{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:41:28Z","timestamp":1782974488954,"version":"3.54.5"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Seventh Framework Programme"},{"name":"Huntington\u2019s Disease"},{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Brain Repair and Intracranial Neurotherapeutics (BRAIN) Unit"},{"DOI":"10.13039\/100015846","name":"Welsh Government","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015846","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012068","name":"Health and Care Research Wales","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012068","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cognitive deficits represent a hallmark of neurodegenerative diseases, but evaluating their progression is complex. Most current evaluations involve lengthy paper-and-pencil tasks which are subject to learning effects dependent on the mode of response (motor or verbal), the countries\u2019 language or the examiners. To address these limitations, we hypothesized that applying neuroscience principles may offer a fruitful alternative. We thus developed the SelfCog, a digitized battery that tests motor, executive, visuospatial, language and memory functions in 15\u2005min. All cognitive functions are tested according to the same paradigm, and a randomization algorithm provides a new test at each assessment with a constant level of difficulty.<\/jats:p><jats:p>Here, we assessed its validity, reliability and sensitivity to detect decline in early-stage Huntington\u2019s disease in a prospective and international multilingual study (France, the UK and Germany). Fifty-one out of 85 participants with Huntington\u2019s disease and 40 of 52 healthy controls included at baseline were followed up for 1 year. Assessments included a comprehensive clinical assessment battery including currently standard cognitive assessments alongside the SelfCog. We estimated associations between each of the clinical assessments and SelfCog using Spearman\u2019s correlation and proneness to retest effects and sensitivity to decline through linear mixed models. Longitudinal effect sizes were estimated for each cognitive score. Voxel-based morphometry and tract-based spatial statistics analyses were conducted to assess the consistency between performance on the SelfCog and MRI 3D-T1 and diffusion-weighted imaging in a subgroup that underwent MRI at baseline and after 12 months.<\/jats:p><jats:p>The SelfCog detected the decline of patients with Huntington\u2019s disease in a 1-year follow-up period with satisfactory psychometric properties. Huntington\u2019s disease patients are correctly differentiated from controls. The SelfCog showed larger effect sizes than the classical cognitive assessments. Its scores were associated with grey and white matter damage at baseline and over 1 year. Given its good performance in longitudinal analyses of the Huntington\u2019s disease cohort, it should likely become a very useful tool for measuring cognition in Huntington\u2019s disease in the future. It highlights the value of moving the field along the neuroscience principles and eventually applying them to the evaluation of all neurodegenerative diseases.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad043","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T06:02:44Z","timestamp":1678168964000},"source":"Crossref","is-referenced-by-count":6,"title":["A new approach to digitized cognitive monitoring: validity of the SelfCog in Huntington\u2019s disease"],"prefix":"10.1093","volume":"5","author":[{"given":"Marine","family":"Lunven","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hernandez Dominguez","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Youssov","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hamet Bagnou","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafika","family":"Fliss","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Vandendriessche","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanche","family":"Bapst","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, AP-HP, Henri Mondor University Hospital , 94010 Cre\u0301teil , France"},{"name":"Faculty of Medicine, Universit\u00e9 Paris Est Cr\u00e9teil , F-94010 Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a","family":"Morgado","sequence":"additional","affiliation":[{"name":"Inserm, Centre d\u2019Investigation Clinique 1430, APHP, H\u00f4pital Henri Mondor , 94010 Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Remy","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Schubert","sequence":"additional","affiliation":[{"name":"George Huntington Institute, Technology-Park , 48149 Muenster , Germany"},{"name":"Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen , 72076 Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Reilmann","sequence":"additional","affiliation":[{"name":"George Huntington Institute, Technology-Park , 48149 Muenster , Germany"},{"name":"Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen , 72076 Tuebingen , Germany"},{"name":"Department of Clinical Radiology, University of Muenster , 48149 Muenster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Busse","sequence":"additional","affiliation":[{"name":"Centre for Trials Research, Cardiff University , Cardiff CF14 4EP , UK"},{"name":"Wales Brain Research And Intracranial Neurotherapeutics (BRAIN) Biomedical Research Unit, College of Biomedical and Life Sciences, Cardiff University , Cardiff CF14 4EP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Craufurd","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine, St Mary\u2019s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester M13 9PL , UK"},{"name":"Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester M13 9PL , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Massart","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , 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CF10 3AX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Catherine","family":"Bachoud-L\u00e9vi","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole normale sup\u00e9rieure, PSL University , 75005 Paris , France"},{"name":"University Paris Est Creteil, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe NeuroPsychologie Interventionnelle , F-94010 Creteil , France"},{"name":"AP-HP, H\u00f4pital Henri Mondor-Albert Chenevier, Centre de r\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie , F-94010 Cr\u00e9teil , France"},{"name":"NeurATRIS, H\u00f4pital Henri Mondor , 94010 Cre\u0301teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"2023031609444915300_","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s004150050299","article-title":"Early diagnosis of dementia: 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