{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:24:44Z","timestamp":1792794284067,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008627","name":"Global Affairs Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008627","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"John R. Evans Leaders and Canada Innovation Funds"},{"name":"Nova Scotia Health Authority","id":[{"id":"https:\/\/ror.org\/035gna214","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NSHA Fibromyalgia Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diplomats representing the USA have reported with unusual neurologic symptoms and MRI changes after being posted in Havana, Cuba between late 2016 and 2018. Here, we examined white matter microstructure and network connectivity of individuals stationed in Havana, using diffusion-weighted MRI, fixel-based analysis and structural connectomics as implemented in MRtrix3. MRI data acquisition and clinical assessments were done in a total of 24 diplomats and their family members and 40 healthy controls. The diplomat data were grouped into an exposed cohort (n\u2009=\u200916) and an unexposed cohort (n\u2009=\u200910), and among these, two individuals were assessed before and after potential exposure. Fixel-based analysis revealed a reduction in fibre density in two specific regions: the fornix and the splenium, in exposed individuals, relative to unexposed individuals and healthy controls. Post hoc analyses showed the effect remained present (P\u2009&amp;lt;\u20090.05) in both regions when comparing exposed and unexposed diplomats; and reduced fibre density was correlated with longer time period stationed in Cuba after age correction. Reduction of fibre density was also found to be linked with clinical symptoms of persistent migraine, tinnitus, sound sensitivity and fatigue. Network statistical comparisons revealed decreased structural connectivity in two distinct networks, comprising subcortical and cortical systems in exposed individuals, relative to unexposed and normative data. While the cause for the differences between the groups remains unknown, our results reveal region-specific white matter injury, that is, significantly correlated with clinical symptoms.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac053","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T15:12:08Z","timestamp":1646320328000},"source":"Crossref","is-referenced-by-count":4,"title":["Symptoms reported by Canadians posted in Havana are linked with reduced white matter fibre density"],"prefix":"10.1093","volume":"4","author":[{"given":"Guillermo","family":"Aristi","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Nova Scotia Health Authority, Halifax, Canada B3H 1V7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyna","family":"Kamintsky","sequence":"additional","affiliation":[{"name":"Departments of Medical Neuroscience, Pediatric and Surgery, Dalhousie University, Nova Scotia Health Authority, Halifax, Canada B3H 4R2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, NSHA, Halifax, Canada B3H 1V7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Dalhousie University, NSHA, Halifax Canada, B3H 1V7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Calkin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, NSHA, Halifax, Canada B3H 1V7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-8456","authenticated-orcid":false,"given":"Alon","family":"Friedman","sequence":"additional","affiliation":[{"name":"Departments of Medical Neuroscience, Pediatric and 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