{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:35:07Z","timestamp":1787974507699,"version":"build-2784847793"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIHR Imperial Clinical Research Facility"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites represent a possible target to map the distribution of reactive astrocytes. In this study, we use 11C-BU99008, an imidazoline-2 binding sites-specific PET radioligand, to image reactive astrocytes in vivo in healthy controls and patients with established Parkinson\u2019s disease dementia. Eighteen healthy controls (age: 45\u201378 years) and six patients with Parkinson\u2019s disease dementia (age: 64\u201377 years) had one 11C-BU99008 PET-CT scan with arterial input function. All subjects underwent one 3\u2005T MRI brain scan to facilitate the analysis of the PET data and to capture individual cerebral atrophy. Regional 11C-BU99008 volumes of distribution were calculated for each subject by the two-tissue compartmental modelling. Positive correlations between 11C-BU99008 volumes of distribution values and age were found for all tested regions across the brain within healthy controls (P\u2009&amp;lt;\u20090.05); furthermore, multiple regression indicated that aging affects 11C-BU99008 volumes of distribution values in a region-specific manner. Independent samples t-test indicated that there was no significant group difference in 11C-BU99008 volumes of distribution values between Parkinson\u2019s disease dementia (n\u2009=\u20096; mean age\u2009=\u200971.97\u2009\u00b1\u20094.66 years) and older healthy controls (n\u2009=\u20099; mean age\u2009=\u200971.90\u2009\u00b1\u20095.51 years). Our data set shows that astrogliosis is common with aging in a region-specific manner. However, in this set-up, 11C-BU99008 PET cannot differentiate patients with Parkinson\u2019s disease dementia from healthy controls of similar age.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac199","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T04:37:00Z","timestamp":1660797420000},"source":"Crossref","is-referenced-by-count":16,"title":["Astrogliosis in aging and Parkinson\u2019s disease dementia: a new clinical study with 11C-BU99008 PET"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-3667","authenticated-orcid":false,"given":"Mohamed A","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-3481","authenticated-orcid":false,"given":"Zhou","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"},{"name":"Xiangya Hospital of Central South University , Changsha, Hunan , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gennaro","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P","family":"Lao-Kaim","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim F M","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Calsolaro","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , 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N","family":"Gunn","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Nutt","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-2002","authenticated-orcid":false,"given":"Paul","family":"Edison","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-6141","authenticated-orcid":false,"given":"Paola","family":"Piccini","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, Hammersmith Hospital , London , 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