{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:59:01Z","timestamp":1793091541360,"version":"4.5.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Translational Research and Advanced Imaging Laboratory"},{"name":"TRAIL","award":["ANR- 10-LABX-57"],"award-info":[{"award-number":["ANR- 10-LABX-57"]}]},{"DOI":"10.13039\/100006259","name":"TEVA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondation ARSEP pour la recherche sur la scl\u00e9rose en plaques"},{"name":"French Observatoire of Multiple Sclerosis"},{"name":"OFSEP"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-COHO-002"],"award-info":[{"award-number":["ANR-10-COHO-002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:p>Changes in both structural and functional connectivities are observed in multiple sclerosis, but little is known about how the evolution of one affects the other. Koubiyr et al. investigate the longitudinal multimodal reorganization of brain networks in the year following clinically isolated syndrome, and reveal structural-functional decoupling in several networks.<\/jats:p>","DOI":"10.1093\/brain\/awz270","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T07:28:36Z","timestamp":1565940516000},"page":"3428-3439","source":"Crossref","is-referenced-by-count":70,"title":["Dynamic modular-level alterations of structural-functional coupling in clinically isolated syndrome"],"prefix":"10.1093","volume":"142","author":[{"given":"Ismail","family":"Koubiyr","sequence":"first","affiliation":[{"name":"University of Bordeaux, F Bordeaux, France"},{"name":"Inserm U1215 - Neurocentre Magendie, F Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-7542","authenticated-orcid":false,"given":"Pierre","family":"Besson","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA"},{"name":"Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Deloire","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, F Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Charre-Morin","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, F Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Saubusse","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, F Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tourdias","sequence":"additional","affiliation":[{"name":"University of Bordeaux, F Bordeaux, France"},{"name":"Inserm U1215 - Neurocentre Magendie, F Bordeaux, France"},{"name":"CHU de Bordeaux, F Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Brochet","sequence":"additional","affiliation":[{"name":"University of Bordeaux, F Bordeaux, France"},{"name":"Inserm U1215 - Neurocentre Magendie, F Bordeaux, France"},{"name":"CHU de Bordeaux, F Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Ruet","sequence":"additional","affiliation":[{"name":"University of Bordeaux, F Bordeaux, France"},{"name":"Inserm U1215 - Neurocentre Magendie, F Bordeaux, France"},{"name":"CHU de Bordeaux, F Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"2019103013420991400_awz270-B1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mri.2017.09.001","article-title":"Inter-vender and test-retest reliabilities of resting-state functional magnetic resonance imaging: Implications for multi-center imaging studies","volume":"44","author":"An","year":"2017","journal-title":"Magn Reson Imaging"},{"key":"2019103013420991400_awz270-B2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/hbm.21079","article-title":"Network anticorrelations, global regression, and phase-shifted soft tissue correction","volume":"32","author":"Anderson","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"2019103013420991400_awz270-B3","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B4","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1177\/1352458514533229","article-title":"Characterizing cognitive function during relapse in multiple sclerosis","volume":"20","author":"Benedict","year":"2014","journal-title":"Mult Scler J"},{"key":"2019103013420991400_awz270-B5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1469-8986.1993.tb02075.x","article-title":"An alternative method for significance testing of waveform difference potentials","volume":"30","author":"Blair","year":"1993","journal-title":"Psychophysiology"},{"key":"2019103013420991400_awz270-B6","doi-asserted-by":"crossref","first-page":"P10008","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","volume":"10","author":"Blondel","year":"2008","journal-title":"J Stat Mech Theor"},{"key":"2019103013420991400_awz270-B7","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrn2618","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"2019103013420991400_awz270-B8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nrn3214","article-title":"The economy of brain network organization","volume":"13","author":"Bullmore","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"2019103013420991400_awz270-B9","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.neuroimage.2009.05.012","article-title":"Effects of model-based physiological noise correction on default mode network anti-correlations and correlations","volume":"47","author":"Chang","year":"2009","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neurobiolaging.2018.11.005","article-title":"Disrupted structural and functional brain networks in Alzheimer\u2019s disease","volume":"75","author":"Dai","year":"2018","journal-title":"Neurobiol Aging"},{"key":"2019103013420991400_awz270-B12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis: I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2010.06.010","article-title":"Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature supplemental","volume":"53","author":"Destrieux","year":"2010","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1212\/WNL.0000000000003689","article-title":"Increased default-mode network centrality in cognitively impaired multiple sclerosis patients","volume":"88","author":"Eijlers","year":"2017","journal-title":"Neurology"},{"key":"2019103013420991400_awz270-B15","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/brain\/awv075","article-title":"Disconnection of network hubs and cognitive impairment after traumatic brain injury","volume":"138","author":"Fagerholm","year":"2015","journal-title":"Brain"},{"key":"2019103013420991400_awz270-B16","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1177\/1352458516651503","article-title":"Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis","volume":"23","author":"Fleischer","year":"2017","journal-title":"Mult Scler J"},{"key":"2019103013420991400_awz270-B17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroscience.2017.10.033","article-title":"Graph theoretical framework of brain networks in multiple sclerosis: a review of concepts","volume":"403","author":"Fleischer","year":"2017","journal-title":"Neuroscience"},{"key":"2019103013420991400_awz270-B18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuroimage.2013.12.008","article-title":"Working memory performance of early MS patients correlates inversely with modularity increases in resting state functional connectivity networks","volume":"94","author":"Gamboa","year":"2014","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B19","doi-asserted-by":"crossref","first-page":"8169","DOI":"10.1038\/s41598-018-26449-7","article-title":"Cognition during and after multiple sclerosis relapse as assessed with the brief international cognitive assessment for multiple sclerosis","volume":"8","author":"Giedraitiene","year":"2018","journal-title":"Sci Rep"},{"key":"2019103013420991400_awz270-B20","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1469-8986.2011.01273.x","article-title":"Mass univariate analysis of event-related brain potentials\/fields I: a critical tutorial review","volume":"48","author":"Groppe","year":"2011","journal-title":"Psychophysiology"},{"key":"2019103013420991400_awz270-B21","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1371\/journal.pbio.0060159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann","year":"2008","journal-title":"PLoS Biol"},{"key":"2019103013420991400_awz270-B22","doi-asserted-by":"crossref","first-page":"19067","DOI":"10.1073\/pnas.1009073107","article-title":"White matter maturation reshapes structural connectivity in the late developing human brain","volume":"107","author":"Hagmann","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"2019103013420991400_awz270-B23","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s00415-018-8846-3","article-title":"Alterations in white matter network topology contribute to freezing of gait in Parkinson\u2019s disease","volume":"265","author":"Hall","year":"2018","journal-title":"J Neurol"},{"key":"2019103013420991400_awz270-B24","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1371\/journal.pone.0005226","article-title":"Uncovering intrinsic modular organization of spontaneous brain activity in humans","volume":"4","author":"He","year":"2009","journal-title":"PLoS One"},{"key":"2019103013420991400_awz270-B25","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1073\/pnas.0811168106","article-title":"Predicting human resting-state functional connectivity from structural connectivity","volume":"106","author":"Honey","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"2019103013420991400_awz270-B26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fnins.2016.00478","article-title":"Graph theory-based brain connectivity for automatic classification of multiple sclerosis clinical courses","volume":"10","author":"Kocevar","year":"2016","journal-title":"Front Neurosci"},{"key":"2019103013420991400_awz270-B27","doi-asserted-by":"crossref","DOI":"10.1177\/1352458518813108","article-title":"Longitudinal study of functional brain network reorganization in clinically isolated syndrome","author":"Koubiyr","year":"2018"},{"key":"2019103013420991400_awz270-B28","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"2019103013420991400_awz270-B29","first-page":"2","article-title":"Consensus clustering in complex networks","author":"Lancichinetti","year":"2012","journal-title":"Sci Rep"},{"key":"2019103013420991400_awz270-B30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fnhum.2018.00138","article-title":"Disrupted module efficiency of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis","volume":"12","author":"Liu","year":"2018","journal-title":"Front Hum Neurosci"},{"key":"2019103013420991400_awz270-B31","doi-asserted-by":"crossref","first-page":"16876","DOI":"10.1523\/JNEUROSCI.4136-10.2010","article-title":"Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer\u2019s disease","volume":"30","author":"Lo","year":"2010","journal-title":"J Neurosci"},{"key":"2019103013420991400_awz270-B32","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1002\/hbm.22505","article-title":"Brain networks disconnection in early multiple sclerosis cognitive deficits: an anatomofunctional study","volume":"35","author":"Louapre","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"2019103013420991400_awz270-B33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fninf.2016.00030","article-title":"volBrain: an online MRI brain volumetry system","volume":"10","author":"Manj\u00f3n","year":"2016","journal-title":"Front Neuroinform"},{"key":"2019103013420991400_awz270-B34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(11)70274-5","article-title":"Clinically isolated syndromes","volume":"11","author":"Miller","year":"2012","journal-title":"Lancet Neurol"},{"key":"2019103013420991400_awz270-B35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnins.2016.00014","article-title":"Structural brain network characteristics can differentiate CIS from early RRMS","volume":"10","author":"Muthuraman","year":"2016","journal-title":"Front Neurosci"},{"key":"2019103013420991400_awz270-B36","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1073\/pnas.0601602103","article-title":"Modularity and community structure in networks","volume":"103","author":"Newman","year":"2006","journal-title":"Proc Natl Acad Sci"},{"key":"2019103013420991400_awz270-B37","doi-asserted-by":"crossref","first-page":"026113","DOI":"10.1103\/PhysRevE.69.026113","article-title":"Finding and evaluating community structure in networks","volume":"69","author":"Newman","year":"2004","journal-title":"Phys Rev E"},{"key":"2019103013420991400_awz270-B38","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1177\/1352458512451512","article-title":"Revisiting the multiple sclerosis functional composite: proceedings from the National Multiple Sclerosis Society (NMSS) task force on clinical disability measures","volume":"18","author":"Ontaneda","year":"2012","journal-title":"Mult Scler J"},{"key":"2019103013420991400_awz270-B39","first-page":"342","article-title":"Structural and functional brain networks: from connections to cognition","volume":"80","author":"Park","year":"2013","journal-title":"Science"},{"key":"2019103013420991400_awz270-B40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann Neurol"},{"key":"2019103013420991400_awz270-B41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.neuron.2011.09.006","article-title":"Functional network organization of the human brain","volume":"72","author":"Power","year":"2011","journal-title":"Neuron"},{"key":"2019103013420991400_awz270-B42","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.neuroimage.2016.06.053","article-title":"A multi-time-point modality-agnostic patch-based method for lesion filling in multiple sclerosis","volume":"139","author":"Prados","year":"2016","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B43","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.nicl.2012.11.006","article-title":"Altered functional and structural brain network organization in autism","volume":"2","author":"Rudie","year":"2013","journal-title":"NeuroImage Clin"},{"key":"2019103013420991400_awz270-B45","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fneur.2015.00082","article-title":"Network collapse and cognitive impairment in multiple sclerosis","volume":"6","author":"Schoonheim","year":"2015","journal-title":"Front Neurol"},{"key":"2019103013420991400_awz270-B46","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1073\/pnas.1503436112","article-title":"Stable long-range interhemispheric coordination is supported by direct anatomical projections","volume":"112","author":"Shen","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"2019103013420991400_awz270-B47","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.biopsych.2013.09.002","article-title":"The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder","volume":"75","author":"Shin","year":"2014","journal-title":"Biol Psychiatry"},{"key":"2019103013420991400_awz270-B48","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neuroimage.2012.11.049","article-title":"SIFT: spherical-deconvolution informed filtering of tractograms","volume":"67","author":"Smith","year":"2013","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B49","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/hbm.23501","article-title":"Modular-level alterations of structure\u2013function coupling in schizophrenia connectome","volume":"38","author":"Sun","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"2019103013420991400_awz270-B50","doi-asserted-by":"crossref","first-page":"28004","DOI":"10.1209\/0295-5075\/86\/28004","article-title":"Improved community structure detection using a modified fine-tuning strategy","volume":"86","author":"Sun","year":"2009","journal-title":"Europhys Lett"},{"key":"2019103013420991400_awz270-B51","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.neuroimage.2007.02.016","article-title":"Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution","volume":"35","author":"Tournier","year":"2007","journal-title":"Neuroimage"},{"key":"2019103013420991400_awz270-B52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ima.22005","article-title":"MRtrix: diffusion tractography in crossing fiber regions","volume":"22","author":"Tournier","year":"2012","journal-title":"Int J Imaging Syst Technol"},{"key":"2019103013420991400_awz270-B53","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/nbm.3017","article-title":"Determination of the appropriate b value and number of gradient directions for high-angular-resolution diffusion-weighted imaging","volume":"26","author":"Tournier","year":"2013","journal-title":"NMR Biomed"},{"key":"2019103013420991400_awz270-B54","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1152\/jn.00783.2009","article-title":"Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization","volume":"103","author":"Van Dijk","year":"2010","journal-title":"J Neurophysiol"},{"key":"2019103013420991400_awz270-B55","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"key":"2019103013420991400_awz270-B56","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/brain\/awr223","article-title":"Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy","volume":"134","author":"Zhang","year":"2011","journal-title":"Brain"},{"key":"2019103013420991400_awz270-B57","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroscience.2017.09.009","article-title":"Disrupted structural and functional connectivity networks in ischemic stroke patients","volume":"364","author":"Zhang","year":"2017","journal-title":"Neuroscience"},{"key":"2019103013420991400_awz270-B58","first-page":"1569","article-title":"Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis","volume":"70","author":"Zipp","year":"2013","journal-title":"JAMA Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/142\/11\/3428\/30329962\/awz270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/142\/11\/3428\/30329962\/awz270.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T16:35:22Z","timestamp":1590078922000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/142\/11\/3428\/5560327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,5]]},"references-count":57,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,9,5]]},"published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awz270","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,9,5]]}}}