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Obesity is also associated with structural and functional alterations in the brain, and this condition has been shown to increase the risk of Alzheimer\u2019s disease. However, while obesity has been associated with neurodegenerative processes, its impact on brain cell composition remains to be determined. In the current study, we used the isotropic fractionator method to determine the absolute composition of neuronal and non-neuronal cells in different brain regions of the genetic mouse models of obesity Lepob\/ob and LepRNull\/Null. Our results show that 10- to 12-month-old female Lepob\/ob and LepRNull\/Null mice have reduced neuronal number and density in the hippocampus compared to C57BL\/6 wild-type mice. Furthermore, LepRNull\/Null mice have increased density of non-neuronal cells, mainly glial cells, in the hippocampus, frontal cortex and hypothalamus compared to wild-type or Lepob\/ob mice, indicating enhanced inflammatory responses in different brain regions of the LepRNull\/Null model. Collectively, our findings suggest that obesity might cause changes in brain cell composition that are associated with neurodegenerative and inflammatory processes in different brain regions of female mice.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad059","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T23:14:47Z","timestamp":1679440487000},"source":"Crossref","is-referenced-by-count":16,"title":["Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity"],"prefix":"10.1093","volume":"5","author":[{"given":"Mayara M","family":"Andrade","sequence":"first","affiliation":[{"name":"Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro , Rio de Janeiro 21941-902 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro , Rio de Janeiro 21941-902 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Forny-Germano","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro , Rio de Janeiro 21941-902 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaella A","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience Studies, Departments of Biomedical and Molecular Sciences and Psychiatry, Queen\u2019s University , Kingston, ON K7L 3N6 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Gomes","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Rio de Janeiro , Rio de Janeiro 21941-902 , 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Humberto","family":"Andrade-Moraes","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Federal University of Rio de Janeiro , Maca\u00e9 27930-560 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jose","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo , S\u00e3o Paulo 05508-000 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-0589","authenticated-orcid":false,"given":"Fernanda G","family":"De Felice","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro , Rio de Janeiro 21941-902 , Brazil"},{"name":"Centre for Neuroscience Studies, Departments of Biomedical and Molecular Sciences and Psychiatry, Queen\u2019s University , Kingston, ON K7L 3N6 , 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