{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:00:19Z","timestamp":1772121619330,"version":"3.50.1"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tourette syndrome is a common neurodevelopmental disorder defined by multiple motor and phonic tics. Tics in Tourette syndrome resemble spontaneously occurring movements in healthy controls and are therefore sometimes difficult to distinguish from these. Tics may in fact be mis-interpreted as a meaningful action, i.e. a signal with social content, whereas they lack such information and could be conceived a surplus of action or \u2018motor noise\u2019. These and other considerations have led to a \u2018neural noise account\u2019 of Tourette syndrome suggesting that the processing of neural noise and adaptation of the signal-to-noise ratio during information processing is relevant for the understanding of Tourette syndrome. So far, there is no direct evidence for this. Here, we tested the \u2018neural noise account\u2019 examining 1\/f noise, also called scale-free neural activity as well as aperiodic activity, in n\u2009=\u200974 children, adolescents and adults with Tourette syndrome and n\u2009=\u200974 healthy controls during task performance using EEG data recorded during a sensorimotor integration task. In keeping with results of a previous study in adults with Tourette syndrome, behavioural data confirmed that sensorimotor integration was also stronger in this larger Tourette syndrome cohort underscoring the relevance of perceptual-action processes in this disorder. More importantly, we show that 1\/f noise and aperiodic activity during sensorimotor processing is increased in patients with Tourette syndrome supporting the \u2018neural noise account\u2019. This implies that asynchronous\/aperiodic neural activity during sensorimotor integration is stronger in patients with Tourette syndrome compared to healthy controls, which is probably related to abnormalities of GABAergic and dopaminergic transmission in these patients. Differences in 1\/f noise and aperiodic activity between patients with Tourette syndrome and healthy controls were driven by high-frequency oscillations and not lower-frequency activity currently discussed to be important in the pathophysiology of tics. This and the fact that Bayesian statistics showed that there is evidence for the absence of a correlation between neural noise and clinical measures of tics, suggest that increased 1\/f noise and aperiodic activity are not directly related to tics but rather represents a novel facet of Tourette syndrome.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab250","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T19:13:50Z","timestamp":1635189230000},"source":"Crossref","is-referenced-by-count":41,"title":["Increased scale-free and aperiodic neural activity during sensorimotor integration\u2014a novel facet in Tourette syndrome"],"prefix":"10.1093","volume":"3","author":[{"given":"Nico","family":"Adelh\u00f6fer","sequence":"first","affiliation":[{"name":"Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, 01069 Dresden, 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Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, 01069 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Takacs","sequence":"additional","affiliation":[{"name":"Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, 01069 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"T\u00f3th-F\u00e1ber","sequence":"additional","affiliation":[{"name":"Doctoral School of Psychology, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, 1064 Budapest, Hungary"},{"name":"Institute of Psychology, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, 1053 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsanett","family":"T\u00e1rnok","sequence":"additional","affiliation":[{"name":"Vadaskert Child and Adolescent Psychiatry Hospital and Outpatient Clinic, 1021 Budapest, 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