{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:20:46Z","timestamp":1789788046020,"version":"4.0.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP19K17030"],"award-info":[{"award-number":["JP19K17030"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Labour, and Welfare"},{"name":"Integrated Research on Neuropsychiatric Disorders"},{"name":"Strategic Research"},{"name":"Brain Sciences"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research","award":["80569781"],"award-info":[{"award-number":["80569781"]}]},{"name":"Scientific Research"},{"name":"Innovative Areas","award":["26117002"],"award-info":[{"award-number":["26117002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cognitive and movement processes involved integration of several large-scale brain networks. Central to these integrative processes are connector hubs, brain regions characterized by strong connections with multiple networks. Growing evidence suggests that many neurodegenerative and psychiatric disorders are associated with connector hub dysfunctions. Using a network metric called functional connectivity overlap ratio, we investigated connector hub alterations in Parkinson\u2019s disease. Resting-state functional MRI data from 99 patients (male\/female\u2009=\u200944\/55) and 99 age- and sex-matched healthy controls (male\/female\u2009=\u200939\/60) participating in our cross-sectional study were used in the analysis. We have identified two sets of connector hubs, mainly located in the sensorimotor cortex and cerebellum, with significant connectivity alterations with multiple resting-state networks. Sensorimotor connector hubs have impaired connections primarily with primary processing (sensorimotor, visual), visuospatial, and basal ganglia networks, whereas cerebellar connector hubs have impaired connections with basal ganglia and executive control networks. These connectivity alterations correlated with patients\u2019 motor symptoms. Specifically, values of the functional connectivity overlap ratio of the cerebellar connector hubs were associated with tremor score, whereas that of the sensorimotor connector hubs with postural instability and gait disturbance score, suggesting potential association of each set of connector hubs with the disorder\u2019s two predominant forms, the akinesia\/rigidity and resting tremor subtypes. In addition, values of the functional connectivity overlap ratio of the sensorimotor connector hubs were highly predictive in classifying patients from controls with an accuracy of 75.76%. These findings suggest that, together with the basal ganglia, cerebellar and sensorimotor connector hubs are significantly involved in Parkinson\u2019s disease with their connectivity dysfunction potentially driving the clinical manifestations typically observed in this disorder.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac214","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T17:17:39Z","timestamp":1661015859000},"source":"Crossref","is-referenced-by-count":19,"title":["Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson\u2019s disease"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-6943","authenticated-orcid":false,"given":"Epifanio","family":"Bagarinao","sequence":"first","affiliation":[{"name":"Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine , Nagoya, Aichi, 461\u20138673 \u00a0 Japan"},{"name":"Brain & Mind Research Center, Nagoya University , Nagoya, Aichi, 466\u20138550 \u00a0 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-4377","authenticated-orcid":false,"given":"Kazuya","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Brain & Mind Research Center, Nagoya University , Nagoya, Aichi, 466\u20138550 \u00a0 Japan"},{"name":"Department of Neurology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, 466-8550 \u00a0 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Brain & Mind Research Center, Nagoya University , Nagoya, Aichi, 466\u20138550 \u00a0 Japan"},{"name":"Department of Neurology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, 466-8550 \u00a0 Japan"},{"name":"Department of Neurology, Fujita Health University School of Medicine , Toyoake, Aichi, 470-1192 \u00a0 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