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Post-mortem studies suggest that alterations in synaptic proteins are associated with cognitive decline in Alzheimer\u2019s disease. We measured the concentration of three synaptic proteins, zinc transporter protein 3, dynamin1 and AMPA glutamate receptor 3 in cerebrospinal fluid of subjects with mild cognitive impairment (n = 18) and Alzheimer\u2019s disease (n = 18) and compared the levels to cognitively and neurologically healthy controls (n = 18) by using ELISA assay. In addition, we aimed to assess the translational potential of these synaptic proteins in two established amyloid precursor protein knock-in Alzheimer\u2019s disease mouse models by assessing the cerebrospinal fluid, hippocampal and cortical synaptic protein concentrations. Using ELISA, we measured in parallel these three proteins in cerebrospinal fluid and\/or brain of 12- and 24-month-old AppNL-F and AppNL-G-F knock-in mice and AppWt control mice. The regional distribution and expression of these proteins were explored upon aging of the App knock-in models by quantitative immunofluorescence microscopy. Notably, we found a significant increase in concentrations of zinc transporter protein 3 and AMPA glutamate receptor 3 in cerebrospinal fluid of both patient groups compared with cognitively healthy controls. Dynamin1 concentration was significantly higher in Alzheimer\u2019s disease patients. Remarkably, patients with mild cognitive impairment who converted to Alzheimer\u2019s disease (n = 7) within 2 years exhibited elevated baseline cerebrospinal fluid zinc transporter protein 3 concentrations compared with mild cognitive impairment patients who did not convert (n = 11). Interestingly, similar to the alterations in Alzheimer\u2019s disease subjects, cerebrospinal fluid AMPA glutamate receptor 3 concentration was significantly higher in AppNL-G-F knock-in mice when compared with wild-type controls. Furthermore, we have detected age and brain regional specific changes of the three synaptic proteins in the hippocampus and prefrontal cortex of both AppNL-F and AppNL-G-F knock-in mice. Notably, all the three cerebrospinal fluid synaptic protein concentrations correlated negatively with concentrations in hippocampal lysates. The elevated zinc transporter protein 3 concentrations in the cerebrospinal fluid of converter versus non-converter mild cognitive impairment patients suggests a prospective role of zinc transporter 3 in differentiating dementia patients of the biological continuum of Alzheimer\u2019s disease. The increased cerebrospinal fluid concentrations of synaptic proteins in both patient groups, potentially reflecting synaptic alterations in the brain, were similarly observed in the amyloid precursor protein knock-in mouse models highlighting the translational potential of these proteins as markers for synaptic alterations. These synaptic markers could potentially help reduce the current disparities between human and animal model-based studies aiding the translation of preclinical discoveries of pathophysiological changes into clinical research.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad001","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T03:18:23Z","timestamp":1673147903000},"source":"Crossref","is-referenced-by-count":3,"title":["Translational potential of synaptic alterations in Alzheimer\u2019s disease patients and amyloid precursor protein knock-in mice"],"prefix":"10.1093","volume":"5","author":[{"given":"Dina","family":"Medina-Vera","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga , M\u00e1laga 29010 , Spain"},{"name":"Facultad de Ciencias, Universidad de M\u00e1laga , M\u00e1laga 29010 , Spain"},{"name":"Facultad de Medicina, Universidad de M\u00e1laga , M\u00e1laga 29010 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Enache","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet , 17164 Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Tambaro","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet , 17164 Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethar","family":"Abuhashish","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet , 17164 Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rosell-Valle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga , M\u00e1laga 29010 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet , 17164 Solna , Sweden"},{"name":"Theme Inflammation and Aging, Karolinska University Hospital , 17164 Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga , M\u00e1laga 29010 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0373-7417","authenticated-orcid":false,"given":"Erika","family":"Bereczki","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet , 17164 Solna , Sweden"},{"name":"Department of Microbiology, Tumor and Cell Biology & National Pandemic Center, Karolinska Institutet , 17177 Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet , 17164 Solna , 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