{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:30:30Z","timestamp":1790461830714,"version":"4.1.0"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["#1060312"],"award-info":[{"award-number":["#1060312"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brain Australia"},{"name":"Brain Foundation"},{"DOI":"10.13039\/100015572","name":"National Imaging Facility","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015572","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Health Research Council"},{"DOI":"10.13039\/100010164","name":"Australian Football League","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010164","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sports-related concussion, a form of mild traumatic brain injury, is characterized by transient disturbances of brain function. There is increasing evidence that functional brain changes may be driven by subtle abnormalities in white matter microstructure, and diffusion MRI has been instrumental in demonstrating these white matter abnormalities in vivo. However, the reported location and direction of the observed white matter changes in mild traumatic brain injury are variable, likely attributable to the inherent limitations of the white matter models used. This cross-sectional study applies an advanced and robust technique known as fixel-based analysis to investigate fibre tract-specific abnormalities in professional Australian Football League players with a recent mild traumatic brain injury. We used the fixel-based analysis framework to identify common abnormalities found in specific fibre tracts in participants with an acute injury (\u226412 days after injury; n\u2009=\u200914). We then assessed whether similar changes exist in subacute injury (&amp;gt;12 days and &amp;lt;3 months after injury; n\u2009=\u200915). The control group was 29 neurologically healthy control participants. We assessed microstructural differences in fibre density and fibre bundle morphology and performed whole-brain fixel-based analysis to compare groups. Subsequent tract-of-interest analyses were performed within five selected white matter tracts to investigate the relationship between the observed tract-specific abnormalities and days since injury and the relationship between these tract-specific changes with cognitive abnormalities. Our whole-brain analyses revealed significant increases in fibre density and bundle cross-section in the acute mild traumatic brain injury group when compared with controls. The acute mild traumatic brain injury group showed even more extensive differences when compared with the subacute injury group than with controls. The fibre structures affected in acute concussion included the corpus callosum, left prefrontal and left parahippocampal white matter. The fibre density and cross-sectional increases were independent of time since injury in the acute injury group, and were not associated with cognitive deficits. Overall, this study demonstrates that acute mild traumatic brain injury is characterized by specific white matter abnormalities, which are compatible with tract-specific cytotoxic oedema. These potential oedematous changes were absent in our subacute mild traumatic brain injury participants, suggesting that they may normalize within 12 days after injury, although subtle abnormalities may persist in the subacute stage. Future longitudinal studies are needed to elucidate individualized recovery after brain injury.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac208","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T02:27:41Z","timestamp":1660703261000},"source":"Crossref","is-referenced-by-count":12,"title":["White matter abnormalities characterize the acute stage of sports-related mild traumatic brain injury"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3945-2293","authenticated-orcid":false,"given":"Remika","family":"Mito","sequence":"first","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health , Melbourne, VIC 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M","family":"Parker","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health , Melbourne, VIC 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-8238","authenticated-orcid":false,"given":"David F","family":"Abbott","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health , Melbourne, VIC 3084 , Australia"},{"name":"Florey Department of Neuroscience and Mental Health, University of Melbourne , Melbourne, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Makdissi","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health , Melbourne, VIC 3084 , Australia"},{"name":"Olympic Park Sports Medicine Centre , Melbourne, VIC 3004 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangor","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Florey Department of Neuroscience and Mental Health, University of Melbourne , Melbourne, VIC 3052 , Australia"},{"name":"Department of Psychology and Neuroscience, Auckland University of Technology (AUT) , Auckland 1010 , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7917-5326","authenticated-orcid":false,"given":"Graeme D","family":"Jackson","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health , Melbourne, VIC 3084 , Australia"},{"name":"Florey Department of Neuroscience and Mental Health, University of Melbourne , Melbourne, VIC 3052 , Australia"},{"name":"Department of Neurology, Austin Health , Melbourne, VIC 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"issue":"Suppl 4","key":"2022082709173408000_fcac208-B1","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1227\/NEU.0000000000000505","article-title":"The new neurometabolic cascade of 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