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The purpose of this study is to examine symptom reporting resembling the research criteria for traumatic encephalopathy syndrome in men and women from the US general population. This is a retrospective analysis of publicly available data from a cross-sectional epidemiological study. The National Comorbidity Survey Replication was designed to examine the prevalence and correlates of mental disorders in the USA. The study included a nationally representative sample of 9282 adults (4139 men and 5143 women). An in-person interview and survey were conducted in the homes of men and women from the general population. The study was conducted with participants residing in New York City, Los Angeles, Chicago, Philadelphia, Detroit, San Francisco, Washington DC, Dallas\/Fort Worth, Houston, Boston, Nassau-Suffolk NY, St. Louis, Pittsburgh, Baltimore, Minneapolis and Atlanta. Symptoms from the research criteria for the diagnosis of traumatic encephalopathy syndrome were applied to men and women in the general population and in sub-groups of people with health problems and mental health problems. A small percentage of the US general population met symptom criteria for traumatic encephalopathy syndrome (6.6\u201311.9%, depending on the definition applied). People with chronic pain were much more likely to meet criteria (i.e. 14.8\u201330.5%), and two out of three people who have experienced suicidality in the past year met symptom criteria for traumatic encephalopathy syndrome (65.2\u201372.2%). The majority of women with a mood disorder and chronic pain met criteria (62.7\u201389.8%). This is the largest study, to date, examining the aspects of the research criteria for the diagnosis of traumatic encephalopathy syndrome in the general population, and the first study to examine these criteria in women. This study has important clinical and public health implications. The potential rate for misdiagnosing traumatic encephalopathy syndrome in adults who are experiencing chronic pain, idiopathic mental health problems or both is high.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab001","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T02:02:30Z","timestamp":1611626550000},"source":"Crossref","is-referenced-by-count":28,"title":["Symptoms of traumatic encephalopathy syndrome are common in the US general population"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-9570","authenticated-orcid":false,"given":"Grant L","family":"Iverson","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02115, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Spaulding Research Institute, Charlestown, MA 02129, USA"},{"name":"MassGeneral Hospital for Children Sports Concussion Program, Boston, MA 02114, USA"},{"name":"Home Base, A Red Sox Foundation and Massachusetts General Hospital Program, Charlestown, MA 02129, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Gardner","sequence":"additional","affiliation":[{"name":"Hunter New England Local Health District, Sports Concussion Program, Waratah, NSW 2298, Australia"},{"name":"Priority Research Centre for Sentre for Stroke and Brain Injury, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"2021100420415371700_fcab001-B1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1037\/neu0000319","article-title":"Cognitive functioning in the first-episode of major depressive disorder: a systematic review and meta-analysis","volume":"31","author":"Ahern","year":"2017","journal-title":"Neuropsychology"},{"key":"2021100420415371700_fcab001-B2","volume-title":"Diagnostic and statistical manual of mental disorders 4th edn","author":"American Psychiatric Association","year":"1994"},{"key":"2021100420415371700_fcab001-B3","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1176\/appi.ajp.2010.09071011","article-title":"Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication","volume":"167","author":"Angst","year":"2010","journal-title":"Am J Psychiatry"},{"key":"2021100420415371700_fcab001-B4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11682-012-9164-5","article-title":"Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma","volume":"6","author":"Baugh","year":"2012","journal-title":"Brain Imaging Behav"},{"key":"2021100420415371700_fcab001-B5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11065-017-9361-5","article-title":"Neuropsychological measures that predict progression from mild cognitive impairment to Alzheimer\u2019s type dementia in older adults: a systematic review and meta-analysis","volume":"27","author":"Belleville","year":"2017","journal-title":"Neuropsychol Rev"},{"key":"2021100420415371700_fcab001-B6","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1017\/S0033291706008786","article-title":"A risk index for 12-month suicide attempts in the National Comorbidity Survey Replication (NCS-R)","volume":"36","author":"Borges","year":"2006","journal-title":"Psychol Med"},{"key":"2021100420415371700_fcab001-B7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neubiorev.2016.08.002","article-title":"Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: a review of the literature","volume":"69","author":"Cardenas","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"2021100420415371700_fcab001-B8","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/00000441-193605000-00014","article-title":"Punch-drunk","volume":"191","author":"Carrol","year":"1936","journal-title":"Am J Med Sci"},{"key":"2021100420415371700_fcab001-B9","first-page":"160","article-title":"Punch drunk. 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