{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:35:44Z","timestamp":1785843344889,"version":"3.56.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":290,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000738","name":"University of Leicester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001703","name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huntington\u2019s disease is a severe but slowly progressive hereditary illness for which only symptomatic treatments are presently available. Clinical measures of disease progression are somewhat subjective and may require years to detect significant change. There is a clear need to identify more sensitive, objective and consistent measures to detect disease progression in Huntington\u2019s disease clinical trials. Whereas Huntington\u2019s disease demonstrates a robust and consistent gene expression signature in the brain, previous studies of blood cell RNAs have lacked concordance with clinical disease stage. Here we utilized longitudinally collected samples from a well-characterized cohort of control, Huntington\u2019s disease-at-risk and Huntington\u2019s disease subjects to evaluate the possible correlation of gene expression and disease status within individuals. We interrogated these data in both cross-sectional and longitudinal analyses. A number of changes in gene expression showed consistency within this study and as compared to previous reports in the literature. The magnitude of the mean disease effect over 2 years\u2019 time was small, however, and did not track closely with motor symptom progression over the same time period. We therefore conclude that while blood-derived gene expression indicators can be of value in understanding Huntington\u2019s disease pathogenesis, they are insufficiently sensitive to be of use as state biomarkers.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaa172","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T05:04:57Z","timestamp":1602911097000},"source":"Crossref","is-referenced-by-count":10,"title":["Longitudinal expression changes are weak correlates of disease progression in Huntington\u2019s disease"],"prefix":"10.1093","volume":"2","author":[{"given":"Christopher T","family":"Mitchell","sequence":"first","affiliation":[{"name":"University of Leicester, University Road, Leicester LE1 7RH, UK"},{"name":"School of Medicine, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Krier","sequence":"additional","affiliation":[{"name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de 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