{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:38:45Z","timestamp":1790905125758,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The precuneus is a functionally heterogeneous area located on the medial face of the parietal cortex, wedged between the occipital cortex and the paracentral lobule. In view of its topological positioning, this associative cortex is well-placed to play an important role in multisensory integration, specific aspects of which participate to bodily awareness. However, this potential implication remains unestablished. We assessed bodily awareness longitudinally in 14 rare patients who underwent a surgery for a low-grade glioma mainly infiltrating the precuneus. To determine the brain locus the most frequently affected in patients showing bodily awareness disorders, we first contrasted the resection cavity distributions of patients with versus without bodily awareness disorders. We next applied \u2018lesion network mapping\u2019 to identify the networks functionally coupled with lesion locations causing bodily awareness disorder. Bodily awareness disorders were observed in half of patients after surgery, especially alien hand, macrosomatognosia and fading limb. Importantly, a dissociation was revealed between the antero-dorsal precuneus (bodily awareness disorders) and postero-dorsal precuneus (no bodily awareness disorders). Furthermore, bodily awareness disorder-related regions were specifically connected to a network of sensorimotor regions while others were connected with the default network. Altogether, the present findings indicate a critical role of the antero-dorsal precuneus in specific aspects of bodily awareness and in the maintenance of body schema.<\/jats:p>","DOI":"10.1093\/brain\/awz179","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T15:11:56Z","timestamp":1559661116000},"page":"2207-2214","source":"Crossref","is-referenced-by-count":52,"title":["The antero-dorsal precuneal cortex supports specific aspects of bodily awareness"],"prefix":"10.1093","volume":"142","author":[{"given":"Guillaume","family":"Herbet","sequence":"first","affiliation":[{"name":"University of Montpellier, Department of Medicine, F-34060, France"},{"name":"Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors research group), Saint Eloi Hospital, Montpellier University Medical Center, F-34091 Montpellier, France"},{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, F-34295 Montpellier"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, F-34295 Montpellier"},{"name":"University of Lille, EA 4072 \u2013 PSITEC \u2013 Psychologie: Interactions, Temps, \u00c9motions, Cognition, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Moritz-Gasser","sequence":"additional","affiliation":[{"name":"University of Montpellier, Department of Medicine, F-34060, France"},{"name":"Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors research group), Saint Eloi Hospital, Montpellier University Medical Center, F-34091 Montpellier, France"},{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, F-34295 Montpellier"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Cochereau","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors research group), Saint Eloi Hospital, Montpellier University Medical Center, F-34091 Montpellier, France"},{"name":"Department of Neurosurgery, La Miletrie Hospital, Poitiers University Medical Center, F-86021 Poitiers"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-2342","authenticated-orcid":false,"given":"Hugues","family":"Duffau","sequence":"additional","affiliation":[{"name":"University of Montpellier, Department of Medicine, F-34060, France"},{"name":"Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors research group), Saint Eloi Hospital, Montpellier University Medical Center, F-34091 Montpellier, France"},{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, F-34295 Montpellier"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"2019072604002655500_awz179-B1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0166-2236(97)01136-3","article-title":"The body in the brain: neural bases of corporeal awareness","volume":"20","author":"Berlucchi","year":"1997","journal-title":"Trends Neurosci"},{"key":"2019072604002655500_awz179-B2","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1093\/brain\/awv228","article-title":"Network localization of neurological symptoms from focal brain lesions","volume":"138","author":"Boes","year":"2015","journal-title":"Brain"},{"key":"2019072604002655500_awz179-B3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"2019072604002655500_awz179-B4","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1212\/01.WNL.0000038905.75660.BD","article-title":"Strokes restricted to the insular cortex","volume":"59","author":"Cereda","year":"2002","journal-title":"Neurology"},{"key":"2019072604002655500_awz179-B5","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.neuropsychologia.2009.10.008","article-title":"Body and movement: consciousness in the parietal lobes","volume":"48","author":"Daprati","year":"2010","journal-title":"Neuropsychologia"},{"key":"2019072604002655500_awz179-B6","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1073\/pnas.1814117115","article-title":"Lesion network localization of free will","volume":"115","author":"Darby","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"2019072604002655500_awz179-B7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.neuropsychologia.2009.09.022","article-title":"Body schema and body image\u2014pros and cons","volume":"48","author":"De Vignemont","year":"2010","journal-title":"Neuropsychologia"},{"key":"2019072604002655500_awz179-B8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1017\/S0140525X07001641","article-title":"Somatosensory processing subserving perception and action: dissociations, interactions, and integration","volume":"30","author":"Dijkerman","year":"2007","journal-title":"Behav Brain Sci"},{"key":"2019072604002655500_awz179-B9","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1212\/WNL.40.9.1391","article-title":"Verbal asomatognosia","volume":"40","author":"Feinberg","year":"1990","journal-title":"Neurology"},{"key":"2019072604002655500_awz179-B10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1136\/jnnp.2009.188946","article-title":"The neuroanatomy of asomatognosia and somatoparaphrenia","volume":"81","author":"Feinberg","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2019072604002655500_awz179-B11","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMra1706158","article-title":"Mapping symptoms to brain networks with the human connectome","volume":"379","author":"Fox","year":"2018","journal-title":"N Engl J Med"},{"key":"2019072604002655500_awz179-B12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1469-7793.1999.609ae.x","article-title":"Perceptual distortions of the human body image produced by local anaesthesia, pain and cutaneous stimulation","volume":"514","author":"Gandevia","year":"1999","journal-title":"J Physiol"},{"key":"2019072604002655500_awz179-B13","doi-asserted-by":"crossref","first-page":"10418","DOI":"10.1073\/pnas.96.18.10418","article-title":"Where is my arm? The relative role of vision and proprioception in the neuronal representation of limb position","volume":"96","author":"Graziano","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"2019072604002655500_awz179-B14","first-page":"136","article-title":"How the brain represents the body: insights from neurophysiology and psychology. Common Mech Percept Action","author":"Graziano","year":"2002"},{"key":"2019072604002655500_awz179-B15","first-page":"261","volume-title":"Oxford: Oxford University Press","author":"Haggard","year":"2005"},{"key":"2019072604002655500_awz179-B16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuropsychologia.2014.01.020","article-title":"Disrupting posterior cingulate connectivity disconnects consciousness from the external environment","volume":"56","author":"Herbet","year":"2014","journal-title":"Neuropsychologia"},{"key":"2019072604002655500_awz179-B17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10339-004-0013-3","article-title":"The body schema and multisensory representation (s) of peripersonal space","volume":"5","author":"Holmes","year":"2004","journal-title":"Cogn Processing"},{"key":"2019072604002655500_awz179-B18","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1523\/JNEUROSCI.1590-05.2005","article-title":"Awareness of the functioning of one\u2019s own limbs mediated by the insular cortex?","volume":"25","author":"Karnath","year":"2005","journal-title":"J Neurosci"},{"key":"2019072604002655500_awz179-B19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"key":"2019072604002655500_awz179-B20","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1523\/JNEUROSCI.5626-10.2011","article-title":"Fractioning the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control","volume":"31","author":"Leech","year":"2011","journal-title":"J Neurosci"},{"key":"2019072604002655500_awz179-B21","doi-asserted-by":"crossref","first-page":"R531","DOI":"10.1016\/S0960-9822(03)00449-4","article-title":"Multisensory integration and the body schema: close to hand and within reach","volume":"13","author":"Maravita","year":"2003","journal-title":"Current Biol"},{"key":"2019072604002655500_awz179-B22","doi-asserted-by":"crossref","first-page":"20069","DOI":"10.1073\/pnas.0905314106","article-title":"Precuneus shares intrinsic functional architecture in humans and monkeys","volume":"106","author":"Margulies","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"2019072604002655500_awz179-B23","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1136\/jnnp-2011-300224","article-title":"Xenomelia: a new right parietal lobe syndrome","volume":"82","author":"McGeoch","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2019072604002655500_awz179-B24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuropsychologia.2009.08.017","article-title":"From maps to form to space: touch and the body schema","volume":"48","author":"Medina","year":"2010","journal-title":"Neuropsychologia"},{"key":"2019072604002655500_awz179-B26","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1093\/brain\/awu168","article-title":"Probabilistic map of critical functional regions of the human cerebral cortex: Broca\u2019s area revisited","volume":"137","author":"Tate","year":"2014","journal-title":"Brain"},{"key":"2019072604002655500_awz179-B27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00221-008-1562-y","article-title":"Somatoparaphrenia: a body delusion. A review of the neuropsychological literature","volume":"192","author":"Vallar","year":"2009","journal-title":"Exp Brain Res"},{"key":"2019072604002655500_awz179-B28","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1001\/archneur.1997.00550240091017","article-title":"Four legs: illusory reduplication of the lower limbs after bilateral parietal lobe damage","volume":"54","author":"Vuilleumier","year":"1997","journal-title":"Arch Neurol"},{"key":"2019072604002655500_awz179-B29","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00415-012-6827-5","article-title":"Macrosomatognosia in frontal lobe infarct: a case report","volume":"260","author":"Weijers","year":"2013","journal-title":"J Neurol"},{"key":"2019072604002655500_awz179-B30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect"},{"key":"2019072604002655500_awz179-B31","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/2245","article-title":"Maintaining internal representations: the role of the human superior parietal lobe","volume":"1","author":"Wolpert","year":"1998","journal-title":"Nat Neurosci"},{"key":"2019072604002655500_awz179-B32","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuroimage.2018.11.046","article-title":"Combining resting state functional MRI with intraoperative cortical stimulation to map the mentalizing network","volume":"186","author":"Yordanova","year":"2019","journal-title":"NeuroImage"},{"key":"2019072604002655500_awz179-B33","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1016\/j.neuroimage.2011.11.023","article-title":"Functional connectivity mapping of the human precuneus by resting state functional MRI","volume":"59","author":"Zhang","year":"2012","journal-title":"Neuroimage"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awz179\/28929774\/awz179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/142\/8\/2207\/29000160\/awz179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T04:01:35Z","timestamp":1564113695000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/142\/8\/2207\/5523047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,6,25]]},"published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awz179","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,8]]},"published":{"date-parts":[[2019,6,25]]}}}