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H.Z. is a Wallenberg Scholar"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["2018-02532"],"award-info":[{"award-number":["2018-02532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the European Research Council","award":["681712"],"award-info":[{"award-number":["681712"]}]},{"name":"Swedish government and the County Councils, the ALF-agreement","award":["ALFGBG-720931"],"award-info":[{"award-number":["ALFGBG-720931"]}]},{"name":"the Alzheimer Drug Discovery Foundation (ADDF), USA","award":["201809-2016862"],"award-info":[{"award-number":["201809-2016862"]}]},{"name":"UK Dementia Research Institute at UCL. 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We found exosome size was not altered between common variant controls and R47Hhet variants, but the amount and constitution of exosomes secreted were different. Exosome quantities were rescued by incubation with an ATP donor or with lipids via a phosphatidylserine triggering receptor expressed on myeloid cells 2 ligand. Following a lipopolysaccharide or phagocytic cell stimulus, exosomes from common variant and R47Hhet microglia were found to contain cytokines, chemokines, APOE and triggering receptor expressed on myeloid cells 2. Differences were observed in the expression of CCL22, IL-1\u03b2 and triggering receptor expressed on myeloid cells 2 between common variant and R47Hhet derived exosomes. Furthermore unlike common variant-derived exosomes, R47Hhet exosomes contained additional proteins linked to negative regulation of transcription and metabolic processes. Subsequent addition of exosomes to stressed neurones showed R47Hhet-derived exosomes to be less protective. These data have ramifications for the responses of microglia in Alzheimer\u2019s disease and may point to further targets for therapeutic intervention.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab009","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T05:01:12Z","timestamp":1612587672000},"source":"Crossref","is-referenced-by-count":23,"title":["The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles"],"prefix":"10.1093","volume":"3","author":[{"given":"Anna","family":"Mallach","sequence":"first","affiliation":[{"name":"Department of Neuroinflammation, Queen Square Institute of Neurology, University College London, London WC1N 1PJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6193-6193","authenticated-orcid":false,"given":"Johan","family":"Gobom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, 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