{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:49:30Z","timestamp":1785944970780,"version":"3.56.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Ministry of Higher Education & Research"},{"name":"Cifre ANRT and Siemens"},{"name":"CYCLOPS","award":["ANR-15-CE17-0020\u201301"],"award-info":[{"award-number":["ANR-15-CE17-0020\u201301"]}]},{"name":"RHU MARVELOUS","award":["ANR-16-RHUS-0009"],"award-info":[{"award-number":["ANR-16-RHUS-0009"]}]},{"name":"French National Agency of Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atherosclerosis is a chronic systemic inflammatory disease, inducing cardiovascular and cerebrovascular acute events. A role of neuroinflammation is suspected, but not yet investigated in the gyrencephalic brain and the related activity at blood\u2212brain interfaces is unknown. A non-human primate model of advanced atherosclerosis was first established using longitudinal blood samples, multimodal imaging and gene analysis in aged animals. Non-human primate carotid lesions were compared with human carotid endarterectomy samples. During the whole-body imaging session, imaging of neuroinflammation and choroid plexus function was performed. Advanced plaques were present in multiple sites, premature deaths occurred and downstream lesions (myocardial fibrosis, lacunar stroke) were present in this model. Vascular lesions were similar to in humans: high plaque activity on PET and MRI imaging and systemic inflammation (high plasma C-reactive protein levels: 42\u2009\u00b1\u200914\u2009\u00b5g\/ml). We also found the same gene association (metabolic, inflammatory and anti-inflammatory markers) as in patients with similar histological features. Metabolic imaging localized abnormal brain glucose metabolism in the frontal cortex. It corresponded to cortical neuro-inflammation (PET imaging) that correlated with C-reactive protein level. Multimodal imaging also revealed pronounced choroid plexus function impairment in aging atherosclerotic non-human primates. In conclusion, multimodal whole-body inflammation exploration at the vascular level and blood\u2212brain interfaces identified high-risk aging atherosclerosis. These results open the way for systemic and central inflammation targeting in atherosclerosis in the new era of immunotherapy.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab064","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T19:14:46Z","timestamp":1617218086000},"source":"Crossref","is-referenced-by-count":6,"title":["Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model"],"prefix":"10.1093","volume":"3","author":[{"given":"Vanessa","family":"Di Cataldo","sequence":"first","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-605X","authenticated-orcid":false,"given":"Justine","family":"Debatisse","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Siemens-Healthcare SAS, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Piraquive","sequence":"additional","affiliation":[{"name":"CERMEP\u2014Imagerie du Vivant, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"G\u00e9lo\u00ebn","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Grandin","sequence":"additional","affiliation":[{"name":"Cynbiose SAS, Marcy-L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-5112","authenticated-orcid":false,"given":"Micha\u00ebl","family":"Verset","sequence":"additional","affiliation":[{"name":"Cynbiose SAS, Marcy-L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Taborik","sequence":"additional","affiliation":[{"name":"Cynbiose SAS, Marcy-L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Labaronne","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Loizon","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Millon","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-7078","authenticated-orcid":false,"given":"Pauline","family":"Mury","sequence":"additional","affiliation":[{"name":"LIBM Laboratory, Univ Lyon, Universit\u00e9 Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pialoux","sequence":"additional","affiliation":[{"name":"LIBM Laboratory, Univ Lyon, Universit\u00e9 Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Serusclat","sequence":"additional","affiliation":[{"name":"Radiology Department, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-4397","authenticated-orcid":false,"given":"Franck","family":"Lamberton","sequence":"additional","affiliation":[{"name":"CERMEP\u2014Imagerie du Vivant, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Ibarrola","sequence":"additional","affiliation":[{"name":"CERMEP\u2014Imagerie du Vivant, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Lavenne","sequence":"additional","affiliation":[{"name":"CERMEP\u2014Imagerie du Vivant, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Le Bars","sequence":"additional","affiliation":[{"name":"CERMEP\u2014Imagerie du Vivant, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Troalen","sequence":"additional","affiliation":[{"name":"Siemens-Healthcare SAS, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Confais","sequence":"additional","affiliation":[{"name":"Cynbiose SAS, Marcy-L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Crola Da Silva","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mechtouff","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Stroke Department, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Contamin","sequence":"additional","affiliation":[{"name":"Cynbiose SAS, Marcy-L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi A","family":"Fayad","sequence":"additional","affiliation":[{"name":"BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-5570","authenticated-orcid":false,"given":"Emmanuelle","family":"Canet-Soulas","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Univ Lyon, INSERM U1060, INRAE 1397, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"6917","key":"2021070810510095000_fcab064-B1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"issue":"12","key":"2021070810510095000_fcab064-B2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"New Engl J Med"},{"issue":"3","key":"2021070810510095000_fcab064-B3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2017.11.024","article-title":"Myocardial inflammation predicts remodeling and neuroinflammation after myocardial infarction","volume":"71","author":"Thackeray","year":"2018","journal-title":"J Am College Cardiol"},{"issue":"6","key":"2021070810510095000_fcab064-B4","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1161\/RES.0000000000000169","article-title":"Recommendation on design, execution, and reporting of animal atherosclerosis studies: A scientific statement from the American Heart Association","volume":"121","author":"Daugherty","year":"2017","journal-title":"Circ Res"},{"issue":"3","key":"2021070810510095000_fcab064-B5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1708538113478758","article-title":"Animal models of atherosclerosis and magnetic resonance imaging for monitoring plaque progression","volume":"22","author":"Millon","year":"2014","journal-title":"Vascular"},{"issue":"38","key":"2021070810510095000_fcab064-B6","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1093\/eurheartj\/ehx581","article-title":"Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases","volume":"39","author":"Hoogeveen","year":"2018","journal-title":"Eur Heart J"},{"issue":"3","key":"2021070810510095000_fcab064-B7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-018-1807-1","article-title":"Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease","volume":"135","author":"Ghersi-Egea","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"6","key":"2021070810510095000_fcab064-B8","first-page":"1051","article-title":"Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone","volume":"10","author":"Adams","year":"1990","journal-title":"Arteriosclerosis (Dallas, Tex)"},{"issue":"3","key":"2021070810510095000_fcab064-B9","first-page":"358","article-title":"Carotid artery atherosclerosis in cholesterol-fed female cynomolgus monkeys. Effects of oral contraceptive treatment, social factors, and regional adiposity","volume":"10","author":"Shively","year":"1990","journal-title":"Arteriosclerosis (Dallas, Tex)"},{"issue":"11","key":"2021070810510095000_fcab064-B10","doi-asserted-by":"crossref","first-page":"E1256","DOI":"10.1212\/WNL.0000000000007094","article-title":"Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study","volume":"92","author":"Walker","year":"2019","journal-title":"Neurology"},{"issue":"1","key":"2021070810510095000_fcab064-B11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12916-017-0793-9","article-title":"Translational models for vascular cognitive impairment: A review including larger species","volume":"15","author":"Hainsworth","year":"2017","journal-title":"BMC Med"},{"issue":"15","key":"2021070810510095000_fcab064-B12","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1161\/01.CIR.0000144307.82502.32","article-title":"Histological correlates of carotid plaque surface morphology on lumen contrast imaging","volume":"110","author":"Lovett","year":"2004","journal-title":"Circulation"},{"issue":"5","key":"2021070810510095000_fcab064-B13","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: A report from the Committee on Vascular Lesions of the council on arteriosclerosis, American heart association","volume":"92","author":"Stary","year":"1995","journal-title":"Circulation"},{"issue":"8","key":"2021070810510095000_fcab064-B14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bjsports-2018-099677","article-title":"Association between physical activity and sedentary behaviour on carotid atherosclerotic plaques: An epidemiological and histological study in 90 asymptomatic patients","volume":"54","author":"Mury","year":"2020","journal-title":"Br J Sports Med"},{"key":"2021070810510095000_fcab064-B15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3389\/fphys.2017.01043","article-title":"Higher daily physical activity level is associated with lower RBC aggregation in carotid artery disease patients at high risk of stroke","volume":"8","author":"Mury","year":"2017","journal-title":"Front Physiol"},{"issue":"4","key":"2021070810510095000_fcab064-B16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2967\/jnumed.114.142596","article-title":"Variability and uncertainty of 18F-FDG PET imaging protocols for assessing inflammation in atherosclerosis: Suggestions for improvement","volume":"56","author":"Huet","year":"2015","journal-title":"J Nuclear Med"},{"key":"2021070810510095000_fcab064-B17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroimage.2013.03.029","article-title":"A multi-atlas based method for automated anatomical Macaca fascicularis brain MRI segmentation and PET kinetic extraction","volume":"77","author":"Ballanger","year":"2013","journal-title":"NeuroImage"},{"issue":"6","key":"2021070810510095000_fcab064-B18","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.immuni.2013.06.009","article-title":"Immune effector mechanisms implicated in atherosclerosis: From mice to humans","volume":"38","author":"Libby","year":"2013","journal-title":"Immunity"},{"issue":"9","key":"2021070810510095000_fcab064-B19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/ajp.20722","article-title":"Primate models in women\u2019s health: Inflammation and atherogenesis in female cynomolgus macaques ({Macaca} fascicularis)","volume":"71","author":"Register","year":"2009","journal-title":"Am J Primatol"},{"issue":"10071","key":"2021070810510095000_fcab064-B20","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0140-6736(16)31714-7","article-title":"Relation between resting amygdalar activity and cardiovascular events: A longitudinal and cohort study","volume":"389","author":"Tawakol","year":"2017","journal-title":"Lancet (London, England)"},{"issue":"5","key":"2021070810510095000_fcab064-B21","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/mec.13536","article-title":"Application of multivariate statistical techniques in microbial ecology","volume":"25","author":"Paliy","year":"2016","journal-title":"Mol Ecol"},{"issue":"4","key":"2021070810510095000_fcab064-B22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2017.09.008","article-title":"Monocyte-macrophages and T cells in atherosclerosis","volume":"47","author":"Tabas","year":"2017","journal-title":"Immunity"},{"issue":"23","key":"2021070810510095000_fcab064-B23","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1113\/JP271903","article-title":"Magnetic resonance imaging biomarkers of exercise-induced improvement of oxidative stress and inflammation in the brain of old high-fat-fed ApoE(-\/-) mice","volume":"594","author":"Chirico","year":"2016","journal-title":"J Physiol"},{"key":"2021070810510095000_fcab064-B24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2016.00453","article-title":"Exercise does not protect against peripheral and central effects of a high cholesterol diet given ad libitum in old ApoE-\/- mice","volume":"7","author":"Di Cataldo","year":"2016","journal-title":"Front Physiol"},{"issue":"9","key":"2021070810510095000_fcab064-B25","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/s41386-018-0085-x","article-title":"Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents","volume":"43","author":"Kim","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"6205","key":"2021070810510095000_fcab064-B26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1252945","article-title":"Aging-induced type I interferon response at the choroid plexus negatively affects brain function","volume":"346","author":"Baruch","year":"2014","journal-title":"Science"},{"issue":"1","key":"2021070810510095000_fcab064-B27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4800(89)90052-X","article-title":"Atherosclerosis research in cynomolgus monkeys (Macaca fascicularis)","volume":"50","author":"Weingand","year":"1989","journal-title":"Exp Mol Pathol"},{"issue":"11","key":"2021070810510095000_fcab064-B28","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1161\/CIRCULATIONAHA.115.016270","article-title":"Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs","volume":"132","author":"Pedrigi","year":"2015","journal-title":"Circulation"},{"issue":"3","key":"2021070810510095000_fcab064-B29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3174\/ajnr.A1410","article-title":"Vulnerable plaque in a swine model of carotid atherosclerosis","volume":"30","author":"Shi","year":"2009","journal-title":"Am J Neuroradiol"},{"issue":"5","key":"2021070810510095000_fcab064-B30","first-page":"2731","article-title":"Of mice and not men: Differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol (Baltimore, Md\u202f: 1950)"},{"issue":"9","key":"2021070810510095000_fcab064-B31","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/nm.3258","article-title":"Accumulation in atherosclerosis","volume":"19","author":"Robbins","year":"2013","journal-title":"Nat Med"},{"issue":"10","key":"2021070810510095000_fcab064-B32","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCRESAHA.114.302761","article-title":"Adaptive (T and B Cells) immunity and control by dendritic cells in atherosclerosis","volume":"114","author":"Ait-Oufella","year":"2014","journal-title":"Circ Res"},{"issue":"6245","key":"2021070810510095000_fcab064-B33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aac7801","article-title":"Neutrophil-macrophage communication in inflammation and atherosclerosis","volume":"349","author":"Nahrendorf","year":"2015","journal-title":"Science"},{"issue":"3","key":"2021070810510095000_fcab064-B34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","author":"Jorch","year":"2017","journal-title":"Nat Med"},{"key":"2021070810510095000_fcab064-B35","doi-asserted-by":"crossref","first-page":"15750","DOI":"10.1038\/ncomms15750","article-title":"Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis","volume":"8","author":"Sergin","year":"2017","journal-title":"Nat Commun"},{"issue":"11","key":"2021070810510095000_fcab064-B36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.117.006775","article-title":"Attenuated superoxide dismutase 2 activity induces atherosclerotic plaque instability during aging in hyperlipidemic mice","volume":"6","author":"Vendrov","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"17","key":"2021070810510095000_fcab064-B37","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.jacc.2018.08.1043","article-title":"Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week","volume":"72","author":"Libby","year":"2018","journal-title":"J Am College Cardiol"},{"issue":"48","key":"2021070810510095000_fcab064-B38","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1093\/eurheartj\/ehz283","article-title":"Immunotherapy for cardiovascular disease","volume":"40","author":"Lutgens","year":"2019","journal-title":"Eur Heart J"},{"issue":"4","key":"2021070810510095000_fcab064-B39","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s13311-016-0458-y","article-title":"Clinical trials of immunomodulation in ischemic stroke","volume":"13","author":"Veltkamp","year":"2016","journal-title":"Neurotherapeutics"},{"issue":"8","key":"2021070810510095000_fcab064-B40","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute ischaemic stroke \u2014 implications for treatment","volume":"15","author":"Stoll","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"2021070810510095000_fcab064-B41","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/STROKEAHA.119.028405","article-title":"Higher plaque burden of middle cerebral artery is associated with recurrent ischemic stroke: A quantitative magnetic resonance imaging study","volume":"51","author":"Ran","year":"2020","journal-title":"Stroke"},{"issue":"3","key":"2021070810510095000_fcab064-B42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00234-017-1970-4","article-title":"Increased variability of watershed areas in patients with high-grade carotid stenosis","volume":"60","author":"Kaczmarz","year":"2018","journal-title":"Neuroradiology"},{"issue":"12","key":"2021070810510095000_fcab064-B43","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1161\/STROKEAHA.116.012407","article-title":"Lectin complement pathway and its bloody interactions in brain ischemia","volume":"47","author":"Fumagalli","year":"2016","journal-title":"Stroke"},{"issue":"11","key":"2021070810510095000_fcab064-B44","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S1474-4422(19)30078-X","article-title":"Global brain inflammation in stroke","volume":"18","author":"Shi","year":"2019","journal-title":"Lancet Neurol"},{"issue":"2","key":"2021070810510095000_fcab064-B45","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa193","article-title":"PET-MRI nanoparticles imaging of blood-brain barrier damage and modulation after stroke reperfusion","volume":"2","author":"Debatisse","year":"2020","journal-title":"Brain Commun"},{"issue":"2","key":"2021070810510095000_fcab064-B46","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neuroimage.2004.09.034","article-title":"Evolution of microglial activation in patients after ischemic stroke: A [11C](R)-PK11195 PET study","volume":"24","author":"Gerhard","year":"2005","journal-title":"NeuroImage"},{"issue":"7","key":"2021070810510095000_fcab064-B47","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1093\/brain\/awy121","article-title":"Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man","volume":"141","author":"Morris","year":"2018","journal-title":"Brain"},{"issue":"4","key":"2021070810510095000_fcab064-B48","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/0271678X20921310","article-title":"A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs","volume":"41","author":"Debatisse","year":"2020","journal-title":"J Cerebr Blood Flow Metab"},{"key":"2021070810510095000_fcab064-B49","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuroimage.2017.12.027","article-title":"Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk","volume":"172","author":"Corlier","year":"2018","journal-title":"NeuroImage"},{"issue":"1","key":"2021070810510095000_fcab064-B50","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/bpa.12763","article-title":"Characterization of the 18 kDa translocator protein (TSPO) expression in post-mortem normal and Alzheimer\u2019s disease brains","volume":"30","author":"Gui","year":"2020","journal-title":"Brain Pathol"},{"issue":"2","key":"2021070810510095000_fcab064-B51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9020512","article-title":"The translocator protein (TSPO) in mitochondrial bioenergetics and immune processes","volume":"9","author":"Betlazar","year":"2020","journal-title":"Cells"},{"key":"2021070810510095000_fcab064-B52","first-page":"496","article-title":"ApoE attenuates unresolvable inflammation by complex formation with activated C1q","author":"Yin","year":"2019"},{"issue":"Pt 3","key":"2021070810510095000_fcab064-B53","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/brain\/awv391","article-title":"Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia","volume":"139","author":"Ejaz","year":"2016","journal-title":"Brain"},{"key":"2021070810510095000_fcab064-B54","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.bbi.2020.10.025","article-title":"Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed patients: Implications for inflammation and depression","volume":"91","author":"Turkheimer","year":"2021","journal-title":"Brain Behav Immunity"},{"issue":"12","key":"2021070810510095000_fcab064-B55","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00234-013-1290-2","article-title":"Measurement of choroid plexus perfusion using dynamic susceptibility MR imaging: Capillary permeability and age-related changes","volume":"55","author":"Bouzerar","year":"2013","journal-title":"Neuroradiology"},{"key":"2021070810510095000_fcab064-B56","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exger.2016.02.008","article-title":"Use of dynamic 18F-fluorodeoxyglucose positron emission tomography to investigate choroid plexus function in Alzheimer\u2019s disease","volume":"77","author":"Daouk","year":"2016","journal-title":"Exp Gerontol"},{"issue":"February","key":"2021070810510095000_fcab064-B57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnmol.2019.00034","article-title":"Clinical imaging of choroid plexus in health and in brain disorders: A mini-review","volume":"12","author":"Hubert","year":"2019","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"2021070810510095000_fcab064-B58","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/s41467-020-16002-4","article-title":"Non-invasive MRI of blood-cerebrospinal fluid barrier function","volume":"11","author":"Evans","year":"2020","journal-title":"Nat Commun"},{"issue":"13","key":"2021070810510095000_fcab064-B59","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.15252\/embj.201591468","article-title":"Cerebral nitric oxide represses choroid plexus NF \u03baB-dependent gateway activity for leukocyte trafficking","volume":"34","author":"Baruch","year":"2015","journal-title":"EMBO J"},{"key":"2021070810510095000_fcab064-B60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jneuroim.2018.07.003","article-title":"Neuroinflammatory responses in experimental and human stroke lesions","volume":"323","author":"Wimmer","year":"2018","journal-title":"J Neuroimmunol"},{"issue":"6","key":"2021070810510095000_fcab064-B61","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: Mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J Clin Invest"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcab064\/36854163\/fcab064.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/2\/fcab064\/37310091\/fcab064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/2\/fcab064\/37310091\/fcab064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T07:29:14Z","timestamp":1724743754000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcab064\/6207985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4,5]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcab064","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2021,4,1]]},"article-number":"fcab064"}}