{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:06:22Z","timestamp":1791497182961,"version":"4.3.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":315,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","award":["ANR-15-CE17-0020"],"award-info":[{"award-number":["ANR-15-CE17-0020"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Neurodis Foundation and the Recherche Hospitalo-Universitaire en Sant\u00e9 (RHU) MARVELOUS","award":["ANR-16-RHUS-0009"],"award-info":[{"award-number":["ANR-16-RHUS-0009"]}]},{"name":"Brain and Mental Health","award":["ANR-10-IBHU-0003"],"award-info":[{"award-number":["ANR-10-IBHU-0003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In an acute ischaemic stroke, understanding the dynamics of blood\u2013brain barrier injury is of particular importance for the prevention of symptomatic haemorrhagic transformation. However, the available techniques assessing blood\u2013brain barrier permeability are not quantitative and are little used in the context of acute reperfusion therapy. Nanoparticles cross the healthy or impaired blood\u2013brain barrier through combined passive and active processes. Imaging and quantifying their transfer rate could better characterize blood\u2013brain barrier damage and refine the delivery of neuroprotective agents. We previously developed an original endovascular stroke model of acute ischaemic stroke treated by mechanical thrombectomy followed by positron emission tomography-magnetic resonance imaging. Cerebral capillary permeability was quantified for two molecule sizes: small clinical gadolinium Gd-DOTA (&amp;lt;1\u2009nm) and AGuIX\u00ae nanoparticles (\u223c5\u2009nm) used for brain theranostics. On dynamic contrast-enhanced magnetic resonance imaging, the baseline transfer constant Ktrans was 0.94 [0.48, 1.72] and 0.16 [0.08, 0.33] \u00d710\u22123\u2009min\u22121, respectively, in the normal brain parenchyma, consistent with their respective sizes, and 1.90 [1.23, 3.95] and 2.86 [1.39, 4.52] \u00d710\u22123\u2009min\u22121 in choroid plexus, confirming higher permeability than brain parenchyma. At early reperfusion, Ktrans for both Gd-DOTA and AGuIX\u00ae nanoparticles was significantly higher within the ischaemic area compared to the contralateral hemisphere; 2.23 [1.17, 4.13] and 0.82 [0.46, 1.87] \u00d710\u22123\u2009min\u22121 for Gd-DOTA and AGuIX\u00ae nanoparticles, respectively. With AGuIX\u00ae nanoparticles, Ktrans also increased within the ischaemic growth areas, suggesting added value for AGuIX\u00ae. Finally, Ktrans was significantly lower in both the lesion and the choroid plexus in a drug-treated group (ciclosporin A, n\u2009=\u20097) compared to placebo (n\u2009=\u20095). Ktrans quantification with AGuIX\u00ae nanoparticles can monitor early blood\u2013brain barrier damage and treatment effect in ischaemic stroke after reperfusion.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaa193","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T14:24:46Z","timestamp":1605104686000},"source":"Crossref","is-referenced-by-count":40,"title":["PET-MRI nanoparticles imaging of blood\u2013brain barrier damage and modulation after stroke reperfusion"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-605X","authenticated-orcid":false,"given":"Justine","family":"Debatisse","sequence":"first","affiliation":[{"name":"Univ Lyon, CarMeN Laboratory, INSERM, INRA, INSA Lyon, Universit\u00e9 Claude Bernard Lyon 1, 69000 Lyon, France"},{"name":"Siemens-Healthcare SAS, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer Faruk","family":"Eker","sequence":"additional","affiliation":[{"name":"CREATIS, CNRS UMR-5220, INSERM U1206, Universit\u00e9 Lyon 1, INSA Lyon B\u00e2t. 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