{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:44:05Z","timestamp":1790401445353,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":239,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019544","name":"Cambridge Centre for Parkinson-Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"National Institute for Health Research Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC-1215-20014"],"award-info":[{"award-number":["BRC-1215-20014"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["SUAG\/051 G101400 JBR"],"award-info":[{"award-number":["SUAG\/051 G101400 JBR"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["146281"],"award-info":[{"award-number":["146281"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220258"],"award-info":[{"award-number":["220258"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association of British Neurologists, Patrick Berthoud Charitable Trust","award":["RG99368"],"award-info":[{"award-number":["RG99368"]}]},{"DOI":"10.13039\/501100004282","name":"Evelyn Trust","doi-asserted-by":"publisher","award":["RG84654"],"award-info":[{"award-number":["RG84654"]}],"id":[{"id":"10.13039\/501100004282","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alzheimer\u2019s Society Junior Research Fellowship","award":["443 AS JF 18017"],"award-info":[{"award-number":["443 AS JF 18017"]}]},{"name":"Research Councils United Kingdom\/United Kingdom Research and Innovation Fellowship"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R007446\/1"],"award-info":[{"award-number":["MR\/R007446\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health Service, the National Institute for Health Research or the Department of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>While [18F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of \u2018off-target\u2019 [18F]-AV-1451 binding to neuromelanin in the substantia nigra could be a surrogate marker of Lewy body diseases. [18F]-AV-1451 binding was measured in the substantia nigra of patients with Parkinson\u2019s disease (n = 35), dementia with Lewy bodies (n = 10) and separate control groups (n = 37; n = 14). Associations with motor symptoms, cognition and disease duration were evaluated using linear regression models. The dementia with Lewy bodies group had significantly reduced substantia nigra [18F]-AV-1451 binding compared to controls after adjusting for age (P &amp;lt; 0.05). However, there were no significant differences in substantia nigra [18F]-AV-1451 binding between Parkinson\u2019s disease and controls. Substantia nigra [18F]-AV-1451 binding was not associated with age, disease duration, Movement Disorders Society\u2014Unified Parkinson\u2019s Disease Rating Scale and cognitive scores in dementia with Lewy bodies and Parkinson\u2019s disease groups. Despite the reduction of substantia nigra [18F]-AV-1451 binding in dementia with Lewy bodies, these findings suggest that substantia nigra [18F]-AV-1451 binding has no value as a diagnostic marker in early Parkinson\u2019s disease. Further investigations in longitudinal cohorts are warranted.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab177","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T16:30:58Z","timestamp":1630168258000},"source":"Crossref","is-referenced-by-count":9,"title":["[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6437-8024","authenticated-orcid":false,"given":"Elijah","family":"Mak","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-6154","authenticated-orcid":false,"given":"Antonina","family":"Kouli","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Nicastro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK"},{"name":"Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-5454","authenticated-orcid":false,"given":"George","family":"Savulich","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-1545","authenticated-orcid":false,"given":"Ajenthan","family":"Surendranathan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-9656","authenticated-orcid":false,"given":"Maura","family":"Malpetti","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roido","family":"Manavaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young T","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"},{"name":"Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D","family":"Fryer","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"},{"name":"Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Aigbirhio","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"},{"name":"Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"},{"name":"Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB37EF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline H","family":"Williams-Gray","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Cambridge CB20SZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"issue":"1","key":"2021090205003743000_fcab177-B1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mds.26844","article-title":"Subcortical 18-F-AV-1451 binding patterns in progressive supranuclear palsy","volume":"32","author":"Cho","year":"2017","journal-title":"Mov Disord"},{"issue":"Pt 7","key":"2021090205003743000_fcab177-B2","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1093\/brain\/aww098","article-title":"In vivo imaging of neuromelanin in Parkinson\u2019s disease using 18F-AV-1451 PET","volume":"139","author":"Hansen","year":"2016","journal-title":"Brain"},{"issue":"2","key":"2021090205003743000_fcab177-B3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00429-017-1507-y","article-title":"[18F]AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP","volume":"223","author":"Coakeley","year":"2018","journal-title":"Brain Struct Funct"},{"issue":"4","key":"2021090205003743000_fcab177-B4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/ana.25060","article-title":"18F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study","volume":"82","author":"Schonhaut","year":"2017","journal-title":"Ann Neurol"},{"issue":"1","key":"2021090205003743000_fcab177-B5","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1038\/s41598-018-23041-x","article-title":"18F-AV-1451 in Parkinson\u2019s disease with and without dementia and in Dementia with Lewy Bodies","volume":"8","author":"Smith","year":"2018","journal-title":"Sci Rep"},{"issue":"8","key":"2021090205003743000_fcab177-B6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1212\/WNL.57.8.1497","article-title":"Improved accuracy of clinical diagnosis of Lewy body Parkinson\u2019s disease","volume":"57","author":"Hughes","year":"2001","journal-title":"Neurology"},{"issue":"12","key":"2021090205003743000_fcab177-B7","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson\u2019s disease","volume":"22","author":"Emre","year":"2007","journal-title":"Mov Disord"},{"issue":"1","key":"2021090205003743000_fcab177-B8","doi-asserted-by":"crossref","first-page":"e013187","DOI":"10.1136\/bmjopen-2016-013187","article-title":"Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: A deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses","volume":"7","author":"Bevan-Jones","year":"2017","journal-title":"BMJ Open"},{"issue":"1","key":"2021090205003743000_fcab177-B9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"issue":"12","key":"2021090205003743000_fcab177-B10","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"issue":"15","key":"2021090205003743000_fcab177-B11","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-Sponsored Revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov Disord"},{"issue":"12","key":"2021090205003743000_fcab177-B12","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1109\/TMI.2014.2340135","article-title":"Attenuation correction synthesis for hybrid PET-MR scanners: Application to brain studies","volume":"33","author":"Burgos","year":"2014","journal-title":"IEEE Trans Med Imaging"},{"key":"2021090205003743000_fcab177-B13","author":"Prados","year":"2016"},{"key":"2021090205003743000_fcab177-B14","author":"Manavaki","year":"2019"},{"issue":"1","key":"2021090205003743000_fcab177-B15","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1109\/23.34585","article-title":"Analytic 3D image reconstruction using all detected events","volume":"36","author":"Kinahan","year":"1989","journal-title":"IEEE Trans Nucl Sci"},{"issue":"4","key":"2021090205003743000_fcab177-B16","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1109\/42.363108","article-title":"Accelerated image reconstruction using ordered subsets of projection data","volume":"13","author":"Hudson","year":"1994","journal-title":"IEEE Trans Med Imaging"},{"issue":"4","key":"2021090205003743000_fcab177-B17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/nimg.1997.0303","article-title":"Parametric imaging of ligand-receptor binding in PET using a simplified reference region model","volume":"6","author":"Gunn","year":"1997","journal-title":"Neuroimage"},{"issue":"2","key":"2021090205003743000_fcab177-B18","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/jamaneurol.2017.3713","article-title":"Associations Between Tau, \u03b2-Amyloid, and Cognition in Parkinson Disease","volume":"75","author":"Winer","year":"2018","journal-title":"JAMA Neurology"},{"issue":"10","key":"2021090205003743000_fcab177-B19","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/mds.25952","article-title":"Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease","volume":"29","author":"Dijkstra","year":"2014","journal-title":"Movement Disorders : official Journal of the Movement Disorder Society"},{"issue":"1","key":"2021090205003743000_fcab177-B20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41531-018-0047-3","article-title":"Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson\u2019s disease","volume":"4","author":"Sulzer","year":"2018","journal-title":"NPJ Park Dis"},{"issue":"11","key":"2021090205003743000_fcab177-B21","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/01.wnr.0000227984.84927.a7","article-title":"Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson\u2019s disease","volume":"17","author":"Sasaki","year":"2006","journal-title":"Neuroreport"},{"issue":"11","key":"2021090205003743000_fcab177-B22","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1073\/pnas.1807983116","article-title":"Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain","volume":"116","author":"Cassidy","year":"2019","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcab177\/40079689\/fcab177.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/3\/fcab177\/40216039\/fcab177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/3\/fcab177\/40216039\/fcab177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T05:00:59Z","timestamp":1630558859000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcab177\/6359177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcab177","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021]]},"published":{"date-parts":[[2021]]},"article-number":"fcab177"}}