{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:35:55Z","timestamp":1791394555058,"version":"4.3.3"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI044924"],"award-info":[{"award-number":["R01AI044924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21AI144193"],"award-info":[{"award-number":["R21AI144193"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease is the most common form of dementia and recent studies identify a type 1 interferon response in Alzheimer\u2019s disease possibly driving neuro-inflammation and other Alzheimer\u2019s disease pathologies. Loss of adenosine-to-inosine editing of endogenous Alu RNAs results in accumulation of Alu double-stranded RNAs, activation of double-stranded RNA sensors, and induction of interferon and nuclear factor kappa B regulated genes. Here, we investigated if changes in adenosine-to-inosine editing were associated with presence of Alzheimer\u2019s disease in total prefrontal cortex, total hippocampus, cortex vasculature and hippocampus vasculature using available RNA sequencing files. We found similar levels of Alu RNA adenosine-to-inosine editing in cortex and cortex vasculature from individuals with Alzheimer\u2019s disease or normal cognition at the time of death and brain donation. We found modest and substantial loss of adenosine-to-inosine editing in hippocampus and hippocampus vasculature, respectively, in Alzheimer\u2019s disease relative to normal cognition and increased expression of interferon and nuclear factor kappa B regulated genes in hippocampus. Unedited Alu RNAs as found in Alzheimer\u2019s disease hippocampus vasculature were potent innate immune activators while edited Alu RNAs as found in normal cognition hippocampus vasculature were weak innate immune activators. Taken together, our results support a model whereby loss of Alu RNA adenosine-to-inosine editing in hippocampus results in innate immune activation that may contribute to Alzheimer\u2019s disease pathogenesis.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac238","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T16:40:31Z","timestamp":1663692031000},"source":"Crossref","is-referenced-by-count":18,"title":["Reduced RNA adenosine-to-inosine editing in hippocampus vasculature associated with Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"4","author":[{"suffix":"III","given":"Philip S","family":"Crooke","sequence":"first","affiliation":[{"name":"Department of Mathematics, Vanderbilt University , Nashville, TN 37212 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Tossberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krislyn P","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Aune","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"},{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, TN 37212 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"2022100308484105700_fcac238-B1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1101\/gr.164749.113","article-title":"A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes","volume":"24","author":"Bazak","year":"2014","journal-title":"Genome Res"},{"key":"2022100308484105700_fcac238-B2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-017-1315-y","article-title":"Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance","volume":"18","author":"Porath","year":"2017","journal-title":"Genome Biol"},{"key":"2022100308484105700_fcac238-B3","doi-asserted-by":"crossref","first-page":"a035352","DOI":"10.1101\/cshperspect.a035352","article-title":"Mapping the dsRNA World","volume":"11","author":"Reich","year":"2019","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2022100308484105700_fcac238-B4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1101\/gr.162537.113","article-title":"A biochemical landscape of A-to-I RNA editing in the human brain transcriptome","volume":"24","author":"Sakurai","year":"2014","journal-title":"Genome Res"},{"key":"2022100308484105700_fcac238-B5","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1261\/rna.058271.116","article-title":"Single-cell transcriptomics reveals specific RNA editing signatures in the human brain","volume":"23","author":"Picardi","year":"2017","journal-title":"RNA"},{"key":"2022100308484105700_fcac238-B6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm.2015.4","article-title":"A-to-I editing of coding and non-coding RNAs by ADARs","volume":"17","author":"Nishikura","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2022100308484105700_fcac238-B7","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1371\/journal.pbio.0020391","article-title":"Widespread A-to-I RNA editing of alu-containing mRNAs in the human transcriptome","volume":"2","author":"Athanasiadis","year":"2004","journal-title":"PLoS Biol"},{"key":"2022100308484105700_fcac238-B8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/gb-2011-12-12-236","article-title":"Alu elements: Know the SINEs","volume":"12","author":"Deininger","year":"2011","journal-title":"Genome Biol"},{"key":"2022100308484105700_fcac238-B9","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1101\/gr.081737.108","article-title":"Active alu retrotransposons in the human genome","volume":"18","author":"Bennett","year":"2008","journal-title":"Genome Res"},{"key":"2022100308484105700_fcac238-B10","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1073\/pnas.85.13.4775","article-title":"A fundamental division in the alu family of repeated sequences","volume":"85","author":"Jurka","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022100308484105700_fcac238-B11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tig.2007.02.002","article-title":"Evolutionary history of 7SL RNA-derived SINEs in supraprimates","volume":"23","author":"Kriegs","year":"2007","journal-title":"Trends Genet"},{"key":"2022100308484105700_fcac238-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(97)01259-3","article-title":"Alu sequences","volume":"417","author":"Mighell","year":"1997","journal-title":"FEBS Lett"},{"key":"2022100308484105700_fcac238-B13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/312171a0","article-title":"Alu sequences are processed 7sl rna genes","volume":"312","author":"Ullu","year":"1984","journal-title":"Nature"},{"key":"2022100308484105700_fcac238-B14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2017.12.016","article-title":"Breaching self-tolerance to alu Duplex RNA underlies MDA5-mediated inflammation","volume":"172","author":"Ahmad","year":"2018","journal-title":"Cell"},{"key":"2022100308484105700_fcac238-B15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41576-018-0006-1","article-title":"A-to-I RNA editing\u2014Immune protector and transcriptome diversifier","volume":"19","author":"Eisenberg","year":"2018","journal-title":"Nat Rev Genet"},{"key":"2022100308484105700_fcac238-B16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature09830","article-title":"DICER1 Deficit induces alu RNA toxicity in age-related macular degeneration","volume":"471","author":"Kaneko","year":"2011","journal-title":"Nature"},{"key":"2022100308484105700_fcac238-B17","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3389\/fimmu.2019.01763","article-title":"ADAR1: \u201ceditor-in-chief\u201d of cytoplasmic innate immunity","volume":"10","author":"Lamers","year":"2019","journal-title":"Front Immunol"},{"key":"2022100308484105700_fcac238-B18","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.aac7049","article-title":"RNA Editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself","volume":"349","author":"Liddicoat","year":"2015","journal-title":"Science"},{"key":"2022100308484105700_fcac238-B19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nsmb.2934","article-title":"Human cells contain natural double-stranded RNAs with potential regulatory functions","volume":"22","author":"Portal","year":"2015","journal-title":"Nat Struct Mol Biol"},{"key":"2022100308484105700_fcac238-B20","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ng.2414","article-title":"Mutations in ADAR1 cause aicardi-gouti\u00e8res syndrome associated with a type I interferon signature","volume":"44","author":"Rice","year":"2012","journal-title":"Nat Genet"},{"key":"2022100308484105700_fcac238-B21","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1074\/jbc.TM118.004166","article-title":"Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA-triggered innate immune responses","volume":"294","author":"Samuel","year":"2019","journal-title":"J Biol Chem"},{"key":"2022100308484105700_fcac238-B22","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.4049\/jimmunol.1500964","article-title":"Nucleic acid-sensing receptors: Rheostats of autoimmunity and autoinflammation","volume":"195","author":"Sharma","year":"2015","journal-title":"J Immunol"},{"key":"2022100308484105700_fcac238-B23","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.4049\/jimmunol.1401136","article-title":"Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs","volume":"193","author":"Yang","year":"2014","journal-title":"J Immunol"},{"key":"2022100308484105700_fcac238-B24","doi-asserted-by":"crossref","first-page":"818023","DOI":"10.3389\/fimmu.2022.818023","article-title":"Alu RNA structural features modulate immune cell activation and A-to-I editing of alu RNAs is diminished in human inflammatory bowel disease","volume":"13","author":"Aune","year":"2022","journal-title":"Front Immunol."},{"key":"2022100308484105700_fcac238-B25","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.4049\/jimmunol.2001428","article-title":"Cutting edge: Reduced adenosine-to- inosine editing of endogenous alu RNAs in severe COVID-19 disease","volume":"206","author":"Crooke","year":"2021","journal-title":"J Immunol"},{"key":"2022100308484105700_fcac238-B26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.crimmu.2021.04.001","article-title":"Reduced A-to-I editing of endogenous alu RNAs in lung after SARS-CoV-2 infection","volume":"2","author":"Crooke","year":"2021","journal-title":"Curr Res Immunol"},{"key":"2022100308484105700_fcac238-B27","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.4049\/jimmunol.2000384","article-title":"Adenosine-to-Inosine RNA editing of alu double-stranded RNAs is markedly decreased in multiple sclerosis and unedited alu dsRNAs are potent activators of proinflammatory transcriptional responses","volume":"205","author":"Tossberg","year":"2020","journal-title":"J Immunol"},{"key":"2022100308484105700_fcac238-B28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaut.2019.02.003","article-title":"Endogenous double-stranded alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis","volume":"100","author":"Heinrich","year":"2019","journal-title":"J Autoimmun"},{"key":"2022100308484105700_fcac238-B29","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1080\/07315724.2015.1116900","article-title":"Preventing Alzheimer\u2019s disease","volume":"35","author":"Perlmutter","year":"2016","journal-title":"J Am Coll Nutr"},{"key":"2022100308484105700_fcac238-B30","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/d41586-018-05717-6","article-title":"Alzheimer\u2019s disease","volume":"559","author":"Hodson","year":"2018","journal-title":"Nature"},{"key":"2022100308484105700_fcac238-B31","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: The role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"2022100308484105700_fcac238-B32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","article-title":"Blood-Brain barrier breakdown in the aging human hippocampus","volume":"85","author":"Montagne","year":"2015","journal-title":"Neuron"},{"key":"2022100308484105700_fcac238-B33","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat Med"},{"key":"2022100308484105700_fcac238-B34","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"2022100308484105700_fcac238-B35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fncel.2014.00095","article-title":"Why looking at the whole hippocampus is not enough\u2014A critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer\u2019s disease diagnosis","volume":"8","author":"Maruszak","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"2022100308484105700_fcac238-B36","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41586-021-04369-3","article-title":"A human brain vascular atlas reveals diverse mediators of Alzheimer\u2019s risk","volume":"603","author":"Yang","year":"2022","journal-title":"Nature"},{"key":"2022100308484105700_fcac238-B37","doi-asserted-by":"crossref","first-page":"577744","DOI":"10.3389\/fnins.2020.577744","article-title":"Antiviral immune response in Alzheimer\u2019s disease: Connecting the dots","volume":"14","author":"Roy","year":"2020","journal-title":"Front Neurosci-Switz"},{"key":"2022100308484105700_fcac238-B38","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1172\/JCI133737","article-title":"Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease","volume":"130","author":"Roy","year":"2020","journal-title":"J Clin Invest"},{"key":"2022100308484105700_fcac238-B39","doi-asserted-by":"crossref","first-page":"10421","DOI":"10.7554\/eLife.10421","article-title":"Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain","volume":"5","author":"Scheckel","year":"2016","journal-title":"Elife"},{"key":"2022100308484105700_fcac238-B40","doi-asserted-by":"crossref","first-page":"e13407","DOI":"10.1111\/bpa.13047","article-title":"Proteomic analysis of human hippocampal subfields provides new insights into the pathogenesis of Alzheimer\u2019s disease and the role of glial cells","volume":"32","author":"Gao","year":"2022","journal-title":"Brain Pathol"},{"key":"2022100308484105700_fcac238-B41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/WAD.0b013e3181b76415","article-title":"Utility of the CERAD neuropsychological battery total score in the progression of Alzheimer\u2019s disease","volume":"24","author":"Rossetti","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"2022100308484105700_fcac238-B42","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s12864-017-4002-1","article-title":"Evaluation and comparison of computational tools for RNA-seq isoform quantification","volume":"18","author":"Zhang","year":"2017","journal-title":"BMC Genomics"},{"key":"2022100308484105700_fcac238-B43","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1093\/bioinformatics\/btx473","article-title":"SPRINT: An SNP-free toolkit for identifying RNA editing sites","volume":"33","author":"Zhang","year":"2017","journal-title":"Bioinformatics"},{"key":"2022100308484105700_fcac238-B44","doi-asserted-by":"crossref","first-page":"D489","DOI":"10.1093\/nar\/gkh132","article-title":"Alugene: A database of alu elements incorporated within protein-coding genes","volume":"32","author":"Dagan","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2022100308484105700_fcac238-B45","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2022100308484105700_fcac238-B46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2144\/btn-2020-0037","article-title":"A simplified method to produce mRNAs and functional proteins from synthetic double-stranded DNA templates","volume":"69","author":"Tossberg","year":"2020","journal-title":"Biotechniques"},{"key":"2022100308484105700_fcac238-B47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s42003-018-0271-8","article-title":"Regulation of RNA editing by RNA-binding proteins in human cells","volume":"2","author":"Quinones-Valdez","year":"2019","journal-title":"Commun Biol"},{"key":"2022100308484105700_fcac238-B48","doi-asserted-by":"crossref","first-page":"D1040","DOI":"10.1093\/nar\/gks1215","article-title":"INTERFEROME V2.0: An updated database of annotated interferon-regulated genes","volume":"41","author":"Rusinova","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2022100308484105700_fcac238-B49","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","article-title":"Activators and target genes of rel\/NF-kappa B transcription factors","volume":"18","author":"Pahl","year":"1999","journal-title":"Oncogene"},{"key":"2022100308484105700_fcac238-B50","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat Neurosci"},{"key":"2022100308484105700_fcac238-B51","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-Brain barrier: From physiology to disease and back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol Rev"},{"key":"2022100308484105700_fcac238-B52","doi-asserted-by":"crossref","first-page":"108976","DOI":"10.1016\/j.celrep.2021.108976","article-title":"TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response","volume":"35","author":"Dunker","year":"2021","journal-title":"Cell Rep"},{"key":"2022100308484105700_fcac238-B53","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.aac7442","article-title":"The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression","volume":"350","author":"Hung","year":"2015","journal-title":"Science"},{"key":"2022100308484105700_fcac238-B54","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1186\/s13059-015-0629-x","article-title":"Defective structural RNA processing in relapsing-remitting multiple sclerosis","volume":"16","author":"Spurlock","year":"2015","journal-title":"Genome Biol"},{"key":"2022100308484105700_fcac238-B55","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1038\/s41467-021-22491-8","article-title":"Common variants in Alzheimer\u2019s disease and risk stratification by polygenic risk scores","volume":"12","author":"de Rojas","year":"2021","journal-title":"Nat Commun"},{"key":"2022100308484105700_fcac238-B56","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/s41588-021-00921-z","article-title":"A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer\u2019s disease","volume":"53","author":"Wightman","year":"2021","journal-title":"Nat Genet"},{"key":"2022100308484105700_fcac238-B57","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/15476286.2020.1867797","article-title":"Adenosine-to-inosine RNA editing in neurological development and disease","volume":"18","author":"Yang","year":"2021","journal-title":"RNA Biol"},{"key":"2022100308484105700_fcac238-B58","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.3390\/ijms23052484","article-title":"The Complex mechanisms by which neurons die following DNA damage in neurodegenerative diseases","volume":"23","author":"Shadfar","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2022100308484105700_fcac238-B59","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40478-018-0574-5","article-title":"RNA Binding proteins co-localize with small tau inclusions in tauopathy","volume":"6","author":"Maziuk","year":"2018","journal-title":"Acta Neuropathol Com"},{"key":"2022100308484105700_fcac238-B60","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1128\/MCB.01149-10","article-title":"RNA Helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5\u2032 splice site","volume":"31","author":"Kar","year":"2011","journal-title":"Mol Cell Biol"},{"key":"2022100308484105700_fcac238-B61","doi-asserted-by":"crossref","first-page":"742790","DOI":"10.3389\/fnmol.2021.742790","article-title":"Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes","volume":"14","author":"Montalbano","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"2022100308484105700_fcac238-B62","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41592-019-0610-9","article-title":"Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity","volume":"16","author":"Roth","year":"2019","journal-title":"Nat Methods"},{"key":"2022100308484105700_fcac238-B63","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.tcb.2017.01.002","article-title":"ALU Ternative regulation for gene expression","volume":"27","author":"Chen","year":"2017","journal-title":"Trends Cell Biol"},{"key":"2022100308484105700_fcac238-B64","doi-asserted-by":"crossref","first-page":"639369","DOI":"10.3389\/fimmu.2021.639369","article-title":"Common peripheral immunity mechanisms in multiple sclerosis and Alzheimer\u2019s disease","volume":"12","author":"Rossi","year":"2021","journal-title":"Front Immunol"},{"key":"2022100308484105700_fcac238-B65","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.3390\/molecules26175113","article-title":"RNA Dynamics in Alzheimer\u2019s disease","volume":"26","author":"Rybak-Wolf","year":"2021","journal-title":"Molecules"},{"key":"2022100308484105700_fcac238-B66","doi-asserted-by":"crossref","first-page":"24974","DOI":"10.1074\/jbc.M116.737098","article-title":"Ubiquitin-dependent turnover of adenosine deaminase acting on RNA 1 (ADAR1) is required for efficient antiviral activity of type I interferon","volume":"291","author":"Li","year":"2016","journal-title":"J Biol Chem"},{"key":"2022100308484105700_fcac238-B67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2018.03.002","article-title":"Next-generation proteasome inhibitors for cancer therapy","volume":"198","author":"Park","year":"2018","journal-title":"Transl Res"},{"key":"2022100308484105700_fcac238-B68","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/dna.2020.5351","article-title":"AKT-Dependent Phosphorylation of ADAR1p110 and ADAR2 represents a new and important link between cell signaling and RNA editing","volume":"39","author":"Piazzi","year":"2020","journal-title":"DNA Cell Biol"},{"key":"2022100308484105700_fcac238-B69","doi-asserted-by":"crossref","first-page":"9044","DOI":"10.1096\/fj.201800490RR","article-title":"AKT-dependent phosphorylation of the adenosine deaminases ADAR-1 and-2 inhibits deaminase activity","volume":"33","author":"Bavelloni","year":"2019","journal-title":"FASEB J"},{"key":"2022100308484105700_fcac238-B70","doi-asserted-by":"crossref","first-page":"662232","DOI":"10.3389\/fphar.2021.662232","article-title":"AKT Inhibitors: New weapons in the fight against breast cancer?","volume":"12","author":"Martorana","year":"2021","journal-title":"Front Pharmacol"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcac238\/45976117\/fcac238.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/4\/5\/fcac238\/46320488\/fcac238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/4\/5\/fcac238\/46320488\/fcac238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T04:49:52Z","timestamp":1664772592000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcac238\/6711535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcac238","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10,1]]},"published":{"date-parts":[[2022,9,1]]},"article-number":"fcac238"}}