{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:04:32Z","timestamp":1787868272931,"version":"build-2784847793"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Common Fund"},{"name":"Director of the National Institutes of Health"},{"name":"National Cancer Institute"},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Heart"},{"name":"Lung, and Blood Institute"},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union's Horizon 2020","award":["847776"],"award-info":[{"award-number":["847776"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intracranial volume, measured through magnetic resonance imaging and\/or estimated from head circumference, is heritable and correlates with cognitive traits and several neurological disorders. We performed a genome-wide association study meta-analysis of intracranial volume (n = 79 174) and found 64 associating sequence variants explaining 5.0% of its variance. We used coding variation, transcript and protein levels, to uncover 12 genes likely mediating the effect of these variants, including GLI3 and CDK6 that affect cranial synostosis and microcephaly, respectively. Intracranial volume correlates genetically with volumes of cortical and sub-cortical regions, cognition, learning, neonatal and neurological traits. Parkinson\u2019s disease cases have greater and attention deficit hyperactivity disorder cases smaller intracranial volume than controls. Our Mendelian randomization studies indicate that intracranial volume associated variants either increase the risk of Parkinson\u2019s disease and decrease the risk of attention deficit hyperactivity disorder and neuroticism or correlate closely with a confounder.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac271","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T18:26:18Z","timestamp":1666722378000},"source":"Crossref","is-referenced-by-count":9,"title":["Thirty novel sequence variants impacting human intracranial volume"],"prefix":"10.1093","volume":"4","author":[{"given":"Muhammad Sulaman","family":"Nawaz","sequence":"first","affiliation":[{"name":"deCODE genetics\/Amgen Inc. , Sturlugata 8, 102 Reykjavik , Iceland"},{"name":"Faculty of Medicine, School of Health Sciences, University of Iceland , Vatnsmyrarvegur 16, 101 Reykjavik , 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