{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:55:35Z","timestamp":1787504135789,"version":"build-2736575974"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health, National Institute of Neurological Disorders and Stroke","award":["R01 NS112816-01"],"award-info":[{"award-number":["R01 NS112816-01"]}]},{"name":"National Institute of Health","award":["R01 NS106611"],"award-info":[{"award-number":["R01 NS106611"]}]},{"name":"National Institute of Health","award":["U01 NS113198"],"award-info":[{"award-number":["U01 NS113198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Temporal lobe epilepsy is associated with impairment in episodic memory. A substantial subgroup, however, is able to maintain adequate memory despite temporal lobe pathology. Missing from prior work in cognitive reorganization is a direct comparison of temporal lobe epilepsy patients with intact status with those who are memory impaired. Little is known about the regional activations, functional connectivities and\/or network reconfigurations that implement changes in primary computations or support functions that drive adaptive plasticity and compensated memory. We utilized task functional MRI on 54 unilateral temporal lobe epilepsy patients and 24 matched healthy controls during the performance of a paired-associate memory task to address three questions: (i) which regions implement paired-associate memory in temporal lobe epilepsy, and do they vary as a function of good versus poor performance, (ii) is there unique functional connectivity present during memory encoding that accounts for intact status by preservation of primary memory computations or the supportive computations that allow for intact memory responses and (iii) what features during memory encoding are most distinctive: is it the magnitude and location of regional activations, or the presence of enhanced functional connections to key structures such as the hippocampus? The study revealed non-dominant hemisphere regions (right posterior temporal regions) involving both increased regional activity and increased modulatory communication with the hippocampi as most important to intact memory in left temporal lobe epilepsy compared to impaired status. The profile involved areas that are neither contralateral homologues to left hemisphere memory areas, nor regions traditionally considered computationally primary for episodic memory. None of these areas of increased activation or functional connectivity were associated with advantaged memory in healthy controls. Our emphasis on different performance levels yielded insight into two forms of cognitive reorganization: computational primacy, where left temporal lobe epilepsy showed little change relative to healthy controls, and computational support where intact left temporal lobe epilepsy patients showed adaptive abnormalities. The analyses isolated the unique regional activations and mediating functional connectivity that implements truly compensatory reorganization in left temporal lobe epilepsy. The results provided a new perspective on memory deficits by making clear that they arise not just from the knockout of a functional hub, but from the failure to instantiate a complex set of reorganization responses. Such responses provided the computational support to ensure successful memory. We demonstrated that by keeping track of performance levels, we can increase understanding of adaptive brain responses and neuroplasticity in epilepsy.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab025","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T15:21:11Z","timestamp":1614957671000},"source":"Crossref","is-referenced-by-count":9,"title":["Computational support, not primacy, distinguishes compensatory memory reorganization in epilepsy"],"prefix":"10.1093","volume":"3","author":[{"given":"Joseph I","family":"Tracy","sequence":"first","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-6212","authenticated-orcid":false,"given":"Andrew","family":"Crow","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashith","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"issue":"5","key":"2021060422121452300_fcab025-B1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1528-1167.2006.00527.x","article-title":"Diffusion tensor imaging findings and their correlation with neuropsychological deficits in patients with temporal lobe epilepsy and interictal psychosis","volume":"47","author":"Flugel","year":"2006","journal-title":"Epilepsia"},{"issue":"1","key":"2021060422121452300_fcab025-B2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1528-1157.2002.24101.x","article-title":"Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy","volume":"43","author":"Gleissner","year":"2002","journal-title":"Epilepsia"},{"issue":"Pt 11","key":"2021060422121452300_fcab025-B3","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1093\/brain\/awn213","article-title":"Structural and functional correlates of unilateral mesial temporal lobe spatial memory impairment","volume":"131","author":"Glikmann-Johnston","year":"2008","journal-title":"Brain"},{"issue":"Pt 3","key":"2021060422121452300_fcab025-B4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/brain\/awp012","article-title":"Verbal memory in mesial temporal lobe epilepsy: beyond material specificity","volume":"132","author":"Saling","year":"2009","journal-title":"Brain"},{"issue":"Pt 7","key":"2021060422121452300_fcab025-B5","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/brain\/awu100","article-title":"Differential influence of hippocampal subfields to memory formation: insights from patients with temporal lobe epilepsy","volume":"137","author":"Coras","year":"2014","journal-title":"Brain"},{"issue":"1","key":"2021060422121452300_fcab025-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(86)90010-9","article-title":"Kindling mechanisms: current progress on an experimental epilepsy model","volume":"27","author":"McIntyre","year":"1986","journal-title":"Prog Neurobiol"},{"issue":"7","key":"2021060422121452300_fcab025-B7","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/epi.12220","article-title":"International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods","volume":"54","author":"Blumcke","year":"2013","journal-title":"Epilepsia"},{"issue":"5","key":"2021060422121452300_fcab025-B8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/nan.12150","article-title":"Review: hippocampal sclerosis in epilepsy: a neuropathology review","volume":"40","author":"Thom","year":"2014","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"1","key":"2021060422121452300_fcab025-B9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0887-8994(94)00122-I","article-title":"Mesial temporal sclerosis: pathogenesis and significance","volume":"12","author":"Liu","year":"1995","journal-title":"Pediatr Neurol"},{"issue":"5","key":"2021060422121452300_fcab025-B10","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/jmri.25447","article-title":"Investigation of hippocampal substructures in focal temporal lobe epilepsy with and without hippocampal sclerosis at 7T","volume":"45","author":"Santyr","year":"2017","journal-title":"J Magn Reson Imaging"},{"issue":"31","key":"2021060422121452300_fcab025-B11","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1523\/JNEUROSCI.2976-17.2018","article-title":"Adult neurogenesis conserves hippocampal memory capacity","volume":"38","author":"Alam","year":"2018","journal-title":"J Neurosci"},{"issue":"10","key":"2021060422121452300_fcab025-B12","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.cub.2018.04.006","article-title":"Replay of episodic memories in the rat","volume":"28","author":"Panoz-Brown","year":"2018","journal-title":"Curr Biol"},{"issue":"5026","key":"2021060422121452300_fcab025-B13","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1896849","article-title":"The medial temporal lobe memory system","volume":"253","author":"Squire","year":"1991","journal-title":"Science"},{"issue":"Pt 2","key":"2021060422121452300_fcab025-B14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neuroimage.2013.06.067","article-title":"Human intracranial high-frequency activity maps episodic memory formation in space and time","volume":"85","author":"Burke","year":"2014","journal-title":"Neuroimage"},{"key":"2021060422121452300_fcab025-B15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.conb.2014.09.003","article-title":"Human intracranial high-frequency activity during memory processing: neural oscillations or stochastic volatility?","volume":"31","author":"Burke","year":"2015","journal-title":"Curr Opin Neurobiol"},{"issue":"34","key":"2021060422121452300_fcab025-B16","doi-asserted-by":"crossref","first-page":"11355","DOI":"10.1523\/JNEUROSCI.2654-13.2014","article-title":"Theta and high-frequency activity mark spontaneous recall of episodic memories","volume":"34","author":"Burke","year":"2014","journal-title":"J Neurosci"},{"key":"2021060422121452300_fcab025-B17","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuroimage.2015.06.073","article-title":"Successful memory formation is driven by contextual encoding in the core memory network","volume":"119","author":"Long","year":"2015","journal-title":"Neuroimage"},{"issue":"11","key":"2021060422121452300_fcab025-B18","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/hipo.20855","article-title":"How hippocampus and cortex contribute to recognition memory: revisiting the complementary learning systems model","volume":"20","author":"Norman","year":"2010","journal-title":"Hippocampus"},{"issue":"10","key":"2021060422121452300_fcab025-B19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tins.2011.06.006","article-title":"Pattern separation in the hippocampus","volume":"34","author":"Yassa","year":"2011","journal-title":"Trends Neurosci"},{"key":"2021060422121452300_fcab025-B20","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1162\/jocn_a_01315","article-title":"Verbal paired associates and the hippocampus: the role of scenes","volume":"30","author":"Clark","year":"2018","journal-title":"J Cogn Neurosci"},{"issue":"2","key":"2021060422121452300_fcab025-B21","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1053-8119(03)00365-3","article-title":"fMRI BOLD response to increasing task difficulty during successful paired associates learning","volume":"20","author":"Gould","year":"2003","journal-title":"Neuroimage"},{"issue":"24","key":"2021060422121452300_fcab025-B22","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1523\/JNEUROSCI.4935-04.2005","article-title":"Functional magnetic resonance imaging activity during the gradual acquisition and expression of paired-associate memory","volume":"25","author":"Law","year":"2005","journal-title":"J Neurosci"},{"issue":"2","key":"2021060422121452300_fcab025-B23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuroimage.2004.09.001","article-title":"Activation of human hippocampal formation reflects success in both encoding and cued recall of paired associates","volume":"24","author":"Meltzer","year":"2005","journal-title":"Neuroimage"},{"issue":"3","key":"2021060422121452300_fcab025-B24","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s002210050853","article-title":"Neuronal correlates of encoding and retrieval in episodic memory during a paired-word association learning task: a functional magnetic resonance imaging study","volume":"128","author":"Mottaghy","year":"1999","journal-title":"Exp Brain Res"},{"key":"2021060422121452300_fcab025-B25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2011.12.020","article-title":"Cortical correlates of self-generation in verbal paired associate learning","volume":"1437","author":"Vannest","year":"2012","journal-title":"Brain Res"},{"issue":"11","key":"2021060422121452300_fcab025-B26","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1111\/j.1528-1167.2006.00810.x","article-title":"Predicting memory decline following epilepsy surgery: a multivariate approach","volume":"47","author":"Baxendale","year":"2006","journal-title":"Epilepsia"},{"issue":"9","key":"2021060422121452300_fcab025-B27","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1016\/j.neuropsychologia.2010.05.010","article-title":"Double dissociation of selective recollection and familiarity impairments following two different surgical treatments for temporal-lobe epilepsy","volume":"48","author":"Bowles","year":"2010","journal-title":"Neuropsychologia"},{"issue":"2","key":"2021060422121452300_fcab025-B28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1528-1157.1996.tb00009.x","article-title":"Cognitive consequences of two-thirds anterior temporal lobectomy on verbal memory in 144 patients: a three-month follow-up study","volume":"37","author":"Helmstaedter","year":"1996","journal-title":"Epilepsia"},{"issue":"11","key":"2021060422121452300_fcab025-B29","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2176\/nmc.oa.2016-0004","article-title":"Verbal dominant memory impairment and low risk for post-operative memory worsening in both left and right temporal lobe epilepsy associated with hippocampal sclerosis","volume":"56","author":"Khalil","year":"2016","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"9","key":"2021060422121452300_fcab025-B30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/hipo.20205","article-title":"Evolution of declarative memory","volume":"16","author":"Manns","year":"2006","journal-title":"Hippocampus"},{"issue":"2","key":"2021060422121452300_fcab025-B31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/hbm.21226","article-title":"Different structural correlates for verbal memory impairment in temporal lobe epilepsy with and without mesial temporal lobe sclerosis","volume":"33","author":"Mueller","year":"2012","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"2021060422121452300_fcab025-B32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/hbm.21432","article-title":"Brain plasticity for verbal and visual memories in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: an fMRI study","volume":"34","author":"Alessio","year":"2013","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"2021060422121452300_fcab025-B33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1025679122911","article-title":"Anterior temporal lobectomy, hippocampal sclerosis, and memory: recent neuropsychological findings","volume":"8","author":"Bell","year":"1998","journal-title":"Neuropsychol Rev"},{"issue":"Pt 4","key":"2021060422121452300_fcab025-B34","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/brain\/awq006","article-title":"Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection","volume":"133","author":"Bonelli","year":"2010","journal-title":"Brain"},{"issue":"Pt 6","key":"2021060422121452300_fcab025-B35","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/brain\/awt099","article-title":"A functional magnetic resonance imaging study mapping the episodic memory encoding network in temporal lobe epilepsy","volume":"136","author":"Sidhu","year":"2013","journal-title":"Brain"},{"issue":"1","key":"2021060422121452300_fcab025-B36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1037\/0894-4105.17.1.59","article-title":"Material-specific memory in temporal lobe epilepsy: effects of seizure laterality and language dominance","volume":"17","author":"Kim","year":"2003","journal-title":"Neuropsychology"},{"issue":"Suppl 1","key":"2021060422121452300_fcab025-B37","doi-asserted-by":"crossref","first-page":"S112\u2013S","DOI":"10.1016\/j.neuroimage.2003.09.008","article-title":"Preserved verbal memory function in left medial temporal pathology involves reorganisation of function to right medial temporal lobe","volume":"20","author":"Richardson","year":"2003","journal-title":"Neuroimage"},{"issue":"5","key":"2021060422121452300_fcab025-B38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1212\/01.wnl.0000201186.07716.98","article-title":"Memory fMRI in left hippocampal sclerosis: optimizing the approach to predicting postsurgical memory","volume":"66","author":"Richardson","year":"2006","journal-title":"Neurology"},{"key":"2021060422121452300_fcab025-B39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yebeh.2014.11.026","article-title":"Incipient preoperative reorganization processes of verbal memory functions in patients with left temporal lobe epilepsy","volume":"42","author":"Milian","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"8","key":"2021060422121452300_fcab025-B40","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1111\/j.1528-1167.2007.01053.x","article-title":"Reorganization of verbal and nonverbal memory in temporal lobe epilepsy due to unilateral hippocampal sclerosis","volume":"48","author":"Powell","year":"2007","journal-title":"Epilepsia"},{"issue":"2","key":"2021060422121452300_fcab025-B41","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.yebeh.2010.11.019","article-title":"Visual paired-associate learning: in search of material-specific effects in adult patients who have undergone temporal lobectomy","volume":"20","author":"Smith","year":"2011","journal-title":"Epilepsy Behav"},{"issue":"4","key":"2021060422121452300_fcab025-B42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3233\/NRE-2011-0709","article-title":"A conceptual framework for interpreting neuroimaging studies of brain neuroplasticity and cognitive recovery","volume":"29","author":"Tracy","year":"2011","journal-title":"NeuroRehabilitation"},{"issue":"Pt 6","key":"2021060422121452300_fcab025-B43","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1093\/brain\/awt105","article-title":"Memory reorganization following anterior temporal lobe resection: a longitudinal functional MRI study","volume":"136","author":"Bonelli","year":"2013","journal-title":"Brain"},{"issue":"10","key":"2021060422121452300_fcab025-B44","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/jnnp.2009.173161","article-title":"Pre- and postoperative fMRI and clinical memory performance in temporal lobe epilepsy","volume":"80","author":"Cheung","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2021060422121452300_fcab025-B45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jocn.2018.06.020","article-title":"Memory loss and memory reorganization patterns in temporal lobe epilepsy patients undergoing anterior temporal lobe resection, as demonstrated by pre-versus post-operative functional MRI","volume":"55","author":"Limotai","year":"2018","journal-title":"J Clin Neurosci"},{"issue":"Pt 2","key":"2021060422121452300_fcab025-B46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/brain\/awv365","article-title":"Memory network plasticity after temporal lobe resection: a longitudinal functional imaging study","volume":"139","author":"Sidhu","year":"2016","journal-title":"Brain"},{"issue":"2","key":"2021060422121452300_fcab025-B47","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/WCO.0000000000000178","article-title":"Resting-state functional connectivity in epilepsy: growing relevance for clinical decision making","volume":"28","author":"Tracy","year":"2015","journal-title":"Curr Opin Neurol"},{"issue":"1","key":"2021060422121452300_fcab025-B48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"issue":"6","key":"2021060422121452300_fcab025-B49","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/jama.1996.03540060046034","article-title":"Temporal lobectomy for refractory epilepsy","volume":"276","author":"Sperling","year":"1996","journal-title":"JAMA"},{"key":"2021060422121452300_fcab025-B50","volume-title":"WAIS-IV administration and scoring manual","author":"Wechsler","year":"2008"},{"key":"2021060422121452300_fcab025-B51","volume-title":"WMS-IV: Wechsler Memory Scale, 4th ed","author":"Wechsler","year":"2009"},{"key":"2021060422121452300_fcab025-B52","doi-asserted-by":"crossref","first-page":"597","DOI":"10.22237\/jmasm\/1257035100","article-title":"New effect size rules of thumb","volume":"8","author":"Sawilowsky","year":"2009","journal-title":"J Mod Appl Stat Methods"},{"key":"2021060422121452300_fcab025-B53","article-title":"Revised comprehensive norms for an expanded Halstead-Reitan battery: demographically adjusted neuropsychological norms for African American and Caucasian adults","author":"Heaton","year":"2004","journal-title":"Psychol Assess Resour"},{"issue":"1","key":"2021060422121452300_fcab025-B54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat Methods"},{"key":"2021060422121452300_fcab025-B55","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fninf.2011.00013","article-title":"Nipype: a flexible, lightweight and extensible neuroimaging data processing framework in python","volume":"5","author":"Gorgolewski","year":"2011","journal-title":"Front Neuroinform"},{"key":"2021060422121452300_fcab025-B56","volume-title":"Statistical parametric mapping: the analysis of functional brain images","author":"Friston","year":"2011"},{"issue":"4","key":"2021060422121452300_fcab025-B57","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.neuroimage.2012.03.068","article-title":"A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches","volume":"61","author":"McLaren","year":"2012","journal-title":"Neuroimage"},{"key":"2021060422121452300_fcab025-B58","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbr.2013.06.009","article-title":"The medial temporal lobe: memory and beyond","volume":"254","author":"Lech","year":"2013","journal-title":"Behav Brain Res"},{"issue":"1","key":"2021060422121452300_fcab025-B59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/jnnp.20.1.11","article-title":"Loss of recent memory after bilateral hippocampal lesions","volume":"20","author":"Scoville","year":"1957","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2021060422121452300_fcab025-B60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fneur.2014.00023","article-title":"Temporal lobe epilepsy and surgery selectively alter the dorsal, not the ventral, default-mode network","volume":"5","author":"Doucet","year":"2014","journal-title":"Front Neurol"},{"issue":"9","key":"2021060422121452300_fcab025-B61","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1093\/cercor\/bhu072","article-title":"Functional characterization of the cingulo-opercular network in the maintenance of tonic alertness","volume":"25","author":"Sadaghiani","year":"2015","journal-title":"Cereb Cortex"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcab025\/36540644\/fcab025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/2\/fcab025\/38489938\/fcab025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/2\/fcab025\/38489938\/fcab025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T20:49:08Z","timestamp":1622839748000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcab025\/6166647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,10]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4,5]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcab025","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.07.138594","asserted-by":"object"}]},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2021,3,10]]},"article-number":"fcab025"}}