{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:24:32Z","timestamp":1793337872702,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"crossref","award":["115952"],"award-info":[{"award-number":["115952"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013322","name":"EFPIA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013322","name":"EFPIA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007576","name":"ALFA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007576","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u201cla Caixa\u201d Foundation","award":["100010434"],"award-info":[{"award-number":["100010434"]}]},{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]},{"name":"TriBEKa Imaging Platform"},{"name":"Universities and Research Secretariat"},{"name":"Ministry of Business and Knowledge of the Catalan Government"},{"name":"EPAD"},{"name":"EU\/EFPIA"},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"crossref","award":["115736"],"award-info":[{"award-number":["115736"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>White matter hyperintensities (WMHs) have a heterogeneous aetiology, associated with both vascular risk factors and amyloidosis due to Alzheimer\u2019s disease. While spatial distribution of both amyloid and WM lesions carry important information for the underlying pathogenic mechanisms, the regional relationship between these two pathologies and their joint contribution to early cognitive deterioration remains largely unexplored.<\/jats:p>\n               <jats:p>We included 662 non-demented participants from three Amyloid Imaging to Prevent Alzheimer\u2019s disease (AMYPAD)-affiliated cohorts: EPAD-LCS (N\u2009=\u2009176), ALFA+ (N\u2009=\u2009310), and EMIF-AD PreclinAD Twin60++ (N\u2009=\u2009176). Using PET imaging, cortical amyloid burden was assessed regionally within early accumulating regions (medial orbitofrontal, precuneus, and cuneus) and globally, using the Centiloid method. Regional WMH volume was computed using Bayesian Model Selection. Global associations between WMH, amyloid, and cardiovascular risk scores (Framingham and CAIDE) were assessed using linear models. Partial least square (PLS) regression was used to identify regional associations. Models were adjusted for age, sex, and APOE-e4 status. Individual PLS scores were then related to cognitive performance in 4 domains (attention, memory, executive functioning, and language).<\/jats:p>\n               <jats:p>While no significant global association was found, the PLS model yielded two components of interest. In the first PLS component, a fronto-parietal WMH pattern was associated with medial orbitofrontal\u2013precuneal amyloid, vascular risk, and age. Component 2 showed a posterior WMH pattern associated with precuneus-cuneus amyloid, less related to age or vascular risk. Component 1 was associated with lower performance in all cognitive domains, while component 2 only with worse memory.<\/jats:p>\n               <jats:p>In a large pre-dementia population, we observed two distinct patterns of regional associations between WMH and amyloid burden, and demonstrated their joint influence on cognitive processes. These two components could reflect the existence of vascular-dependent and -independent manifestations of WMH-amyloid regional association that might be related to distinct primary pathophysiology.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac150","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T14:40:42Z","timestamp":1655304042000},"source":"Crossref","is-referenced-by-count":37,"title":["Regional associations of white matter hyperintensities and early cortical amyloid pathology"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9756-881X","authenticated-orcid":false,"given":"Luigi","family":"Lorenzini","sequence":"first","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loes T","family":"Ansems","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora","family":"Lopes Alves","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ingala","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3308-3167","authenticated-orcid":false,"given":"David","family":"V\u00e1llez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jori","family":"Tomassen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Sudre","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing (CMIC), Departments of Medical Physics & Biomedical Engineering and Computer Science, University College London , UK"},{"name":"MRC Unit for Lifelong Health and Ageing - University College London , UK"},{"name":"School of Biomedical Engineering , King\u2019s College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Salvad\u00f3","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona , Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Shekari","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona , Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute) , Barcelona , Spain"},{"name":"Universitat Pompeu Fabra , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Operto","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona , Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute) , Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brugulat-Serrat","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona , Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute) , Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES) , Madrid , Spain"},{"name":"Atlantic Fellow for Equity in Brain Health at the University of California San Francisco , SanFrancisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"S\u00e1nchez-Benavides","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona , Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute) , Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"ten Kate","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"},{"name":"Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-1797","authenticated-orcid":false,"given":"Betty","family":"Tijms","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-0118","authenticated-orcid":false,"given":"Alle Meije","family":"Wink","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk J M M","family":"Mutsaerts","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"den Braber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC , Amsterdam , The Netherlands"},{"name":"Department. of Biological Psychology, Vrije Universiteit Amsterdam, Neuroscience Amsterdam , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC , Amsterdam , The Netherlands"},{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N M","family":"van Berckel","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5564-2025","authenticated-orcid":false,"given":"Juan Domingo","family":"Gispert","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona , Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute) , Barcelona , Spain"},{"name":"Universitat Pompeu Fabra , Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Bioingenier\u00eda, Biomateriales Y Nanomedicina , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"},{"name":"Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-2268","authenticated-orcid":false,"given":"Lyduine E","family":"Collij","sequence":"additional","affiliation":[{"name":"Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EPAD consortium for the ALFA cohort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabella","family":"Beteta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brugulat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Cacciaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Ca\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Deulofeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cumplido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Emilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Fauria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherezade","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Huesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Huguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Marne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Mench\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Pradas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Rodriguez-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleix","family":"Sala-Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"S\u00e1nchez-Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Soteras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vilanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"2022063017470776400_fcac150-B1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(00)03589-3","article-title":"Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)","volume":"357","author":"1. Neuropathology Group. Medical Research Council Cognitive Function and Aging Study","year":"2001","journal-title":"Lancet."},{"key":"2022063017470776400_fcac150-B2","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.STR.27.8.1274","article-title":"Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study","volume":"27","author":"Longstreth","year":"1996","journal-title":"Stroke."},{"key":"2022063017470776400_fcac150-B3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","article-title":"White matter hyperintensities, cognitive impairment and dementia: An update","volume":"11","author":"Prins","year":"2015","journal-title":"Nat Rev Neurol."},{"key":"2022063017470776400_fcac150-B4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"2022063017470776400_fcac150-B5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science."},{"key":"2022063017470776400_fcac150-B6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0962-8924(98)01368-3","article-title":"Tau in Alzheimer\u2019s disease","volume":"8","author":"Mandelkow","year":"1998","journal-title":"Trends Cell Biol."},{"key":"2022063017470776400_fcac150-B7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1212\/WNL.0000000000002923","article-title":"A\/T\/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers","volume":"87","author":"Jack","year":"2016","journal-title":"Neurology."},{"key":"2022063017470776400_fcac150-B8","doi-asserted-by":"crossref","first-page":"e2845","DOI":"10.1212\/WNL.0000000000011029","article-title":"Brain amyloid \u03b2, cerebral small vessel disease, and cognition: A memory clinic study","volume":"95","author":"Saridin","year":"2020","journal-title":"Neurology."},{"key":"2022063017470776400_fcac150-B9","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1007\/s11682-019-00151-2","article-title":"Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals","volume":"14","author":"Brugulat-Serrat","year":"2020","journal-title":"Brain Imaging Behav."},{"key":"2022063017470776400_fcac150-B10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/bpa.12218","article-title":"White matter changes in dementia: Role of impaired drainage of interstitial fluid","volume":"25","author":"Weller","year":"2015","journal-title":"Brain Pathol."},{"key":"2022063017470776400_fcac150-B11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/380168a0","article-title":"beta-Amyloid-mediated vasoactivity and vascular endothelial damage","volume":"380","author":"Thomas","year":"1996","journal-title":"Nature."},{"key":"2022063017470776400_fcac150-B12","article-title":"Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns","author":"P\u00e5lhaugen","year":"2020","journal-title":"J Cereb Blood Flow Metab."},{"key":"2022063017470776400_fcac150-B13","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-021-02376-2","article-title":"Frontal white matter lesions in Alzheimer\u2019s disease are associated with both small vessel disease and AD-associated cortical pathology","author":"McAleese","year":"2021","journal-title":"Acta Neuropathol."},{"key":"2022063017470776400_fcac150-B14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-017-1738-2","article-title":"Parietal white matter lesions in Alzheimer\u2019s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease","volume":"134","author":"McAleese","year":"2017","journal-title":"Acta Neuropathol."},{"key":"2022063017470776400_fcac150-B15","article-title":"Data-driven spatial-temporal subtypes of amyloid-\u03b2 accumulation","author":"Collij","year":"2021","journal-title":"Neurology"},{"key":"2022063017470776400_fcac150-B16","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/alz.12069","article-title":"Quantitative amyloid PET in Alzheimer\u2019s disease: The AMYPAD prognostic and natural history study","volume":"16","author":"Lopes Alves","year":"2020","journal-title":"Alzheimers Dement."},{"key":"2022063017470776400_fcac150-B17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.trci.2016.02.003","article-title":"The ALFA project: A research platform to identify early pathophysiological features of Alzheimer\u2019s disease","volume":"2","author":"Molinuevo","year":"2016","journal-title":"Alzheimers Dement"},{"key":"2022063017470776400_fcac150-B18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13195-018-0406-7","article-title":"The EMIF-AD PreclinAD study: Study design and baseline cohort overview","volume":"10","author":"Konijnenberg","year":"2018","journal-title":"Alzheimers Res Ther."},{"key":"2022063017470776400_fcac150-B19","doi-asserted-by":"crossref","first-page":"e021017","DOI":"10.1136\/bmjopen-2017-021017","article-title":"European prevention of alzheimer\u2019s dementia longitudinal cohort study (EPAD LCS): Study protocol","volume":"8","author":"Solomon","year":"2019","journal-title":"BMJ Open."},{"key":"2022063017470776400_fcac150-B20","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.43.11.2412-a","volume-title":"The Clinical Dementia Rating (CDR): Current Version and Scoring Rules","author":"Morris","year":"1993"},{"key":"2022063017470776400_fcac150-B21","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part I. clinical and neuropsychological assesment of Alzheimer\u2019s disease","volume":"39","author":"Moms","year":"1989","journal-title":"Neurology."},{"key":"2022063017470776400_fcac150-B22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/gps.830","article-title":"Utility of TICS-M for the assessment of cognitive function in older adults","volume":"18","author":"de Jager","year":"2003","journal-title":"Int J Geriatr Psychiatry."},{"key":"2022063017470776400_fcac150-B23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: A preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res."},{"key":"2022063017470776400_fcac150-B24","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1474-4422(06)70537-3","article-title":"Risk score for the prediction of dementia risk in 20 years among middle aged people: A longitudinal, population-based study","volume":"5","author":"Kivipelto","year":"2006","journal-title":"Lancet Neurol."},{"key":"2022063017470776400_fcac150-B25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: The Framingham Heart Study","volume":"117","author":"D\u2019Agostino","year":"2008","journal-title":"Circulation."},{"key":"2022063017470776400_fcac150-B26","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-020-00711-5","article-title":"Prediction of Alzheimer\u2019s disease biomarker status defined by the \u2018ATN framework\u2019 among cognitively healthy individuals: Results from the EPAD longitudinal cohort study","volume":"12","author":"Calvin","year":"2020","journal-title":"Alzheimers Res Ther."},{"key":"2022063017470776400_fcac150-B27","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s00259-020-05174-2","article-title":"Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent","volume":"48","author":"Collij","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2022063017470776400_fcac150-B28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2014.07.003","article-title":"The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET","volume":"11","author":"Klunk","year":"2015","journal-title":"Alzheimers Dement."},{"key":"2022063017470776400_fcac150-B29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13195-019-0478-z","article-title":"Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers","volume":"11","author":"Salvad\u00f3","year":"2019","journal-title":"Alzheimers Res Ther."},{"key":"2022063017470776400_fcac150-B30","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.neuroimage.2009.09.069","article-title":"LEAP: Learning embeddings for atlas propagation","volume":"49","author":"Wolz","year":"2010","journal-title":"Neuroimage."},{"key":"2022063017470776400_fcac150-B31","doi-asserted-by":"crossref","first-page":"e1538","DOI":"10.1212\/WNL.0000000000010256","article-title":"Multitracer model for staging cortical amyloid deposition using PET imaging","volume":"95","author":"Collij","year":"2020","journal-title":"Neurology."},{"key":"2022063017470776400_fcac150-B32","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-018-0460-1","article-title":"Spatial patterns of white matter hyperintensities associated with Alzheimer\u2019s disease risk factors in a cognitively healthy middle-aged cohort","volume":"vol. 11","author":"Salvad\u00f3","year":"2019","journal-title":"Alzheimers Res Ther."},{"key":"2022063017470776400_fcac150-B33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neurobiolaging.2018.02.002","article-title":"White matter hyperintensities and vascular risk factors in monozygotic twins","volume":"66","author":"Ten Kate","year":"2018","journal-title":"Neurobiol Aging."},{"key":"2022063017470776400_fcac150-B34","article-title":"The European Prevention of Alzheimer\u2019s Dementia (EPAD) MRI dataset and processing workflow","author":"Lorenzini","year":"2021","journal-title":"bioRxiv."},{"key":"2022063017470776400_fcac150-B35","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1109\/TMI.2015.2419072","article-title":"Bayesian model selection for pathological neuroimaging data applied to white matter lesion segmentation","volume":"34","author":"Sudre","year":"2015","journal-title":"IEEE Trans Med Imaging."},{"key":"2022063017470776400_fcac150-B36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neurad.2017.10.001","article-title":"Bullseye\u2019s representation of cerebral white matter hyperintensities","volume":"45","author":"Sudre","year":"2018","journal-title":"J. Neuroradiol."},{"key":"2022063017470776400_fcac150-B37","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1109\/TMI.2015.2418298","article-title":"Geodesic information flows: Spatially-variant graphs and their application to segmentation and fusion","volume":"34","author":"Cardoso","year":"2015","journal-title":"IEEE Trans Med Imaging."},{"key":"2022063017470776400_fcac150-B38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/bib\/bbl016","article-title":"Partial least squares: A versatile tool for the analysis of high-dimensional genomic data","volume":"8","author":"Boulesteix","year":"2007","journal-title":"Brief Bioinform."},{"key":"2022063017470776400_fcac150-B39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0169-7439(89)80110-8","article-title":"Interpretation of latent-variable regression models","volume":"7","author":"Kvalheim","year":"1989","journal-title":"Chemometrics Intellig Lab Syst."},{"key":"2022063017470776400_fcac150-B40","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jalz.2017.01.026","article-title":"Associations between amyloid \u03b2 and white matter hyperintensities: A systematic review","volume":"13","author":"Roseborough","year":"2017","journal-title":"Alzheimers Dement."},{"key":"2022063017470776400_fcac150-B41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.nicl.2017.12.006","article-title":"Altered intrinsic and extrinsic connectivity in schizophrenia","volume":"17","author":"Zhou","year":"2018","journal-title":"Neuroimage Clin."},{"key":"2022063017470776400_fcac150-B42","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/brain\/awu393","article-title":"Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly","volume":"138","author":"Vemuri","year":"2015","journal-title":"Brain."},{"key":"2022063017470776400_fcac150-B43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fnagi.2020.00109","article-title":"Clinical features and experimental models of cerebral small vessel disease","volume":"12","author":"Shindo","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"2022063017470776400_fcac150-B44","doi-asserted-by":"crossref","first-page":"116944","DOI":"10.1016\/j.neuroimage.2020.116944","article-title":"White matter hyperintensities are associated with subthreshold amyloid accumulation","volume":"218","author":"Moscoso","year":"2020","journal-title":"Neuroimage."},{"key":"2022063017470776400_fcac150-B45","first-page":"22","article-title":"The neurovascular unit dysfunction in Alzheimer\u2019s disease","author":"Soto-Rojas","year":"2021","journal-title":"Int J Mol Sci."},{"key":"2022063017470776400_fcac150-B46","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbadis.2015.12.016","article-title":"Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer\u2019s disease","volume":"1862","author":"Nelson","year":"2016","journal-title":"Biochim Biophys Acta."},{"key":"2022063017470776400_fcac150-B47","first-page":"14","article-title":"Late-onset Alzheimer disease","volume":"25","author":"Rabinovici","year":"2019","journal-title":"Continuum."},{"key":"2022063017470776400_fcac150-B48","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer\u2019s disease based on multifactorial data-driven analysis","volume":"7","author":"Iturria-Medina","year":"2016","journal-title":"Nat Commun."},{"key":"2022063017470776400_fcac150-B49","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1001\/archneurol.2012.1527","article-title":"Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community","volume":"69","author":"Brickman","year":"2012","journal-title":"Arch Neurol."},{"key":"2022063017470776400_fcac150-B50","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00276-006-0111-2","article-title":"White matter damage of patients with Alzheimer\u2019s disease correlated with the decreased cognitive function","volume":"28","author":"Duan","year":"2006","journal-title":"Surg Radiol Anat."},{"key":"2022063017470776400_fcac150-B51","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3174\/ajnr.A0700","article-title":"Diffusion tensor imaging of normal-appearing white matter in mild cognitive impairment and early Alzheimer disease: Preliminary evidence of axonal degeneration in the temporal lobe","volume":"28","author":"Huang","year":"2007","journal-title":"AJNR Am J Neuroradiol."},{"key":"2022063017470776400_fcac150-B52","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3233\/JAD-170367","article-title":"Low prevalence and clinical effect of vascular risk factors in early-onset alzheimer\u2019s disease","volume":"60","author":"Chen","year":"2017","journal-title":"J Alzheimers Dis."},{"key":"2022063017470776400_fcac150-B53","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1093\/brain\/aws113","article-title":"Amyloid burden and metabolic function in early-onset Alzheimer\u2019s disease: Parietal lobe involvement","volume":"135","author":"Ossenkoppele","year":"2012","journal-title":"Brain."},{"key":"2022063017470776400_fcac150-B54","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11091232","article-title":"Clinical Implications of Amyloid-Beta Accumulation in Occipital Lobes in Alzheimer\u2019s Continuum","volume":"11","author":"Hwang","year":"2021","journal-title":"Brain Sci."},{"key":"2022063017470776400_fcac150-B55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-0035-1555115","article-title":"The impact of age on cognition","volume":"36","author":"Murman","year":"2015","journal-title":"Semin Hear."},{"key":"2022063017470776400_fcac150-B56","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/0271678X17740501","article-title":"Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly","volume":"39","author":"Lampe","year":"2019","journal-title":"J Cereb Blood Flow Metab."},{"key":"2022063017470776400_fcac150-B57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/brain\/awt286","article-title":"Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer\u2019s disease","volume":"137","author":"Lim","year":"2014","journal-title":"Brain."},{"key":"2022063017470776400_fcac150-B58","doi-asserted-by":"crossref","first-page":"11606","DOI":"10.1073\/pnas.1221536110","article-title":"Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer\u2019s disease","volume":"110","author":"Lehmann","year":"2013","journal-title":"Proc Natl Acad Sci. U S A."},{"key":"2022063017470776400_fcac150-B59","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1212\/WNL.0000000000000732","article-title":"Posterior white matter disease distribution as a predictor of amyloid angiopathy","volume":"83","author":"Thanprasertsuk","year":"2014","journal-title":"Neurology."},{"key":"2022063017470776400_fcac150-B60","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00415-011-6218-3","article-title":"Distribution of white matter hyperintensity in cerebral hemorrhage and healthy aging","volume":"259","author":"Zhu","year":"2012","journal-title":"J Neurol."}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcac150\/44080732\/fcac150.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcac150\/44351960\/fcac150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcac150\/44351960\/fcac150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T17:48:19Z","timestamp":1656611299000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcac150\/6608716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcac150","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,5,2]]},"article-number":"fcac150"}}