CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice","volume":"18","author":"Barrera","year":"2010","journal-title":"Dev Cell"},{"key":"2019042609531240200_awz045-B8","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.cell.2008.05.039","article-title":"Centrosome amplification can initiate tumorigenesis in flies","volume":"133","author":"Basto","year":"2008","journal-title":"Cell"},{"key":"2019042609531240200_awz045-B9","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1523\/JNEUROSCI.1030-05.2005","article-title":"Nucleokinesis in tangentially migrating neurons comprises two alternating phases: forward migration of the Golgi\/centrosome associated with centrosome splitting and myosin contraction at the rear","volume":"25","author":"Bellion","year":"2005","journal-title":"J Neurosci"},{"key":"2019042609531240200_awz045-B10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.tig.2011.05.004","article-title":"Centrosomes and cilia in human disease","volume":"27","author":"Bettencourt-Dias","year":"2011","journal-title":"Trends Genet"},{"key":"2019042609531240200_awz045-B11","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.cub.2015.02.012","article-title":"Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments","volume":"25","author":"Billington","year":"2015","journal-title":"Curr Biol"},{"key":"2019042609531240200_awz045-B12","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ejmg.2018.08.001","article-title":"Recurrent RTTN mutation leading to severe microcephaly, polymicrogyria and growth restriction","volume":"61","author":"Cavallin","year":"2018","journal-title":"Eur J Med Genet"},{"key":"2019042609531240200_awz045-B13","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/bdr2.1204","article-title":"A neuropathological study of novel RTTN gene mutations causing a familial microcephaly with simplified gyral pattern","volume":"110","author":"Chartier","year":"2018","journal-title":"Birth Defects Res"},{"key":"2019042609531240200_awz045-B14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00335-007-9023-7","article-title":"Nt mutation causing laterality defects associated with deletion of rotatin","volume":"18","author":"Chatterjee","year":"2007","journal-title":"Mamm Genome"},{"key":"2019042609531240200_awz045-B15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41467-017-00305-0","article-title":"Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles","volume":"8","author":"Chen","year":"2017","journal-title":"Nat Commun"},{"key":"2019042609531240200_awz045-B16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ajhg.2017.08.017","article-title":"Hypomorphic recessive variants in SUFU impair the sonic hedgehog pathway and cause joubert syndrome with cranio-facial and skeletal defects","volume":"101","author":"De Mori","year":"2017","journal-title":"Am J Hum Genet"},{"key":"2019042609531240200_awz045-B17","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1755-8794-8-S1-S4","article-title":"Molecular genetics of human primary microcephaly: an overview","volume":"8","author":"Faheem","year":"2015","journal-title":"BMC Med Genom"},{"key":"2019042609531240200_awz045-B18","doi-asserted-by":"crossref","first-page":"D1100","DOI":"10.1093\/nar\/gkw936","article-title":"The ProteomeXchange Consortium in 2017: supporting the cultural change in proteomics public data deposition","volume":"54","author":"Deutsch","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2019042609531240200_awz045-B19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4773(02)00003-5","article-title":"Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos","volume":"113","author":"Faisst","year":"2002","journal-title":"Mech Dev"},{"key":"2019042609531240200_awz045-B20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-3-7091-1903-7_5","article-title":"Consequences of numerical centrosome defects in development and disease","volume-title":"The Microtubule Cytoskeleton: Organisation, Function and Role in Disease","author":"Gambarotto","year":"2016"},{"key":"2019042609531240200_awz045-B21","first-page":"369","article-title":"Causes and consequences of centrosome abnormalities in cancer","author":"Godinho","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2019042609531240200_awz045-B22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/cge.12771","article-title":"Expanding the phenotype of RTTN variations: a new family with primary microcephaly, severe growth failure, brain malformations and dermatitis","volume":"90","author":"Grandone","year":"2016","journal-title":"Clin Genet"},{"key":"2019042609531240200_awz045-B23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.neuron.2014.04.024","article-title":"Primary cilia in the developing and mature brain","volume":"82","author":"Guemez-Gamboa","year":"2014","journal-title":"Neuron"},{"key":"2019042609531240200_awz045-B24","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S1474-4422(14)70040-7","article-title":"Malformations of cortical development: clinical features and genetic causes","volume":"13","author":"Guerrini","year":"2014","journal-title":"Lancet Neurol"},{"key":"2019042609531240200_awz045-B25","doi-asserted-by":"crossref","first-page":"7857","DOI":"10.1038\/ncomms8857","article-title":"Developmental disruptions underlying brain abnormalities in ciliopathies","volume":"6","author":"Guo","year":"2015","journal-title":"Nat Commun"},{"key":"2019042609531240200_awz045-B26","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.cell.2015.10.065","article-title":"A dynamic protein interaction landscape of the human centrosome-cilium interface","volume":"163","author":"Gupta","year":"2015","journal-title":"Cell"},{"key":"2019042609531240200_awz045-B27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbrc.2015.04.028","article-title":"Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia","volume":"461","author":"Hong","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"2019042609531240200_awz045-B28","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ajhg.2012.03.016","article-title":"A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function","volume":"90","author":"Hussain","year":"2012","journal-title":"Am J Hum Genet"},{"key":"2019042609531240200_awz045-B29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13630-015-0021-1","article-title":"Current topics of functional links between primary cilia and cell cycle","volume":"4","author":"Izawa","year":"2015","journal-title":"Cilia"},{"key":"2019042609531240200_awz045-B30","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/emboj.2011.63","article-title":"Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods","volume":"30","author":"Jakobsen","year":"2011","journal-title":"EMBO J"},{"key":"2019042609531240200_awz045-B31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.201407059","article-title":"A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity","volume":"209","author":"Juanes-Garcia","year":"2015","journal-title":"J Cell Biol"},{"key":"2019042609531240200_awz045-B32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ajhg.2012.07.008","article-title":"RTTN mutations link primary cilia function to organization of the human cerebral cortex","volume":"91","author":"Kheradmand Kia","year":"2012","journal-title":"Am J Hum Genet"},{"key":"2019042609531240200_awz045-B33","first-page":"53","article-title":"Centrosomes in checkpoint responses","volume-title":"Checkpoint Controls and Targets in Cancer Therapy","author":"Kr\u00e4mer","year":"2009"},{"key":"2019042609531240200_awz045-B34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/CIRCGENETICS.113.000455","article-title":"A point mutation in Myh10 causes major defects in heart development and body wall closure","volume":"7","author":"Ma","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"2019042609531240200_awz045-B35","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1091\/mbc.e10-04-0293","article-title":"Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis","volume":"21","author":"Ma","year":"2010","journal-title":"Mol Biol Cell"},{"key":"2019042609531240200_awz045-B36","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1091\/mbc.e03-11-0836","article-title":"A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons","volume":"15","author":"Ma","year":"2004","journal-title":"Mol Biol Cell"},{"key":"2019042609531240200_awz045-B37","doi-asserted-by":"crossref","first-page":"R162","DOI":"10.1016\/j.cub.2013.12.054","article-title":"Microcephaly: STIL(l) a tale of too many centrosomes","volume":"24","author":"Marthiens","year":"2014","journal-title":"Curr Biol"},{"issue":"Pt 14","key":"2019042609531240200_awz045-B38","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1242\/jcs.094797","article-title":"Never tear us apart\u2013the importance of centrosome clustering","volume":"125","author":"Marthiens","year":"2012","journal-title":"J Cell Sci"},{"key":"2019042609531240200_awz045-B39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ncb2746","article-title":"Centrosome amplification causes microcephaly","volume":"15","author":"Marthiens","year":"2013","journal-title":"Nat Cell Biol"},{"key":"2019042609531240200_awz045-B40","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.tcb.2011.04.007","article-title":"Cdk5rap2 exposes the centrosomal root of microcephaly syndromes","volume":"21","author":"Megraw","year":"2011","journal-title":"Trends Cell Biol"},{"key":"2019042609531240200_awz045-B41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41419-017-0101-9","article-title":"STIL balancing primary microcephaly and cancer","volume":"9","author":"Patwardhan","year":"2018","journal-title":"Cell Death Dis"},{"key":"2019042609531240200_awz045-B42","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1474-4422(18)30179-0","article-title":"LRP10 genetic variants in familial Parkinson\u2019s disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study","volume":"17","author":"Quadri","year":"2018","journal-title":"Lancet Neurol"},{"key":"2019042609531240200_awz045-B43","doi-asserted-by":"crossref","first-page":"e59252","DOI":"10.1371\/journal.pone.0059252","article-title":"Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling","volume":"8","author":"Reinhardt","year":"2013","journal-title":"PLoS One"},{"key":"2019042609531240200_awz045-B44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcdb.2017.09.031","article-title":"Genetics and mechanisms leading to human cortical malformations","volume":"76","author":"Romero","year":"2018","journal-title":"Semin Cell Dev Biol"},{"key":"2019042609531240200_awz045-B45","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ncb2858","article-title":"The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II","volume":"15","author":"Rujano","year":"2013","journal-title":"Nat Cell Biol"},{"key":"2019042609531240200_awz045-B46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12920-016-0167-8","article-title":"Whole-exome sequencing is a powerful approach for establishing the etiological diagnosis in patients with intellectual disability and microcephaly","volume":"9","author":"Rump","year":"2016","journal-title":"BMC Med Genom"},{"key":"2019042609531240200_awz045-B47","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.ajhg.2015.10.012","article-title":"RTTN mutations cause primary microcephaly and primordial dwarfism in humans","volume":"97","author":"Shamseldin","year":"2015","journal-title":"Am J Hum Genet"},{"key":"2019042609531240200_awz045-B48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuron.2009.05.028","article-title":"Myosin II motors and F-actin dynamics drive the coordinated movement of the centrosome and soma during CNS glial-guided neuronal migration","volume":"63","author":"Solecki","year":"2009","journal-title":"Neuron"},{"key":"2019042609531240200_awz045-B49","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1083\/jcb.200910016","article-title":"Drosophila Ana2 is a conserved centriole duplication factor","volume":"188","author":"Stevens","year":"2010","journal-title":"J Cell Biol"},{"key":"2019042609531240200_awz045-B50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1083\/jcb.200905031","article-title":"Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies","volume":"187","author":"Stevens","year":"2009","journal-title":"J Cell Biol"},{"key":"2019042609531240200_awz045-B51","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ejmg.2018.06.001","article-title":"Biallelic mutations in RTTN are associated with microcephaly, short stature and a wide range of brain malformations","volume":"61","author":"Stouffs","year":"2018","journal-title":"Eur J Med Genet"},{"issue":"e37846","key":"2019042609531240200_awz045-B52","article-title":"PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN","volume":"7","author":"Sydor","year":"2018","journal-title":"Elife"},{"key":"2019042609531240200_awz045-B53","doi-asserted-by":"crossref","first-page":"e26144","DOI":"10.4161\/rdis.26144","article-title":"A human de novo mutation in MYH10 phenocopies the loss of function mutation in mice","volume":"1","author":"Tuzovic","year":"2013","journal-title":"Rare Dis"},{"key":"2019042609531240200_awz045-B54","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and related tools","volume":"44","author":"Vizca\u00edno","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2019042609531240200_awz045-B55","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/gim.2017.33","article-title":"Prenatal exome sequencing in anomalous fetuses: new opportunities and challenges","volume":"19","author":"Vora","year":"2017","journal-title":"Genet Med"},{"key":"2019042609531240200_awz045-B56","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41390-018-0083-z","article-title":"Functional characterization of biallelic RTTN variants identified in an infant with microcephaly, simplified gyral pattern, pontocerebellar hypoplasia, and seizures","volume":"84","author":"Wambach","year":"2018","journal-title":"Pediatr Res"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/142\/4\/867\/28532542\/awz045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T09:58:47Z","timestamp":1556272727000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/142\/4\/867\/5382247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,16]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,3,16]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awz045","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,3,16]]}}}