{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:14:59Z","timestamp":1784121299544,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sattaripour Charitable Foundation and the Motor Neurone Disease Association","award":["Shaw\/Jul15\/932-794"],"award-info":[{"award-number":["Shaw\/Jul15\/932-794"]}]},{"name":"Medical Research Council\/Motor Neurone Disease Association Lady Edith Wolfson Clinical Research Training Fellowship","award":["MR\/P000983\/1"],"award-info":[{"award-number":["MR\/P000983\/1"]}]},{"name":"Engineering and Physical Sciences Research Council\u2019s Centre for Doctoral Training in Neurotechnology for Life and Health"},{"name":"Clinical Neuroscience MSc course at King\u2019s College London"},{"name":"NIHR BioResource Centre Maudsley at South London and Maudsley NHS Foundation Trust"},{"DOI":"10.13039\/100013376","name":"Institute of Psychiatry, Psychology and Neuroscience","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013376","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009360","name":"King\u2019s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Delayed diagnosis of amyotrophic lateral sclerosis prevents early entry into clinical trials at a time when neuroprotective therapies would be most effective. Fasciculations are an early hallmark of amyotrophic lateral sclerosis, preceding muscle weakness and atrophy. To assess the potential diagnostic utility of fasciculations measured by high-density surface electromyography, we carried out 30-min biceps brachii recordings in 39 patients with amyotrophic lateral sclerosis, 7 patients with benign fasciculation syndrome, 1 patient with multifocal motor neuropathy and 17 healthy individuals. We employed the surface potential quantification engine to compute fasciculation frequency, fasciculation amplitude and inter-fasciculation interval. Inter-group comparison was assessed by Welch\u2019s analysis of variance. Logistic regression, receiver operating characteristic curves and decision trees discerned the diagnostic performance of these measures. Fasciculation frequency, median fasciculation amplitude and proportion of inter-fasciculation intervals &amp;lt;100 ms showed significant differences between the groups. In the best-fit regression model, increasing fasciculation frequency and median fasciculation amplitude were independently associated with the diagnosis of amyotrophic lateral sclerosis. Fasciculation frequency was the single best measure predictive of the disease, with an area under the curve of 0.89 (95% confidence interval 0.81\u20130.98). The cut-off of more than 14 fasciculation potentials per minute achieved 80% sensitivity (95% confidence interval 63\u201390%) and 96% specificity (95% confidence interval 78\u2013100%). In conclusion, non-invasive measurement of fasciculation frequency at a single time-point reliably distinguished amyotrophic lateral sclerosis from its mimicking conditions and healthy individuals, warranting further research into its diagnostic applications.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaa141","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T16:14:04Z","timestamp":1599495244000},"source":"Crossref","is-referenced-by-count":13,"title":["Non-invasive measurement of fasciculation frequency demonstrates diagnostic accuracy in amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-8407","authenticated-orcid":false,"given":"Arina","family":"Tamborska","sequence":"first","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-0748","authenticated-orcid":false,"given":"James","family":"Bashford","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Wickham","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Iniesta","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urooba","family":"Masood","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cabassi","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domen","family":"Planinc","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Hodson-Tole","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Musculoskeletal Sciences and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, 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