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Indeed, the physiological process of ageing causes a variety of molecular and cellular phenotypes. With dysfunction at the neuromuscular junction implicated as a key pathological mechanism in ALS, and each lower motor unit cell type vulnerable to its own set of age-related phenotypes, the effects of ageing might in fact prove a prerequisite to ALS, rendering the cells susceptible to disease-specific mechanisms. Moreover, we discuss evidence for overlap between age and ALS-associated hallmarks, potentially implicating cell type-specific ageing as a key contributor to this multifactorial and complex disease. With a dearth of disease-modifying therapy currently available for ALS patients and a substantial failure in bench to bedside translation of other potential therapies, the unification of research in ageing and ALS requires high fidelity models to better recapitulate age-related human disease and will ultimately yield more reliable candidate therapeutics for patients, with the aim of enhancing healthspan and life expectancy.<\/jats:p>","DOI":"10.1093\/brain\/awz360","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T08:11:27Z","timestamp":1572423087000},"page":"1057-1072","source":"Crossref","is-referenced-by-count":89,"title":["Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective"],"prefix":"10.1093","volume":"143","author":[{"given":"Virenkumar A","family":"Pandya","sequence":"first","affiliation":[{"name":"Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology, Queen Square, London, UK"},{"name":"The Francis Crick Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rickie","family":"Patani","sequence":"first","affiliation":[{"name":"Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology, Queen Square, London, UK"},{"name":"The Francis Crick Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"2020042119474489700_awz360-B1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.21974","article-title":"Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain","volume":"513","author":"Azevedo","year":"2009","journal-title":"J Comp 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