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However, little is understood of the central mechanisms associated with its pain, symptom presentation, and treatment-related resolution. This longitudinal study evaluated carpal tunnel syndrome-related alterations in brain network communication and relationships to behavioural signs of central sensitization before and after carpal tunnel release surgery. We tested the hypothesis that carpal tunnel syndrome is associated with condition- and treatment-related plasticity in brain regions involved in somatosensation. We used quantitative sensory testing and clinical and pain questionnaires to assess sensory and pain function in 25 patients with carpal tunnel syndrome before (18 women, 7 men) and after (n\u2009=\u200916) surgery, and 25 sex- and age-matched healthy controls. We also acquired resting-state functional MRI to determine functional connectivity of two key nodes in the somatosensory system, the thalamus and primary somatosensory cortex. Seed-to-whole brain resting-state static functional connectivity analyses revealed abnormally low functional connectivity for the hand area of the primary somatosensory cortex with the contralateral somatosensory association cortex (supramarginal gyrus) before surgery (P\u2009&amp;lt;\u20090.01). After clinically effective surgery: (i) Primary somatosensory functional connectivity was normalized with the contralateral somatosensory association cortex and reduced with the dorsolateral prefrontal cortex (a region associated with cognitive and emotional modulation of pain) and primary visual areas (P\u2009&amp;lt;\u20090.001) from pre-op levels; and (ii) Functional connectivity of the thalamus with the primary somatosensory and motor cortices was attenuated from pre-op levels (P\u2009&amp;lt;\u20090.001) but did not correlate with temporal summation of pain (a behavioural measure of central sensitization) or clinical measures. This study is the first to reveal treatment-related neuroplasticity in resting-state functional connectivity of the somatosensory system in carpal tunnel syndrome. The findings of dysfunctional resting-state functional connectivity point to aberrant neural synchrony between the brain\u2019s representation of the hand with regions involved in processing and integrating tactile and nociceptive stimuli and proprioception in carpal tunnel syndrome. Aberrant neural communication between the primary somatosensory hand area and the dorsolateral prefrontal cortex could reflect increased attention to pain, paraesthesia, and altered sensation in the hand. Finally, reduced thalamocortical functional connectivity after surgery may reflect central plasticity in response to the resolution of abnormal sensory signals from the periphery. Our findings support the concept of underlying brain contributions to this peripheral neuropathy, specifically aberrant thalamocortical and corticocortical communication, and point to potential central therapeutic targets to complement peripheral treatments.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac237","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T12:25:08Z","timestamp":1663763108000},"source":"Crossref","is-referenced-by-count":10,"title":["Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity"],"prefix":"10.1093","volume":"4","author":[{"given":"Natalie R","family":"Osborne","sequence":"first","affiliation":[{"name":"Krembil Brain Institute, Krembil Research Institute, University Health Network , Toronto, M5T 1M8 , Canada"},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, M5S 1A8 , 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, Krembil Research Institute, University Health Network , Toronto, M5T 1M8 , Canada"},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C","family":"Cheng","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, Krembil Research Institute, University Health Network , Toronto, M5T 1M8 , Canada"},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Rogachov","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, Krembil Research Institute, University Health Network , Toronto, M5T 1M8 , 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