{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:04:12Z","timestamp":1781557452704,"version":"3.54.5"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Munich Cluster for Systems Neurology\u2014EXC 2145 SyNergy","award":["390857198 (S.L., J.H.), EXC 1010 (S.B.)"],"award-info":[{"award-number":["390857198 (S.L., J.H.), EXC 1010 (S.B.)"]}]},{"name":"DFG, Emmy Noether Programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Considerable fluctuations in cognitive performance and eventual dementia are an important characteristic of alpha-synucleinopathies, such as Parkinson\u2019s disease and Lewy Body dementia and are linked to cortical dysfunction. The presence of misfolded and aggregated alpha-synuclein in the cerebral cortex of patients has been suggested to play a crucial role in this process. However, the consequences of a-synuclein accumulation on the function of cortical networks at cellular resolution in vivo are largely unknown. Here, we induced robust a-synuclein pathology in the cerebral cortex using the striatal seeding model in wild-type mice. Nine months after a single intrastriatal injection of a-synuclein preformed fibrils, we observed profound alterations of the function of layer 2\/3 cortical neurons in somatosensory cortex by in vivo two-photon calcium imaging in awake mice. We detected increased spontaneous activity levels, an enhanced response to whisking and increased synchrony. Stereological analyses revealed a reduction in glutamic acid decarboxylase 67-positive inhibitory neurons in the somatosensory cortex of mice injected with preformed fibrils. Importantly, these findings point to a disturbed excitation\/inhibition balance as a relevant driver of circuit dysfunction, potentially underlying cognitive changes in alpha-synucleinopathies.<\/jats:p>","DOI":"10.1093\/braincomms\/fcab273","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T16:10:53Z","timestamp":1636560653000},"source":"Crossref","is-referenced-by-count":15,"title":["Cortical circuit dysfunction in a mouse model of alpha-synucleinopathy\n                    <i>in vivo<\/i>"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-3295","authenticated-orcid":false,"given":"Sonja","family":"Blumenstock","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Center for Neuropathology and Prion Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Sun","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Klaus","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Marinkovi\u0107","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Sgobio","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Paeger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Liebscher","sequence":"additional","affiliation":[{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"},{"name":"Institute of Clinical Neuroimmunology, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians University, 82152 Martinsried, Germany"},{"name":"Biomedical Center, Medical Faculty, Ludwig-Maximilians University Munich, 82152 Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Herms","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Center for Neuropathology and Prion Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"issue":"1","key":"2021120506330640700_fcab273-B1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/brain\/awz311","article-title":"Cognitive fluctuations in Lewy body dementia: Towards a pathophysiological framework","volume":"143","author":"Matar","year":"2020","journal-title":"Brain"},{"issue":"6","key":"2021120506330640700_fcab273-B2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/0004867419885165","article-title":"Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia","volume":"54","author":"Colloby","year":"2020","journal-title":"Aust N Z J 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