{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:04Z","timestamp":1787008564521,"version":"build-2736575974"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Research Activity","award":["JP18H06343"],"award-info":[{"award-number":["JP18H06343"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP19J01300"],"award-info":[{"award-number":["JP19J01300"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary progressive aphasia, a neurodegenerative syndrome, presents mainly with language impairment. Both semantic and logopenic variants are fluent variants of primary progressive aphasia. Before the research criteria of primary progressive aphasia were proposed, progressive fluent aphasias, such as progressive anomic aphasia, transcortical sensory aphasia and Wernicke\u2019s aphasia, were reported as classical progressive fluent aphasias seen in Alzheimer\u2019s disease. However, since the research criteria of primary progressive aphasia were established, classical fluent variants (other than semantic and logopenic variants) have been neglected and have not been included in the current classification of primary progressive aphasia. This study aimed to determine whether unclassified fluent variants (other than semantic and logopenic variants) can be manifestations of primary progressive aphasia. This study also reconfirmed the characteristics of classical progressive fluent aphasia, such as progressive anomic aphasia, progressive transcortical sensory aphasia and progressive Wernicke\u2019s aphasia as unclassified fluent variants of primary progressive aphasia, using comparison with the current model of primary progressive aphasia. Twelve consecutive patients with an unclassified fluent variant other than semantic or logopenic variant underwent language, neurological, neuropsychological and neuroimaging (MRI and single-photon emission computed tomography) testing. Based on comprehensive language tests, we redefined the diagnoses as primary progressive anomic aphasia (n\u2009=\u20098), primary progressive transcortical sensory aphasia (n\u2009=\u20093) and primary progressive Wernicke\u2019s aphasia (n\u2009=\u20091). Anomic aphasia was characterized by anomia but preserved repetition and comprehension; transcortical sensory aphasia by relatively preserved repetition but poor word comprehension; and Wernicke\u2019s aphasia by poor repetition and word comprehension. In patients with anomic aphasia, voxel-based morphometry of MRI data revealed cortical atrophy, which was most prominent in the temporoparietal lobes, with no obvious lateralization; in two-thirds of patients with transcortical sensory aphasia and in one patient with Wernicke\u2019s aphasia, it revealed atrophy, predominantly in the left temporoparietal lobe. Statistical analysis of single-photon emission computed tomography using three-dimensional stereotactic surface projections revealed patterns of left-sided hypoperfusion in the majority of patients. The temporal and parietal lobes were involved in all cases; the degree of hypoperfusion was higher in patients with transcortical sensory aphasia or Wernicke\u2019s aphasia than in patients with anomic aphasia. The present study demonstrated the clinical and imaging features of 12 patients with an unclassified fluent variant of primary progressive aphasia, which we redefined as primary progressive anomic aphasia, primary progressive transcortical sensory aphasia and primary progressive Wernicke\u2019s aphasia. Classical fluent variants other than semantic and logopenic variants can be found in primary progressive aphasia.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac015","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T07:18:34Z","timestamp":1643699914000},"source":"Crossref","is-referenced-by-count":20,"title":["Unclassified fluent variants of primary progressive aphasia: distinction from semantic and logopenic variants"],"prefix":"10.1093","volume":"4","author":[{"given":"Hiroyuki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Behavioral Neurology and Neuropsychiatry, Osaka University United Graduate School of Child Development , Suita, Japan"},{"name":"Department of Psychiatry, Osaka University Graduate School of Medicine , Suita, Japan"},{"name":"Brain Function Center, Nippon Life Hospital , Osaka, 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