{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:56:40Z","timestamp":1774907800721,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009406","name":"Centre Hospitalier Universitaire de Nantes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009406","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009371","name":"University of Nantes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009371","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Idiopathic normal pressure hydrocephalus has a complex multifactorial pathogenesis and is associated with Alzheimer\u2019s disease in many patients. To date, it is not well known if a similar association exists with behavioural variant of frontotemporal lobar degeneration. In a first step, we compare the prevalence of idiopathic normal pressure hydrocephalus in two groups of patients, one with behavioural variant of frontotemporal lobar degeneration (n = 69) and the other with Alzheimer\u2019s disease (n = 178). In the second step, we describe more precisely the phenotype of patients with the association of idiopathic normal pressure hydrocephalus and behavioural variant of frontotemporal lobar degeneration. Firstly, we report that the prevalence of idiopathic normal pressure hydrocephalus was far higher in the group of patients with behavioural variant of frontotemporal lobar degeneration than in the group of patients with Alzheimer\u2019s disease (7.25% and 1.1%, respectively, P = 0.02). Secondly, we show that patients with the double diagnosis share common clinical and para-clinical features of both idiopathic normal pressure hydrocephalus and behavioural variant of frontotemporal lobar degeneration patients, including CSF shunting efficacy in real-life experience. Overall, our results suggest a link between these two conditions and should encourage neurologists to look for idiopathic normal pressure hydrocephalus in their behavioural variant of frontotemporal lobar degeneration patients in the event of gait disturbances; the benefit\/risk balance could indeed be in favour of shunt surgery for selected patients with this newly described entity.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac319","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T11:59:23Z","timestamp":1671019163000},"source":"Crossref","is-referenced-by-count":11,"title":["Idiopathic normal pressure hydrocephalus and frontotemporal dementia: an unexpected association"],"prefix":"10.1093","volume":"4","author":[{"given":"Adrien","family":"de Guilhem de Lataillade","sequence":"first","affiliation":[{"name":"Centre d'investigations cliniques, INSERM 1413, CHU Nantes , 44093 Nantes , France"},{"name":"Department of Neurology, CHU Nantes , 44093 Nantes , France"},{"name":"Nantes University , 44093 Nantes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Boutoleau-Bretonni\u00e8re","sequence":"additional","affiliation":[{"name":"Centre d'investigations cliniques, INSERM 1413, CHU Nantes , 44093 Nantes , France"},{"name":"Department of Memory Resource and Research Centre, CHU Nantes , 44093 Nantes , France"},{"name":"Department of Neurology, CHU Nantes , 44093 Nantes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Aguilar-Garcia","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Nantes , 44093 Nantes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Pallardy","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, CHU Nantes , 44093 Nantes , 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Neurology, CHU Nantes , 44093 Nantes , France"},{"name":"Nantes University , 44093 Nantes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5044-2286","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Pouclet-Courtemanche","sequence":"additional","affiliation":[{"name":"Centre d'investigations cliniques, INSERM 1413, CHU Nantes , 44093 Nantes , France"},{"name":"Department of Memory Resource and Research Centre, CHU Nantes , 44093 Nantes , France"},{"name":"Department of Neurology, CHU Nantes , 44093 Nantes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"issue":"2 Dementia","key":"2022122208395577700_fcac319-B1","first-page":"579","article-title":"Diagnosis and treatment of idiopathic normal pressure hydrocephalus","volume":"22","author":"Williams","year":"2016","journal-title":"Continuum (Minneap 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