{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:12:59Z","timestamp":1784002379223,"version":"3.55.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Forefront"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australia program","award":["APP1037746"],"award-info":[{"award-number":["APP1037746"]}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centre of Excellence in Cognition and its Disorders Memory Program","award":["CE110001021"],"award-info":[{"award-number":["CE110001021"]}]},{"name":"NHMRC Senior Research Fellowship","award":["APP1103258"],"award-info":[{"award-number":["APP1103258"]}]},{"name":"ARC Future Fellowship","award":["FT160100096"],"award-info":[{"award-number":["FT160100096"]}]},{"name":"ARC Discovery Project","award":["DP180101548"],"award-info":[{"award-number":["DP180101548"]}]},{"name":"United Kingdom Research and Innovation\u2013Medical Research Council","award":["MR\/R023883\/1"],"award-info":[{"award-number":["MR\/R023883\/1"]}]},{"name":"European Research Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Two common clinical variants of frontotemporal dementia are the behavioural variant frontotemporal dementia, presenting with behavioural and personality changes attributable to prefrontal atrophy, and semantic dementia, displaying early semantic dysfunction primarily due to anterior temporal degeneration. Despite representing independent diagnostic entities, mounting evidence indicates overlapping cognitive\u2013behavioural profiles in these syndromes, particularly with disease progression. Why such overlap occurs remains unclear. Understanding the nature of this overlap, however, is essential to improve early diagnosis, characterization and management of those affected. Here, we explored common cognitive\u2013behavioural and neural mechanisms contributing to heterogeneous frontotemporal dementia presentations, irrespective of clinical diagnosis. This transdiagnostic approach allowed us to ascertain whether symptoms not currently considered core to these two syndromes are present in a significant proportion of cases and to explore the neural basis of clinical heterogeneity. Sixty-two frontotemporal dementia patients (31 behavioural variant frontotemporal dementia and 31 semantic dementia) underwent comprehensive neuropsychological, behavioural and structural neuroimaging assessments. Orthogonally rotated principal component analysis of neuropsychological and behavioural data uncovered eight statistically independent factors explaining the majority of cognitive\u2013behavioural performance variation in behavioural variant frontotemporal dementia and semantic dementia. These factors included Behavioural changes, Semantic dysfunction, General Cognition, Executive function, Initiation, Disinhibition, Visuospatial function and Affective changes. Marked individual-level overlap between behavioural variant frontotemporal dementia and semantic dementia was evident on the Behavioural changes, General Cognition, Initiation, Disinhibition and Affective changes factors. Compared to behavioural variant frontotemporal dementia, semantic dementia patients displayed disproportionate impairment on the Semantic dysfunction factor, whereas greater impairment on Executive and Visuospatial function factors was noted in behavioural variant frontotemporal dementia. Both patient groups showed comparable magnitude of atrophy to frontal regions, whereas severe temporal lobe atrophy was characteristic of semantic dementia. Whole-brain voxel-based morphometry correlations with emergent factors revealed associations between fronto-insular and striatal grey matter changes with Behavioural, Executive and Initiation factor performance, bilateral temporal atrophy with Semantic dysfunction factor scores, parietal-subcortical regions with General Cognitive performance and ventral temporal atrophy associated with Visuospatial factor scores. Together, these findings indicate that cognitive\u2013behavioural overlap (i) occurs systematically in frontotemporal dementia; (ii) varies in a graded manner between individuals and (iii) is associated with degeneration of different neural systems. Our findings suggest that phenotypic heterogeneity in frontotemporal dementia syndromes can be captured along continuous, multidimensional spectra of cognitive\u2013behavioural changes. This has implications for the diagnosis of both syndromes amidst overlapping features as well as the design of symptomatic treatments applicable to multiple syndromes.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac344","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T08:09:32Z","timestamp":1672733372000},"source":"Crossref","is-referenced-by-count":18,"title":["Mapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia"],"prefix":"10.1093","volume":"5","author":[{"given":"Siddharth","family":"Ramanan","sequence":"first","affiliation":[{"name":"Medical Research Council Cognition and Brain Sciences Unit, The University of Cambridge , Cambridge CB3 1AU , UK"},{"name":"Brain and Mind Centre, The University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"School of Psychology, The University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"El-Omar","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Roquet","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"School of Psychology, The University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-8317","authenticated-orcid":false,"given":"Rebekah M","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Memory and Cognition Clinic, Department of Clinical Neurosciences, Royal Prince Alfred Hospital , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Hodges","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"School of Psychology, The University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"School of Medical Sciences, The University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-1440","authenticated-orcid":false,"given":"Olivier","family":"Piguet","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"School of Psychology, The University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5907-2488","authenticated-orcid":false,"given":"Matthew A","family":"Lambon Ralph","sequence":"additional","affiliation":[{"name":"Medical Research Council Cognition and Brain Sciences Unit, The University of Cambridge , Cambridge CB3 1AU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-8169","authenticated-orcid":false,"given":"Muireann","family":"Irish","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"School of Psychology, The University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"issue":"10004","key":"2023011816251179600_fcac344-B1","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"issue":"2","key":"2023011816251179600_fcac344-B2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(10)70299-4","article-title":"Behavioural-variant frontotemporal dementia: Diagnosis, clinical staging, and management","volume":"10","author":"Piguet","year":"2011","journal-title":"Lancet Neurol"},{"issue":"1","key":"2023011816251179600_fcac344-B3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S1355617716000837","article-title":"Longitudinal executive function and episodic memory profiles in behavioral-variant frontotemporal dementia and Alzheimer's disease","volume":"23","author":"Ramanan","year":"2017","journal-title":"J Int Neuropsychol Soc"},{"issue":"4","key":"2023011816251179600_fcac344-B4","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/brain\/awaa057","article-title":"White matter basis for the hub-and-spoke semantic representation: Evidence from semantic dementia","volume":"143","author":"Chen","year":"2020","journal-title":"Brain"},{"issue":"11","key":"2023011816251179600_fcac344-B5","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(07)70266-1","article-title":"Semantic dementia: A unique clinicopathological syndrome","volume":"6","author":"Hodges","year":"2007","journal-title":"Lancet Neurol"},{"issue":"1","key":"2023011816251179600_fcac344-B6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrn.2016.150","article-title":"The neural and computational bases of semantic cognition","volume":"18","author":"Lambon Ralph","year":"2017","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2023011816251179600_fcac344-B7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1590\/S1980-57642013DN70100014","article-title":"A tale of two hemispheres: Contrasting socioemotional dysfunction in right- versus left-lateralised semantic dementia","volume":"7","author":"Irish","year":"2013","journal-title":"Dement Neuropsychol"},{"issue":"10","key":"2023011816251179600_fcac344-B8","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/jnnp-2014-309120","article-title":"Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: An examination of clinical characteristics and emotion processing","volume":"86","author":"Kamminga","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2023011816251179600_fcac344-B9","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1038\/s41467-020-16089-9","article-title":"A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia","volume":"11","author":"Ding","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"2023011816251179600_fcac344-B10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jnnp.2010.212225","article-title":"Clinical, genetic and pathological heterogeneity of frontotemporal dementia: A review","volume":"82","author":"Seelaar","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"2023011816251179600_fcac344-B11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1212\/WNL.0000000000002373","article-title":"Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage","volume":"86","author":"Ranasinghe","year":"2016","journal-title":"Neurology"},{"issue":"7","key":"2023011816251179600_fcac344-B12","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/02687038.2019.1659935","article-title":"Verbal semantics and the left dorsolateral anterior temporal lobe: A longitudinal case of bilateral temporal degeneration","volume":"34","author":"Vonk","year":"2020","journal-title":"Aphasiology"},{"issue":"5","key":"2023011816251179600_fcac344-B13","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/brain\/awaa097","article-title":"Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes","volume":"143","author":"Murley","year":"2020","journal-title":"Brain"},{"issue":"2","key":"2023011816251179600_fcac344-B14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-150806","article-title":"The language profile of behavioral variant frontotemporal dementia","volume":"50","author":"Hardy","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"2023011816251179600_fcac344-B15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cortex.2019.04.027","article-title":"Naming and conceptual understanding in frontotemporal dementia","volume":"120","author":"Snowden","year":"2019","journal-title":"Cortex"},{"key":"2023011816251179600_fcac344-B16","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.neubiorev.2021.10.015","article-title":"Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review","volume":"131","author":"Geraudie","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"2023011816251179600_fcac344-B17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000444848","article-title":"Co-occurrence of language and behavioural change in frontotemporal lobar degeneration","volume":"6","author":"Harris","year":"2016","journal-title":"Dement Geriatr Cogn Dis Extra"},{"issue":"4","key":"2023011816251179600_fcac344-B18","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3233\/JAD-190877","article-title":"Cognitive and behavioral profiles of left and right semantic dementia: Differential diagnosis with behavioral variant frontotemporal dementia and Alzheimer's disease","volume":"72","author":"Pozueta","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"2023011816251179600_fcac344-B19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2147\/NDT.S158996","article-title":"Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: A transdiagnostic approach","volume":"15","author":"Strikwerda-Brown","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"4","key":"2023011816251179600_fcac344-B20","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/brain\/awu003","article-title":"Right anterior temporal lobe dysfunction underlies theory of mind impairments in semantic dementia","volume":"137","author":"Irish","year":"2014","journal-title":"Brain"},{"issue":"9","key":"2023011816251179600_fcac344-B21","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1212\/01.WNL.0000091868.28557.B8","article-title":"Left\/right asymmetry of atrophy in semantic dementia: Behavioral-cognitive implications","volume":"61","author":"Thompson","year":"2003","journal-title":"Neurology"},{"issue":"18","key":"2023011816251179600_fcac344-B22","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/WNL.0000000000002638","article-title":"Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes","volume":"86","author":"Coyle-Gilchrist","year":"2016","journal-title":"Neurology"},{"issue":"9","key":"2023011816251179600_fcac344-B23","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1093\/brain\/awaa225","article-title":"A clinical-radiological framework of the right temporal variant of frontotemporal dementia","volume":"143","author":"Erkoyun","year":"2020","journal-title":"Brain"},{"issue":"18","key":"2023011816251179600_fcac344-B24","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1212\/WNL.0b013e3181bf9945","article-title":"Two distinct subtypes of right temporal variant frontotemporal dementia","volume":"73","author":"Josephs","year":"2009","journal-title":"Neurology"},{"issue":"Pt 5","key":"2023011816251179600_fcac344-B25","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/brain\/awp037","article-title":"The clinical profile of right temporal lobe atrophy","volume":"132","author":"Chan","year":"2009","journal-title":"Brain"},{"issue":"6","key":"2023011816251179600_fcac344-B26","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/brain\/awx115","article-title":"Transdiagnostic neurology: Neuropsychiatric symptoms in neurodegenerative diseases","volume":"140","author":"Husain","year":"2017","journal-title":"Brain"},{"issue":"3","key":"2023011816251179600_fcac344-B27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1037\/ccp0000482","article-title":"Transdiagnostic approaches to mental health problems: Current status and future directions","volume":"88","author":"Dalgleish","year":"2020","journal-title":"J Consult Clin Psychol"},{"key":"2023011816251179600_fcac344-B28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cortex.2016.04.016","article-title":"Using principal component analysis to capture individual differences within a unified neuropsychological model of chronic post-stroke aphasia: Revealing the unique neural correlates of speech fluency, phonology and semantics","volume":"86","author":"Halai","year":"2017","journal-title":"Cortex"},{"issue":"Pt 12","key":"2023011816251179600_fcac344-B29","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1093\/brain\/awu286","article-title":"Capturing multidimensionality in stroke aphasia: Mapping principal behavioural components to neural structures","volume":"137","author":"Butler","year":"2014","journal-title":"Brain"},{"issue":"3","key":"2023011816251179600_fcac344-B30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/psyp.12518","article-title":"The NIMH research domain criteria initiative: Background, issues, and pragmatics","volume":"53","author":"Kozak","year":"2016","journal-title":"Psychophysiology"},{"issue":"10):","key":"2023011816251179600_fcac344-B31","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1093\/brain\/awaa245","article-title":"Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia","volume":"143","author":"Ingram","year":"2020","journal-title":"Brain"},{"issue":"2","key":"2023011816251179600_fcac344-B32","article-title":"Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia","volume":"2","author":"Ramanan","year":"2020","journal-title":"Brain Commun"},{"issue":"Pt 11","key":"2023011816251179600_fcac344-B33","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/brain\/awg236","article-title":"Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer's disease: A cross-sectional and longitudinal study of 55 cases","volume":"126","author":"Lambon Ralph","year":"2003","journal-title":"Brain"},{"key":"2023011816251179600_fcac344-B34","doi-asserted-by":"crossref","first-page":"616764","DOI":"10.3389\/fneur.2020.616764","article-title":"Data-Driven, visual framework for the characterization of aphasias across stroke, post-resective, and neurodegenerative disorders over time","volume":"11","author":"Fan","year":"2020","journal-title":"Front Neurol"},{"issue":"9","key":"2023011816251179600_fcac344-B35","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1093\/brain\/awac208","article-title":"Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia","volume":"145","author":"Ramanan","year":"2022","journal-title":"Brain"},{"issue":"1","key":"2023011816251179600_fcac344-B36","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/s41467-022-29047-4","article-title":"A computational model of neurodegeneration in Alzheimer's disease","volume":"13","author":"Jones","year":"2022","journal-title":"Nat Commun"},{"issue":"8","key":"2023011816251179600_fcac344-B37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41551-020-0593-y","article-title":"Defining and predicting transdiagnostic categories of neurodegenerative disease","volume":"4","author":"Cornblath","year":"2020","journal-title":"Nat Biomed Eng"},{"issue":"Pt 9","key":"2023011816251179600_fcac344-B38","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"issue":"6","key":"2023011816251179600_fcac344-B39","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"issue":"Pt 11","key":"2023011816251179600_fcac344-B40","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/awn234","article-title":"Development of methodology for conducting clinical trials in frontotemporal lobar degeneration","volume":"131","author":"Knopman","year":"2008","journal-title":"Brain"},{"issue":"2","key":"2023011816251179600_fcac344-B41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1590\/S1980-57642009DN20200005","article-title":"The Cambridge Behavioural Inventory revised","volume":"2","author":"Wear","year":"2008","journal-title":"Dement Neuropsychol"},{"issue":"5 Suppl 6","key":"2023011816251179600_fcac344-B42","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1212\/WNL.48.5_Suppl_6.10S","article-title":"The neuropsychiatric inventory: Assessing psychopathology in dementia patients","volume":"48","author":"Cummings","year":"1997","journal-title":"Neurology"},{"issue":"11","key":"2023011816251179600_fcac344-B43","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/gps.1610","article-title":"The Addenbrooke's Cognitive Examination Revised (ACE-R): A brief cognitive test battery for dementia screening","volume":"21","author":"Mioshi","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"key":"2023011816251179600_fcac344-B44","volume-title":"The hidden victims of Alzheimer's disease: Families under stress","author":"Zarit","year":"1985"},{"key":"2023011816251179600_fcac344-B45","volume-title":"RStudio: integrated development for R","year":"2020"},{"key":"2023011816251179600_fcac344-B46","volume-title":"Principal component analysis","author":"Jolliffe","year":"2002","edition":"2nd edn"},{"issue":"3","key":"2023011816251179600_fcac344-B47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"2023011816251179600_fcac344-B48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans Med Imaging"},{"key":"2023011816251179600_fcac344-B49","volume-title":"Non-linear optimisation","author":"Andersson","year":"2007"},{"key":"2023011816251179600_fcac344-B50","volume-title":"Non-linear registration, aka spatial normalisation","author":"Andersson","year":"2007"},{"issue":"8","key":"2023011816251179600_fcac344-B51","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3390\/brainsci11080998","article-title":"Anhedonia in semantic dementia\u2014Exploring right hemispheric contributions to the loss of pleasure","volume":"11","author":"Shaw","year":"2021","journal-title":"Brain Sci."},{"key":"2023011816251179600_fcac344-B52","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/13554794.2021.1924208","article-title":"\u201cMore than words\u201d\u2014Longitudinal linguistic changes in the works of a writer diagnosed with semantic dementia","volume":"27","author":"Hwang","year":"2021","journal-title":"Neurocase"},{"issue":"10)","key":"2023011816251179600_fcac344-B53","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1093\/brain\/awab165","article-title":"Beyond the average patient: How neuroimaging models can address heterogeneity in dementia","volume":"144","author":"Verdi","year":"2021","journal-title":"Brain"},{"issue":"2","key":"2023011816251179600_fcac344-B54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbr.2012.08.003","article-title":"Neuroanatomical correlates of behavioural phenotypes in behavioural variant of frontotemporal dementia","volume":"235","author":"Borroni","year":"2012","journal-title":"Behav Brain Res"},{"issue":"4","key":"2023011816251179600_fcac344-B55","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.neuroimage.2004.10.023","article-title":"Neural correlates of semantic and behavioural deficits in frontotemporal dementia","volume":"24","author":"Williams","year":"2005","journal-title":"Neuroimage"},{"issue":"8):","key":"2023011816251179600_fcac344-B56","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/brain\/awy123","article-title":"A new framework for conceptualizing symptoms in frontotemporal dementia: From animal models to the clinic","volume":"141","author":"Wong","year":"2018","journal-title":"Brain"},{"key":"2023011816251179600_fcac344-B57","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/jnnp-2017-316277","article-title":"Apathy: A neurocircuitry model based on frontotemporal dementia","volume":"89","author":"Ducharme","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"2023011816251179600_fcac344-B58","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/1073858411410354","article-title":"Frontotemporal dementia: What can the behavioral variant teach us about human brain organization?","volume":"18","author":"Seeley","year":"2012","journal-title":"Neuroscientist"},{"issue":"6","key":"2023011816251179600_fcac344-B59","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00415-011-6300-x","article-title":"Executive dysfunction in frontotemporal dementia is related to abnormalities in frontal white matter tracts","volume":"259","author":"Tartaglia","year":"2012","journal-title":"J Neurol"},{"issue":"5","key":"2023011816251179600_fcac344-B60","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/awab032","article-title":"Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia","volume":"144","author":"Shaw","year":"2021","journal-title":"Brain"},{"issue":"Pt 7","key":"2023011816251179600_fcac344-B61","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1093\/brain\/awr119","article-title":"Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story","volume":"134","author":"Acosta-Cabronero","year":"2011","journal-title":"Brain"},{"key":"2023011816251179600_fcac344-B62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bandl.2019.04.006","article-title":"A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia","volume":"194","author":"Ash","year":"2019","journal-title":"Brain Lang"},{"issue":"1","key":"2023011816251179600_fcac344-B63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tics.2012.10.011","article-title":"The ventral visual pathway: An expanded neural framework for the processing of object quality","volume":"17","author":"Kravitz","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"2023011816251179600_fcac344-B64","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cortex.2017.08.024","article-title":"Semantic dementia and the left and right temporal lobes","volume":"107","author":"Snowden","year":"2018","journal-title":"Cortex"},{"key":"2023011816251179600_fcac344-B65","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuroimage.2016.03.032","article-title":"Disease-specific patterns of cortical and subcortical degeneration in a longitudinal study of Alzheimer's disease and behavioural-variant frontotemporal dementia","volume":"151","author":"Landin-Romero","year":"2017","journal-title":"Neuroimage"},{"issue":"Pt 9","key":"2023011816251179600_fcac344-B66","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awv191","article-title":"The behavioural\/dysexecutive variant of Alzheimer's disease: Clinical, neuroimaging and pathological features","volume":"138","author":"Ossenkoppele","year":"2015","journal-title":"Brain"},{"issue":"1","key":"2023011816251179600_fcac344-B67","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa068","article-title":"Progressive dysexecutive syndrome due to Alzheimer's disease: A description of 55 cases and comparison to other phenotypes","volume":"2","author":"Townley","year":"2020","journal-title":"Brain Commun"},{"key":"2023011816251179600_fcac344-B68","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.nicl.2018.02.019","article-title":"Thalamic atrophy in frontotemporal dementia\u2014Not just a C9orf72 problem","volume":"18","author":"Bocchetta","year":"2018","journal-title":"Neuroimage Clin"},{"issue":"1","key":"2023011816251179600_fcac344-B69","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/WAD.0b013e31824a7df4","article-title":"Patterns of striatal degeneration in frontotemporal dementia","volume":"27","author":"Halabi","year":"2013","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"3","key":"2023011816251179600_fcac344-B70","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab158","article-title":"Looking beneath the surface: The importance of subcortical structures in frontotemporal dementia","volume":"3","author":"Bocchetta","year":"2021","journal-title":"Brain Commun"},{"issue":"11","key":"2023011816251179600_fcac344-B71","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"issue":"11):","key":"2023011816251179600_fcac344-B72","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1093\/brain\/awac217","article-title":"Right temporal lobe and socioemotional semantics: Semantic behavioural variant frontotemporal dementia","volume":"145","author":"Younes","year":"2022","journal-title":"Brain"},{"issue":"Pt 1","key":"2023011816251179600_fcac344-B73","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/brain\/awp248","article-title":"Semantic dementia: Demography, familial factors and survival in a consecutive series of 100 cases","volume":"133","author":"Hodges","year":"2010","journal-title":"Brain"},{"issue":"8","key":"2023011816251179600_fcac344-B74","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/jnnp-2013-306948","article-title":"New criteria for frontotemporal dementia syndromes: Clinical and pathological diagnostic implications","volume":"85","author":"Chare","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"21","key":"2023011816251179600_fcac344-B75","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1212\/WNL.0b013e3181feb2e8","article-title":"Imaging correlates of pathology in corticobasal syndrome","volume":"75","author":"Whitwell","year":"2010","journal-title":"Neurology"},{"key":"2023011816251179600_fcac344-B76","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1007\/s11682-019-00150-3","article-title":"Neuroanatomical correlates of apathy and disinhibition in behavioural variant frontotemporal dementia","volume":"14","author":"Sheelakumari","year":"2019","journal-title":"Brain Imaging Behav"},{"issue":"11)","key":"2023011816251179600_fcac344-B77","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1136\/jnnp-2014-308350","article-title":"Neuronal network disintegration: Common pathways linking neurodegenerative diseases","volume":"87","author":"Ahmed","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2023011816251179600_fcac344-B78","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cortex.2022.07.014","article-title":"Efficient and effective assessment of deficits and their neural bases in stroke aphasia","volume":"155","author":"Halai","year":"2022","journal-title":"Cortex"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcac344\/48497482\/fcac344.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/1\/fcac344\/48757057\/fcac344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/1\/fcac344\/48757057\/fcac344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T11:26:24Z","timestamp":1674041184000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcac344\/6969394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,29]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcac344","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.10.29.21265655","asserted-by":"object"}]},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,12,29]]},"article-number":"fcac344"}}