{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:23:58Z","timestamp":1785111838892,"version":"3.55.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R01NS102279"],"award-info":[{"award-number":["R01NS102279"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mutations in p97\/VCP cause two motor neuron diseases: inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia and familial amyotrophic lateral sclerosis. How p97 mutations lead to motor neuron degeneration is, however, unknown. Here we used patient-derived induced pluripotent stem cells to generate p97 mutant motor neurons. We reduced the genetic background variation by comparing mutant motor neurons to its isogenic wild type lines. Proteomic analysis reveals that p97R155H\/+ motor neurons upregulate several cell cycle proteins at Day 14, but this effect diminishes by Day 20. Molecular changes linked to delayed cell cycle exit are observed in p97 mutant motor neurons. We also find that two p97 inhibitors, CB-5083 and NMS-873, restore some dysregulated protein levels. In addition, two p97 inhibitors and a food and drug administration-approved cyclin-dependent kinase 4\/6 inhibitor, Abemaciclib, can rescue motor neuron death. Overall, we successfully used iPSC-derived motor neurons, identified dysregulated proteome and transcriptome and showed that p97 inhibitors rescue phenotypes in this disease model.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac176","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T16:58:40Z","timestamp":1657126720000},"source":"Crossref","is-referenced-by-count":20,"title":["P97\/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration"],"prefix":"10.1093","volume":"4","author":[{"given":"F","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A","family":"Lopez","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Antoshechkin","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-2186","authenticated-orcid":false,"given":"T F","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, CA 91125 , USA"},{"name":"Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"2022082914285889700_fcac176-B1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.gene.2016.02.042","article-title":"Structure and function of the AAA+ ATPase p97\/Cdc48p","volume":"583","author":"Xia","year":"2016","journal-title":"Gene"},{"key":"2022082914285889700_fcac176-B2","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.4161\/auto.7.9.16489","article-title":"Development of p97 AAA ATPase inhibitors","volume":"7","author":"Chou","year":"2011","journal-title":"Autophagy"},{"key":"2022082914285889700_fcac176-B3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fmolb.2016.00079","article-title":"Mutations in 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