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To date, no consistent locus of injury is associated with this complication. Here, we probed network dynamics and structural alterations in post-stroke depression in four functional circuits linked to major depressive disorder and a visual network, which served as a control network. Forty-four participants with recent stroke (mean age = 69.03, standard deviation age = 8.59, age range = 51\u201386 and gender: female = 10) and 16 healthy volunteers (mean age = 71.53, standard deviation age = 10.62, age range = 51\u201384 and gender: female = 11) were imaged with 3-Tesla structural, diffusion and resting-state functional MRI. The Geriatric Depression Scale was administered to measure depression severity. Associations between depression severity and functional connectivity were investigated within networks seeded from nucleus accumbens, amygdala, dorsolateral prefrontal cortex and primary visual cortex. In addition, the default mode network was identified by connectivity with medial prefrontal cortex and posterior cingulate cortex. Circuits that exhibited altered activity associated with depression severity were further investigated by extracting within-network volumetric and microstructural measures from structural images. In the stroke group, functional connectivity within the nucleus accumbens-seeded network (left hemisphere: P = 0.001; and right hemisphere: P = 0.004) and default mode network (cluster one: P &amp;lt; 0.001; and cluster two: P &amp;lt; 0.001) correlated positively with depressive symptoms. Normal anticorrelations between these two networks were absent in patients with post-stroke depression. Grey matter volume of the right posterior cingulate cortex (Pearson correlation coefficient = \u22120.286, P = 0.03), as well as microstructural measures in the posterior cingulate cortex (right: Pearson correlation coefficient = 0.4, P = 0.024; and left: Pearson correlation coefficient = 0.3, P = 0.048), right medial prefrontal cortex (Pearson correlation coefficient = 0.312, P = 0.039) and the medial forebrain bundle (Pearson correlation coefficient = 0.450, P = 0.003), a major projection pathway interconnecting the nucleus accumbens-seeded network and linking to medial prefrontal cortex, were associated with depression severity. Depression after stroke is marked by reduced mutual inhibition between functional circuits involving nucleus accumbens and default mode network as well as volumetric and microstructural changes within these networks. Aberrant network dynamics present in patients with post-stroke depression are therefore likely to be influenced by secondary, pervasive alterations in grey and white matter, remote from the site of injury.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac281","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T09:44:34Z","timestamp":1667295874000},"source":"Crossref","is-referenced-by-count":17,"title":["Hyperconnectivity and altered interactions of a nucleus accumbens network in post-stroke depression"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-7794","authenticated-orcid":false,"given":"Lena K L","family":"Oestreich","sequence":"first","affiliation":[{"name":"UQ Centre for Clinical Research, The University of Queensland , Brisbane 4072 , Australia"},{"name":"Centre for Advanced Imaging, The University of Queensland , Brisbane 4072 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-6257","authenticated-orcid":false,"given":"Paul","family":"Wright","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department, King\u2019s College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-4580","authenticated-orcid":false,"given":"Michael J","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"UQ Centre for Clinical Research, The University of Queensland , Brisbane 4072 , Australia"},{"name":"Biomedical Engineering Department, King\u2019s College London , London , UK"},{"name":"Department of Neurology, Royal Brisbane and Women\u2019s Hospital , Brisbane 4072 , Australia"},{"name":"Institute of Molecular Bioscience, The University of Queensland , Brisbane 4072 , 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