{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:36:02Z","timestamp":1780043762809,"version":"3.53.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Specialized Neuroscience Research Program","award":["3U54NS041073, NINDS-NIH"],"award-info":[{"award-number":["3U54NS041073, NINDS-NIH"]}]},{"name":"Specialized Neuroscience Research Program","award":["R01NS037060 (NINDS-NIH)"],"award-info":[{"award-number":["R01NS037060 (NINDS-NIH)"]}]},{"name":"M.T. Filbin, Research Centers in Minority Institutions Programs","award":["RR00307, NCRR-NIH"],"award-info":[{"award-number":["RR00307, NCRR-NIH"]}]},{"DOI":"10.13039\/100006926","name":"Hunter College","doi-asserted-by":"publisher","award":["R01GM054508"],"award-info":[{"award-number":["R01GM054508"]}],"id":[{"id":"10.13039\/100006926","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006926","name":"Hunter College","doi-asserted-by":"publisher","award":["R01GM137056"],"award-info":[{"award-number":["R01GM137056"]}],"id":[{"id":"10.13039\/100006926","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Systems Biology Center","award":["P50GM071558"],"award-info":[{"award-number":["P50GM071558"]}]},{"name":"Systems Biology Center","award":["F32NS054511"],"award-info":[{"award-number":["F32NS054511"]}]},{"name":"NYS Spinal Cord Injury Research Program","award":["#C34460GG"],"award-info":[{"award-number":["#C34460GG"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Triple knockout mice lacking the major myelin-associated inhibitors do not display spontaneous regeneration after injury, indicating the presence of other inhibitors. Searching for such inhibitors, we have detected elevated levels of histone H3 in human CSF 24 h after spinal cord injury. Following dorsal column lesions in mice and optic nerve crushes in rats, elevated levels of extracellular histone H3 were detected at the injury site. Similar to myelin-associated inhibitors, these extracellular histones induced growth cone collapse and inhibited neurite outgrowth. Histones mediate inhibition through the transcription factor Y-box-binding protein 1 and Toll-like receptor 2, and these effects are independent of the Nogo receptor. Histone-mediated inhibition can be reversed by the addition of activated protein C in vitro, and activated protein C treatment promotes axonal regeneration in the crushed optic nerve in vivo. These findings identify extracellular histones as a new class of nerve regeneration-inhibiting molecules within the injured CNS.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab271","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T07:23:10Z","timestamp":1636442590000},"source":"Crossref","is-referenced-by-count":13,"title":["Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-7376","authenticated-orcid":false,"given":"Mustafa M","family":"Siddiq","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA"},{"name":"Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari S","family":"Hannila","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA"},{"name":"Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Zorina","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Gene Editing and Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Nikulina","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA"},{"name":"Department of Physiology and Pharmacology, SUNY Downstate Health Science University, Brooklyn, NY 11203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Rabinovich","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumana","family":"Huq","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L","family":"Richman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-3230","authenticated-orcid":false,"given":"Rosa E","family":"Tolentino","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-2415","authenticated-orcid":false,"given":"Adam","family":"Velenosi","sequence":"additional","affiliation":[{"name":"Praxis Spinal Cord Institute, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K","family":"Kwon","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, University of British Columbia (UBC), Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella E","family":"Tsirka","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794-8651, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Maze","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sebra","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Studies, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Icahn Institute for Data Science and Genomic Technology, Black Family Stem Cell Institute, New York, NY 10029, USA"},{"name":"Sema4, a Mount Sinai Venture, Stamford, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin G","family":"Beaumont","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Studies, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Icahn Institute for Data Science and Genomic Technology, Black Family Stem Cell Institute, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Toro","sequence":"additional","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, New York, NY 10468, USA"},{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P","family":"Cardozo","sequence":"additional","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, New York, NY 10468, USA"},{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie T","family":"Filbin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"issue":"9","key":"2021121112573542500_fcab271-B1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrn1195","article-title":"Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS","volume":"4","author":"Filbin","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"2021121112573542500_fcab271-B2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/07853890500407520","article-title":"Inhibition of Nogo: A key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system","volume":"37","author":"Buchli","year":"2005","journal-title":"Ann Med"},{"issue":"1","key":"2021121112573542500_fcab271-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2006.09.006","article-title":"The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system","volume":"54","author":"Galtrey","year":"2007","journal-title":"Brain Res Rev"},{"issue":"3","key":"2021121112573542500_fcab271-B4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuron.2016.04.022","article-title":"Intrinsic control of axon regeneration","volume":"90","author":"He","year":"2016","journal-title":"Neuron"},{"issue":"20","key":"2021121112573542500_fcab271-B5","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1523\/JNEUROSCI.6239-09.2010","article-title":"MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma","volume":"30","author":"Cafferty","year":"2010","journal-title":"J Neurosci"},{"issue":"11","key":"2021121112573542500_fcab271-B6","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat Med"},{"issue":"5","key":"2021121112573542500_fcab271-B7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1046\/j.1365-2990.1999.00171.x","article-title":"Non-nuclear histone H1 is upregulated in neurons and astrocytes in prion and Alzheimer\u2019s diseases but not in acute neurodegeneration","volume":"25","author":"Bolton","year":"1999","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"148","key":"2021121112573542500_fcab271-B8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.12688\/f1000research.2-148.v1","article-title":"Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia","volume":"2","author":"Gilthorpe","year":"2013","journal-title":"F1000 Res"},{"issue":"8","key":"2021121112573542500_fcab271-B9","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1161\/ATVBAHA.112.250993","article-title":"Extracellular chromatin is an important mediator of ischemic stroke in mice","volume":"32","author":"De Meyer","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021121112573542500_fcab271-B10","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S0049-3848(16)30368-1","article-title":"Activated protein C promotes neuroprotection: Mechanisms and translations to the clinic","volume":"141(Suppl 2)","author":"Griffin","year":"2016","journal-title":"Thromb Res"},{"issue":"34","key":"2021121112573542500_fcab271-B11","doi-asserted-by":"crossref","first-page":"13798","DOI":"10.1073\/pnas.0702553104","article-title":"Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits","volume":"104","author":"Tang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2021121112573542500_fcab271-B12","doi-asserted-by":"crossref","first-page":"e2518","DOI":"10.1038\/cddis.2016.410","article-title":"Extracellular histones, cell-free DNA, or nucleosomes: Differences in immunostimulation","volume":"7","author":"Marsman","year":"2016","journal-title":"Cell Death Dis"},{"issue":"3","key":"2021121112573542500_fcab271-B13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0896-6273(94)90042-6","article-title":"A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration","volume":"13","author":"Mukhopadhyay","year":"1994","journal-title":"Neuron"},{"issue":"1","key":"2021121112573542500_fcab271-B14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nm.2600","article-title":"Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury","volume":"18","author":"Ert\u00fcrk","year":"2011","journal-title":"Nat Med"},{"issue":"1","key":"2021121112573542500_fcab271-B15","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1038\/s41467-019-11781-x","article-title":"Wilm\u2019s tumor 1 promotes memory flexibility","volume":"10","author":"Mariottini","year":"2019","journal-title":"Nat Commun"},{"key":"2021121112573542500_fcab271-B16","doi-asserted-by":"crossref","first-page":"e19406","DOI":"10.7554\/eLife.19406","article-title":"Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells","volume":"6","author":"Stillitano","year":"2017","journal-title":"Elife"},{"issue":"1","key":"2021121112573542500_fcab271-B17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"5","key":"2021121112573542500_fcab271-B18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"14","key":"2021121112573542500_fcab271-B19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"2021121112573542500_fcab271-B20","doi-asserted-by":"crossref","first-page":"gkw377","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: A comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2021121112573542500_fcab271-B21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5966\/sctm.2013-0110","article-title":"Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes","volume":"3","author":"Karakikes","year":"2014","journal-title":"Stem Cells Transl Med"},{"issue":"17","key":"2021121112573542500_fcab271-B22","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1523\/JNEUROSCI.19-17-07537.1999","article-title":"Inactivation of Rho signaling pathway promotes CNS axon regeneration","volume":"19","author":"Lehmann","year":"1999","journal-title":"J Neurosci"},{"issue":"10","key":"2021121112573542500_fcab271-B23","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1523\/JNEUROSCI.4012-15.2016","article-title":"Cyclic AMP and polyamines overcome inhibition by myelin-associated glycoprotein through eIF5A-mediated increases in p35 expression and activation of Cdk5","volume":"36","author":"He","year":"2016","journal-title":"J Neurosci"},{"issue":"4","key":"2021121112573542500_fcab271-B24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0006-3495(86)83510-X","article-title":"Optical second-harmonic microscopy, crossed-beam summation, and small-angle scattering in rat-tail tendon","volume":"50","author":"Freund","year":"1986","journal-title":"Biophys J"},{"issue":"2","key":"2021121112573542500_fcab271-B25","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ymeth.2013.08.012","article-title":"Methods of peripheral nerve tissue preparation for second harmonic generation imaging of collagen fibers","volume":"66","author":"Vijayaraghavan","year":"2014","journal-title":"Methods"},{"issue":"1","key":"2021121112573542500_fcab271-B26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0896-6273(00)80681-9","article-title":"Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMPdependent mechanism","volume":"22","author":"Cai","year":"1999","journal-title":"Neuron"},{"issue":"5878","key":"2021121112573542500_fcab271-B27","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1126\/science.1152662","article-title":"Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth","volume":"320","author":"Bromberg","year":"2008","journal-title":"Science"},{"issue":"6818","key":"2021121112573542500_fcab271-B28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/35053072","article-title":"Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration","volume":"409","author":"Fournier","year":"2001","journal-title":"Nature"},{"issue":"5584","key":"2021121112573542500_fcab271-B29","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1073031","article-title":"Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor","volume":"297","author":"Liu","year":"2002","journal-title":"Science"},{"issue":"2","key":"2021121112573542500_fcab271-B30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0896-6273(02)00770-5","article-title":"Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth","volume":"35","author":"Domeniconi","year":"2002","journal-title":"Neuron"},{"issue":"13","key":"2021121112573542500_fcab271-B31","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1523\/JNEUROSCI.23-13-05393.2003","article-title":"Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions","volume":"23","author":"Oertle","year":"2003","journal-title":"J Neurosci"},{"issue":"5952","key":"2021121112573542500_fcab271-B32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1126\/science.1178310","article-title":"PTP\u03c3 is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration","volume":"326","author":"Shen","year":"2009","journal-title":"Science"},{"issue":"26","key":"2021121112573542500_fcab271-B33","doi-asserted-by":"crossref","first-page":"16343","DOI":"10.1074\/jbc.M114.630574","article-title":"Metallothionein-I\/II promotes axonal regeneration in the central nervous system","volume":"290","author":"Siddiq","year":"2015","journal-title":"J Biol Chem"},{"issue":"6881","key":"2021121112573542500_fcab271-B34","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/416636a","article-title":"Chondroitinase ABC promotes functional recovery after spinal cord injury","volume":"416","author":"Bradbury","year":"2002","journal-title":"Nature"},{"key":"2021121112573542500_fcab271-B35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2091-9-23","article-title":"YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules","volume":"9","author":"Chernov","year":"2008","journal-title":"BMC Biochem"},{"issue":"28","key":"2021121112573542500_fcab271-B36","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1523\/JNEUROSCI.1492-04.2004","article-title":"Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury","volume":"24","author":"Lu","year":"2004","journal-title":"J. Neurosci"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcab271\/41154042\/fcab271.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/4\/fcab271\/41724634\/fcab271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/3\/4\/fcab271\/41724634\/fcab271.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T07:58:39Z","timestamp":1639209519000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcab271\/6427625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcab271","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/365825","asserted-by":"object"}]},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,10,1]]},"article-number":"fcab271"}}