{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:01Z","timestamp":1787008561252,"version":"build-2736575974"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":64,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Ministry of Education and Research","award":["BMBF 01GM1907C"],"award-info":[{"award-number":["BMBF 01GM1907C"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Episodic ataxia type 6 is an inherited neurological condition characterized by combined ataxia and epilepsy. A severe form of this disease with episodes combining ataxia, epilepsy and hemiplegia was recently associated with a proline to arginine substitution at position 290 of the excitatory amino acid transporter 1 in a heterozygous patient. The excitatory amino acid transporter 1 is the predominant glial glutamate transporter in the cerebellum. However, this glutamate transporter also functions as an anion channel and earlier work in heterologous expression systems demonstrated that the mutation impairs the glutamate transport rate, while increasing channel activity. To understand how these changes cause ataxia, we developed a constitutive transgenic mouse model. Transgenic mice display epilepsy, ataxia and cerebellar atrophy and, thus, closely resemble the human disease. We observed increased glutamate-activated chloride efflux in Bergmann glia that triggers the apoptosis of these cells during infancy. The loss of Bergmann glia results in reduced glutamate uptake and impaired neural network formation in the cerebellar cortex. This study shows how gain-of-function of glutamate transporter-associated anion channels causes ataxia through modifying cerebellar development.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaa022","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T23:59:56Z","timestamp":1583366396000},"source":"Crossref","is-referenced-by-count":37,"title":["Increased glutamate transporter-associated anion currents cause glial apoptosis in episodic ataxia 6"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-4918","authenticated-orcid":false,"given":"Peter","family":"Kovermann","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Biologische Informationsprozesse, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1888-6378","authenticated-orcid":false,"given":"Verena","family":"Untiet","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biologische Informationsprozesse, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Kolobkova","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biologische Informationsprozesse, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-4929","authenticated-orcid":false,"given":"Miriam","family":"Engels","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biologische Informationsprozesse, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8669-723X","authenticated-orcid":false,"given":"Stephan","family":"Baader","sequence":"additional","affiliation":[{"name":"Anatomisches Institut, Anatomie und Zellbiologie, Rheinische Friedrich-Wilhelm Universit\u00e4t Bonn, 53115 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Schilling","sequence":"additional","affiliation":[{"name":"Anatomisches Institut, Anatomie und Zellbiologie, Rheinische Friedrich-Wilhelm Universit\u00e4t Bonn, 53115 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8602-9952","authenticated-orcid":false,"given":"Christoph","family":"Fahlke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biologische Informationsprozesse, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"2020081108571774100_fcaa022-B1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1523\/JNEUROSCI.3396-12.2013","article-title":"Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain","volume":"33","author":"Abrahamsen","year":"2013","journal-title":"J Neurosci"},{"key":"2020081108571774100_fcaa022-B2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/YPG.0b013e328341a307","article-title":"Genetic and functional studies of a missense variant in a glutamate transporter, SLC1A3, in Tourette syndrome","volume":"21","author":"Adamczyk","year":"2011","journal-title":"Psychiat Genet"},{"key":"2020081108571774100_fcaa022-B3","doi-asserted-by":"crossref","first-page":"7258","DOI":"10.1523\/JNEUROSCI.3582-09.2010","article-title":"The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia","volume":"30","author":"Alvina","year":"2010","journal-title":"J Neurosci"},{"key":"2020081108571774100_fcaa022-B4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2013.12.030","article-title":"Heterogeneity of reactive astrocytes","volume":"565","author":"Anderson","year":"2014","journal-title":"Neurosci Lett"},{"key":"2020081108571774100_fcaa022-B5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1152\/jn.00586.2014","article-title":"In vivo analysis of Purkinje cell firing properties during postnatal mouse development","volume":"113","author":"Arancillo","year":"2015","journal-title":"J Neurophysiol"},{"key":"2020081108571774100_fcaa022-B6","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1152\/jn.1969.32.6.1044","article-title":"Discharge properties of Purkinje cells recorded on single and double microelectrodes","volume":"32","author":"Bell","year":"1969","journal-title":"J Neurophysiol"},{"key":"2020081108571774100_fcaa022-B9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0896-6273(95)90158-2","article-title":"Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry","volume":"15","author":"Chaudhry","year":"1995","journal-title":"Neuron"},{"key":"2020081108571774100_fcaa022-B10","doi-asserted-by":"crossref","first-page":"e7991","DOI":"10.1371\/journal.pone.0007991","article-title":"BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo","volume":"4","author":"Cheron","year":"2009","journal-title":"PLoS One"},{"key":"2020081108571774100_fcaa022-B11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/jhg.2016.137","article-title":"Late-onset episodic ataxia associated with SLC1A3 mutation","volume":"62","author":"Choi","year":"2017","journal-title":"J Hum Genet"},{"key":"2020081108571774100_fcaa022-B12","doi-asserted-by":"crossref","first-page":"13855","DOI":"10.1038\/s41598-017-14254-7","article-title":"Genetic variants associated with episodic ataxia in Korea","volume":"7","author":"Choi","year":"2017","journal-title":"Sci Rep"},{"key":"2020081108571774100_fcaa022-B14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0166-2236(82)90168-0","article-title":"Regression of functional synapses in the immature mammalian cerebellum","volume":"5 (Suppl C","author":"Crepel","year":"1982","journal-title":"Trends Neurosci"},{"key":"2020081108571774100_fcaa022-B16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archneurol.2008.535","article-title":"Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake","volume":"66","author":"de Vries","year":"2009","journal-title":"Arch Neurol"},{"key":"2020081108571774100_fcaa022-B17","doi-asserted-by":"crossref","first-page":"12576","DOI":"10.1523\/JNEUROSCI.3080-06.2006","article-title":"The ducky2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression","volume":"26","author":"Donato","year":"2006","journal-title":"J Neurosci"},{"key":"2020081108571774100_fcaa022-B18","doi-asserted-by":"crossref","first-page":"44817","DOI":"10.1038\/srep44817","article-title":"Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes","volume":"7","author":"Droste","year":"2017","journal-title":"Sci Rep"},{"key":"2020081108571774100_fcaa022-B19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1113\/jphysiol.1966.sp007824","article-title":"The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum","volume":"182","author":"Eccles","year":"1966","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1242\/jcs.017343","article-title":"Cytoplasmic condensation is both necessary and sufficient to induce apoptotic cell death","volume":"121","author":"Ernest","year":"2008","journal-title":"J Cell Sci"},{"key":"2020081108571774100_fcaa022-B21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00424-015-1768-3","article-title":"Molecular physiology of EAAT anion channels","volume":"468","author":"Fahlke","year":"2016","journal-title":"Pflugers Arch"},{"key":"2020081108571774100_fcaa022-B22","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0896-6273(94)90341-7","article-title":"Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS","volume":"12","author":"Feng","year":"1994","journal-title":"Neuron"},{"key":"2020081108571774100_fcaa022-B23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1113\/jphysiol.2005.087130","article-title":"Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts","volume":"567","author":"Friis","year":"2005","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B24","doi-asserted-by":"crossref","first-page":"15533","DOI":"10.1523\/JNEUROSCI.2454-12.2012","article-title":"Cerebellar ataxia by enhanced CaV2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a (S218L) mutant mice","volume":"32","author":"Gao","year":"2012","journal-title":"J Neurosci"},{"key":"2020081108571774100_fcaa022-B25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J Cell Biol"},{"key":"2020081108571774100_fcaa022-B26","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-14929-5_4","volume-title":"Determination of intracellular chloride concentrations by fluorescence lifetime imaging","author":"Gensch","year":"2015"},{"key":"2020081108571774100_fcaa022-B27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/5692","article-title":"Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells","volume":"2","author":"Grosche","year":"1999","journal-title":"Nat Neurosci"},{"key":"2020081108571774100_fcaa022-B28","first-page":"1787","article-title":"A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia","volume":"39","author":"Guyenet","year":"2010","journal-title":"J Vis Exp"},{"key":"2020081108571774100_fcaa022-B29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/hmg\/dds427","article-title":"Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2","volume":"22","author":"Hansen","year":"2013","journal-title":"Hum Mol Genet"},{"key":"2020081108571774100_fcaa022-B30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.98.1.193","article-title":"Two forms of cerebellar glial cells interact differently with neurons in vitro","volume":"98","author":"Hatten","year":"1984","journal-title":"J Cell Biol"},{"key":"2020081108571774100_fcaa022-B31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(00)80379-7","article-title":"Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration","volume":"19","author":"Hausser","year":"1997","journal-title":"Neuron"},{"key":"2020081108571774100_fcaa022-B32","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuron.2005.02.012","article-title":"Increased noise level of Purkinje cell activities minimizes impact of their modulation during sensorimotor control","volume":"45","author":"Hoebeek","year":"2005","journal-title":"Neuron"},{"key":"2020081108571774100_fcaa022-B33","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1152\/jn.1996.75.5.1806","article-title":"Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons","volume":"75","author":"Holt","year":"1996","journal-title":"J Neurophysiol"},{"key":"2020081108571774100_fcaa022-B34","doi-asserted-by":"crossref","first-page":"36492","DOI":"10.1074\/jbc.M113.489385","article-title":"Mutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes","volume":"288","author":"Hotzy","year":"2013","journal-title":"J Biol Chem"},{"key":"2020081108571774100_fcaa022-B35","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.1058827","article-title":"Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia","volume":"292","author":"Iino","year":"2001","journal-title":"Science"},{"key":"2020081108571774100_fcaa022-B36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s10038-017-0365-z","article-title":"A novel mutation in SLC1A3 causes episodic ataxia","volume":"63","author":"Iwama","year":"2018","journal-title":"J Hum Genet"},{"key":"2020081108571774100_fcaa022-B37","doi-asserted-by":"crossref","first-page":"29489","DOI":"10.1038\/srep29489","article-title":"4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6","volume":"6","author":"Jayabal","year":"2016","journal-title":"Sci Rep"},{"key":"2020081108571774100_fcaa022-B38","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1113\/JP273184","article-title":"Transient cerebellar alterations during development prior to obvious motor phenotype in a mouse model of spinocerebellar ataxia type 6","volume":"595","author":"Jayabal","year":"2017","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B39","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1093\/brain\/awm126","article-title":"Primary episodic ataxias: diagnosis, pathogenesis and treatment","volume":"130","author":"Jen","year":"2007","journal-title":"Brain"},{"key":"2020081108571774100_fcaa022-B40","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/01.WNL.0000172638.58172.5a","article-title":"Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures","volume":"65","author":"Jen","year":"2005","journal-title":"Neurology"},{"key":"2020081108571774100_fcaa022-B41","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.2042-7158.1968.tb09743.x","article-title":"The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod","volume":"20","author":"Jones","year":"1968","journal-title":"J Pharm Pharmacol"},{"key":"2020081108571774100_fcaa022-B42","first-page":"34","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Ass"},{"key":"2020081108571774100_fcaa022-B43","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1126\/science.2166337","article-title":"A family of AMPA-selective glutamate receptors","volume":"249","author":"Keinanen","year":"1990","journal-title":"Science"},{"key":"2020081108571774100_fcaa022-B45","doi-asserted-by":"crossref","first-page":"13913","DOI":"10.1038\/s41598-017-14176-4","article-title":"Impaired K+ binding to glial glutamate transporter EAAT1 in migraine","volume":"7","author":"Kovermann","year":"2017","journal-title":"Sci Rep"},{"key":"2020081108571774100_fcaa022-B46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1113\/jphysiol.1971.sp009373","article-title":"Spontaneous activity of cerebellar Purkinje cells and their responses to impulses in climbing fibres","volume":"213","author":"Latham","year":"1971","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/glia.20200","article-title":"Purkinje cell dendrites grow in alignment with Bergmann glia","volume":"51","author":"Lordkipanidze","year":"2005","journal-title":"Glia"},{"key":"2020081108571774100_fcaa022-B48","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cell.2014.12.035","article-title":"Mechanisms of anion conduction by coupled glutamate transporters","volume":"160","author":"Machtens","year":"2015","journal-title":"Cell"},{"key":"2020081108571774100_fcaa022-B49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/neu.480130204","article-title":"Extent of multiple innervation of Purkinje cells by climbing fibers in the olivocerebellar system of weaver, reeler, and staggerer mutant mice","volume":"13","author":"Mariani","year":"1982","journal-title":"J Neurobiol"},{"key":"2020081108571774100_fcaa022-B50","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1113\/jphysiol.1969.sp008820","article-title":"A theory of cerebellar cortex","volume":"202","author":"Marr","year":"1969","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B51","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the ARRIVE guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Brit J Pharmacol"},{"key":"2020081108571774100_fcaa022-B52","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1113\/jphysiol.2005.089383","article-title":"Physiological and morphological development of the rat cerebellar Purkinje cell","volume":"567","author":"McKay","year":"2005","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B53","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1113\/jphysiol.1992.sp019382","article-title":"Stellate cell inhibition of Purkinje cells in the turtle cerebellum in vitro","volume":"457","author":"Midtgaard","year":"1992","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B54","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1046\/j.1460-9568.2003.02698.x","article-title":"Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum","volume":"17","author":"Miyazaki","year":"2003","journal-title":"Eur J Neurosci"},{"key":"2020081108571774100_fcaa022-B55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","article-title":"NeuN, a neuronal specific nuclear protein in vertebrates","volume":"116","author":"Mullen","year":"1992","journal-title":"Development"},{"key":"2020081108571774100_fcaa022-B56","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cne.20223","article-title":"Active caspase-3 expression during postnatal development of rat cerebellum is not systematically or consistently associated with apoptosis","volume":"476","author":"Oomman","year":"2004","journal-title":"J Comp Neurol"},{"key":"2020081108571774100_fcaa022-B57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.devbrainres.2005.07.010","article-title":"Non-lethal active caspase-3 expression in Bergmann glia of postnatal rat cerebellum","volume":"160","author":"Oomman","year":"2005","journal-title":"Brain Res Dev Brain Res"},{"key":"2020081108571774100_fcaa022-B59","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fncir.2012.00095","article-title":"How do climbing fibers teach?","volume":"6","author":"Otis","year":"2012","journal-title":"Front Neural Circuits"},{"key":"2020081108571774100_fcaa022-B60","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-65581-4","volume-title":"Cerebellar cortex","author":"Palay","year":"1974"},{"key":"2020081108571774100_fcaa022-B61","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1523\/JNEUROSCI.0197-16.2016","article-title":"Disruption of an EAAT-mediated chloride channel in a Drosophila model of ataxia","volume":"36","author":"Parinejad","year":"2016","journal-title":"J Neurosci"},{"key":"2020081108571774100_fcaa022-B62","first-page":"4448","article-title":"Posterior cerebellar Purkinje cells in an SCA5\/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of beta-III spectrin and GLAST","volume":"25","author":"Perkins","year":"2016","journal-title":"Hum Mol Genet"},{"key":"2020081108571774100_fcaa022-B63","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/sj.cdd.4401396","article-title":"Apoptosis induced by staurosporine in ECV304 cells requires cell shrinkage and upregulation of Cl- conductance","volume":"11","author":"Porcelli","year":"2004","journal-title":"Cell Death Differ"},{"key":"2020081108571774100_fcaa022-B64","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/brain\/awu348","article-title":"Exome sequencing in undiagnosed inherited and sporadic ataxias","volume":"138","author":"Pyle","year":"2015","journal-title":"Brain"},{"key":"2020081108571774100_fcaa022-B65","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/cne.901410303","article-title":"Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus rhesus","volume":"141","author":"Rakic","year":"1971","journal-title":"J Comp Neurol"},{"key":"2020081108571774100_fcaa022-B66","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0896-6273(94)90038-8","article-title":"Localization of neuronal and glial glutamate transporters","volume":"13","author":"Rothstein","year":"1994","journal-title":"Neuron"},{"key":"2020081108571774100_fcaa022-B67","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1152\/jn.1992.68.6.2051","article-title":"Short-term modulation of cerebellar Purkinje cell activity after spontaneous climbing fiber input","volume":"68","author":"Sato","year":"1992","journal-title":"J Neurophysiol"},{"key":"2020081108571774100_fcaa022-B68","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cne.23450","article-title":"Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus","volume":"522","author":"Schreiner","year":"2014","journal-title":"J Comp Neurol"},{"key":"2020081108571774100_fcaa022-B69","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1073858405278321","article-title":"Reactive astrocytes in neural repair and protection","volume":"11","author":"Sofroniew","year":"2005","journal-title":"Neuroscientist"},{"key":"2020081108571774100_fcaa022-B70","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1073\/pnas.89.22.10955","article-title":"Structure, expression, and functional analysis of a Na+-dependent glutamate\/aspartate transporter from rat brain","volume":"89","author":"Storck","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020081108571774100_fcaa022-B71","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1113\/JP274252","article-title":"Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations","volume":"595","author":"Tang","year":"2017","journal-title":"J Physiol"},{"key":"2020081108571774100_fcaa022-B72","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1460-9568.1994.tb00587.x","article-title":"Differential expression of two glial glutamate transporters in the rat brain: an in situ hybridization study","volume":"6","author":"Torp","year":"1994","journal-title":"Eur J Neurosci"},{"key":"2020081108571774100_fcaa022-B73","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/glia.23098","article-title":"Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation","volume":"65","author":"Untiet","year":"2017","journal-title":"Glia"},{"key":"2020081108571774100_fcaa022-B74","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejmg.2016.06.003","article-title":"Duplications of SLC1A3: Associated with ADHD and autism","volume":"59","author":"van Amen-Hellebrekers","year":"2016","journal-title":"Eur J Med Genet"},{"key":"2020081108571774100_fcaa022-B75","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.1990.259.3.C375","article-title":"Development and biological applications of chloride-sensitive fluorescent indicators","volume":"259","author":"Verkman","year":"1990","journal-title":"Am J Physiol"},{"key":"2020081108571774100_fcaa022-B76","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0896-6273(95)90159-0","article-title":"Ion fluxes associated with excitatory amino acid transport","volume":"15","author":"Wadiche","year":"1995","journal-title":"Neuron"},{"key":"2020081108571774100_fcaa022-B77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0896-6273(01)00488-3","article-title":"Multivesicular release at climbing fiber-Purkinje cell synapses","volume":"32","author":"Wadiche","year":"2001","journal-title":"Neuron"},{"key":"2020081108571774100_fcaa022-B78","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/j.1460-2075.1995.tb07149.x","article-title":"Potassium-inhibited processing of IL-1 beta in human monocytes","volume":"14","author":"Walev","year":"1995","journal-title":"EMBO J"},{"key":"2020081108571774100_fcaa022-B79","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nn1648","article-title":"Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia","volume":"9","author":"Walter","year":"2006","journal-title":"Nat Neurosci"},{"key":"2020081108571774100_fcaa022-B80","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1111\/j.1460-9568.2011.07894.x","article-title":"Climbing fiber synapse elimination in cerebellar Purkinje cells","volume":"34","author":"Watanabe","year":"2011","journal-title":"Eur J Neurosci"},{"key":"2020081108571774100_fcaa022-B81","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1046\/j.1460-9568.1998.00108.x","article-title":"Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice","volume":"10","author":"Watase","year":"1998","journal-title":"Eur J Neurosci"},{"key":"2020081108571774100_fcaa022-B82","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/jnr.10655","article-title":"Developmental and cell type-specific expression of the neuronal marker NeuN in the murine cerebellum","volume":"73","author":"Weyer","year":"2003","journal-title":"J Neurosci Res"},{"key":"2020081108571774100_fcaa022-B83","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1093\/brain\/aws255","article-title":"A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents","volume":"135","author":"Winter","year":"2012","journal-title":"Brain"},{"key":"2020081108571774100_fcaa022-B84","doi-asserted-by":"crossref","first-page":"10603","DOI":"10.1523\/JNEUROSCI.22-24-10603.2002","article-title":"Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons","volume":"22","author":"Womack","year":"2002","journal-title":"J Neurosci"},{"key":"2020081108571774100_fcaa022-B85","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/neu.480050402","article-title":"Physiological and pharmacological properties of Purkinje cells in rat cerebellum degranulated by postnatal x-irradiation","volume":"5","author":"Woodward","year":"1974","journal-title":"J Neurobiol"},{"key":"2020081108571774100_fcaa022-B86","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nn.2348","article-title":"Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning","volume":"12","author":"Wulff","year":"2009","journal-title":"Nat Neurosci"},{"key":"2020081108571774100_fcaa022-B87","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/(SICI)1096-9861(20000228)418:1<106::AID-CNE8>3.0.CO;2-N","article-title":"Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth and synapse formation of cerebellar Purkinje cells","volume":"418","author":"Yamada","year":"2000","journal-title":"J Comp Neurol"},{"key":"2020081108571774100_fcaa022-B88","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1754","article-title":"Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy","volume":"9","author":"Yu","year":"2006","journal-title":"Nat Neurosci"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcaa022\/32788128\/fcaa022.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/2\/1\/fcaa022\/33639137\/fcaa022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/2\/1\/fcaa022\/33639137\/fcaa022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:51:14Z","timestamp":1666007474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcaa022\/5781169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcaa022","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020]]},"published":{"date-parts":[[2020,1,1]]},"article-number":"fcaa022"}}