{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:41Z","timestamp":1772138141755,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIA"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Health and Human Services","award":["1ZIA-NS003154"],"award-info":[{"award-number":["1ZIA-NS003154"]}]},{"name":"Department of Health and Human Services","award":["Z01-AG000949-02"],"award-info":[{"award-number":["Z01-AG000949-02"]}]},{"name":"Department of Health and Human Services","award":["ZO1 AG000535"],"award-info":[{"award-number":["ZO1 AG000535"]}]},{"name":"Department of Health and Human Services","award":["Z01-ES101986"],"award-info":[{"award-number":["Z01-ES101986"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parkinson\u2019s disease is a complex neurodegenerative disorder that is about 1.5 times more prevalent in males than females. Extensive work has been done to identify the genetic risk factors behind Parkinson\u2019s disease on autosomes and more recently on Chromosome X, but work remains to be done on the male-specific Y chromosome. In an effort to explore the role of the Y chromosome in Parkinson\u2019s disease, we analysed whole-genome sequencing data from the Accelerating Medicines Partnership\u2014Parkinson\u2019s disease initiative (1466 cases and 1664 controls), genotype data from NeuroX (3491 cases and 3232 controls) and genotype data from UKBiobank (182 517 controls, 1892 cases and 3783 proxy cases), all consisting of male European ancestry samples. We classified sample Y chromosomes by haplogroup using three different tools for comparison (Snappy, Yhaplo and Y-LineageTracker) and meta-analysed this data to identify haplogroups associated with Parkinson\u2019s disease. This was followed up with a Y-chromosome association study to identify specific variants associated with disease. We also analysed blood-based RNASeq data obtained from the Accelerating Medicines Partnership\u2014Parkinson\u2019s disease initiative (1020 samples) and RNASeq data obtained from the North American Brain Expression Consortium (171 samples) to identify Y-chromosome genes differentially expressed in cases, controls, specific haplogroups and specific tissues. RNASeq analyses suggest Y-chromosome gene expression differs between brain and blood tissues but does not differ significantly in cases, controls or specific haplogroups. Overall, we did not find any strong associations between Y-chromosome genetics and Parkinson\u2019s disease, suggesting the explanation for the increased prevalence in males may lie elsewhere.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac277","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T14:27:43Z","timestamp":1666967263000},"source":"Crossref","is-referenced-by-count":9,"title":["Analysis of Y chromosome haplogroups in Parkinson\u2019s disease"],"prefix":"10.1093","volume":"4","author":[{"given":"Francis P","family":"Grenn","sequence":"first","affiliation":[{"name":"Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-6281","authenticated-orcid":false,"given":"Mary B","family":"Makarious","sequence":"additional","affiliation":[{"name":"Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, MD , USA"},{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology , London , UK"},{"name":"UCL Movement Disorders Centre, University College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Bandres-Ciga","sequence":"additional","affiliation":[{"name":"Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-7885","authenticated-orcid":false,"given":"Hirotaka","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, MD , USA"},{"name":"Center for Alzheimer\u2019s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD , USA"},{"name":"Data Tecnica International , Washington, DC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew B","family":"Singleton","sequence":"additional","affiliation":[{"name":"Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, MD , USA"},{"name":"Center for Alzheimer\u2019s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike A","family":"Nalls","sequence":"additional","affiliation":[{"name":"Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, MD , USA"},{"name":"Center for Alzheimer\u2019s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD , USA"},{"name":"Data Tecnica International , Washington, DC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-8111","authenticated-orcid":false,"given":"Cornelis","family":"Blauwendraat","sequence":"additional","affiliation":[{"name":"Center for Alzheimer\u2019s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD , USA"},{"name":"Integrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The International Parkinson Disease Genomics Consortium (IPDGC)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"issue":"2","key":"2022111516590481300_fcac277-B1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol"},{"issue":"12","key":"2022111516590481300_fcac277-B2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: A meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol"},{"issue":"6","key":"2022111516590481300_fcac277-B3","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1001\/jamaneurol.2020.0428","article-title":"Identification of risk loci for Parkinson disease in Asians and comparison of risk between Asians and Europeans: A genome-wide association study","volume":"77","author":"Foo","year":"2020","journal-title":"JAMA Neurol"},{"issue":"9","key":"2022111516590481300_fcac277-B4","doi-asserted-by":"crossref","first-page":"E881","DOI":"10.3390\/ijerph13090881","article-title":"Environmental exposures and Parkinson\u2019s disease","volume":"13","author":"Nandipati","year":"2016","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"2022111516590481300_fcac277-B5","first-page":"912","article-title":"Exploring causality of the association between smoking and Parkinson\u2019s disease","volume":"48","author":"Gallo","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"10","key":"2022111516590481300_fcac277-B6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/aje\/kwh312","article-title":"Coffee consumption, gender, and Parkinson\u2019s disease mortality in the cancer prevention study II cohort: The modifying effects of estrogen","volume":"160","author":"Ascherio","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"6","key":"2022111516590481300_fcac277-B7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease","volume":"72","author":"Noyce","year":"2012","journal-title":"Ann Neurol"},{"issue":"9","key":"2022111516590481300_fcac277-B8","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1136\/jnnp-2015-312283","article-title":"Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis","volume":"87","author":"Moisan","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2022111516590481300_fcac277-B9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/mds.28312","article-title":"Differences in the presentation and progression of Parkinson\u2019s disease by sex","volume":"36","author":"Iwaki","year":"2021","journal-title":"Mov Disord"},{"issue":"1","key":"2022111516590481300_fcac277-B10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.26090","article-title":"Investigation of autosomal genetic sex differences in Parkinson\u2019s disease","volume":"90","author":"Blauwendraat","year":"2021","journal-title":"Ann Neurol"},{"issue":"1","key":"2022111516590481300_fcac277-B11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ana.26051","article-title":"Common X-chromosome variants are associated with Parkinson disease risk","volume":"90","author":"Le Guen","year":"2021","journal-title":"Ann Neurol"},{"issue":"11","key":"2022111516590481300_fcac277-B12","doi-asserted-by":"crossref","first-page":"E1273","DOI":"10.3390\/genes11111273","article-title":"The Y chromosome: A complex locus for genetic analyses of complex human traits","volume":"11","author":"Parker","year":"2020","journal-title":"Genes (Basel)."},{"key":"2022111516590481300_fcac277-B13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3389\/fgene.2019.00781","article-title":"The challenges of chromosome Y analysis and the implications for chronic kidney disease","volume":"10","author":"Anderson","year":"2019","journal-title":"Front Genet"},{"issue":"3","key":"2022111516590481300_fcac277-B14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00439-008-0620-7","article-title":"Association of Y chromosome haplogroup I with HIV progression, and HAART outcome","volume":"125","author":"Sezgin","year":"2009","journal-title":"Hum Genet"},{"issue":"9819","key":"2022111516590481300_fcac277-B15","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0140-6736(11)61453-0","article-title":"Inheritance of coronary artery disease in men: An analysis of the role of the Y chromosome","volume":"379","author":"Charchar","year":"2012","journal-title":"Lancet Lond Engl"},{"issue":"1","key":"2022111516590481300_fcac277-B16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4238\/2012.January.22.4","article-title":"Association study between Y-chromosome haplogroups and susceptibility to spermatogenic impairment in Han People from southwest China","volume":"12","author":"Ran","year":"2013","journal-title":"Genet Mol Res"},{"issue":"11","key":"2022111516590481300_fcac277-B17","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1161\/ATVBAHA.119.312405","article-title":"Human Y chromosome exerts pleiotropic effects on susceptibility to atherosclerosis","volume":"39","author":"Eales","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"2022111516590481300_fcac277-B18","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/mds.28549","article-title":"Accelerating medicines partnership: Parkinson\u2019s disease. Genetic resource","volume":"36","author":"Iwaki","year":"2021","journal-title":"Mov Disord"},{"key":"2022111516590481300_fcac277-B19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"issue":"7726","key":"2022111516590481300_fcac277-B20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"issue":"3","key":"2022111516590481300_fcac277-B21","doi-asserted-by":"crossref","first-page":"1605.e7","DOI":"10.1016\/j.neurobiolaging.2014.07.028","article-title":"NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases","volume":"36","author":"Nalls","year":"2015","journal-title":"Neurobiol Aging"},{"key":"2022111516590481300_fcac277-B22","first-page":"454736","article-title":"Snappy: Single nucleotide assignment of phylogenetic parameters on the Y chromosome","author":"Severson","year":"2018","journal-title":"bioRxiv"},{"key":"2022111516590481300_fcac277-B23","first-page":"088716","article-title":"Identifying Y-chromosome haplogroups in arbitrarily large samples of sequenced or genotyped men","author":"Poznik","year":"2016","journal-title":"bioRxiv"},{"issue":"1","key":"2022111516590481300_fcac277-B24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12859-021-04057-z","article-title":"Y-LineageTracker: A high-throughput analysis framework for Y-chromosomal next-generation sequencing data","volume":"22","author":"Chen","year":"2021","journal-title":"BMC Bioinf."},{"key":"2022111516590481300_fcac277-B25","author":"International Society of Genetic Genealogy"},{"issue":"22","key":"2022111516590481300_fcac277-B26","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","article-title":"Robust relationship inference in genome-wide association studies","volume":"26","author":"Manichaikul","year":"2010","journal-title":"Bioinforma Oxf Engl"},{"issue":"17","key":"2022111516590481300_fcac277-B27","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1093\/bioinformatics\/btx299","article-title":"Flashpca2: Principal component analysis of Biobank-scale genotype datasets","volume":"33","author":"Abraham","year":"2017","journal-title":"Bioinforma Oxf Engl"},{"key":"2022111516590481300_fcac277-B28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"issue":"17","key":"2022111516590481300_fcac277-B29","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"Metal: Fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinforma Oxf Engl"},{"issue":"16","key":"2022111516590481300_fcac277-B30","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"Annovar: Functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"2022111516590481300_fcac277-B31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000952","article-title":"Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain","volume":"6","author":"Gibbs","year":"2010","journal-title":"PLoS Genet"},{"issue":"D1","key":"2022111516590481300_fcac277-B32","doi-asserted-by":"crossref","first-page":"D916","DOI":"10.1093\/nar\/gkaa1087","article-title":"Gencode 2021","volume":"49","author":"Frankish","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"2022111516590481300_fcac277-B33","doi-asserted-by":"crossref","first-page":"giz074","DOI":"10.1093\/gigascience\/giz074","article-title":"Identifying, understanding, and correcting technical artifacts on the sex chromosomes in next-generation sequencing data","volume":"8","author":"Webster","year":"2019","journal-title":"GigaScience"},{"issue":"1","key":"2022111516590481300_fcac277-B34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"Star: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinforma Oxf Engl"},{"issue":"8","key":"2022111516590481300_fcac277-B35","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkz114","article-title":"The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2022111516590481300_fcac277-B36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"Edger: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinforma Oxf Engl"},{"issue":"2","key":"2022111516590481300_fcac277-B37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsigen.2010.08.020","article-title":"Micro-geographic distribution of Y-chromosomal variation in the central-western European region Brabant","volume":"5","author":"Larmuseau","year":"2011","journal-title":"Forensic Sci Int Genet"},{"key":"2022111516590481300_fcac277-B38","doi-asserted-by":"crossref","first-page":"567309","DOI":"10.3389\/fgene.2020.567309","article-title":"Y-chromosome genetic analysis of modern polish population","volume":"11","author":"Grochowalski","year":"2020","journal-title":"Front Genet"},{"issue":"6","key":"2022111516590481300_fcac277-B39","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ajhg.2008.11.007","article-title":"The genetic legacy of religious diversity and intolerance: Paternal lineages of Christians, Jews, and Muslims in the Iberian Peninsula","volume":"83","author":"Adams","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"6","key":"2022111516590481300_fcac277-B40","doi-asserted-by":"crossref","first-page":"e66499","DOI":"10.1371\/journal.pone.0066499","article-title":"Uniparental genetic heritage of Belarusians: Encounter of rare middle eastern matrilineages with a central European mitochondrial DNA pool","volume":"8","author":"Kushniarevich","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2022111516590481300_fcac277-B41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/molbev\/msm255","article-title":"Excavating past population structures by surname-based sampling: The genetic legacy of the Vikings in northwest England","volume":"25","author":"Bowden","year":"2008","journal-title":"Mol Biol Evol"},{"issue":"2","key":"2022111516590481300_fcac277-B42","doi-asserted-by":"crossref","first-page":"e56775","DOI":"10.1371\/journal.pone.0056775","article-title":"Introducing the Algerian mitochondrial DNA and Y-chromosome profiles into the North African landscape","volume":"8","author":"Bekada","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"2022111516590481300_fcac277-B43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1101\/gr.186684.114","article-title":"A recent bottleneck of Y chromosome diversity coincides with a global change in culture","volume":"25","author":"Karmin","year":"2015","journal-title":"Genome Res"},{"issue":"2","key":"2022111516590481300_fcac277-B44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1101\/gr.217602","article-title":"A nomenclature system for the tree of human Y-chromosomal binary haplogroups","volume":"12","author":"Y Chromosome Consortium","year":"2002","journal-title":"Genome Res"},{"issue":"6","key":"2022111516590481300_fcac277-B45","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1101\/gr.261248.120","article-title":"Quantitative analysis of Y-chromosome gene expression across 36 human tissues","volume":"30","author":"Godfrey","year":"2020","journal-title":"Genome Res"},{"issue":"7","key":"2022111516590481300_fcac277-B46","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1210\/en.2013-2158","article-title":"Transient neuroprotection by SRY upregulation in dopamine cells following injury in males","volume":"155","author":"Czech","year":"2014","journal-title":"Endocrinology"},{"issue":"33","key":"2022111516590481300_fcac277-B47","doi-asserted-by":"crossref","first-page":"16577","DOI":"10.1073\/pnas.1900406116","article-title":"Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson\u2019s disease","volume":"116","author":"Lee","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022111516590481300_fcac277-B48","doi-asserted-by":"crossref","first-page":"119.e3","DOI":"10.1016\/j.neurobiolaging.2020.09.013","article-title":"No relationship between SRY variants and risk of Parkinson\u2019s disease in Chinese population","volume":"100","author":"Pan","year":"2021","journal-title":"Neurobiol Aging"},{"issue":"11","key":"2022111516590481300_fcac277-B49","first-page":"2195","article-title":"Switching on sex: Transcriptional regulation of the testis-determining gene SRY","volume":"141","author":"Larney","year":"2014","journal-title":"Dev Camb Engl"},{"key":"2022111516590481300_fcac277-B50","doi-asserted-by":"crossref","first-page":"147118","DOI":"10.1016\/j.brainres.2020.147118","article-title":"Changes in the metabolic profiles of the serum and putamen in Parkinson\u2019s disease patients\u2014In vitro and in vivo NMR spectroscopy studies","volume":"1748","author":"Toczylowska","year":"2020","journal-title":"Brain Res"},{"key":"2022111516590481300_fcac277-B51","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/1876528900902010020","article-title":"The role of the Y chromosome in brain function","volume":"2","author":"Kopsida","year":"2009","journal-title":"Open Neuroendocrinol J"},{"issue":"3","key":"2022111516590481300_fcac277-B52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0890-8508(92)90025-S","article-title":"Arrangement of DYZ1 and DYZ2 repeats on the human Y-chromosome: A case with presence of DYZ1 and absence of DYZ2","volume":"6","author":"Manz","year":"1992","journal-title":"Mol Cell Probes"},{"issue":"5","key":"2022111516590481300_fcac277-B53","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-2-5-reviews1016","article-title":"Towards a complete sequence of the human Y chromosome","volume":"2","author":"Bachtrog","year":"2001","journal-title":"Genome Biol"},{"issue":"4","key":"2022111516590481300_fcac277-B54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1101\/gr.5155706","article-title":"Novel noncoding RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric CDC2L2","volume":"17","author":"Jehan","year":"2007","journal-title":"Genome Res"},{"issue":"11","key":"2022111516590481300_fcac277-B55","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/pd.1280","article-title":"Y chromosome heterochromatin variation detected at prenatal diagnosis","volume":"25","author":"Cotter","year":"2005","journal-title":"Prenat Diagn"},{"key":"2022111516590481300_fcac277-B56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fnbeh.2018.00215","article-title":"Mice with partial deletion of Y-heterochromatin exhibits stress vulnerability","volume":"12","author":"Dey","year":"2018","journal-title":"Front Behav Neurosci"},{"key":"2022111516590481300_fcac277-B57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1101\/SQB.1951.016.01.004","article-title":"Chromosome organization and genic expression","volume":"16","author":"McClintock","year":"1951","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"2022111516590481300_fcac277-B58","doi-asserted-by":"crossref","first-page":"36665","DOI":"10.1038\/srep36665","article-title":"Sequencing of long stretches of repetitive DNA","volume":"6","author":"De Bustos","year":"2016","journal-title":"Sci Rep"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcac277\/46680228\/fcac277.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/4\/6\/fcac277\/47057066\/fcac277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/4\/6\/fcac277\/47057066\/fcac277.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T12:00:28Z","timestamp":1668513628000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcac277\/6779561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcac277","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.02.28.22271633","asserted-by":"object"}]},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,10,28]]},"article-number":"fcac277"}}