{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:45:45Z","timestamp":1753875945450,"version":"3.41.2"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council","award":["G0701497","MR\/J012084\/1"],"award-info":[{"award-number":["G0701497","MR\/J012084\/1"]}]},{"name":"National Institute of Health Research Cambridge Biomedical Research Centre"},{"name":"Behavioural and Clinical Neuroscience Institute"},{"name":"Medical Research Council"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Physiology"},{"name":"Development and Neuroscience"},{"DOI":"10.13039\/501100000735","name":"University of Cambridge","doi-asserted-by":"crossref","award":["1202805"],"award-info":[{"award-number":["1202805"]}],"id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic drug use negatively impacts ageing, resulting in diminished health and quality of life. However, little is known about biomarkers of abnormal ageing in stimulant drug users. Using morphometric similarity network mapping, a novel approach to structural connectomics, we first mapped cross-sectional morphometric similarity trajectories of ageing in the publicly available Rockland Sample (20\u201380 years of age, n\u2009=\u2009665). We then compared morphometric similarity and neuropsychological function between non-treatment-seeking, actively using patients with stimulant use disorder (n\u2009=\u2009183, mean age: 35.6 years) and healthy control participants (n\u2009=\u2009148, mean age: 36.0 years). The significantly altered mean regional morphometric similarity was found in 43 cortical regions including the inferior and orbital frontal gyri, pre\/postcentral gyri and anterior temporal, superior parietal and occipital areas. Deviations from normative morphometric similarity trajectories in patients with stimulant use disorder suggested abnormal brain ageing. Furthermore, deficits in paired associates learning were consistent with neuropathology associated with both ageing and stimulant use disorder. Morphometric similarity mapping provides a promising biomarker for ageing in health and disease and may complement existing neuropsychological markers of age-related cognitive decline. Neuropathological ageing mechanisms in stimulant use disorder warrant further investigation to develop more age-appropriate treatments for older people addicted to stimulant drugs.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac079","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T11:07:58Z","timestamp":1648379278000},"source":"Crossref","is-referenced-by-count":6,"title":["Morphometric similarity deviations in stimulant use disorder point towards abnormal brain ageing"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-2095","authenticated-orcid":false,"given":"Peter","family":"Zhukovsky","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Cambridge , Cambridge , UK"},{"name":"Department of Psychiatry, University of Cambridge, School of Clinical Medicine , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-5454","authenticated-orcid":false,"given":"George","family":"Savulich","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, School of Clinical Medicine , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, School of Clinical Medicine , Cambridge , UK"},{"name":"Department of Computer Science and Technology, University of Cambridge , Cambridge , UK"},{"name":"The Alan Turing Institute , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Dalley","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Cambridge , Cambridge , UK"},{"name":"Department of Psychiatry, University of Cambridge, School of Clinical Medicine , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy B.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge , Cambridge , UK"},{"name":"Wolfson Brain Imaging Centre, Cambridge Biomedical Campus , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-1878","authenticated-orcid":false,"given":"Karen D.","family":"Ersche","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, School of Clinical Medicine , Cambridge , UK"},{"name":"Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"issue":"7721","key":"2022060912213025200_fcac079-B1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","article-title":"Facing up to the global challenges of ageing","volume":"561","author":"Partridge","year":"2018","journal-title":"Nature"},{"issue":"1","key":"2022060912213025200_fcac079-B2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/ageing\/afn251","article-title":"Drug use and ageing: Older people do take drugs!","volume":"38","author":"Beynon","year":"2008","journal-title":"Age Ageing"},{"issue":"4","key":"2022060912213025200_fcac079-B3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/ageing\/afs020","article-title":"Prevalences of illicit drug use in people aged 50 years and over from two surveys","volume":"41","author":"Fahmy","year":"2012","journal-title":"Age Ageing"},{"issue":"24","key":"2022060912213025200_fcac079-B4","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1056\/NEJMra1805981","article-title":"Substance-use disorders in later life","volume":"379","author":"Lehmann","year":"2018","journal-title":"N Engl J Med"},{"article-title":"ACMD Report 2019: Ageing cohort of drug users","year":"2019","author":"Advisory Council on the Misuse of Drugs","key":"2022060912213025200_fcac079-B5"},{"issue":"2","key":"2022060912213025200_fcac079-B6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.npp.1301412","article-title":"Drugs of abuse and the aging brain","volume":"33","author":"Dowling","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"2022060912213025200_fcac079-B7","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/sj.npp.1300889","article-title":"Profile of executive and memory function associated with amphetamine and opiate dependence","volume":"31","author":"Ersche","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"2022060912213025200_fcac079-B8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1017\/S1092852918001426","article-title":"Cognitive impairment in substance use disorders","volume":"24","author":"Ramey","year":"2019","journal-title":"CNS Spectr"},{"issue":"3","key":"2022060912213025200_fcac079-B9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.31887\/DCNS.2019.21.3\/gdom","article-title":"Cognition and addiction","volume":"21","author":"Verdejo-Garcia","year":"2019","journal-title":"Dialogues Clin Neurosci"},{"key":"2022060912213025200_fcac079-B10","volume-title":"Essential Psychopathology and Its Treatment","author":"Kilgus","year":"2015","edition":"4th edn"},{"issue":"1","key":"2022060912213025200_fcac079-B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1192\/bjp.2019.98","article-title":"Are neuropsychiatric symptoms modifiable risk factors for cognitive decline in Alzheimer\u2019s disease and vascular dementia?","volume":"216","author":"Savulich","year":"2020","journal-title":"Br J Psychiatry"},{"key":"2022060912213025200_fcac079-B12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cobeha.2016.09.007","article-title":"Is biological aging accelerated in drug addiction?","volume":"13","author":"Bachi","year":"2017","journal-title":"Curr Opin Behav Sci"},{"issue":"8","key":"2022060912213025200_fcac079-B13","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1360-0443.2011.03433.x","article-title":"Methamphetamine users show greater than normal age-related cortical gray matter loss","volume":"106","author":"Nakama","year":"2011","journal-title":"Addiction"},{"issue":"2","key":"2022060912213025200_fcac079-B14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/mp.2012.31","article-title":"Cocaine dependence: A fast-track for brain ageing","volume":"18","author":"Ersche","year":"2013","journal-title":"Mol Psychiatry"},{"key":"2022060912213025200_fcac079-B15","doi-asserted-by":"crossref","first-page":"101652","DOI":"10.1016\/j.nicl.2019.101652","article-title":"Longitudinal changes in cocaine intake and cognition are linked to cortical thickness adaptations in cocaine users","volume":"21","author":"Hirsiger","year":"2019","journal-title":"NeuroImage Clin"},{"issue":"2","key":"2022060912213025200_fcac079-B16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1176\/appi.ajp.2018.17040415","article-title":"Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects","volume":"176","author":"Mackey","year":"2019","journal-title":"Am J Psychiatry"},{"issue":"4","key":"2022060912213025200_fcac079-B17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/13556210020077073","article-title":"Separate and interactive effects of cocaine and alcohol dependence on brain structures and metabolites: Quantitative MRI and proton MR spectroscopic imaging","volume":"6","author":"O\u2019Neill","year":"2001","journal-title":"Addict Biol"},{"key":"2022060912213025200_fcac079-B18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cobeha.2016.07.006","article-title":"Structural neuroimaging in polysubstance users","volume":"13","author":"Meyerhoff","year":"2017","journal-title":"Curr Opin Behav Sci"},{"key":"2022060912213025200_fcac079-B19","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-800634-4.00086-X","volume-title":"Multimodal Magnetic Resonance Neuroimaging and Cognition in Polysubstance Users","author":"Meyerhoff","year":"2016"},{"issue":"1","key":"2022060912213025200_fcac079-B20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11065-014-9249-6","article-title":"Functional brain connectivity using fMRI in aging and Alzheimer\u2019s disease","volume":"24","author":"Dennis","year":"2014","journal-title":"Neuropsychol Rev"},{"issue":"1","key":"2022060912213025200_fcac079-B21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuron.2017.11.039","article-title":"Morphometric similarity networks detect microscale cortical organization and predict inter-individual cognitive variation","volume":"97","author":"Seidlitz","year":"2018","journal-title":"Neuron"},{"issue":"19","key":"2022060912213025200_fcac079-B22","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1073\/pnas.1820754116","article-title":"Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes","volume":"116","author":"Morgan","year":"2019","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"2022060912213025200_fcac079-B23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1162\/netn_a_00123","article-title":"Clinically feasible brain morphometric similarity network construction approaches with restricted magnetic resonance imaging acquisitions","volume":"4","author":"King","year":"2020","journal-title":"Netw Neurosci"},{"key":"2022060912213025200_fcac079-B24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/7854_2015_5001","article-title":"The Paired Associates Learning (PAL) Test: 30 years of CANTAB translational neuroscience from laboratory to bedside in dementia research","volume":"28","author":"Barnett","year":"2016","journal-title":"Curr Top Behav Neurosci"},{"key":"2022060912213025200_fcac079-B25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fnins.2012.00152","article-title":"The NKI-Rockland sample: A model for accelerating the pace of discovery science in psychiatry","volume":"6","author":"Nooner","year":"2012","journal-title":"Front Neurosci"},{"issue":"2","key":"2022060912213025200_fcac079-B26","doi-asserted-by":"crossref","first-page":"e1040","DOI":"10.1038\/tp.2016.271","article-title":"Disrupted iron regulation in the brain and periphery in cocaine addiction","volume":"7","author":"Ersche","year":"2017","journal-title":"Transl Psychiatry"},{"issue":"2","key":"2022060912213025200_fcac079-B27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biopsych.2012.11.016","article-title":"Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence","volume":"74","author":"Ersche","year":"2013","journal-title":"Biol Psychiatry"},{"issue":"6068","key":"2022060912213025200_fcac079-B28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1126\/science.1214463","article-title":"Abnormal brain structure implicated in stimulant drug addiction","volume":"335","author":"Ersche","year":"2012","journal-title":"Science"},{"issue":"5","key":"2022060912213025200_fcac079-B29","doi-asserted-by":"crossref","first-page":"e570","DOI":"10.1038\/tp.2015.58","article-title":"In the face of threat: Neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence","volume":"5","author":"Ersche","year":"2015","journal-title":"Transl Psychiatry"},{"issue":"7","key":"2022060912213025200_fcac079-B30","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/brain\/awr138","article-title":"Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence","volume":"134","author":"Ersche","year":"2011","journal-title":"Brain"},{"issue":"1","key":"2022060912213025200_fcac079-B31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/adb.12081","article-title":"Overlapping decline in orbitofrontal gray matter volume related to cocaine use and body mass index","volume":"20","author":"Smith","year":"2015","journal-title":"Addict Biol"},{"key":"2022060912213025200_fcac079-B32","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000","edition":"4th edn"},{"issue":"3","key":"2022060912213025200_fcac079-B33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/brain\/111.3.695","article-title":"A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson\u2019s disease","volume":"111","author":"Sahakian","year":"1988","journal-title":"Brain"},{"volume-title":"Cocaine and Crack Cocaine: A Growing Public Health Issue","year":"2007","author":"European Monitoring Centre for Drugs and Drug Addiction","key":"2022060912213025200_fcac079-B34"},{"issue":"5","key":"2022060912213025200_fcac079-B35","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/schbul\/sbt142","article-title":"Accelerated brain aging in schizophrenia and beyond: A neuroanatomical marker of psychiatric disorders","volume":"40","author":"Koutsouleris","year":"2014","journal-title":"Schizophr Bull"},{"issue":"10","key":"2022060912213025200_fcac079-B36","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41593-019-0471-7","article-title":"Common brain disorders are associated with heritable patterns of apparent aging of the brain","volume":"22","author":"Kaufmann","year":"2019","journal-title":"Nat Neurosci"},{"issue":"1","key":"2022060912213025200_fcac079-B37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1369-1600.2008.00129.x","article-title":"Impulsivity as a determinant and consequence of drug use: A review of underlying processes","volume":"14","author":"De Wit","year":"2009","journal-title":"Addict Biol"},{"issue":"7","key":"2022060912213025200_fcac079-B38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/1568026620666200131124608","article-title":"Neurocognitive and psychiatric markers for addiction: Common vs. specific endophenotypes for heroin and amphetamine dependence","volume":"20","author":"Long","year":"2020","journal-title":"Curr Top Med Chem"},{"journal-title":"Treatment and Care for Older Drug Users","year":"2010","author":"European Monitoring Centre for Drugs and Drug Addiction","key":"2022060912213025200_fcac079-B39"},{"key":"2022060912213025200_fcac079-B40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2008.07.060","article-title":"Altered prefrontal function with aging: Insights into age-associated performance decline","volume":"1232","author":"Solbakk","year":"2008","journal-title":"Brain Res"},{"issue":"5","key":"2022060912213025200_fcac079-B41","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.1038\/tp.2013.32","article-title":"Cognitive control dysfunction and abnormal frontal cortex activation in stimulant drug users and their biological siblings","volume":"3","author":"Smith","year":"2013","journal-title":"Transl Psychiatry"},{"issue":"1","key":"2022060912213025200_fcac079-B42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0376-8716(02)00110-2","article-title":"Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men","volume":"68","author":"Fein","year":"2002","journal-title":"Drug Alcohol Depend"},{"issue":"1","key":"2022060912213025200_fcac079-B43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/13803395.2016.1196165","article-title":"Neurocognition and inhibitory control in polysubstance use disorders: Comparison with alcohol use disorders and changes with abstinence","volume":"39","author":"Schmidt","year":"2017","journal-title":"J Clin Exp Neuropsychol"},{"issue":"7","key":"2022060912213025200_fcac079-B44","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/cercor\/bhh032","article-title":"Thinning of the cerebral cortex in aging","volume":"14","author":"Salat","year":"2004","journal-title":"Cereb Cortex"},{"issue":"3","key":"2022060912213025200_fcac079-B45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/cercor\/7.3.268","article-title":"Selective aging of the human cerebral cortex observed in vivo: Differential vulnerability of the prefrontal gray matter","volume":"7","author":"Raz","year":"1997","journal-title":"Cereb Cortex"},{"key":"2022060912213025200_fcac079-B46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/pgmj.2005.036665","article-title":"Ageing and the brain","volume":"82","author":"Peters","year":"2006","journal-title":"Postgr Med J"},{"key":"2022060912213025200_fcac079-B47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3389\/fpsyg.2015.00663","article-title":"Reorganization of brain networks in aging: A review of functional connectivity studies","volume":"6","author":"Sala-Llonch","year":"2015","journal-title":"Front Psychol"},{"issue":"7","key":"2022060912213025200_fcac079-B48","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/cercor\/bhu012","article-title":"A brain-wide study of age-related changes in functional connectivity","volume":"25","author":"Geerligs","year":"2015","journal-title":"Cereb Cortex"},{"key":"2022060912213025200_fcac079-B49","doi-asserted-by":"crossref","first-page":"13629","DOI":"10.1038\/ncomms13629","article-title":"Ageing and brain white matter structure in 3,513 UK Biobank participants","volume":"7","author":"Cox","year":"2016","journal-title":"Nat Commun"},{"issue":"3","key":"2022060912213025200_fcac079-B50","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.neubiorev.2012.12.003","article-title":"Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants?","volume":"37","author":"Mackey","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"2022060912213025200_fcac079-B51","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.biopsych.2008.07.030","article-title":"Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individuals","volume":"65","author":"Tanabe","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"01","key":"2022060912213025200_fcac079-B52","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0006-3223(01)01269-0","article-title":"Decreased gray matter concentration in the insular, cocaine patients","volume":"51","author":"Franklin","year":"2002","journal-title":"Biol Psychiatry"},{"issue":"8","key":"2022060912213025200_fcac079-B53","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awu132","article-title":"The hubs of the human connectome are generally implicated in the anatomy of brain disorders","volume":"137","author":"Crossley","year":"2014","journal-title":"Brain"},{"issue":"6","key":"2022060912213025200_fcac079-B54","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1007\/s11682-019-00090-y","article-title":"Connectivity and morphology of hubs of the cerebral structural connectome are associated with brain resilience in AD- and age-related pathology","volume":"13","author":"Fischer","year":"2019","journal-title":"Brain Imaging Behav"},{"issue":"1","key":"2022060912213025200_fcac079-B55","doi-asserted-by":"crossref","first-page":"e12860","DOI":"10.1111\/adb.12860","article-title":"The gray matter structural connectome and its relationship to alcohol relapse: Reconnecting for recovery","volume":"26","author":"Mueller","year":"2021","journal-title":"Addict Biol"},{"issue":"3","key":"2022060912213025200_fcac079-B56","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1371\/journal.pone.0059645","article-title":"Dissociated grey matter changes with prolonged addiction and extended abstinence in cocaine users","volume":"8","author":"Connolly","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"2022060912213025200_fcac079-B57","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.conb.2013.02.017","article-title":"Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience","volume":"23","author":"Ersche","year":"2013","journal-title":"Curr Opin Neurobiol"},{"issue":"2","key":"2022060912213025200_fcac079-B58","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41380-018-0098-1","article-title":"Brain age and other bodily \u2018ages\u2019: Implications for neuropsychiatry","volume":"24","author":"Cole","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"12","key":"2022060912213025200_fcac079-B59","first-page":"1095","article-title":"Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study","volume":"5","author":"T\u00f8nnesen","year":"2020","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"11","key":"2022060912213025200_fcac079-B60","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1038\/npp.2013.123","article-title":"Inferior frontal cortex modulation with an acute dose of heroin during cognitive control","volume":"38","author":"Schmidt","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"2022060912213025200_fcac079-B61","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2990.2005.00670.x","article-title":"Hyperphosphorylated tau and amyloid precursor protein deposition is increased in the brains of young drug abusers","volume":"31","author":"Ramage","year":"2005","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"11","key":"2022060912213025200_fcac079-B62","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1016\/j.neurobiolaging.2015.07.018","article-title":"Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions","volume":"36","author":"Kovacs","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"5","key":"2022060912213025200_fcac079-B63","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1556-4029.2010.01410.x","article-title":"Cocaine-induced intracerebral hemorrhage in a patient with cerebral amyloid angiopathy","volume":"55","author":"Shvartsbeyn","year":"2010","journal-title":"J Forensic Sci"},{"key":"2022060912213025200_fcac079-B64","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-4933-4-6","article-title":"Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers","volume":"4","author":"Reece","year":"2007","journal-title":"Immun Ageing"},{"issue":"10","key":"2022060912213025200_fcac079-B65","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/lm.042192.116","article-title":"Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: Contributions to development and maintenance of addiction","volume":"23","author":"Kutlu","year":"2016","journal-title":"Learn Mem"},{"issue":"1","key":"2022060912213025200_fcac079-B66","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0896-6273(01)00280-X","article-title":"Human hippocampal neurons predict how well word pairs will be remembered","volume":"30","author":"Cameron","year":"2001","journal-title":"Neuron"},{"issue":"1","key":"2022060912213025200_fcac079-B67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/lm.024554.111","article-title":"Hippocampus is required for paired associate memory with neither delay nor trial uniqueness","volume":"19","author":"Yoon","year":"2012","journal-title":"Learn Mem"},{"issue":"1635","key":"2022060912213025200_fcac079-B68","doi-asserted-by":"crossref","first-page":"20120510","DOI":"10.1098\/rstb.2012.0510","article-title":"Space in the brain: How the hippocampal formation supports spatial cognition","volume":"369","author":"Hartley","year":"2014","journal-title":"Philos Trans R Soc B Biol Sci"},{"issue":"3","key":"2022060912213025200_fcac079-B69","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/nlme.2002.4103","article-title":"Limbic-striatal memory systems and drug addiction","volume":"78","author":"Robbins","year":"2002","journal-title":"Neurobiol Learn Mem"},{"issue":"8","key":"2022060912213025200_fcac079-B70","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41582-018-0031-x","article-title":"Spatial navigation deficits \u2013 the overlooked cognitive fingerprint for incipient Alzheimer pathophysiology?","volume":"14","author":"Coughlan","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2022060912213025200_fcac079-B71","doi-asserted-by":"crossref","first-page":"e013187","DOI":"10.1136\/bmjopen-2016-013187","article-title":"Neuroimaging of inflammation in memory and related other disorders (NIMROD) study protocol: A deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses","volume":"7","author":"Bevan-Jones","year":"2017","journal-title":"BMJ Open"},{"issue":"9","key":"2022060912213025200_fcac079-B72","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1038\/npp.2014.71","article-title":"Cognitive impairment in cocaine users is drug-induced but partially reversible: Evidence from a longitudinal study","volume":"39","author":"Vonmoos","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"2022060912213025200_fcac079-B73","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fpsyt.2019.00213","article-title":"Improvement of emotional empathy and cluster B personality disorder symptoms associated with decreased cocaine use severity","volume":"10","author":"Vonmoos","year":"2019","journal-title":"Front Psychiatry"},{"issue":"5","key":"2022060912213025200_fcac079-B74","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/adb.12403","article-title":"Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: A longitudinal study","volume":"22","author":"Parvaz","year":"2017","journal-title":"Addict Biol"},{"key":"2022060912213025200_fcac079-B75","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pbb.2017.07.013","article-title":"Age and impulsive behavior in drug addiction: A review of past research and future directions","volume":"164","author":"Argyriou","year":"2018","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"2022060912213025200_fcac079-B76","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41380-019-0555-5","article-title":"Identifying biological markers for improved precision medicine in psychiatry","volume":"25","author":"Quinlan","year":"2020","journal-title":"Mol Psychiatry"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcac079\/43113804\/fcac079.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/4\/3\/fcac079\/43989466\/fcac079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/4\/3\/fcac079\/43989466\/fcac079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T12:24:29Z","timestamp":1654777469000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcac079\/6555235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcac079","relation":{},"ISSN":["2632-1297"],"issn-type":[{"type":"electronic","value":"2632-1297"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,3,28]]},"article-number":"fcac079"}}